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The quality and clinical translation of radiomics studies based on MRI for predicting Ki-67 levels in patients with breast cancer
CONCLUSION: Ki-67 index is a common tumor biomarker with high clinical value. Radiomics is an ever-growing quantitative data-mining method helping predict tumor biomarkers from medical images. However, the quality of the reviewed studies evaluated by the RQS was not so satisfactory and there are ample opportunities for improvement. Open science and data, external validation, phantom study, publicly open radiomics database and standardization in the radiomics practice are what researchers should pay more attention to in the future.ADVANCES IN KNOWLEDGE: The RQS tool considered the radiomics used to predict the Ki-67 level w...
Source: The British Journal of Radiology - September 19, 2023 Category: Radiology Authors: Min Wang Ting Mei Youling Gong Source Type: research

Cephalochordate Hemocytes: First Demonstration for < em > Asymmetron lucayanum < /em > (Bahamas Lancelet) Plus Augmented Description for < em > Branchiostoma floridae < /em > (Florida Amphioxus)
Biol Bull. 2023 Apr;244(2):71-81. doi: 10.1086/726774. Epub 2023 Aug 16.ABSTRACTAbstractWithin phylum Chordata, the subphylum Cephalochordata (amphioxus and lancelets) has figured large in considerations of the evolutionary origin of the vertebrates. To date, these discussions have been predominantly based on knowledge of a single cephalochordate genus (Branchiostoma), almost to the exclusion of the other two genera (Asymmetron and Epigonichthys). This uneven pattern is illustrated by cephalochordate hematology, until now known entirely from work done on Branchiostoma. The main part of the present study is to describe hemo...
Source: The Biological Bulletin - September 19, 2023 Category: Biology Authors: Nicholas D Holland Linda Z Holland Source Type: research

Point-of-care AI-assisted stepwise ultrasound pneumothorax diagnosis
Phys Med Biol. 2023 Sep 19. doi: 10.1088/1361-6560/acfb70. Online ahead of print.ABSTRACTUltrasound is extensively utilized as a convenient and costeffective method in emergency situations. Unfortunately, the limited availability of skilled clinicians in emergency hinders the wider adoption of point-of-care ultrasound. To overcome this challenge, this paper aims to aid less experienced healthcare providers in emergency lung ultrasound scans.&#xD;Approach: To assist healthcare providers, it is important to have a comprehensive model that can automatically guide the entire process of lung ultrasound based on the clinicia...
Source: Physics in Medicine and Biology - September 19, 2023 Category: Physics Authors: Kyungsang Kim Fabiola Macruz Dufan Wu Christopher Bridge Suzannah McKinney Ahad Alhassan Al Saud Elshaimaa Sharaf Adam Pely Paul Danset Tom Duffy Davin Dhatt Varun Buch Andrew Liteplo Quanzheng Li Source Type: research

Apoptin NLS2 homodimerization strategy for improved antibacterial activity and bio-stability
In conclusion, these results suggest that nuclear localization sequence with a modified dimeric approach could represent a rich source of template for designing future antimicrobial peptides.PMID:37725185 | DOI:10.1007/s00726-023-03321-1
Source: Amino Acids - September 19, 2023 Category: Biochemistry Authors: Anu Kumari Mahavir Singh Ruchi Sharma Tarun Kumar Naresh Jindal Sushila Maan Vinay G Joshi Source Type: research

The biocide triclosan as a potential developmental disruptor in Mytilus early larvae
Environ Sci Pollut Res Int. 2023 Sep 20. doi: 10.1007/s11356-023-29854-2. Online ahead of print.ABSTRACTThe broadly utilized biocide triclosan (TCS) is continuously discharged in water compartments worldwide, where it is detected at concentrations of ng-µg/L. Given its lipophilicity and bioaccumulation, TCS is considered potentially harmful to human and environmental health and also as a potential endocrine disruptor (ED) in different species. In aquatic organisms, TCS can induce a variety of effects: however, little information is available on its possible impact on invertebrate development. Early larval stages of the ma...
Source: Environmental Science and Pollution Research International - September 19, 2023 Category: Environmental Health Authors: Teresa Balbi Angelica Miglioli Michele Montagna Davide Piazza Beatrice Risso Remi Dumollard Laura Canesi Source Type: research

Study of microscopic properties and heavy metal solidification mechanism of electrolytic manganese residue-based cementitious materials
This study aimed to prepare cementitious materials containing abundant ettringite crystals by mixing EMR with various proportions of granulated blast furnace slag (GBFS) and alkaline activators (CaO, Ca(OH)2, clinker, NaOH). The resulting cementitious material not only utilized a substantial amount of EMR but also exhibited comparable strength to ordinary Portland cement. The optimal ratios were determined through mechanical testing. Additionally, the leaching toxicity of cementitious materials was assessed using ICP-MS (inductively coupled plasma mass spectrometer) tests. The microscopic properties, hydration, and mechani...
Source: Environmental Science and Pollution Research International - September 19, 2023 Category: Environmental Health Authors: Liang Tang Zhaoyi He Kefan Chen Xiaoli Wang Yixun Xiao Zhou Yu Haixin Xiao Source Type: research

Heparin-collagen I bilayers stimulate FAK/ERK ½ signaling via α2β1 integrin to support the growth and anti-inflammatory potency of mesenchymal stromal cells
J Biomed Mater Res A. 2023 Sep 18. doi: 10.1002/jbm.a.37614. Online ahead of print.ABSTRACTUnderstanding mesenchymal stromal cells (MSCs) growth mechanisms in response to surface chemistries is essential to optimize culture methods for high-quality and robust cell yields in cell manufacturing applications. Heparin (HEP) and collagen 1 (COL) substrates have been reported to enhance cell adhesion, growth, viability, and secretory potential in MSCs. However, the biomolecular mechanisms underlying the benefits of combined HEP/COL substrates are unknown. This work used HEP/COL bilayered surfaces to investigate the role of integ...
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Said J Cifuentes Maribella Domenech Source Type: research

Aortic Annulus Detection Based on Deep Learning for Transcatheter Aortic Valve Replacement Using Cardiac Computed Tomography
CONCLUSION: Our deep learning framework was feasible to detect the 3D complex structure of the aortic annulus plane using cardiac CT for TAVR. The performance of our algorithms was higher than other convolutional neural networks.PMID:37724499 | DOI:10.3346/jkms.2023.38.e306
Source: J Korean Med Sci - September 19, 2023 Category: General Medicine Authors: Yongwon Cho Soojung Park Sung Ho Hwang Minseok Ko Do-Sun Lim Cheol Woong Yu Seong-Mi Park Mi-Na Kim Yu-Whan Oh Guang Yang Source Type: research

Prediction of large-for-gestational age at 36  weeks' gestation: two-dimensional vs three-Dimensional vs magnetic resonance imaging
CONCLUSION: At 36 WG, MRI performs better than 2D-US and 3D-US in predicting birthweight > 95th percentile at birth, especially in patients at high-risk for macrosomia, while 2D-US and 3D-US are comparable. For low-risk patients, the three modalities perform similarly. This article is protected by copyright. All rights reserved.PMID:37725758 | DOI:10.1002/uog.27485
Source: The Ultrasound Review of Obstetrics and Gynecology - September 19, 2023 Category: Radiology Authors: E Mazzone C Kadji M M Cannie D A Badr J C Jani Source Type: research

Prospective diagnostic test accuracy of uterosacral ligament and torus uterinus endometriosis using transvaginal ultrasound posterior approach
CONCLUSION: We observed high diagnostic test accuracy of the examined standardized TVS technique for assessing DE of USLs and TU. More studies evaluating this technique should be performed, particularly with less trained observers, before considering this technique as the standard approach. This article is protected by copyright. All rights reserved.PMID:37725753 | DOI:10.1002/uog.27492
Source: The Ultrasound Review of Obstetrics and Gynecology - September 19, 2023 Category: Radiology Authors: S M Freger V Turnbull K McGowan M Leonardi Source Type: research

Residential overcrowding in relation to children's health, environment and schooling - a qualitative study
CONCLUSIONS: Our qualitative evidence suggest that overcrowding has a negative impact on children's health, environment and schooling.PMID:37723969 | DOI:10.1177/14034948231198285
Source: Scandinavian Journal of Public Health - September 19, 2023 Category: International Medicine & Public Health Authors: Johnny C Lorentzen Antonios Georgellis Maria Albin Marina Jonsson Source Type: research

A case of panuveitis caused by caterpillar setae
CONCLUSION: Clinicians should be more vigilant about history of contact with caterpillars while examining uveitis that has recurred for many years. Identification of the root cause of the disease can ensure better treatment.PMID:37723890 | DOI:10.1177/11206721231203262
Source: European Journal of Ophthalmology - September 19, 2023 Category: Opthalmology Authors: Ying Zhang Yuan Yuan Ruyi Zhao Wei Tan Source Type: research

Is duration of residence a proxy for acculturation? The case of health risk behaviors among international immigrants
CONCLUSIONS: Our findings suggest that duration of residence should not be used as a proxy for acculturation when studying health risk behaviors among immigrants. Researchers should consider additional time-dependent factors to explain behavioral changes by duration of residence.PMID:37723980 | DOI:10.1177/14034948231199534
Source: Scandinavian Journal of Public Health - September 19, 2023 Category: International Medicine & Public Health Authors: Sol P Ju Árez Helena Honkaniemi Nina-Katri Gustafsson Lisa Berg Source Type: research

Residential overcrowding in relation to children's health, environment and schooling - a qualitative study
CONCLUSIONS: Our qualitative evidence suggest that overcrowding has a negative impact on children's health, environment and schooling.PMID:37723969 | DOI:10.1177/14034948231198285
Source: Scandinavian Journal of Public Health - September 19, 2023 Category: International Medicine & Public Health Authors: Johnny C Lorentzen Antonios Georgellis Maria Albin Marina Jonsson Source Type: research

Heparin-collagen I bilayers stimulate FAK/ERK ½ signaling via α2β1 integrin to support the growth and anti-inflammatory potency of mesenchymal stromal cells
J Biomed Mater Res A. 2023 Sep 18. doi: 10.1002/jbm.a.37614. Online ahead of print.ABSTRACTUnderstanding mesenchymal stromal cells (MSCs) growth mechanisms in response to surface chemistries is essential to optimize culture methods for high-quality and robust cell yields in cell manufacturing applications. Heparin (HEP) and collagen 1 (COL) substrates have been reported to enhance cell adhesion, growth, viability, and secretory potential in MSCs. However, the biomolecular mechanisms underlying the benefits of combined HEP/COL substrates are unknown. This work used HEP/COL bilayered surfaces to investigate the role of integ...
Source: Biomed Res - September 19, 2023 Category: Research Authors: Said J Cifuentes Maribella Domenech Source Type: research