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Total 122032 results found since Jan 2013.
Co-administration of Thymoquinone and Propolis in Liposomal Formulations as a Potential Approach for Treatment of Acetic Acid-Induced Ulcerative Colitis: Physiological and Histopathological Analysis
This study is aimed at assessing the potential of liposomal formulations of TQ and Egyptian PP in combination therapy on improving their therapeutic efficacy against ulcerative colitis in order to maximize the potential of their beneficial clinical effects. Clinical, biochemical, and histological evaluations of colonic mucosal damage and inflammation were evaluated. The results exhibited a significant increase in tissue MDA, TNFα, and nitrite levels with activation of caspase-3 in the acetic acid-induced colitis group, which is predominantly downregulated in the treatment groups. The prepared formulations of TQ and PP rev...
Source: AAPS PharmSciTech - September 19, 2023 Category: Drugs & Pharmacology Authors: Eman Alaaeldin Hesham Refaat Entesar Ali Saber Neven Makram Aziz Nehad M Reda Abdel-Maqsoud Mohammed Mustafa Abd El Aleem Maha Yehia Kamel Fatma M Mady Source Type: research
Heterogeneity in RAG 1/2 Deficiency: 35 Cases From A Single Center
This study aimed to define the clinical/laboratory spectrum of RAG1/2 deficiency. We retrospectively reviewed the clinical/laboratory data of 35 patients, grouped them as severe combined immunodeficiency (SCID), Omenn Syndrome (OS), and delayed-onset combined immunodeficiency (CID) and reported nine novel mutations. Male/female ratio was 23/12. Median age of clinical manifestations was 1 months (mo) (0.5-2), 2 mo (1.25-5), and 14 mo (3.63-27), age at diagnosis was 4 mo (3-6), 4.5 mo (2.5-9.75), and 27 mo (14.5-70) in SCID (n=25;71.4%), OS (n=5;14.3%), and CID (n=5;14.3%) patients, respectively. Common clinical manifestatio...
Source: Clinical and Developmental Immunology - September 19, 2023 Category: Allergy & Immunology Authors: Betul Karaatmaca Deniz Cagdas Saliha Esenboga Baran Erman Cagman Tan Tuba Turul Ozgur Kaan Boztug Mirjam Van Der Burg Ozden Sanal Ilhan Tezcan Source Type: research
Interleukin-11 and its eminent role in tissue fibrosis: A possible therapeutic target
Clin Exp Immunol. 2023 Sep 19:uxad108. doi: 10.1093/cei/uxad108. Online ahead of print.ABSTRACTInterleukin-11 is a cytokine from the IL-6 family of cytokines that includes IL-6 and OSM. Initially described for its role in platelet generation, it is now appreciated that this cytokine has multiple functions. Recently it has been found that IL-11 is critical in fibrosis in multiple different organ systems and systemically as in the autoimmune disease systemic sclerosis. Animal models of fibrosis have determined that animals with IL-11 receptor deletions have retarded fibrosis and that in wild type animals IL-11 is found at th...
Source: Clinical and Developmental Immunology - September 19, 2023 Category: Allergy & Immunology Authors: Steven O'Reilly Source Type: research
Fracture incidence in Graves' disease: A population-based study
Conclusions There were no significant differences in total fracture rate between GD and the general population. However, men older than 52 years had a higher vertebral fracture rate. This study also shows that patients with treated GD receive more osteoporosis treatments compared to the general population.PMID:37725590 | DOI:10.1089/thy.2023.0162
Source: Thyroid : official journal of the American Thyroid Association - September 19, 2023 Category: Endocrinology Authors: Selwan Khamisi Ruzan Udumyan Gabriel Sj ölin Jan Calissendorff Helena Filipsson Nystr öm Mats Holmberg Bengt Hallengren Mikael Lantz Tereza Planck G öran Wallin Östen Ljunggren Source Type: research
Thyroglobulin antibodies in women with recurrent pregnancy loss: a systematic review and meta-analysis
Conclusions: Women with RPL were significantly more often TgAb-positive than women without RPL. Although there was a lack of studies reporting prospective outcomes, the findings of this study support the significance of awareness about the strong association between RPL and thyroid autoimmunity.PMID:37725583 | DOI:10.1089/thy.2023.0292
Source: Thyroid : official journal of the American Thyroid Association - September 19, 2023 Category: Endocrinology Authors: Perrine Shu Ting Huisman Jesper Krogh Claus Henrik Nielsen Henriette Svarre Nielsen Ulla Feldt-Rasmussen Sofie Bliddal Source Type: research
A Prospective, Multicenter Study Examining the Relationship between Thyroid Cancer Treatment Outcomes and the Presence of Autoimmune Thyroiditis
Conclusions In this large prospective series, biochemical persistence was more frequent, at one-year follow-up, in AT patients. However, there was no significant association between the presence of AT and structural persistence of disease. These findings may be explained by the presence of a residual thyroid tissue.PMID:37725571 | DOI:10.1089/thy.2023.0052
Source: Thyroid : official journal of the American Thyroid Association - September 19, 2023 Category: Endocrinology Authors: Simone De Leo Silvia D'Elia Giorgio Grani Francesco Dondi Francesco Bertagna Efisio Puxeddu Silvia Morelli Alessandro Piovesan Alice Nervo Maria Chiara Zatelli Irene Gagliardi Maria Teresa Sam à Gianluca Aimaretti Umberto Crocetti Michela Massa Maurilio Source Type: research
CSNK1A1/CK1 α suppresses autoimmunity by restraining the CGAS-STING1 signaling
Autophagy. 2023 Sep 18:1-18. doi: 10.1080/15548627.2023.2256135. Online ahead of print.ABSTRACTSTING1 (stimulator of interferon response cGAMP interactor 1) is the quintessential protein in the CGAS-STING1 signaling pathway, crucial for the induction of type I IFN (interferon) production and eliciting innate immunity. Nevertheless, the overactivation or sustained activation of STING1 has been closely associated with the onset of autoimmune disorders. Notably, the majority of these disorders manifest as an upregulated expression of type I interferons and IFN-stimulated genes (ISGs). Hence, strict regulation of STING1 activi...
Source: Autophagy - September 19, 2023 Category: Cytology Authors: Mingyu Pan Tongyu Hu Jiao Lyu Yue Yin Jing Sun Quanyi Wang Lingxiao Xu Haiyang Hu Chen Wang Source Type: research
Anti ‐aquaporin‐4 immunoglobulin G/anti‐myelin oligodendrocyte glycoprotein immunoglobulin G double‐positive paraneoplastic neurological syndrome in a patient with triple‐negative breast cancer
We report a rare case of paraneoplastic neurological syndrome with dual seropositivity of anti-aquaporin-4 and myelin oligodendrocyte glycoprotein antibodies in a 40 year-old woman with metastatic triple-negative breast cancer. She received multiple lines of anti-neoplastic treatment, including immunotherapy with pembrolizumab, as well as cytotoxic chemotherapy. Paraneoplastic meningoencephalomyelitis developed 2 years after diagnosis of breast cancer and 1 year after discontinuation of immunotherapy with pembrolizumab. She first developed longitudinally extending transverse myelitis followed by left optic neuritis...
Source: Clinical and Experimental Neuroimmunology - September 19, 2023 Category: Neurology Authors: Amna Siddiqui,
Dylan Ross,
Ronak H. Jani,
Vikram C. Prabhu,
Shelly Lo,
Derek A. Wainwright,
Stasia Rouse,
Tamer Refaat,
Yirong Zhu,
Jigisha P. Thakkar Tags: CASE REPORT Source Type: research
Hepatoprotective Properties of Water Kefir: A Traditional Fermented Drink and Its Potential Role
The liver is extremely vulnerable to damage because of its role in metabolism. Toxin, metabolic syndrome, alcohol, microorganisms, and autoimmune diseases can be the cause of liver damage. While different etiologies can cause liver disease, pathophysiologically, there are similarities in the role of free radicals, inflammatory mediators, and gut microbiome during the disease development. Therefore, ingredients with antioxidant, antiinflammatory, and antidysbiotic properties have the potential to act as hepatoprotectors; and water kefir is one of them. Water kefir is a traditional fermented drink made from water kefir grain...
Source: International Journal of Preventive Medicine - September 19, 2023 Category: International Medicine & Public Health Source Type: research
Viruses, Vol. 15, Pages 1952: Real-World Experience of the Comparative Effectiveness and Safety of Combination Therapy with Remdesivir and Monoclonal Antibodies versus Remdesivir Alone for Patients with Mild-to-Moderate COVID-19 and Immunosuppression: A Retrospective Single-Center Study in Aichi, Japan
Hiroshige Mikamo
The coronavirus disease (COVID-19) pandemic continues to threaten global public health. Remdesivir and monoclonal antibodies have shown promise for COVID-19 treatment of patients who are immunocompromised, including those with cancer, transplant recipients, and those with autoimmune disorder. However, the effectiveness and safety of this combination therapy for patients who are immunosuppressed remain unclear. We compared the efficacy and safety of combination therapy and remdesivir monotherapy for patients with mild-to-moderate COVID-19 who were immunosuppressed. Eighty-six patients treated in July 2...
Source: Viruses - September 19, 2023 Category: Virology Authors: Jun Hirai Nobuaki Mori Daisuke Sakanashi Wataru Ohashi Yuichi Shibata Nobuhiro Asai Hideo Kato Mao Hagihara Hiroshige Mikamo Tags: Article Source Type: research
SGLT2 inhibitors alleviated podocyte damage in lupus nephritis by decreasing inflammation and enhancing autophagy
Conclusion
This study confirmed the renoprotective effect of SGLT2 inhibitors in lupus mice, providing more evidence for non-immunosuppressive therapies to improve renal function in classic autoimmune kidney diseases such as LN.
Source: Annals of the Rheumatic Diseases - September 19, 2023 Category: Rheumatology Authors: Zhao, X.-y., Li, S.-s., He, Y.-x., Yan, L.-j., Lv, F., Liang, Q.-m., Gan, Y.-h., Han, L.-p., Xu, H.-d., Li, Y.-c., Qi, Y.-y. Tags: ARD, Systemic Lupus erythematosus Source Type: research
Single-cell transcriptome analysis profiles cellular and molecular alterations in submandibular gland and blood in IgG4-related disease
Conclusion
Our data revealed the cellular and molecular changes at the single-cell resolution of IgG4-RD and provide valuable insights into the aetiology and novel therapeutic targets of the autoimmune disease.
Source: Annals of the Rheumatic Diseases - September 19, 2023 Category: Rheumatology Authors: Li, Y., Wang, Z., Han, F., Zhang, M., Yang, T., Chen, M., Du, J., Wang, Y., Zhu, L., Hou, H., Chang, Y., Han, L., Lyu, X., Zhang, N., Sun, W., Cai, Z., Wei, W. Tags: ARD, IgG4 related disease Source Type: research
Developmental and behavioural outcomes at 2 years in babies born during the COVID-19 pandemic: communication concerns in a pandemic birth cohort
Conclusion
24-month-old pandemic-born infants had largely similar developmental and behavioural scores compared with their prepandemic counterparts. Concerns have been raised in the communication developmental domain.
Source: Archives of Disease in Childhood - September 19, 2023 Category: Pediatrics Authors: Byrne, S., Sledge, H., Hurley, S., Hoolahan, S., Franklin, R., Jordan, N., Boland, F., Murray, D. M., Hourihane, J., on behalf of the CORAL Study group, OMahony, McCallion, White, Lawler, Byrne, Fitzsimons Tags: Open access, COVID-19 Original research Source Type: research
Through the looking crystal: clarifying the pathogenesis and laboratory work-up of cryocrystalglobulinaemia
Cryoglobulins are immunoglobulins that precipitate or gel out of serum at temperatures less than 37°C and resolubilise on warming.1 Cryoglobulinaemia can cause vascular sludging or immune-mediated inflammation that classically presents with Meltzer’s triad of pupura, arthralgia and weakness.2 Cryocrystal formation is rare and can induce occlusive vasculopathy, thrombosis and inflammation.3 The aetiology of cryoglobulinaemia commonly includes infections, autoimmune diseases and haematological malignancies.2 Cryoglobulins are classified into three types based on clonality and immunoglobulin typing.4 Type 1 consists...
Source: Journal of Clinical Pathology - September 19, 2023 Category: Pathology Authors: Punchoo, R. Tags: JCP Education Grand rounds commentary Source Type: research
Identification of biomarkers in patients with rheumatoid arthritis responsive to DMARDs but with progressive bone erosion
ConclusionWe show that patients with progressive erosive disease are characterized by abnormalities in B cells and in cytokines with a proven role in bone reabsorption. Understanding the role played by B cells and the cytokine IL-11 and IL-17A in progressive erosive disease can help identify novel biomarkers of erosive disease and design treatment approaches aimed at halting joint damage in RA.
Source: Frontiers in Immunology - September 19, 2023 Category: Allergy & Immunology Source Type: research
