This page shows you your search results in order of date. This is page number 9.
Order by Relevance | Date
Total 122032 results found since Jan 2013.
Clinical characteristics and outcomes of patients with inflammatory and autoimmune rheumatological diseases admitted for intensive care in Colombia
CONCLUSIONS: Rheumatic diseases in the ICU are still associated with high morbidity and mortality. Patients with inflammatory and autoimmune rheumatic diseases require a meticulous clinical approach, strict clinical monitoring, frequent assessment of complications, evaluation of systemic support needs, and specific management.PMID:37721350 | DOI:10.4081/reumatismo.2023.1563
Source: Reumatismo - September 18, 2023 Category: Rheumatology Authors: D G Fern ández-Ávila Ó R Vargas-Vanegas L Galindo-Rozo Á García-Peña Ó Muñoz-Velandia Source Type: research
Coronary and Extracoronary Manifestations of Systemic Inflammatory, Autoimmune, and Connective Tissue Diseases: Pathophysiologic Drivers of Vasculopathy Beyond Atherosclerosis
Am J Cardiol. 2023 Sep 16:S0002-9149(23)00949-9. doi: 10.1016/j.amjcard.2023.08.170. Online ahead of print.NO ABSTRACTPMID:37722970 | DOI:10.1016/j.amjcard.2023.08.170
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Josip A Borovac Chun Shing Kwok Source Type: research
Treatment with a tissue-selective oestrogen complex does not affect disease pathology but reduces pre-BI cells in lupus-prone mice
CONCLUSION: TSEC does not aggravate a mouse model of lupus, when given in doses that protect against postmenopausal lupus-associated bone loss. This indicates that further investigations into TSEC as a treatment for osteoporosis or vasomotor symptoms in postmenopausal women with SLE are warranted.PMID:37722827 | DOI:10.1080/03009742.2023.2251753
Source: Scandinavian Journal of Rheumatology - September 18, 2023 Category: Rheumatology Authors: C Drevinge J M Scheffler J Nordqvist C Engdahl H Carlsten U Islander Source Type: research
Molecular action mechanisms of two novel and selective calcium release-activated calcium channel antagonists
Int J Biol Macromol. 2023 Sep 16:126937. doi: 10.1016/j.ijbiomac.2023.126937. Online ahead of print.ABSTRACTThe prototypical calcium release-activated calcium (CRAC) channel, composed of STIM1 and Orai1, is a sought-after drug target for treating autoimmune disorders. Herein, we identified two novel and selective CRAC channel inhibitors, the indole-like compound C63368 and pyrazole core-containing compound C79413, potently and reversibly inhibiting the CRAC channel with low micromolar IC50s and sparing various off-target ion channels. These two compounds did not inhibit STIM1 activation or its coupling with Orai1, nor did ...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Xiangjin Kong Feifan Wang Yan Chen Xinyao Liang Yuan Yin Hao Liu Guoqing Luo Yinping Li Songping Liang Youjun Wang Zhonghua Liu Cheng Tang Source Type: research
Genetic Reduction of IRF5 Expression after Disease Initiation Reduces Disease in a Mouse Lupus Model by Impacting Systemic and End-Organ Pathogenic Pathways
In this study, we demonstrate that genetic reduction of IRF5 expression after disease initiation reduces disease severity in the FcγRIIB-/- Y-linked autoimmune accelerating mouse lupus model. Reduction of IRF5 expression resulted in a decrease in splenomegaly and lymphadenopathy and a reduction in splenic B cell activation and plasmablast numbers. Splenic T cell activation and differentiation were also impacted as demonstrated by an increase in the number of naive CD4+ and CD8+ T cells and a reduction in the number of memory/effector CD4+ and CD8+ T cells. Although serum antinuclear autoantibody levels were not altered, r...
Source: Journal of Immunology - September 18, 2023 Category: Allergy & Immunology Authors: Alex Pellerin Ying Tan Simon Lu Ramon G Bonegio Ian R Rifkin Source Type: research
Clinical features, risk factors, and outcomes of diffuse alveolar hemorrhage in antiphospholipid syndrome: A mixed-method approach combining a multicenter cohort with a systematic literature review
CONCLUSION: APS-associated DAH is associated with high morbidity and mortality, particularly when presenting with triple positivity, thrombocytopenia, valvular involvement, and CAPS.PMID:37722463 | DOI:10.1016/j.clim.2023.109775
Source: Clinical Immunology - September 18, 2023 Category: Allergy & Immunology Authors: Gabriel Figueroa-Parra Jose A Meade-Aguilar Hannah E Langenfeld Mariana Gonz ález-Treviño Mehmet Hocaoglu Andrew C Hanson Larry J Prokop M Hassan Murad Rodrigo Cartin-Ceba Ulrich Specks Vikas Majithia Cynthia S Crowson Al í Duarte-García Source Type: research
Autoimmune responses and therapeutic interventions for systemic lupus erythematosus: a comprehensive review
Endocr Metab Immune Disord Drug Targets. 2023 Sep 15. doi: 10.2174/1871530323666230915112642. Online ahead of print.ABSTRACTSystemic Lupus Erythematosus (SLE) or Lupus is a multifactorial autoimmune disease of multiorgan malfunctioning of extremely heterogeneous and unclear etiology that affects multiple organs and physiological systems. Some racial groups and women of childbearing age are more susceptible to SLE pathogenesis. Impressive progress has been made towards a better understanding of different immune components contributing to SLE pathogenesis. Recent investigations have uncovered the detailed mechanisms of infla...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 18, 2023 Category: Endocrinology Authors: Surya Prakash Pandey Rakesh Bhaskar Sung Soon Han Kannan Badri Narayanan Source Type: research
Prevalence of Autoimmune Diseases in Cutaneous B-Cell Lymphoma: A Retrospective Cross Sectional Analysis
Source: Journal of the American Academy of Dermatology - September 18, 2023 Category: Dermatology Authors: D.H. Xiang, K.L. Perlman, B. Brumbaugh, R.M. Reardon, J. Barnes, C.G. Patel, S. Jain, S.T. Chen Source Type: research
Severe autoimmune hemolytic anemia; epidemiology, clinical management, outcomes and knowledge gaps
Autoimmune hemolytic anemia (AIHA) is an acquired hemolytic disorder, mediated by auto-antibodies, and has a variable clinical course ranging from fully compensated low grade hemolysis to severe life-threatening cases. The rarity, heterogeneity and incomplete understanding of severe AIHA complicate the recognition and management of severe cases. In this review, we describe how severe AIHA can be defined and what is currently known of the severity and outcome of AIHA. There are no validated predictors for severe clinical course, but certain risk factors for poor outcomes (hospitalisation, transfusion need and mortality) can...
Source: Frontiers in Immunology - September 18, 2023 Category: Allergy & Immunology Source Type: research
TLR8 escapes X chromosome inactivation in human monocytes and CD4+ T cells
ConclusionsTLR8, mirroringTLR7, escapes XCI in human monocytes and CD4+ T cells. Co-dependent transcription from the active X chromosome and escape from XCI could both contribute to higher TLR8 protein abundance in female cells, which may have implications for the response to viruses and bacteria, and the risk of developing inflammatory and autoimmune diseases.
Source: Biology of Sex Differences - September 18, 2023 Category: Biology Source Type: research
Panniculitic gamma delta t-cell lymphoma with concomitant features of autoimmune disease emphasizing a pathophysiologic continuum with the panniculitic t cell lymphomas
There are T-cell lymphomas, which exhibit unique homing properties of the neoplastic lymphocytes for the subcutaneous fat. Primary cutaneous gamma delta T-cell lymphomas of the fat (PGD-TCL) typically have an aggressive clinical course; the more indolent variant is subcutaneous panniculitis like T-cell lymphoma (SPTCL), comprising T-cells of the alpha beta subset. These t wo forms of subcutaneous T-cell neoplasms exhibit many overlapping histologic features with lupus profundus (LP); it has been previously suggested by one of the authors that lupus profundus is a form of a panniculitic T-cell dyscrasia.
Source: Clinics in Dermatology - September 18, 2023 Category: Dermatology Authors: Cynthia Magro, Taylor Kalomeris Source Type: research
Identification and functional analysis of serine protease inhibitor gene family of Eocanthecona furcellata (Wolff)
In this study, we sequenced the transcriptome of E. furcellata salivary gland and identified 38 SPIs genes named EfSPI1∼EfSPI38. Through gene structure, multiple sequence alignment and phylogenetic tree analysis, real-time quantitative PCR (RT-PCR) expression profiles of different developmental stages and different tissues were analyzed. RNAi technology was used to explore the gene function of EFSPI20. The results showed that these 38 EfSPIs genes contained 8 SPI domains, which were serpin, TIL, Kunitz, Kazal, Antistasin, Pacifastin, WAP and A2M. The expression profile results showed that the expression of different type...
Source: Frontiers in Physiology - September 18, 2023 Category: Physiology Source Type: research
