This page shows you your search results in order of date.
Order by Relevance | Date
Total 122032 results found since Jan 2013.
Genes, Vol. 14, Pages 1844: Association between Gastric Cancer and 12 Autoimmune Diseases: A Mendelian Randomization Study
Conclusion: Our study did not find a genetic causal relationship between susceptibility to these autoimmune diseases and GC, which suggests that unmeasured confounders (e.g., inflammatory processes) or shared genetic architecture may be responsible for the reported epidemiologic associations. Further studies of ancestral diversity are warranted to validate such causal associations.
Source: Genes - September 23, 2023 Category: Genetics & Stem Cells Authors: Qi Wei Ziyu Wang Xuanyu Liu Haibin Liang Lei Chen Tags: Article Source Type: research
Ginger Consumption May Mitigate Neutrophil Dysfunction Ginger Consumption May Mitigate Neutrophil Dysfunction
An oral ginger extract was associated with reduced action of the neutrophil activity associated with the development of autoimmune and inflammatory diseases.Medscape Medical News
Source: Medscape Allergy Headlines - September 22, 2023 Category: Allergy & Immunology Tags: Rheumatology News Source Type: news
Association between Hashimoto ’s thyroiditis and melanoma: a retrospective matched cohort study
AbstractAn inflammatory microenvironment has been shown to increase risk for malignant melanoma, suggesting that melanoma may be related to a pro-inflammatory state. Though Hashimoto ’s thyroiditis is one of the most common autoimmune diseases, there are no investigations of its relationship with melanoma. We aim to determine if Hashimoto’s increases risk of developing melanoma. A retrospective, validated cohort of patients with a diagnosis of Hashimoto’s between 2005 and 2020 were identified using the Olmsted County database. Patients were age and sex matched to controls without a Hashimoto’s diagnosis. The primar...
Source: Archives of Dermatological Research - September 22, 2023 Category: Dermatology Source Type: research
Oxidized galectin-1 in SLE fails to bind the inhibitory receptor VSTM1 and increases reactive oxygen species levels in neutrophils
Cell Mol Immunol. 2023 Sep 22. doi: 10.1038/s41423-023-01084-z. Online ahead of print.ABSTRACTInhibitory immune receptors set thresholds for immune cell activation, and their deficiency predisposes a person to autoimmune responses. However, the agonists of inhibitory immune receptors remain largely unknown, representing untapped sources of treatments for autoimmune diseases. Here, we show that V-set and transmembrane domain-containing 1 (VSTM1) is an inhibitory receptor and that its binding by the competent ligand soluble galectin-1 (Gal1) is essential for maintaining neutrophil viability mediated by downregulated reactive...
Source: Cellular and Molecular Immunology - September 22, 2023 Category: Molecular Biology Authors: Xu Jiang Xinyue Xiao Hao Li Yiyi Gong Min Wang Huaxia Yang Lidan Zhao Ying Jiang Yanping Wei Chongchong Zhao Jin Li Yuling Chen Shan Feng Haiteng Deng Shiliang Ma Yue Xu Yudong Liu George C Tsokos Minghong Jiang Xuan Zhang Source Type: research
Genetic Disorders in Pediatric Rheumatology Clinic: When to Suspect, and Why?
Indian J Pediatr. 2023 Sep 22. doi: 10.1007/s12098-023-04845-w. Online ahead of print.ABSTRACTJust under a decade ago, most children with genetic disorders received a phenotypic diagnosis, often by atlas matching. With advances in genomics (decoding of human genome, easy availability of genetic testing, and reduction in cost of tests), genotypic diagnosis is now a reality. Genetic diseases can lead to non-inflammatory arthritis that can mimic juvenile idiopathic arthritis (JIA). A small but growing number (as newer genes are discovered) of genetic diseases are being diagnosed in children with a seemingly inflammatory muscu...
Source: Pain Physician - September 22, 2023 Category: Anesthesiology Authors: Naziya Perveen Maldar Raju Khubchandani Archana Khan Source Type: research
Clinical significance of human neutrophil antigen-1 antibodies in children with neutropenia
This study analyzed the clinical characteristics of 402 children with neutropenia to identify differences between those with and without HNA-1 antibodies (HNA1abs). HNAabs in sera were detected by granulocyte immunofluorescence testing using flow cytometry. Relative fluorescence intensity (RFI) values were used to divide patients into positive (PG, n = 302), borderline (BG, n = 34), and negative (NG, n = 66) groups. The antibodies reacted to HNA-1a alone (59%), HNA-1b alone (1%), and HNA-1a/1b (40%). The PG had a significantly lower absolute neutrophil count before definitive diagnosis and a 1.6- to 2-times greater risk of...
Source: International Journal of Hematology - September 22, 2023 Category: Hematology Authors: Satoshi Goda Shuhei Karakawa Satoshi Okada Hiroshi Kawaguchi Emi Kurita Mitsunori Noma Aiko Yamaoka Mayumi Komatsu Ayaka Yanai Mayu Kashihara Teruhisa Fujii Rie Onodera Kikuyo Taniguchi Mika Aizawa Masao Kobayashi Source Type: research
Role of telitacicept in the treatment of IgA nephropathy
This article reviews the role of telitacicept in IgA nephropathy and discusses its potential for use in the treatment of IgAN and other autoimmune diseases where pathogenesis is driven by B cells.PMID:37737205 | DOI:10.1186/s40001-023-01320-2
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Lijun Wu Xinru Du Xuehong Lu Source Type: research
Maternal autoimmune disease associated with a higher risk of offspring with type 1 diabetes: A nationwide mother –child cohort study in Taiwan
Source: International Journal of Rheumatic Diseases - September 22, 2023 Category: Rheumatology Authors: Yi ‐Ting Lee,
Han‐Lin Shih,
Renin Chang,
Su‐Boon Yong Tags: CORRESPONDENCE Source Type: research
Case Report: High-dose steroid and IVIG successful treatment in a case of COVID-19-associated autoimmune encephalitis: a literature review
This study presented a patient with critical COVID-19 autoimmune encephalitis who rapidly recovered after the initiation of corticosteroids and IVIG therapy. This study reviewed the current literature on the pathophysiological mechanisms, diagnosis, and management of COVID-19-associated autoimmune encephalitis.
Source: Frontiers in Immunology - September 22, 2023 Category: Allergy & Immunology Source Type: research
Antigen-driven T cell-macrophage interactions mediate the interface between innate and adaptive immunity in histidyl-tRNA synthetase-induced myositis
DiscussionOverall, HRS-induced myositis reflects the complex interplay between multiple cell types that collectively drive a TH1-predominant, pro-inflammatory tissue phenotype requiring antigen-mediated activation of both MyD88- and TCR-dependent T cell signaling pathways.
Source: Frontiers in Immunology - September 22, 2023 Category: Allergy & Immunology Source Type: research
Potential involvement of the bone marrow in experimental Graves ’ disease and thyroid eye disease
ConclusionCollectively, these data indicate that the bone marrow is activated in experimental Graves’ disease and TED, which is prevented by linsitinib. Linsitinib-mediated immune-inhibition is mediated, at least in part, by arginase-1 up-regulation, consumption of arginine and thereby immune inhibition.
Source: Frontiers in Endocrinology - September 22, 2023 Category: Endocrinology Source Type: research
Nephrotic syndrome induced by aortic regurgitation with Takayasu arteritis: an autopsy case with long-term clinical follow-up
AbstractTakayasu arteritis is a rare, chronic, and large-vessel vasculitis involving the aorta and its branches in a complex autoimmune reaction. Takayasu arteritis sometimes complicates aortic regurgitation and chronic kidney disease, but rarely accompanies nephrotic syndrome. We had a patient with Takayasu arteritis and concomitant aortic regurgitation. She had nephrotic syndrome that was refractory to immunosuppressive therapy but was promptly improved after surgical aortic valve replacement. In her kidney biopsy, glomeruli had mild mesangial proliferative changes without immune complex deposition. Her proteinuria remai...
Source: CEN Case Reports - September 22, 2023 Category: Urology & Nephrology Source Type: research
Myasthenic crisis in thymoma-associated myasthenia gravis: a multicenter retrospective cohort study
Myasthenia gravis (MG) is an autoimmune disorder with antibodies targeting the postsynaptic endplate leading to fluctuating muscle weakness in extraocular, bulbar, limb, and axial muscles. Approximately 85% of MG patients are serum positive for anti-acetylcholine receptors (AChR) antibodies, while anti-muscle-specific kinase (MuSK) antibodies are detected in around 5-6% of all patients [1]. Thymoma-associated myasthenia gravis (TMG) is almost exclusively linked to AChR antibodies with a peak age of 50 years.
Source: Neuromuscular Disorders - September 22, 2023 Category: Neurology Authors: Xiao Huan, Zhe Ruan, Rui Zhao, Manqiqige Su, Fan Ning, Zhangyu Zou, Song Tan, Lijun Luo, Song Yang, Jianquan Shi, Yanping Liu, Qilong Jiang, Jianying Xi, Ting Chang, Sushan Luo, Chongbo Zhao, Pan-Yangtze River Delta Alliance for Neuromuscular Disorders (P Source Type: research
Non-criteria autoantibodies in antiphospholipid syndrome may be associated with underlying disease activity
ConclusionSystemic lupus erythematosus (SLE) is the most commonly associated disease with APS, being present in approximately 35% of cases [1]. Since the majority of the patient group in our study had APS that was secondary to SLE, non-criteria antibody positivity may be linked to the immunological activity of SLE. Large multicenter studies are necessary to investigate the clinical significance of isolated/combined positivity for criterion/non-criteria aPLs.
Source: Irish Journal of Medical Science - September 22, 2023 Category: General Medicine Source Type: research
The Cardiovascular Burden of Rheumatoid Arthritis – Implications for Treatment
Mortality in rheumatoid arthritis is increased, about twice vs. controls, and cardiovascular diseases are a major cause. The pathogenesis is primarily accelerated atherosclerosis of the coronary, cervical, and cerebral arteries which is premature, pervasive, and progressive but often occult, under-recognized and under-treated. It is mostly driven by the chronic, systemic autoimmune inflammation but increased prevalence of traditional risk factors and adverse effects of treatments are also very important.
Source: The American Journal of Medicine - September 22, 2023 Category: General Medicine Authors: Ami Schattner Tags: Review Source Type: research
