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Digital Motor Biomarkers of Cerebellar Ataxia Using an RGB-Depth Camera-Based Motion Analysis System
This study aimed to identify quantitative biomarkers of motor function for cerebellar ataxia by evaluating gait and postural control using an RGB-depth camera-based motion analysis system. In 28 patients with degenerative cerebellar ataxia and 33 age- and sex-matched healthy controls, motor tasks (short-distance walk, closed feet stance, and stepping in place) were selected from a previously reported protocol, and scanned using Kinect V2 and customized software. The Clinical Assessment Scale for the Assessment and Rating of Ataxia (SARA) was also evaluated. Compared with the normal control group, the cerebellar ataxia grou...
Source: Cerebellum - September 18, 2023 Category: Neuroscience Authors: Masahide Suzuki Shigeki Hirano Karen Otte Tanja Schmitz-H übsch Michiko Izumi Mitsuyoshi Tamura Ryota Kuroiwa Atsuhiko Sugiyama Masahiro Mori Hanna M R öhling Alexander U Brandt Atsushi Murata Friedemann Paul Satoshi Kuwabara Source Type: research
Treatment with a tissue-selective oestrogen complex does not affect disease pathology but reduces pre-BI cells in lupus-prone mice
CONCLUSION: TSEC does not aggravate a mouse model of lupus, when given in doses that protect against postmenopausal lupus-associated bone loss. This indicates that further investigations into TSEC as a treatment for osteoporosis or vasomotor symptoms in postmenopausal women with SLE are warranted.PMID:37722827 | DOI:10.1080/03009742.2023.2251753
Source: Scandinavian Journal of Rheumatology - September 18, 2023 Category: Rheumatology Authors: C Drevinge J M Scheffler J Nordqvist C Engdahl H Carlsten U Islander Source Type: research
T-scans in implant procedures
Bioinformation. 2023 Jan 31;19(1):35-38. doi: 10.6026/97320630019035. eCollection 2023.ABSTRACTT scans are a breakthrough in technology which allows the user to accurately analyze the occlusion of a patient with minimal to zero errors. They are used during prosthodontic rehabilitation to map out the patient's occlusion to plan for replacements. Such a high advancement in technology has a backdraw. The cost of the equipment is a concern for simple dental practitioners. There are no large scale studies using T scans in determining the occlusion. Therefore, it is of interest to analyze the use of T scans in determining the pe...
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Prabhav Kumar Iyer Suresh Venugopalan Thiyaneswaran N Sam Jebaraj Source Type: research
Comparing the effectiveness of novel high-end compression garment with common compression garment and kinesio tape in preventing edema and improving tissue perfusion in lower extremities
CONCLUSION: The novel bandage showed a statistically significant reduction in edema when compared intraindividually, but no statistically significant advantage was found when compared with the other compression garment B and kinesio tape.Despite the widespread use of kinesio tape, we did not find any improvement in the range of motion, edema prevention and circulation in the lower limb after application of kinesio tape.PMID:37718791 | DOI:10.3233/CH-238111
Source: Clinical Hemorheology and Microcirculation - September 18, 2023 Category: Hematology Authors: Sophia T Diesch Daniel Schiltz Julian Kammermeier Lukas Prantl Christian D Taeger Source Type: research
Diseases of the Coronary Microcirculation: Diagnosis and Treatment
CONCLUSION: Approximately 25% of patients with CMD have symptoms that do not respond to intensive treatment with the currently available modalities. New treatments, including interventional therapies, are being studied. Their long-term benefit remains to be assessed and compared to that of the existing methods.PMID:37721132 | DOI:10.3238/arztebl.m2023.0205
Source: Deutsches Arzteblatt International - September 18, 2023 Category: General Medicine Authors: Helen Ullrich-Daub Steffen Daub Maximilian Olschewski Thomas M ünzel Tommaso Gori Source Type: research
Exploring the Potential of Nanogels: From Drug Carriers to Radiopharmaceutical Agents
This article is protected by copyright. All rights reserved.PMID:37717209 | DOI:10.1002/adhm.202301404
Source: Adv Data - September 17, 2023 Category: Epidemiology Authors: Manja Kubeil Yota Suzuki Maria Antonietta Casulli Rozy Kamal Takeshi Hashimoto Michael Bachmann Takashi Hayashita Holger Stephan Source Type: research
Ecotoxicological assessment of water phase exfoliated two-dimensional Group-VI transition metal dichalcogenides using zebrafish embryo model
Chemosphere. 2023 Sep 15:140167. doi: 10.1016/j.chemosphere.2023.140167. Online ahead of print.ABSTRACTAmong emerging layered materials, 2D transition metal dichalcogenides (TMDs) nanosheets (n-sheets) have received increasing attention for optoelectronics, energy storage, and, recently, for bioremediation and advanced biomedical applications; however, a lack of ecotoxicological in vivo studies is evident. Herein, for the first time, the potential nanotoxicity of liquid phase exfoliated Group VI TMDs n-sheets (MoS2, WS2, WSe2, and MoSe2) was comparatively investigated using zebrafish embryos (Z-EBs) as an in-vivo model. Th...
Source: Chemosphere - September 17, 2023 Category: Chemistry Authors: Carmine Merola Annalisa Scroccarello Flavio Della Pelle Giovanni Ferraro Giulia Caioni Monia Perugini Michele Amorena Dario Compagnone Source Type: research
Gelatin-assisted fabrication of reduced nanographene oxide for dual-modal imaging of melanoma cells
Colloids Surf B Biointerfaces. 2023 Sep 14;231:113546. doi: 10.1016/j.colsurfb.2023.113546. Online ahead of print.ABSTRACTIn this work we report a gelatin-based, simple two-steps approach for fabrication of reduced graphene oxide (rGO-GEL) possessing high stability and biocompatibility, as novel label-free intracellular contrast agents. Gelatin, a biopolymer that is known for its versatility, was employed not only to biocompatibilize the rGO, but also to prevent the aggregation of the GO nanosheets during the reduction process. To confirm the successful reduction process and the attachment of the gelatin to the rGO nanoshe...
Source: Colloids and Surfaces - September 17, 2023 Category: Biotechnology Authors: Vlad Cucuiet Maria Iliu ţ Monica Potara Klara Magyari Septimiu Tripon Olga Soritau Dana Maniu Simion Astilean Monica Focsan Source Type: research
Activities of cellulose acetate and microcrystalline cellulose on the thermal and morphomechanical performances of a biobased hybrid composite made polybutylene succinate
Int J Biol Macromol. 2023 Sep 15:126918. doi: 10.1016/j.ijbiomac.2023.126918. Online ahead of print.ABSTRACTMicrocrystalline cellulose (MCC-30 wt%) was extruded with a blend of polybutylene succinate (PBS) and cellulose acetate (CADS=2.5-20 wt%) to produce two grades of binary (PBS/CA, PBS/MCC) and ternary (PBS/CA/MCC) specimens by injection into a mold previously thermostated at 22 °C and 78 °C. The structure-property relationships of neat PBS (n-PBS) and PBS-based blends were investigated by Fourier transform infrared (FTIR) spectroscopy, diffuse reflectance infrared Fourier transform (DRIFT) spectroscopy, scanning ele...
Source: International Journal of Biological Macromolecules - September 17, 2023 Category: Biochemistry Authors: Thomas Sango Ahmed Koubaa Mohamed Ragoubi Martin Claude Ngueho Yemele Nathalie Leblanc Source Type: research
Bioderived cellulose fibre-guar gum grafted poly (N, N'-dimethylacrylamide) polymer network for controlled release of metformin hydrochloride
Int J Biol Macromol. 2023 Sep 15:126882. doi: 10.1016/j.ijbiomac.2023.126882. Online ahead of print.ABSTRACTAn interpenetrating polymer network (IPN) of areca cellulose and guar gum grafted with poly (N, N'-dimethylacrylamide) was made by microwave irradiation technique. N, N-methylenebisacrylamide (MBA) was used as the crosslinking agent. The network polymer was characterised using Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), Powder X-ray Diffraction (XRD) and Field Emission Scanning Electron Microscopy (FESEM). The chemical interaction between the drug and the polymer was studied usin...
Source: International Journal of Biological Macromolecules - September 17, 2023 Category: Biochemistry Authors: Smitha Rai Ruchira Raychaudhuri Ritu Kudarha Srinivas Mutalik B Vishalakshi K M Usha Source Type: research
Carboxymethyl chitosan-TK resistant starch complex ameliorates type 2 diabetes by regulating the gut microbiota
Int J Biol Macromol. 2023 Sep 15:126930. doi: 10.1016/j.ijbiomac.2023.126930. Online ahead of print.ABSTRACTCarboxymethyl chitosan and resistant starch exhibit good performance in diabetes regulation. We prepared carboxymethyl chitosan - resistant starch complex. Test the properties of composite resistant starch by using X-ray diffraction, water contact angle, infrared spectroscopy, and scanning electron microscopy, interactions with intestinal microbiota and mouse experiments were also conducted. The results indicated that the composite resistant starch had a good effect on promoting the proliferation of probiotics on Bif...
Source: International Journal of Biological Macromolecules - September 17, 2023 Category: Biochemistry Authors: Xin Pan Pei Liu Ye-Jun Zhang Hao-Kuang Zhang Hao Wei Jing-Yi Jiang None Hui-Yan Er-Xin Shang Wei-Wen Li Yiwei Wang Jin-Ao Duan Source Type: research
Ecotoxicological assessment of water phase exfoliated two-dimensional Group-VI transition metal dichalcogenides using zebrafish embryo model
Chemosphere. 2023 Sep 15:140167. doi: 10.1016/j.chemosphere.2023.140167. Online ahead of print.ABSTRACTAmong emerging layered materials, 2D transition metal dichalcogenides (TMDs) nanosheets (n-sheets) have received increasing attention for optoelectronics, energy storage, and, recently, for bioremediation and advanced biomedical applications; however, a lack of ecotoxicological in vivo studies is evident. Herein, for the first time, the potential nanotoxicity of liquid phase exfoliated Group VI TMDs n-sheets (MoS2, WS2, WSe2, and MoSe2) was comparatively investigated using zebrafish embryos (Z-EBs) as an in-vivo model. Th...
Source: Chemosphere - September 17, 2023 Category: Chemistry Authors: Carmine Merola Annalisa Scroccarello Flavio Della Pelle Giovanni Ferraro Giulia Caioni Monia Perugini Michele Amorena Dario Compagnone Source Type: research
Opening a window to skin biomarkers for diabetes stage with optoacoustic mesoscopy
Light Sci Appl. 2023 Sep 18;12(1):231. doi: 10.1038/s41377-023-01275-3.ABSTRACTBeing the largest and most accessible organ of the human body, the skin could offer a window to diabetes-related complications on the microvasculature. However, skin microvasculature is typically assessed by histological analysis, which is not suited for applications to large populations or longitudinal studies. We introduce ultra-wideband raster-scan optoacoustic mesoscopy (RSOM) for precise, non-invasive assessment of diabetes-related changes in the dermal microvasculature and skin micro-anatomy, resolved with unprecedented sensitivity and det...
Source: Appl Human Sci - September 17, 2023 Category: Physiology Authors: Hailong He Nikolina-Alexia Fasoula Angelos Karlas Murad Omar Juan Aguirre Jessica Lutz Michael Kallmayer Martin F üchtenbusch Hans-Henning Eckstein Annette Ziegler Vasilis Ntziachristos Source Type: research
A new SERS quantitative analysis method for trace malathion with recognition and catalytic amplification difunctional MOF < sub > Tb < /sub > @Au@MIP nanoprobe
Talanta. 2023 Sep 13;267:125166. doi: 10.1016/j.talanta.2023.125166. Online ahead of print.ABSTRACTNew multifunctional nanomaterial preparation and its application to trace pollutant analysis are interesting to peoples. Using terbium metal-organic framework loaded gold nanoparticles (MOFTb@Au) as the nanosubstrate and 3-aminopropyltriethoxysilane (APTES) as the functional monomer, a new bifunctional nanosurface molecularly imprinted polymer nanoprobe of MOFTb@Au@MIP with strongly recognition and catalytic amplification functions was prepared by the microwave sol-gel procedure. It was characterized by scanning electron micr...
Source: Talanta - September 17, 2023 Category: Chemistry Authors: Yiyi Shu Jingjing Li Hongyan Bai Aihui Liang Guiqing Wen Zhiliang Jiang Source Type: research
HSAFM-MIREBA - Methodology for Inferring REsolution in biological applications
Anal Biochem. 2023 Sep 15:115320. doi: 10.1016/j.ab.2023.115320. Online ahead of print.ABSTRACTDue to a lack of requirement for any direct labelling of the target molecule, high speed atomic force microscopy (HS-AFM) is a potentially powerful procedure for the assessment of biological processes involving macromolecules. When the sample is static the AFM device can be purposefully setup to recover high-resolution information about the feature in question. However, when the feature to be studied moves an appreciable amount during the course of the measurement, the obtained image will be blurred. Encountering such blurred obs...
Source: Analytical Biochemistry - September 17, 2023 Category: Biochemistry Authors: Damien Hall Source Type: research
