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Total 122032 results found since Jan 2013.
Impact of blood-brain barrier disruption on clinical features and treatment response in patients with newly diagnosed autoimmune encephalitis
Blood-brain barrier (BBB) breakdown is an essential mechanism in inflammatory diseases of the central nervous system. However, the association between BBB integrity and autoimmune encephalitis (AE) has not been investigated. Our study aimed to analyze this relationship in patients with AE between BBB integrity with clinical manifestations and therapeutic responses.
Source: Journal of Neuroimmunology - September 18, 2023 Category: Allergy & Immunology Authors: Xuan Cheng, Yimeng Li, Yaoyao Wang, Yidi Sun, Yajun Lian Source Type: research
Chimeric CNS-targeting-peptide engineered exosomes for experimental autoimmune encephalomyelitis therapy
Int Immunopharmacol. 2023 Sep 15;124(Pt B):110835. doi: 10.1016/j.intimp.2023.110835. Online ahead of print.ABSTRACTMultiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) that causes demyelination, neuronal damage and white matter loss, but there is still no known cure. Exosomes are 30-200 nm-sized double-layered membrane vesicles that can easily cross the blood-brain barrier (BBB). Exosomes from umbilical cord mesenchymal stem cells（UMSCs） have been found to treat experimental autoimmune encephalomyelitis (EAE) through the action of anti-inflammatory and immunomodulatory, but its clinic...
Source: International Immunopharmacology - September 17, 2023 Category: Allergy & Immunology Authors: Ying-Kai Wang Yun-Peng Zhao Ming-Zhu Ye Ling Wang Tian-Shu Lan Yue Wang Zhong-Quan Qi Source Type: research
Language impairments in people with autoimmune neurological diseases: A scoping review
CONCLUSIONS: Language symptoms in people with ANDs are commonly reported. These are often not full descriptions or only focus on specific time points in the course of the disease. Future research needs to assess specific language functions in people with ANDs and relate their language impairments to brain damage at different stages of disease evolution.PMID:37717472 | DOI:10.1016/j.jcomdis.2023.106368
Source: Journal of Communication Disorders - September 17, 2023 Category: Speech-Language Pathology Authors: Janine Rook Sara Llufriu D örte de Kok Adri à Rofes Source Type: research
Regulatory effect of zinc finger protein A20 on rheumatoid arthritis through NLRP3/Caspase-1 signaling axis mediating pyroptosis of HFLS- RA cells
In conclusion, this study is of great significance for understanding the role of the NLRP3-caspase-1-IL-1β/ pyroptosis signaling pathway in the occurrence and development of RA. It is expected that the results will provide a theoretical basis for the immune regulation of innate immunity in the occurrence and development of RA, while providing a new therapeutic target for the clinical treatment of RA.PMID:37715399 | DOI:10.14715/cmb/2023.69.8.27
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Ziqin Zhao Xinlong Ma Shuhui Dong Haibo Yin Yong Yang Guangyi Xiong Source Type: research
Immune-Related Adverse Event Likelihood Score Identifies "Pure" IRAEs Strongly Associated With Outcome in a Phase I-II Trial Population
CONCLUSION: ILS provides a simple system to identify bona fide IRAEs, pruning for other treatment-related events likely due to different pathophysiology. Applying stringent criteria leads to lower and more reliable estimates of IRAE incidence and identifies events with significant impact on survival.PMID:37715957 | DOI:10.1093/oncolo/oyad239
Source: The Oncologist - September 16, 2023 Category: Cancer & Oncology Authors: Luca Mazzarella Federica Giugliano Eleonora Nicolo Angela Esposito Edoardo Crimini Giulia Tini Jacopo Uliano Chiara Corti Paolo D'Amico Pamela Trillo Aliaga Carmine Valenza Matteo Repetto Gabriele Antonarelli Liliana Ascione Grazia Vivanet Pierpaolo Berto Source Type: research
Hepatic safety and efficacy of immunomodulatory drugs used in patients with autoimmune hepatitis
CONCLUSION: Among 25 AIH patients who were treated with immunomodulatory drugs for different reasons, the majority had a fovorable course, relapse was frequent in difficult-to-treat patients who received belimumab, and four with concomitant IBD had insufficient response.PMID:37716078 | DOI:10.1016/j.jaut.2023.103113
Source: Journal of Autoimmunity - September 16, 2023 Category: Allergy & Immunology Authors: Benedetta Terziroli Beretta-Piccoli Gustav Buescher George Dalekos Kalliopi Zachou Anja Geerts Nasser Semmo Mirjam Kolev Eleonora De Martin Maciej K Janik Jo ão Madaleno Milica Lalosevic Stojkovic J érôme Dumortier Thomas Vanwolleghem Ida Schregel Silj Source Type: research
Harnessing autoimmunity with dominant self-peptide: Modulating the sustainability of tissue-preferential antigen-specific Tregs by governing the binding stability via peptide flanking residues
J Autoimmun. 2023 Sep 14;140:103094. doi: 10.1016/j.jaut.2023.103094. Online ahead of print.ABSTRACTSensitization to self-peptides induces various immunological responses, from autoimmunity to tumor immunity, depending on the peptide sequence; however, the underlying mechanisms remain unclear, and thus, curative therapeutic options considering immunity balance are limited. Herein, two overlapping dominant peptides of myelin proteolipid protein, PLP136-150 and PLP139-151, which induce different forms of experimental autoimmune encephalomyelitis (EAE), monophasic and relapsing EAE, respectively, were investigated. Mice with ...
Source: Journal of Autoimmunity - September 16, 2023 Category: Allergy & Immunology Authors: Youwei Lin Shun Sakuraba Chandirasegaran Massilamany Jayagopala Reddy Yoshimasa Tanaka Sachiko Miyake Takashi Yamamura Source Type: research
Regulatory effect of zinc finger protein A20 on rheumatoid arthritis through NLRP3/Caspase-1 signaling axis mediating pyroptosis of HFLS- RA cells
In conclusion, this study is of great significance for understanding the role of the NLRP3-caspase-1-IL-1β/ pyroptosis signaling pathway in the occurrence and development of RA. It is expected that the results will provide a theoretical basis for the immune regulation of innate immunity in the occurrence and development of RA, while providing a new therapeutic target for the clinical treatment of RA.PMID:37715399 | DOI:10.14715/cmb/2023.69.8.27
Source: Cellular and Molecular Biology - September 16, 2023 Category: Molecular Biology Authors: Ziqin Zhao Xinlong Ma Shuhui Dong Haibo Yin Yong Yang Guangyi Xiong Source Type: research
Acquired angioedema due to C1-inhibitor-deficiency (AAE-C1-INH) - a bi-center retrospective study on diagnosis, course and therapy
CONCLUSION: AAE-C1-INH is characterized by late onset swellings mainly involving the face and low C1-INH levels. Diagnostic delay for AAE-C1-INH is further decreasing despite being about 10-fold rarer than HAE. Patients severely affected without underlying condition or no indication for treatment could benefit from off-label therapy.PMID:37716525 | DOI:10.1016/j.jaip.2023.09.003
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Felix Johnson Janina Hahn Benedikt Hofauer Jens Greve Barbara Wollenberg Thomas K Hoffmann Robin Lochbaum Susanne Trainotti Source Type: research
Immune-Related Adverse Event Likelihood Score Identifies "Pure" IRAEs Strongly Associated With Outcome in a Phase I-II Trial Population
CONCLUSION: ILS provides a simple system to identify bona fide IRAEs, pruning for other treatment-related events likely due to different pathophysiology. Applying stringent criteria leads to lower and more reliable estimates of IRAE incidence and identifies events with significant impact on survival.PMID:37715957 | DOI:10.1093/oncolo/oyad239
Source: The Oncologist - September 16, 2023 Category: Cancer & Oncology Authors: Luca Mazzarella Federica Giugliano Eleonora Nicolo Angela Esposito Edoardo Crimini Giulia Tini Jacopo Uliano Chiara Corti Paolo D'Amico Pamela Trillo Aliaga Carmine Valenza Matteo Repetto Gabriele Antonarelli Liliana Ascione Grazia Vivanet Pierpaolo Berto Source Type: research
Hepatic safety and efficacy of immunomodulatory drugs used in patients with autoimmune hepatitis
CONCLUSION: Among 25 AIH patients who were treated with immunomodulatory drugs for different reasons, the majority had a fovorable course, relapse was frequent in difficult-to-treat patients who received belimumab, and four with concomitant IBD had insufficient response.PMID:37716078 | DOI:10.1016/j.jaut.2023.103113
Source: Journal of Autoimmunity - September 16, 2023 Category: Allergy & Immunology Authors: Benedetta Terziroli Beretta-Piccoli Gustav Buescher George Dalekos Kalliopi Zachou Anja Geerts Nasser Semmo Mirjam Kolev Eleonora De Martin Maciej K Janik Jo ão Madaleno Milica Lalosevic Stojkovic J érôme Dumortier Thomas Vanwolleghem Ida Schregel Silj Source Type: research
Harnessing autoimmunity with dominant self-peptide: Modulating the sustainability of tissue-preferential antigen-specific Tregs by governing the binding stability via peptide flanking residues
J Autoimmun. 2023 Sep 14;140:103094. doi: 10.1016/j.jaut.2023.103094. Online ahead of print.ABSTRACTSensitization to self-peptides induces various immunological responses, from autoimmunity to tumor immunity, depending on the peptide sequence; however, the underlying mechanisms remain unclear, and thus, curative therapeutic options considering immunity balance are limited. Herein, two overlapping dominant peptides of myelin proteolipid protein, PLP136-150 and PLP139-151, which induce different forms of experimental autoimmune encephalomyelitis (EAE), monophasic and relapsing EAE, respectively, were investigated. Mice with ...
Source: Journal of Autoimmunity - September 16, 2023 Category: Allergy & Immunology Authors: Youwei Lin Shun Sakuraba Chandirasegaran Massilamany Jayagopala Reddy Yoshimasa Tanaka Sachiko Miyake Takashi Yamamura Source Type: research
