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Total 11811 results found since Jan 2013.

Kaolin-induced chronic hydrocephalus accelerates amyloid deposition and vascular disease in transgenic rats expressing high levels of human APP
Conclusions: Kaolin-hydrocephalus can accelerate intraneuronal Abeta40 accumulation and vascular pathology in tgAPP21 rats. In addition, disrupted CSF production and reduced CSF turnover results in impaired Abeta clearance and accelerated vascular pathology in chronic hydrocephalus. The high co-morbidity seen in NPH, AD and CVD is likely not to be an age-related coincidence, but rather a convergence of pathologies related to diminished CSF clearance.
Source: BioMed Central - January 24, 2015 Category: Journals (General) Authors: Gerald D SilverbergMiles C MillerCrissey L PascaleIlias N CaralopoulosYuksel AgcaCansu AgcaEdward G Stopa Source Type: research

Factors Associated with Acute and Chronic Hydrocephalus in Nonaneurysmal Subarachnoid Hemorrhage
Conclusion Acute hydrocephalus occurs in one-quarter of NA-SAH patients. The greater risk in diffuse bleeding appears to be mediated by greater cisternal blood volume but not by greater ventriculomegaly. Imaging characteristics may aid in anticipatory management of hydrocephalus in NA-SAH.
Source: Neurocritical Care - July 2, 2015 Category: Neurology Source Type: research

Epidemiology of adult-onset hydrocephalus: institutional experience with 2001 patients.
CONCLUSIONS Knowledge of the demographic variations in adult-onset hydrocephalus is helpful in achieving better risk stratification and better managing the disease in patients. For general applicability, these results should be validated in a large-scale meta-analysis based on a national population database. PMID: 27581317 [PubMed - in process]
Source: Neurosurgical Focus - August 31, 2016 Category: Neurosurgery Authors: Bir SC, Patra DP, Maiti TK, Sun H, Guthikonda B, Notarianni C, Nanda A Tags: Neurosurg Focus Source Type: research

Alcyone Lifesciences wins FDA nod for Alivio hydrocephalus shunt flusher
Alcyone Lifesciences said yesterday it won FDA 510(k) clearance for its Alivio ventricular catheter and flusher system designed for treating hydrocephalus. The newly cleared Alivio device is designed for the non-invasive retrograde flushing of the ventricular catheter to unblock occluded inlet holes or open a relief membrane to restore or increase cerebrospinal fluid flow in non-flowing shunts, the Lowell, Mass.-based company said. “For the first time in over half a century there has been a game changing improvement in the field of hydrocephalus treatment.  Ventricular shunting can help save lives and improve the qu...
Source: Mass Device - November 16, 2017 Category: Medical Devices Authors: Fink Densford Tags: 510(k) Food & Drug Administration (FDA) Neurological Regulatory/Compliance Alcyone Lifesciences Source Type: news

Factors Associated Postoperative Hydrocephalus in Patients with Traumatic Acute Subdural Hemorrhage.
Conclusion: In patients with acute traumatic SDH with coexisting IVH, a large amount of SDH, and a larger midline shift, close follow-up is necessary for the early prediction of postoperative hydrocephalus. Furthermore, craniectomy margin need not be limited in acute traumatic SDH patients for the reason of postoperative hydrocephalus. PMID: 29142634 [PubMed]
Source: Journal of Korean Neurosurgical Society - November 18, 2017 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Role of 3D SPACE sequence and susceptibility weighted imaging in the evaluation of hydrocephalus and treatment-oriented refined classification of hydrocephalus
Conclusion: We strongly suggest to include 3D SPACE and SWI sequences in the set of routine MRI sequences, as they are powerful diagnostic tools and offer complementary information regarding the precise evaluation of the etiopathogenesis of hydrocephalus and have an effective impact in selecting the mode of management.
Source: Indian Journal of Radiology and Imaging - December 18, 2018 Category: Radiology Authors: Amarnath Chellathurai Komalavalli Subbiah Barakath Nisha Abdul Ajis Suhasini Balasubramaniam Sathyan Gnanasigamani Source Type: research

Co-occurring hydrocephalus in autism spectrum disorder: a Danish population-based cohort study
ConclusionsGiven the considerable risk of hydrocephalus among patients with autism spectrum disorder, we suggest that patients with autism spectrum disorder should be evaluated for co-occurring hydrocephalus on a routine basis as timely neurosurgical intervention is important. Likewise, attention must be paid to traits of autism spectrum disorder in children with hydrocephalus. The results of this study call for future investigations on a potential shared aetiology between hydrocephalus and autism spectrum disorder, including the role abnormal CSF dynamics in the pathogenesis of autism spectrum disorder.
Source: Journal of Neurodevelopmental Disorders - April 28, 2021 Category: Neurology Source Type: research

Curcumin Attenuates Hydrocephalus via Activation of E2F Transcription Factor 4
Conclusion: Curcumin suppresses hydrocephalus progression via activation of E2F4, which could be a target for hydrocephalus treatment.Cerebrovasc Dis
Source: Cerebrovascular Diseases - April 14, 2022 Category: Neurology Source Type: research

Association of chronic hydrocephalus after aneurysmal subarachnoid hemorrhage with transforming growth factor-β1 levels and other risk factors.
CONCLUSIONS: In adult patients with aSAH, the risk factors for chronic hydrocephalus include ventricular expansion, aneurysm position, Fisher classification, ventricular hemorrhage score and postoperative intracranial infections. These risk factors can have greater clinical value than TGF-β1 levels in the CSF in predicting the occurrence of chronic hydrocephalus following aSAH. PMID: 23529236 [PubMed - in process]
Source: Journal of Southern Medical University - March 1, 2013 Category: Universities & Medical Training Authors: Liu F, Yuan W, Liao D, Zhang T, Wang Z Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

Long-term hydrocephalus alters the cytoarchitecture of the adult subventricular zone.
Abstract Hydrocephalus can develop secondarily to a disturbance in production, flow and/or absorption of cerebrospinal fluid. Experimental models of hydrocephalus, especially subacute and chronic hydrocephalus, are few and limited, and the effects of hydrocephalus on the subventricular zone are unclear. The aim of this study was to analyze the effects of long-term obstructive hydrocephalus on the subventricular zone, which is the neurogenic niche lining the lateral ventricles. We developed a new method to induce hydrocephalus by obstructing the aqueduct of Sylvius in the mouse brain, thus simulating aqueductal ste...
Source: Experimental Neurology - May 21, 2014 Category: Neurology Authors: Campos-Ordoñez T, Herranz-Pérez V, Chaichana KL, Rincon-Torroella J, Rigamonti D, García-Verdugo JM, Quiñones-Hinojosa A, Gonzalez-Perez O Tags: Exp Neurol Source Type: research

Deferoxamine Attenuates Acute Hydrocephalus After Traumatic Brain Injury in Rats
In conclusion, iron may contribute to acute hydrocephalus after TBI.
Source: Translational Stroke Research - October 1, 2014 Category: Neurology Source Type: research

Abnormal structural connectivity in the brain networks of children with hydrocephalus
This study seeks to investigate the impact of hydrocephalus on topological features of brain networks in children. The goal was to investigate structural network connectivity, at both global and regional levels, in the brains in children with hydrocephalus using graph theory analysis and diffusion tensor tractography. Three groups of children were included in the study (29 normally developing controls, 9 preoperative hydrocephalus patients, and 17 postoperative hydrocephalus patients). Graph theory analysis was applied to calculate the global network measures including small-worldness, normalized clustering coefficients, n...
Source: NeuroImage: Clinical - April 30, 2015 Category: Radiology Source Type: research

Reappraisal of Radionuclide Cisternography in the diagnosis of chronic hydrocephalus – a single institution report
We present our retrospective clinical experience with a series of patients with signs and symptoms of chronic hydrocephalus that were investigated by radionuclide cisternography (RC) and discuss the method's possible contemporary role. During the past five years, RC was used during the investigation of 12 possible hydrocephalus patients (5 male, 7 female, ages 26 to 77years, mean 59.5, std 18.19). The patients' symptoms ranged from headache to gait disturbance, dementia and urine incontinence. Patients were investigated with CT and MRI scans and had a RC examination using In-111-DTPA. According to the RC results the patien...
Source: Interdisciplinary Neurosurgery - June 16, 2015 Category: Neurosurgery Source Type: research

The Risk Factors for Hydrocephalus and Subdural Hygroma after Decompressive Craniectomy in Head Injured Patients.
CONCLUSION: For patients who are subjected to DC following severe head trauma, hydrocephalus is associated with a large craniectomy area and contralateral SDG. For SDGs after DC that occur on the interhemispherical or controlateral side of the craniectomy, careful follow-up monitoring for the potential progression into hydrocephalus is needed. PMID: 26539270 [PubMed]
Source: Journal of Korean Neurosurgical Society - November 20, 2015 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research