"Autoimmune Bullous" RSS Page 20

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Total 122032 results found since Jan 2013.

Design and synthesis of amino-substituted < em > N < /em > -arylpiperidinyl-based inhibitors of the (immuno)proteasome
Acta Pharm. 2023 Sep 14;73(3):441-456. doi: 10.2478/acph-2023-0032. Print 2023 Sep 1.ABSTRACTThe constitutive proteasome and the immunoproteasome represent validated targets for pharmacological intervention in the context of various diseases, such as cancer, inflammation, and autoimmune diseases. The development of novel chemical scaffolds of non-peptidic nature, capable of inhibiting different catalytically active subunits of both isoforms, is a viable approach against these diseases. Such compounds are also useful as leads for the development of biochemical probes that enable the studies of the roles of both isoforms in ...
Source: Acta Pharmaceutica - September 14, 2023 Category: Drugs & Pharmacology Authors: Martina Gobec Ale š Obreza Marko Juki č Ana Baumgartner Nja Mihel čič Špela Potočnik Julija Virant Irena Mlinari č Ra ščan Stanislav Gobec Izidor Sosi č Source Type: research

Cardiopulmonary bypass surgery-cold alert!
We report a case of CAs diagnosed intraoperatively during emergency mitral valve replacement.PMID:37706393 | PMC:PMC10284479 | DOI:10.4103/aca.aca_78_21
Source: Annals of Cardiac Anaesthesia - September 14, 2023 Category: Anesthesiology Authors: Nazmeen I Sayed Shakuntala Basantwani Chetana Bhalerao Usha Nair Priyanka Navalkar Source Type: research

Immunopathological features of myopathy associated with small-to-medium-sized vessel vasculitis and differences from autoimmune myositis
CONCLUSIONS: Patients with vasculitis demonstrated mild myofiber damage based on the lower involvement of CD56/NCAM-expressing myofibers compared to those with AIM. Complement component deposits on the vessel walls and hypervascularity in the endomysium areas may be immunopathological features of vasculitic myopathy.PMID:37706291 | DOI:10.55563/clinexprheumatol/hpoapl
Source: Clinical and Experimental Rheumatology - September 14, 2023 Category: Rheumatology Authors: Shun Nomura Yasuhiro Shimojima Takanori Ichikawa Daigo Miyazaki Akinori Uruha Dai Kishida Yoshiki Sekijima Source Type: research

Bullous emphysema and breast surgery: could fascial blocks be the best strategy?
Minerva Anestesiol. 2023 Sep 13. doi: 10.23736/S0375-9393.23.17592-4. Online ahead of print.NO ABSTRACTPMID:37705432 | DOI:10.23736/S0375-9393.23.17592-4
Source: Minerva Anestesiologica - September 14, 2023 Category: Anesthesiology Authors: Gabriele DI Silvestre Paola Sciamanna Chiara Angeletti Franco Marinangeli Federica Venturoni Paolo Scimia Source Type: research

Autoimmune hemolytic anemia due to mediastinal teratoma: A case report and review article
Autoimmune hemolytic anemia due to teatoma Key Clinical MassageAutoimmune hemolytic anemia (AIHA) is a rare disease that is divided into primary and secondary types. In patients with AIHA we should consider mediastinal tumors as a serious cause. If such teratoma was found surgical removal of it is in order.AbstractAutoimmune hemolytic anemia (AIHA) is a rare disease that is divided into primary and secondary types. The secondary type usually appears as a complication to some diseases such as chronic inflammatory diseases, systemic lupus erythematosus (SLE), and malignancies. A 26 years-old female with a chief complaint ...
Source: Clinical Case Reports - September 14, 2023 Category: General Medicine Authors: Maryam Ghazizadeh, Mohammad Moini, Matin Ghazizadeh Tags: CASE REPORT Source Type: research

Noninvasive approach to indicate risk factors of nonalcoholic steatohepatitis overlapping autoimmune hepatitis based on peripheral lymphocyte pattern
ConclusionsThe decreased frequency of peripheral CD8+ PD1+ T cells is an independent risk factor of NASH overlapping with AIH in the present cohort. Our findings will facilitate development of a new noninvasive FCM method for indicating risk factors of NASH, including autoimmunity.
Source: Journal of Gastroenterology - September 14, 2023 Category: Gastroenterology Source Type: research

Clinical features of myasthenia gravis with neurological and systemic autoimmune diseases
Multiple reports on the co-existence of autoimmune diseases and myasthenia gravis (MG) have raised considerable concern. Therefore, we reviewed autoimmune diseases in MG to explore their clinical presentations and determine whether the presence of autoimmune diseases affects the disease severity and treatment strategies for MG. We reviewed all the major immune-mediated coexisting autoimmune conditions associated with MG. PubMed, Embase and Web of Science were searched for relevant studies from their inception to January 2023. There is a higher frequency of concomitant autoimmune diseases in patients with MG than in the gen...
Source: Frontiers in Immunology - September 14, 2023 Category: Allergy & Immunology Source Type: research

Updated roles of cGAS-STING signaling in autoimmune diseases
This article reviews the activation process of the cGAS-STING signaling pathways and its related important roles, and therapeutic drugs in AID, aiming to improve our understanding of AID and achieve better diagnosis and treatment of AID.
Source: Frontiers in Immunology - September 14, 2023 Category: Allergy & Immunology Source Type: research

The involvement of NETs in ANCA-associated vasculitis
Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a serious autoimmune disease that is characterized by vascular necrosis. The pathogenesis of AAV includes ANCA-mediated neutrophil activation, subsequent release of inflammatory cytokines and reactive oxygen species (ROS), and formation of neutrophil extracellular traps (NETs). Excessive NETs could participate not only in ANCA-mediated vascular injury but also in the production of ANCAs per se as autoantigens. Thus, a vicious cycle of NET formation and ANCA production is critical for AAV pathogenesis. Elucidating the molecular signaling pathways...
Source: Frontiers in Immunology - September 14, 2023 Category: Allergy & Immunology Source Type: research

Three-dimensional analysis of ductular reactions and their correlation with liver regeneration and fibrosis
AbstractThe liver has multiple regeneration modes, including hepatocellular hypertrophy and self-renewal of hepatocytes. When hepatocyte proliferation is impaired, hepatic progenitor cells may proliferate through ductular reaction (DR), differentiate into hepatocytes, and contribute to fibrosis. However, the three-dimensional spatial relationship between DR and regenerating hepatocytes and dynamic changes in DR associated with fibrosis remain poorly understood. Here, we performed three-dimensional (3D) imaging of cleared 42 liver explants with chronic and acute liver diseases and 4 normal livers to visualize DR. In chronic...
Source: Virchows Archiv - September 14, 2023 Category: Pathology Source Type: research

Characterizing cognitive function in patients with autoimmune encephalitis: an Australian prospective study
ConclusionsThe study identified deficits in perceptual reasoning, processing speed, and working memory among chronic AE patients. Pattern analysis highlighted positive long-term cognitive outcomes for many but varied outcomes for those with ongoing difficulties. Although severely cognitively impaired patients were not included, the findings apply to AE cohorts who attend outpatient clinical neuropsychology consultations emphasizing the need for thorough cognitive assessment. The results suggest a need for further research targeting other cognitive domains, including executive functions.
Source: Journal of Neurology - September 14, 2023 Category: Neurology Source Type: research

Protocol for a double-blinded randomised controlled trial to assess the effect of faecal microbiota transplantations on thyroid reserve in patients with subclinical autoimmune hypothyroidism in the Netherlands: the IMITHOT trial
Background Hashimoto’s thyroiditis (HT) is a common endocrine autoimmune disease affecting roughly 5% of the general population and involves life-long treatment with levothyroxine, as no curative treatment yet exists. Over the past decade, the crosstalk between gut microbiota and the host immune system has been well-recognised, identifying the gut microbiome as an important factor in host health and disease, including susceptibility to autoimmune diseases. Previous observational studies yielded a link between disruption of the gut microbiome composition and HT. This is the first study that investigates the potential ...
Source: BMJ Open - September 14, 2023 Category: General Medicine Authors: Fenneman, A. C., Rampanelli, E., van der Spek, A. H., Fliers, E., Nieuwdorp, M. Tags: Open access, Diabetes and Endocrinology Source Type: research

Autoimmune disease, including Lupus Panniculitis in association with Panniculitic Cell Lymphomas
Some T cell lymphomas exhibit unique homing properties of the neoplastic lymphocytes for the subcutaneous fat. There are two primary forms of subcutaneous panniculitic lymphomas of T cell origin. The first falls under the designation of primary cutaneous gamma delta T cell lymphomas of the fat (PGD-TCL). The neoplastic cells are double negative for CD8+ gamma delta T cells and often have an aggressive clinical course. The other form of panniculitis, T cell lymphoma, falls under the designation of subcutaneous panniculitis-like T cell lymphoma (SPTCL).
Source: Clinics in Dermatology - September 14, 2023 Category: Dermatology Authors: Cynthia M. Magro, Taylor Kalomeris, Alicia Dillard Source Type: research

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