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Tregs with an MHC class II peptide–specific chimeric antigen receptor prevent autoimmune diabetes in mice
Adoptive immunotherapy with Tregs is a promising approach for preventing or treating type 1 diabetes. Islet antigen–specific Tregs have more potent therapeutic effects than polyclonal cells, but their low frequency is a barrier for clinical application. To generate Tregs that recognize islet antigens, we engineered a chimeric antigen receptor (CAR) derived from a monoclonal antibody with specificity for the insulin B chain 10–23 peptide presented in the context of the IAg7 MHC class II allele present in NOD mice. Peptide specificity of the resulting InsB-g7 CAR was confirmed by tetramer staining and T cell proliferatio...
Source: Journal of Clinical Investigation - September 15, 2023 Category: Biomedical Science Authors: Justin A. Spanier, Vivian Fung, Christine M. Wardell, Mohannad H. Alkhatib, Yixin Chen, Linnea A. Swanson, Alexander J. Dwyer, Matthew E. Weno, Nubia Silva, Jason S. Mitchell, Paul C. Orban, Majid Mojibian, C. Bruce Verchere, Brian T. Fife, Megan K. Levin Source Type: research
Nanotopography by chromatic confocal microscopy of the endothelium in Fuchs endothelial corneal dystrophy, pseudophakic bullous keratopathy and healthy corneas
CONCLUSIONS: CCM is an innovative approach to describe and quantify different morphologies of guttae. It could be useful to analyse the different stages of FECD and define subgroups of patients.PMID:37714683 | DOI:10.1136/bjo-2023-323297
Source: The British Journal of Ophthalmology - September 15, 2023 Category: Opthalmology Authors: Hanielle Vaitinadapoul é Sylvain Poinard Zhiguo He Alina Pascale-Hamri Justin Thomas Philippe Gain Jean-Yves Thuret Fr édéric Mascarelli Gilles Thuret French Fuchs Study Group (FFSG) Source Type: research
Intracavitary cardiac metastasis of cervical squamous cell carcinoma with immune thrombocytopenia: a rare case report
We present the case of an adult patient diagnosed with cervical cancer and concurrent right ventricular cancer thrombus, accompanied by immune thrombocytopenia (ITP). The patient exhibited resistance to conventional ITP drugs, with suboptimal platelet response. However, upon achieving initial control of the tumor, the patient's platelet counts returned to normal. Notably, the addition of immune checkpoint inhibitors targeting PD-L1 resulted in effective tumor control, accompanied by sustained high platelet levels. Unfortunately, during subsequent anti-tumor therapy, the patient experienced a prolonged platelet rise time, r...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Ning Liu Deguan Lv Raydonna Rachel Schneider Hongyan Yang Mingyan Zhang Yanan Liu Meili Sun Source Type: research
Autoimmune inflammatory reactions triggered by the COVID-19 genetic vaccines in terminally differentiated tissues
Autoimmunity. 2023 Dec;56(1):2259123. doi: 10.1080/08916934.2023.2259123.ABSTRACTAs a result of the spread of SARS-CoV-2, a global pandemic was declared. Indiscriminate COVID-19 vaccination has been extended to include age groups and naturally immune people with minimal danger of suffering serious complications due to COVID-19. Solid immuno-histopathological evidence demonstrates that the COVID-19 genetic vaccines can display a wide distribution within the body, affecting tissues that are terminally differentiated and far away from the injection site. These include the heart and brain, which may incur in situ production of...
Source: Autoimmunity - September 15, 2023 Category: Allergy & Immunology Authors: Panagis Polykretis Alberto Donzelli Janci C Lindsay David Wiseman Anthony M Kyriakopoulos Michael M örz Paolo Bellavite Masanori Fukushima Stephanie Seneff Peter A McCullough Source Type: research
Biomarkers for systemic lupus erythematosus - a focus on organ Damage
Expert Rev Clin Immunol. 2023 Sep 15. doi: 10.1080/1744666X.2023.2260098. Online ahead of print.ABSTRACTINTRODUCTION: Systemic lupus erythematosus (SLE) is complex autoimmune disease with heterogenous manifestations, unpredictable disease course and response to treatment. One of the critical needs in SLE management is the identification of reliable biomarkers that can aid in early diagnosis, accurate monitoring of disease activity, and assessment of treatment response.AREAS COVERED: In the current review, we focus on the commonly affected organs (skin, kidney, and nervous system) in SLE to summarize the emerging biomarkers...
Source: Expert Review of Clinical Immunology - September 15, 2023 Category: Allergy & Immunology Authors: Huihua Ding Yiwei Shen Soon-Min Hong Chunyan Xiang Nan Shen Source Type: research
Triggers and regulation: the gut microbiome in rheumatoid arthritis
Expert Rev Clin Immunol. 2023 Sep 15. doi: 10.1080/1744666X.2023.2260103. Online ahead of print.ABSTRACTINTRODUCTION: Rheumatoid arthritis is a chronic inflammatory disease marked by systemic symptoms and joint degeneration. Interestingly, the development and progression of rheumatoid arthritis have been linked to the microbiome, notably the gut microbiome. Dysbiosis, an alteration in the gut microbiome, has been connected to the etiology and pathogenesis of rheumatoid arthritis. For instance, dysbiosis increases intestinal permeability and promotes the movement of bacteria and its products, which in turn triggers and aggr...
Source: Expert Review of Clinical Immunology - September 15, 2023 Category: Allergy & Immunology Authors: Naim Mahroum Ravend Seida Yehuda Shoenfeld Source Type: research
Applications of oxetanes in drug discovery and medicinal chemistry
Eur J Med Chem. 2023 Sep 11;261:115802. doi: 10.1016/j.ejmech.2023.115802. Online ahead of print.ABSTRACTThe compact and versatile oxetane motifs have gained significant attention in drug discovery and medicinal chemistry campaigns. This review presents an overview of the diverse applications of oxetanes in clinical and preclinical drug candidates targeting various human diseases, including cancer, viral infections, autoimmune disorders, neurodegenerative conditions, metabolic disorders, and others. Special attention is given to biologically active oxetane-containing compounds and their disease-related targets, such as kin...
Source: European Journal of Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Guang Huang Devon Hucek Tomasz Cierpicki Jolanta Grembecka Source Type: research
Immune podocytes in the immune microenvironment of lupus nephritis (Review)
Mol Med Rep. 2023 Nov;28(5):204. doi: 10.3892/mmr.2023.13091. Epub 2023 Sep 15.ABSTRACTSystemic lupus erythematosus (SLE) is a systemic autoimmune disorder caused by the loss of tolerance to endogenous nuclear antigens such as double‑stranded DNA, leading to the proliferation of T cells and subsequent activation of B cells, which results in serious organ damage and life‑threatening complications such as lupus nephritis. Lupus nephritis (LN) develops as a frequent complication of SLE, accounting for >60% of SLE cases, and is characterized by proteinuria and heterogeneous histopathological findings. Glomerular injury ...
Source: Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Ruiling Liu Xiaoting Wen Xinyue Peng Miaomiao Zhao Liangyu Mi Jiamin Lei Ke Xu Source Type: research
Chew on This: The Afterbite of Temporomandibular Joint Involvement in Adults With Juvenile Idiopathic Arthritis
J Rheumatol. 2023 Sep 15:jrheum.2023-0776. doi: 10.3899/jrheum.2023-0776. Online ahead of print.ABSTRACTJuvenile idiopathic arthritis (JIA) is a chronic autoimmune disease that continues into adulthood in approximately 50% of patients.1 Growth considerations are unique to pediatric-onset disease and can lead to permanent joint damage.PMID:37714549 | DOI:10.3899/jrheum.2023-0776
Source: J Rheumatol - September 15, 2023 Category: Rheumatology Authors: Evelyn Victoria Rozenblyum Mercedes Olivia Chan Natasha Kaur Gakhal Source Type: research
Drug Delivery System Approaches for Rheumatoid Arthritis Treatment: A Review
In conclusion, nanocarrier-based drug delivery systems have emerged as a promising solution for improving the treatment of rheumatoid arthritis. Further advancements in nanotechnology hold promise for enhancing the efficacy and safety of RA therapies, offering new hope for patients suffering from this debilitating disease.PMID:37711105 | DOI:10.2174/1389557523666230913105803
Source: Mini Reviews in Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Anushka Garhwal Priyadarshi Kendya Sakshi Soni Shivam Kori Vandana Soni Sushil Kumar Kashaw Source Type: research
VH2+ Antigen-Experienced B Cells in the Cerebrospinal Fluid Are Expanded and Enriched in Pediatric Anti-NMDA Receptor Encephalitis
J Immunol. 2023 Sep 15:ji2300156. doi: 10.4049/jimmunol.2300156. Online ahead of print.ABSTRACTPediatric and adult autoimmune encephalitis (AE) are often associated with Abs to the NR1 subunit of the N-methyl-d-aspartate (NMDA) receptor (NMDAR). Very little is known regarding the cerebrospinal fluid humoral immune profile and Ab genetics associated with pediatric anti-NMDAR-AE. Using a combination of cellular, molecular, and immunogenetics tools, we collected cerebrospinal fluid from pediatric subjects and generated 1) flow cytometry data to calculate the frequency of B cell subtypes in the cerebrospinal fluid of pediatric...
Source: Journal of Immunology - September 15, 2023 Category: Allergy & Immunology Authors: Nancy Monson Chad Smith Hannah Greenberg Patricia Plumb Alyssa Guzman Key Tse Ding Chen Wei Zhang Miles Morgan Haley Speed Craig Powell Sushobhna Batra Lindsay Cowell Scott Christley Steve Vernino Kyle Blackburn Benjamin Greenberg Source Type: research
Role of Bioactive Compounds, Novel Drug Delivery Systems, and Polyherbal Formulations in the Management of Rheumatoid Arthritis
Comb Chem High Throughput Screen. 2023 Sep 14. doi: 10.2174/1386207326666230914103714. Online ahead of print.ABSTRACTRheumatoid Arthritis (RA) is an autoimmune disorder that generally causes joint synovial inflammation as well as gradual cartilage and degenerative changes, resulting in progressive immobility. Cartilage destruction induces synovial inflammation, including synovial cell hyperplasia, increased synovial fluid, and synovial pane development. This phenomenon causes articular cartilage damage and joint alkalosis. Traditional medicinal system exerts their effect through several cellular mechanisms, including inhib...
Source: Combinatorial Chemistry and High Throughput Screening - September 15, 2023 Category: Chemistry Authors: Neha Rana Piyush Gupta Hridayanand Singh K Nagarajan Source Type: research
Integrated BATF transcriptional network regulates suppressive intratumoral regulatory T cells
Sci Immunol. 2023 Sep 15;8(87):eadf6717. doi: 10.1126/sciimmunol.adf6717. Epub 2023 Sep 15.ABSTRACTHuman regulatory T cells (Tregs) are crucial regulators of tissue repair, autoimmune diseases, and cancer. However, it is challenging to inhibit the suppressive function of Tregs for cancer therapy without affecting immune homeostasis. Identifying pathways that may distinguish tumor-restricted Tregs is important, yet the transcriptional programs that control intratumoral Treg gene expression, and that are distinct from Tregs in healthy tissues, remain largely unknown. We profiled single-cell transcriptomes of CD4+ T cells in ...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Feng Shan Anthony R Cillo Carly Cardello Daniel Y Yuan Sheryl R Kunning Jian Cui Caleb Lampenfeld Asia M Williams Alexandra P McDonough Arjun Pennathur James D Luketich John M Kirkwood Robert L Ferris Tullia C Bruno Creg J Workman Panayiotis V Benos Dario Source Type: research
