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Total 11811 results found since Jan 2013.

Modulation of striatal glutamatergic, dopaminergic and cholinergic neurotransmission pathways concomitant with motor disturbance in rats with kaolin-induced hydrocephalus
ConclusionsHydrocephalus altered striatal glutamatergic, dopaminergic, and cholinergic neurotransmission pathways and tipped the balance between the direct and indirect basal ganglia circuits, which could have contributed to the motor impairments in hydrocephalus.
Source: Fluids and Barriers of the CNS - November 27, 2022 Category: Neuroscience Source Type: research

Establishing ranked priorities for future hydrocephalus research
CONCLUSIONS: By gathering extensive input from the hydrocephalus community and using an iterative process of consensus building, a ranked list of the top 20 hydrocephalus research priorities was developed. The HA will use this ranked list to guide future research programs and encourages the healthcare and scientific community to do the same.PMID:36681979 | DOI:10.3171/2022.10.JNS22753
Source: Journal of Neurosurgery - January 22, 2023 Category: Neurosurgery Authors: Noriana E Jakopin Elliot Myong Trish Bogucki Diana Gray Paul Gross J Gordon McComb Chevis N Shannon Mandeep S Tamber Maiko Toyama Tessa van der Willigen Amir Yazdani Mark G Hamilton Jenna E Koschnitzky Source Type: research

Family-base rare variant association analysis in Saudi Arabian hydrocephalus subjects using whole exome sequencing
CONCLUSIONS: We identified three potentially impactful variants from our cohort in 73 known hydrocephalus genes previously identified in literature.PMID:37158713 | DOI:10.23736/S0390-5616.23.06010-1
Source: Journal of Neurosurgical Sciences - May 9, 2023 Category: Neurosurgery Authors: Ahmed Ammar Dalal K Bubshait Abdulrazaq Al Ojan Shuroq A Alshari Cyril Cyrus Rawan Alanazi Mohammed A Al Ghamdi Brendan J Keating Abdulrahman Al-Anazi Noorah H Al Qahtani Amein K Al-Ali Source Type: research

Hydrocephalus in the emergency department: descriptive nationwide data and analysis of transfer
CONCLUSIONS: Patients with hydrocephalus make heavy use of EDs, and they make more visits for reasons unrelated to their hydrocephalus than for neurosurgical reasons. Transfer to another acute care facility is an adverse clinical outcome that is much more common after neurosurgical visits. It is a system inefficiency that might be minimized by proactive case management and coordination of care.PMID:37310053 | DOI:10.3171/2023.4.JNS23562
Source: Journal of Neurosurgery - June 13, 2023 Category: Neurosurgery Authors: Joseph Piatt Source Type: research

VEGF, which is elevated in the CSF of patients with hydrocephalus, causes ventriculomegaly and ependymal changes in rats.
Abstract Hydrocephalus is a condition characterized primarily by excessive accumulation of fluid in the ventricles of the brain for which there is currently no effective pharmacological treatment. Surgery, often accompanied by complications, is the only current treatment. Extensive research in our laboratory along with work from others has suggested a link between hydrocephalus and vascular function. We hypothesized that vascular endothelial growth factor (VEGF), the major angiogenic factor, could play a role in the pathogenesis of hydrocephalus. We tested this hypothesis by examining two predictions of such a lin...
Source: Experimental Neurology - March 19, 2013 Category: Neurology Authors: Shim JW, Sandlund J, Han CH, Hameed MQ, Connors S, Klagsbrun M, Madsen JR, Irwin N Tags: Exp Neurol Source Type: research

Decompressive craniectomy, interhemispheric hygroma and hydrocephalus: A timeline of events?
Conclusion: Craniectomy close to the midline can predispose patients to the development of hydrocephalus. SH could be generated with the same mechanism, and these three events could be correlated on a timeline.
Source: Clinical Neurology and Neurosurgery - January 7, 2013 Category: Neurosurgery Authors: Pasquale De Bonis, Carmelo Lucio Sturiale, Carmelo Anile, Simona Gaudino, Annunziato Mangiola, Matia Martucci, Cesare Colosimo, Luigi Rigante, Angelo Pompucci Tags: Original articles Source Type: research

Management of hydrocephalus secondary to pineal region tumors
Conclusion: Pineal region tumors resection usually should be performed before shunting, unless there is an acute obstructive hydrocephalus. The posterior third ventricle should be opened after tumor resection. Intraoperative third ventriculostomy and ventriculocisternal shunt are reliable ways to manage hydrocephalus secondary to pineal region tumors.
Source: Clinical Neurology and Neurosurgery - June 5, 2013 Category: Neurosurgery Authors: ZhiYuan Zhang, HanDong Wang, HuiLin Cheng, YouWu Fan, ChunHua Hang, KangJian Sun, Lin Zhu Tags: Original articles Source Type: research