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Regulatory effect of zinc finger protein A20 on rheumatoid arthritis through NLRP3/Caspase-1 signaling axis mediating pyroptosis of HFLS- RA cells
In conclusion, this study is of great significance for understanding the role of the NLRP3-caspase-1-IL-1β/ pyroptosis signaling pathway in the occurrence and development of RA. It is expected that the results will provide a theoretical basis for the immune regulation of innate immunity in the occurrence and development of RA, while providing a new therapeutic target for the clinical treatment of RA.PMID:37715399 | DOI:10.14715/cmb/2023.69.8.27
Source: Cellular and Molecular Biology - September 16, 2023 Category: Molecular Biology Authors: Ziqin Zhao Xinlong Ma Shuhui Dong Haibo Yin Yong Yang Guangyi Xiong Source Type: research

Hepatic safety and efficacy of immunomodulatory drugs used in patients with autoimmune hepatitis
CONCLUSION: Among 25 AIH patients who were treated with immunomodulatory drugs for different reasons, the majority had a fovorable course, relapse was frequent in difficult-to-treat patients who received belimumab, and four with concomitant IBD had insufficient response.PMID:37716078 | DOI:10.1016/j.jaut.2023.103113
Source: Journal of Autoimmunity - September 16, 2023 Category: Allergy & Immunology Authors: Benedetta Terziroli Beretta-Piccoli Gustav Buescher George Dalekos Kalliopi Zachou Anja Geerts Nasser Semmo Mirjam Kolev Eleonora De Martin Maciej K Janik Jo ão Madaleno Milica Lalosevic Stojkovic J érôme Dumortier Thomas Vanwolleghem Ida Schregel Silj Source Type: research

Harnessing autoimmunity with dominant self-peptide: Modulating the sustainability of tissue-preferential antigen-specific Tregs by governing the binding stability via peptide flanking residues
J Autoimmun. 2023 Sep 14;140:103094. doi: 10.1016/j.jaut.2023.103094. Online ahead of print.ABSTRACTSensitization to self-peptides induces various immunological responses, from autoimmunity to tumor immunity, depending on the peptide sequence; however, the underlying mechanisms remain unclear, and thus, curative therapeutic options considering immunity balance are limited. Herein, two overlapping dominant peptides of myelin proteolipid protein, PLP136-150 and PLP139-151, which induce different forms of experimental autoimmune encephalomyelitis (EAE), monophasic and relapsing EAE, respectively, were investigated. Mice with ...
Source: Journal of Autoimmunity - September 16, 2023 Category: Allergy & Immunology Authors: Youwei Lin Shun Sakuraba Chandirasegaran Massilamany Jayagopala Reddy Yoshimasa Tanaka Sachiko Miyake Takashi Yamamura Source Type: research

Regulatory effect of zinc finger protein A20 on rheumatoid arthritis through NLRP3/Caspase-1 signaling axis mediating pyroptosis of HFLS- RA cells
In conclusion, this study is of great significance for understanding the role of the NLRP3-caspase-1-IL-1β/ pyroptosis signaling pathway in the occurrence and development of RA. It is expected that the results will provide a theoretical basis for the immune regulation of innate immunity in the occurrence and development of RA, while providing a new therapeutic target for the clinical treatment of RA.PMID:37715399 | DOI:10.14715/cmb/2023.69.8.27
Source: Cellular and Molecular Biology - September 16, 2023 Category: Molecular Biology Authors: Ziqin Zhao Xinlong Ma Shuhui Dong Haibo Yin Yong Yang Guangyi Xiong Source Type: research

Hepatic safety and efficacy of immunomodulatory drugs used in patients with autoimmune hepatitis
CONCLUSION: Among 25 AIH patients who were treated with immunomodulatory drugs for different reasons, the majority had a fovorable course, relapse was frequent in difficult-to-treat patients who received belimumab, and four with concomitant IBD had insufficient response.PMID:37716078 | DOI:10.1016/j.jaut.2023.103113
Source: Journal of Autoimmunity - September 16, 2023 Category: Allergy & Immunology Authors: Benedetta Terziroli Beretta-Piccoli Gustav Buescher George Dalekos Kalliopi Zachou Anja Geerts Nasser Semmo Mirjam Kolev Eleonora De Martin Maciej K Janik Jo ão Madaleno Milica Lalosevic Stojkovic J érôme Dumortier Thomas Vanwolleghem Ida Schregel Silj Source Type: research

Harnessing autoimmunity with dominant self-peptide: Modulating the sustainability of tissue-preferential antigen-specific Tregs by governing the binding stability via peptide flanking residues
J Autoimmun. 2023 Sep 14;140:103094. doi: 10.1016/j.jaut.2023.103094. Online ahead of print.ABSTRACTSensitization to self-peptides induces various immunological responses, from autoimmunity to tumor immunity, depending on the peptide sequence; however, the underlying mechanisms remain unclear, and thus, curative therapeutic options considering immunity balance are limited. Herein, two overlapping dominant peptides of myelin proteolipid protein, PLP136-150 and PLP139-151, which induce different forms of experimental autoimmune encephalomyelitis (EAE), monophasic and relapsing EAE, respectively, were investigated. Mice with ...
Source: Journal of Autoimmunity - September 16, 2023 Category: Allergy & Immunology Authors: Youwei Lin Shun Sakuraba Chandirasegaran Massilamany Jayagopala Reddy Yoshimasa Tanaka Sachiko Miyake Takashi Yamamura Source Type: research

Regulatory effect of zinc finger protein A20 on rheumatoid arthritis through NLRP3/Caspase-1 signaling axis mediating pyroptosis of HFLS- RA cells
In conclusion, this study is of great significance for understanding the role of the NLRP3-caspase-1-IL-1β/ pyroptosis signaling pathway in the occurrence and development of RA. It is expected that the results will provide a theoretical basis for the immune regulation of innate immunity in the occurrence and development of RA, while providing a new therapeutic target for the clinical treatment of RA.PMID:37715399 | DOI:10.14715/cmb/2023.69.8.27
Source: Cellular and Molecular Biology - September 16, 2023 Category: Molecular Biology Authors: Ziqin Zhao Xinlong Ma Shuhui Dong Haibo Yin Yong Yang Guangyi Xiong Source Type: research

Hepatic safety and efficacy of immunomodulatory drugs used in patients with autoimmune hepatitis
CONCLUSION: Among 25 AIH patients who were treated with immunomodulatory drugs for different reasons, the majority had a fovorable course, relapse was frequent in difficult-to-treat patients who received belimumab, and four with concomitant IBD had insufficient response.PMID:37716078 | DOI:10.1016/j.jaut.2023.103113
Source: Journal of Autoimmunity - September 16, 2023 Category: Allergy & Immunology Authors: Benedetta Terziroli Beretta-Piccoli Gustav Buescher George Dalekos Kalliopi Zachou Anja Geerts Nasser Semmo Mirjam Kolev Eleonora De Martin Maciej K Janik Jo ão Madaleno Milica Lalosevic Stojkovic J érôme Dumortier Thomas Vanwolleghem Ida Schregel Silj Source Type: research

Harnessing autoimmunity with dominant self-peptide: Modulating the sustainability of tissue-preferential antigen-specific Tregs by governing the binding stability via peptide flanking residues
J Autoimmun. 2023 Sep 14;140:103094. doi: 10.1016/j.jaut.2023.103094. Online ahead of print.ABSTRACTSensitization to self-peptides induces various immunological responses, from autoimmunity to tumor immunity, depending on the peptide sequence; however, the underlying mechanisms remain unclear, and thus, curative therapeutic options considering immunity balance are limited. Herein, two overlapping dominant peptides of myelin proteolipid protein, PLP136-150 and PLP139-151, which induce different forms of experimental autoimmune encephalomyelitis (EAE), monophasic and relapsing EAE, respectively, were investigated. Mice with ...
Source: Journal of Autoimmunity - September 16, 2023 Category: Allergy & Immunology Authors: Youwei Lin Shun Sakuraba Chandirasegaran Massilamany Jayagopala Reddy Yoshimasa Tanaka Sachiko Miyake Takashi Yamamura Source Type: research

LncRNA Neat1 targets NonO and miR-128-3p to promote antigen-specific Th17 cell responses and autoimmune inflammation
Cell Death & Disease, Published online: 16 September 2023; doi:10.1038/s41419-023-06132-0LncRNA Neat1 targets NonO and miR-128-3p to promote antigen-specific Th17 cell responses and autoimmune inflammation
Source: Cell death and disease - September 16, 2023 Category: Internal Medicine Authors: Sisi Chen Jiali Wang Kailang Zhang Binyun Ma Xiaorong Li Ruihua Wei Hong Nian Source Type: research

Coronary and Extracoronary Manifestations of Systemic Inflammatory, Autoimmune, and Connective Tissue Diseases: Pathophysiologic Drivers of Vasculopathy Beyond Atherosclerosis
With special interest, we read the original research report by Chalikias et al1 examining the association of coronary artery ectasia (CAE) with autoimmune disease activity, as evidenced by positive antinuclear antibody (ANA) titers. The authors executed an observational case-control study that encompassed almost 7,500 patients who underwent coronary angiography. The team of investigators should be congratulated on this important effort because their study provides several key findings. Firstly, their results show that the real-world prevalence of CAE in the studied cohort was 4.3%, and when the 319 patients with confirmed ...
Source: The American Journal of Cardiology - September 16, 2023 Category: Cardiology Authors: Josip A. Borovac, Chun Shing Kwok Tags: Readers ’ Comments Source Type: research

Mayo Clinic advances research on mysterious blood vessel disease
Immunofluorescent image of highly activated immune cells in giant cell arteritis (GCA). This inflammatory blood vessel condition is an autoimmune disease that affects about 200,000 people in the U.S.   Giant cell arteritis (GCA), formerly known as temporal arteritis, was first described by Mayo doctors and classified as an inflammatory condition of the blood vessels in the early to mid-20th century. The condition causes bulging blood vessels at the temples, which, left untreated, may lead to…
Source: News from Mayo Clinic - September 16, 2023 Category: Databases & Libraries Source Type: news

Prevalence of markers of beta cell autoimmunity and thyroid disease in children with coeliac disease
Over the last decades, the prevalence of coeliac disease (CD), an autoimmune disorder, rose to 1 –2%. Whether patients with CD have higher risk of developing other autoimmune disorders such as type 1 diabetes, ...
Source: BMC Pediatrics - September 16, 2023 Category: Pediatrics Authors: Corinne L égeret, Alexander Kutz, Brunner Jessica, Esther Mundwiler, Henrik Köhler and Luca Bernasconi Tags: Research Source Type: research

Leber congenital amaurosis as the initial and essential manifestation in a Chinese patient with autoimmune polyglandular syndrome Type 1
ConclusionWe presented one case diagnosed with APS-1 based on clinical characteristics and genetic analysis. Our study demonstrated that LCA could serve as a warning sign for APS-1 and a potential trigger of early screening, which might prevent life-threatening complications.
Source: Documenta Ophthalmologica - September 16, 2023 Category: Opthalmology Source Type: research

‘Inverse vaccine’ could help tame autoimmune diseases
Vaccines rile up the immune system against pathogen invaders. But in autoimmune diseases, the immune system becomes the enemy. Scientists have now figured out a way to tamp down this self-destructive response in mice by attaching sugars to molecules that provoke immune cells. This “inverse vaccine,” reported this month in Nature Biomedical Engineering , could potentially lead to new ways to combat autoimmune diseases such as multiple sclerosis (MS) and lupus. “It’s a strong piece of work,” says Lawrence Steinman, a neuroimmunologist at Stanford Medicine who wasn’t connected to the study. The wo...
Source: Science of Aging Knowledge Environment - September 15, 2023 Category: Geriatrics Source Type: research