This page shows you your search results in order of date. This is page number 13.
Order by Relevance | Date
Total 122032 results found since Jan 2013.
Chew on This: The Afterbite of Temporomandibular Joint Involvement in Adults With Juvenile Idiopathic Arthritis
J Rheumatol. 2023 Sep 15:jrheum.2023-0776. doi: 10.3899/jrheum.2023-0776. Online ahead of print.ABSTRACTJuvenile idiopathic arthritis (JIA) is a chronic autoimmune disease that continues into adulthood in approximately 50% of patients.1 Growth considerations are unique to pediatric-onset disease and can lead to permanent joint damage.PMID:37714549 | DOI:10.3899/jrheum.2023-0776
Source: Journal of Rheumatology - September 15, 2023 Category: Rheumatology Authors: Evelyn Victoria Rozenblyum Mercedes Olivia Chan Natasha Kaur Gakhal Source Type: research
Triggers and regulation: the gut microbiome in rheumatoid arthritis
Expert Rev Clin Immunol. 2023 Sep 15. doi: 10.1080/1744666X.2023.2260103. Online ahead of print.ABSTRACTINTRODUCTION: Rheumatoid arthritis is a chronic inflammatory disease marked by systemic symptoms and joint degeneration. Interestingly, the development and progression of rheumatoid arthritis have been linked to the microbiome, notably the gut microbiome. Dysbiosis, an alteration in the gut microbiome, has been connected to the etiology and pathogenesis of rheumatoid arthritis. For instance, dysbiosis increases intestinal permeability and promotes the movement of bacteria and its products, which in turn triggers and aggr...
Source: Expert Review of Clinical Immunology - September 15, 2023 Category: Allergy & Immunology Authors: Naim Mahroum Ravend Seida Yehuda Shoenfeld Source Type: research
Nuclear transport receptor KA120 regulates molecular condensation of MAC3 to coordinate plant immune activation
Cell Host Microbe. 2023 Sep 2:S1931-3128(23)00340-2. doi: 10.1016/j.chom.2023.08.015. Online ahead of print.ABSTRACTThe nucleocytoplasmic exchange is of fundamental importance to eukaryotic life and is mediated by karyopherins, a superfamily of nuclear transport receptors. However, the function and cargo spectrum of plant karyopherins are largely obscure. Here, we report proximity-labeling-based proteomic profiling of in vivo substrates of KA120, a karyopherin-β required for suppressing autoimmune induction in Arabidopsis. We identify multiple components of the MOS4-associated complex (MAC), a conserved splicing regulator...
Source: Cell Host and Microbe - September 15, 2023 Category: Microbiology Authors: Min Jia Xuanyi Chen Xuetao Shi Yiling Fang Yangnan Gu Source Type: research
Immune podocytes in the immune microenvironment of lupus nephritis (Review)
Mol Med Rep. 2023 Nov;28(5):204. doi: 10.3892/mmr.2023.13091. Epub 2023 Sep 15.ABSTRACTSystemic lupus erythematosus (SLE) is a systemic autoimmune disorder caused by the loss of tolerance to endogenous nuclear antigens such as double‑stranded DNA, leading to the proliferation of T cells and subsequent activation of B cells, which results in serious organ damage and life‑threatening complications such as lupus nephritis. Lupus nephritis (LN) develops as a frequent complication of SLE, accounting for >60% of SLE cases, and is characterized by proteinuria and heterogeneous histopathological findings. Glomerular injury ...
Source: Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Ruiling Liu Xiaoting Wen Xinyue Peng Miaomiao Zhao Liangyu Mi Jiamin Lei Ke Xu Source Type: research
Biomarkers for systemic lupus erythematosus - a focus on organ Damage
Expert Rev Clin Immunol. 2023 Sep 15. doi: 10.1080/1744666X.2023.2260098. Online ahead of print.ABSTRACTINTRODUCTION: Systemic lupus erythematosus (SLE) is complex autoimmune disease with heterogenous manifestations, unpredictable disease course and response to treatment. One of the critical needs in SLE management is the identification of reliable biomarkers that can aid in early diagnosis, accurate monitoring of disease activity, and assessment of treatment response.AREAS COVERED: In the current review, we focus on the commonly affected organs (skin, kidney, and nervous system) in SLE to summarize the emerging biomarkers...
Source: Expert Review of Clinical Immunology - September 15, 2023 Category: Allergy & Immunology Authors: Huihua Ding Yiwei Shen Soon-Min Hong Chunyan Xiang Nan Shen Source Type: research
VH2+ Antigen-Experienced B Cells in the Cerebrospinal Fluid Are Expanded and Enriched in Pediatric Anti-NMDA Receptor Encephalitis
J Immunol. 2023 Sep 15:ji2300156. doi: 10.4049/jimmunol.2300156. Online ahead of print.ABSTRACTPediatric and adult autoimmune encephalitis (AE) are often associated with Abs to the NR1 subunit of the N-methyl-d-aspartate (NMDA) receptor (NMDAR). Very little is known regarding the cerebrospinal fluid humoral immune profile and Ab genetics associated with pediatric anti-NMDAR-AE. Using a combination of cellular, molecular, and immunogenetics tools, we collected cerebrospinal fluid from pediatric subjects and generated 1) flow cytometry data to calculate the frequency of B cell subtypes in the cerebrospinal fluid of pediatric...
Source: Journal of Immunology - September 15, 2023 Category: Allergy & Immunology Authors: Nancy Monson Chad Smith Hannah Greenberg Patricia Plumb Alyssa Guzman Key Tse Ding Chen Wei Zhang Miles Morgan Haley Speed Craig Powell Sushobhna Batra Lindsay Cowell Scott Christley Steve Vernino Kyle Blackburn Benjamin Greenberg Source Type: research
Significant CA 19-9 Elevation in IgG4-Related Autoimmune Pancreatitis - A Diagnostic Dilemma
We describe the case of a 65-year-old male with history of IgG4-RD, presenting with jaundice and abdominal pain. He was found to have a pancreatic mass with significantly elevated IgG4 162 (2-96 mg/dL and CA19-9 levels 2830 (0-35 U/ml). Patient underwent ERCP and biopsy, which ruled out pancreatic cancer and cholangiocarcinoma. He was diagnosed with IgG4-RD autoimmune pancreatitis (AIP) and sclerosing cholangitis. Treatment with steroids and rituximab resulted in significant improvement in the bilirubin and a dramatic decrease in CA19-9 levels.PMID:37714269 | DOI:10.1016/j.amjms.2023.09.016
Source: The American Journal of the Medical Sciences - September 15, 2023 Category: General Medicine Authors: Larabe Farrukh Muhammad Farhan Akhtar Hafiza Hareem Waqar Ruben Peredo-Wende Source Type: research
Applications of oxetanes in drug discovery and medicinal chemistry
Eur J Med Chem. 2023 Sep 11;261:115802. doi: 10.1016/j.ejmech.2023.115802. Online ahead of print.ABSTRACTThe compact and versatile oxetane motifs have gained significant attention in drug discovery and medicinal chemistry campaigns. This review presents an overview of the diverse applications of oxetanes in clinical and preclinical drug candidates targeting various human diseases, including cancer, viral infections, autoimmune disorders, neurodegenerative conditions, metabolic disorders, and others. Special attention is given to biologically active oxetane-containing compounds and their disease-related targets, such as kin...
Source: European Journal of Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Guang Huang Devon Hucek Tomasz Cierpicki Jolanta Grembecka Source Type: research
Chew on This: The Afterbite of Temporomandibular Joint Involvement in Adults With Juvenile Idiopathic Arthritis
J Rheumatol. 2023 Sep 15:jrheum.2023-0776. doi: 10.3899/jrheum.2023-0776. Online ahead of print.ABSTRACTJuvenile idiopathic arthritis (JIA) is a chronic autoimmune disease that continues into adulthood in approximately 50% of patients.1 Growth considerations are unique to pediatric-onset disease and can lead to permanent joint damage.PMID:37714549 | DOI:10.3899/jrheum.2023-0776
Source: J Rheumatol - September 15, 2023 Category: Rheumatology Authors: Evelyn Victoria Rozenblyum Mercedes Olivia Chan Natasha Kaur Gakhal Source Type: research
Role of Bioactive Compounds, Novel Drug Delivery Systems, and Polyherbal Formulations in the Management of Rheumatoid Arthritis
Comb Chem High Throughput Screen. 2023 Sep 14. doi: 10.2174/1386207326666230914103714. Online ahead of print.ABSTRACTRheumatoid Arthritis (RA) is an autoimmune disorder that generally causes joint synovial inflammation as well as gradual cartilage and degenerative changes, resulting in progressive immobility. Cartilage destruction induces synovial inflammation, including synovial cell hyperplasia, increased synovial fluid, and synovial pane development. This phenomenon causes articular cartilage damage and joint alkalosis. Traditional medicinal system exerts their effect through several cellular mechanisms, including inhib...
Source: Combinatorial Chemistry and High Throughput Screening - September 15, 2023 Category: Chemistry Authors: Neha Rana Piyush Gupta Hridayanand Singh K Nagarajan Source Type: research
Nanotopography by chromatic confocal microscopy of the endothelium in Fuchs endothelial corneal dystrophy, pseudophakic bullous keratopathy and healthy corneas
CONCLUSIONS: CCM is an innovative approach to describe and quantify different morphologies of guttae. It could be useful to analyse the different stages of FECD and define subgroups of patients.PMID:37714683 | DOI:10.1136/bjo-2023-323297
Source: The British Journal of Ophthalmology - September 15, 2023 Category: Opthalmology Authors: Hanielle Vaitinadapoul é Sylvain Poinard Zhiguo He Alina Pascale-Hamri Justin Thomas Philippe Gain Jean-Yves Thuret Fr édéric Mascarelli Gilles Thuret French Fuchs Study Group (FFSG) Source Type: research
Autoimmune inflammatory reactions triggered by the COVID-19 genetic vaccines in terminally differentiated tissues
Autoimmunity. 2023 Dec;56(1):2259123. doi: 10.1080/08916934.2023.2259123.ABSTRACTAs a result of the spread of SARS-CoV-2, a global pandemic was declared. Indiscriminate COVID-19 vaccination has been extended to include age groups and naturally immune people with minimal danger of suffering serious complications due to COVID-19. Solid immuno-histopathological evidence demonstrates that the COVID-19 genetic vaccines can display a wide distribution within the body, affecting tissues that are terminally differentiated and far away from the injection site. These include the heart and brain, which may incur in situ production of...
Source: Autoimmunity - September 15, 2023 Category: Allergy & Immunology Authors: Panagis Polykretis Alberto Donzelli Janci C Lindsay David Wiseman Anthony M Kyriakopoulos Michael M örz Paolo Bellavite Masanori Fukushima Stephanie Seneff Peter A McCullough Source Type: research
Alterations of fecal microbiome and metabolome in pemphigus patients
J Autoimmun. 2023 Sep 13:103108. doi: 10.1016/j.jaut.2023.103108. Online ahead of print.ABSTRACTThe role of gut microbiome and metabolic substances in the development of autoimmune diseases has gradually been revealed. However, the relevant gut features in pemphigus have not been well clarified. We collected stool samples from pemphigus patients and healthy controls (HCs). Metagenomic sequencing and liquid chromatography-mass spectrometry (LC/MS) metabolome sequencing were performed to analyze the compositional and metabolic alternations of the gut microbiome in pemphigus patients and HCs. We observed the reduced richness ...
Source: Journal of Autoimmunity - September 15, 2023 Category: Allergy & Immunology Authors: Ziyu Guo Nam Yiu Zhi Hu Wenyu Zhou Xuan Long Miao Yang Jieyue Liao Guiying Zhang Qianjin Lu Ming Zhao Source Type: research
Drug Delivery System Approaches for Rheumatoid Arthritis Treatment: A Review
In conclusion, nanocarrier-based drug delivery systems have emerged as a promising solution for improving the treatment of rheumatoid arthritis. Further advancements in nanotechnology hold promise for enhancing the efficacy and safety of RA therapies, offering new hope for patients suffering from this debilitating disease.PMID:37711105 | DOI:10.2174/1389557523666230913105803
Source: Mini Reviews in Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Anushka Garhwal Priyadarshi Kendya Sakshi Soni Shivam Kori Vandana Soni Sushil Kumar Kashaw Source Type: research
