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Total 122032 results found since Jan 2013.

Early Growth Response Gene-1 Deficiency Interrupts TGF β1 Signaling Activation and Aggravates Neurodegeneration in Experimental Autoimmune Encephalomyelitis Mice
This study demonstrated that Egr-1 was down-regulated at mRNA and protein levels in the central nervous system (CNS) of experimental autoimmune encephalomyelitis (EAE) mice. Egr-1 knockout exacerbated EAE progression in mice, as shown by increased disease severity and incidence; it also aggravated neuronal apoptosis, which was associated with weakened activation of the BDNF/TGF β 1/MAPK/Akt signaling pathways in the CNS of EAE mice. Consistently, Egr-1 siRNA promoted apoptosis but mitigated the activation of BDNF/TGFβ 1/MAPK/Akt signaling in SH-SY5Y cells. Our results revealed that Egr-1 is a crucial regulator of neurona...
Source: Neuroscience Bulletin - September 19, 2023 Category: Neuroscience Source Type: research

Associations between immune-mediated diseases (IMDs) and the risk of HPV-associated diseases: a UK Biobank cohort analysis
Conclusion In this large retrospective cohort study, IMDs were significantly associated with an elevated risk of HPV-associated diseases. Besides, gender-specific and region-specific associations were also observed between individual IMDs and HPV-associated diseases.
Source: BMJ Open - September 19, 2023 Category: General Medicine Authors: Feng, L., Qiu, K., Rao, Y., Shu, T., Song, Y., Cheng, D., Mao, M., Li, J., Zhang, Z., Wang, X., Zeng, X., Zhao, Y., Ren, J. Tags: Open access, Epidemiology Source Type: research

Featured immune characteristics of COVID-19 and systemic lupus erythematosus revealed by multidimensional integrated analyses
ConclusionsOur results demonstrate the immune response differences and immune characteristic similarities, such as the cytokine storm, between COVID-19 and SLE, which might pivotally function in the pathogenesis of the two diseases and provide potential intervention targets for both diseases.
Source: Inflammation Research - September 19, 2023 Category: Research Source Type: research

Identification of novel protein biomarkers and drug targets for colorectal cancer by integrating human plasma proteome with genome
ConclusionsThis study identified several protein biomarkers to be associated with CRC risk and provided new insights into the etiology and promising targets for the development of screening biomarkers and therapeutic drugs for CRC.
Source: Genome Medicine - September 19, 2023 Category: Genetics & Stem Cells Source Type: research

Microfluidic Single-Cell Migration Chip Reveals Insights into the Impact of Extracellular Matrices on Cell Movement
Lab Chip, 2023, Accepted Manuscript DOI: 10.1039/D3LC00651D, PaperMengli Zhou, Yushu Ma, Edwin C. Rock, Chun-Cheng Chiang, Kathryn E. Luker, Gary Luker, Yu-Chih Chen Cell migration is a complex process that plays a crucial role in normal physiology and pathologies such as cancer, autoimmune diseases, and mental disorders. Conventional cell migration assays face limitations... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Lab Chip latest articles - September 18, 2023 Category: Chemistry Authors: Mengli Zhou Source Type: research

Clinical characteristics and outcomes of patients with inflammatory and autoimmune rheumatological diseases admitted for intensive care in Colombia
CONCLUSIONS: Rheumatic diseases in the ICU are still associated with high morbidity and mortality. Patients with inflammatory and autoimmune rheumatic diseases require a meticulous clinical approach, strict clinical monitoring, frequent assessment of complications, evaluation of systemic support needs, and specific management.PMID:37721350 | DOI:10.4081/reumatismo.2023.1563
Source: Reumatismo - September 18, 2023 Category: Rheumatology Authors: D G Fern ández-Ávila Ó R Vargas-Vanegas L Galindo-Rozo Á García-Peña Ó Muñoz-Velandia Source Type: research

Molecular action mechanisms of two novel and selective calcium release-activated calcium channel antagonists
Int J Biol Macromol. 2023 Sep 16:126937. doi: 10.1016/j.ijbiomac.2023.126937. Online ahead of print.ABSTRACTThe prototypical calcium release-activated calcium (CRAC) channel, composed of STIM1 and Orai1, is a sought-after drug target for treating autoimmune disorders. Herein, we identified two novel and selective CRAC channel inhibitors, the indole-like compound C63368 and pyrazole core-containing compound C79413, potently and reversibly inhibiting the CRAC channel with low micromolar IC50s and sparing various off-target ion channels. These two compounds did not inhibit STIM1 activation or its coupling with Orai1, nor did ...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Xiangjin Kong Feifan Wang Yan Chen Xinyao Liang Yuan Yin Hao Liu Guoqing Luo Yinping Li Songping Liang Youjun Wang Zhonghua Liu Cheng Tang Source Type: research

CXCL1 enhances COX-II expression in rheumatoid arthritis synovial fibroblasts by CXCR2, PLC, PKC, and NF- κB signal pathway
In conclusion, the current study provided a novel insight into the role of CXCL1 in RA pathogenesis.PMID:37722260 | DOI:10.1016/j.intimp.2023.110909
Source: International Immunopharmacology - September 18, 2023 Category: Allergy & Immunology Authors: Chun-Han Hou Po-Chun Chen Ju-Fang Liu Source Type: research

Autoimmune responses and therapeutic interventions for systemic lupus erythematosus: a comprehensive review
Endocr Metab Immune Disord Drug Targets. 2023 Sep 15. doi: 10.2174/1871530323666230915112642. Online ahead of print.ABSTRACTSystemic Lupus Erythematosus (SLE) or Lupus is a multifactorial autoimmune disease of multiorgan malfunctioning of extremely heterogeneous and unclear etiology that affects multiple organs and physiological systems. Some racial groups and women of childbearing age are more susceptible to SLE pathogenesis. Impressive progress has been made towards a better understanding of different immune components contributing to SLE pathogenesis. Recent investigations have uncovered the detailed mechanisms of infla...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 18, 2023 Category: Drugs & Pharmacology Authors: Surya Prakash Pandey Rakesh Bhaskar Sung Soon Han Kannan Badri Narayanan Source Type: research

Treatment with a tissue-selective oestrogen complex does not affect disease pathology but reduces pre-BI cells in lupus-prone mice
CONCLUSION: TSEC does not aggravate a mouse model of lupus, when given in doses that protect against postmenopausal lupus-associated bone loss. This indicates that further investigations into TSEC as a treatment for osteoporosis or vasomotor symptoms in postmenopausal women with SLE are warranted.PMID:37722827 | DOI:10.1080/03009742.2023.2251753
Source: Scandinavian Journal of Rheumatology - September 18, 2023 Category: Rheumatology Authors: C Drevinge J M Scheffler J Nordqvist C Engdahl H Carlsten U Islander Source Type: research

Genetic Reduction of IRF5 Expression after Disease Initiation Reduces Disease in a Mouse Lupus Model by Impacting Systemic and End-Organ Pathogenic Pathways
In this study, we demonstrate that genetic reduction of IRF5 expression after disease initiation reduces disease severity in the FcγRIIB-/- Y-linked autoimmune accelerating mouse lupus model. Reduction of IRF5 expression resulted in a decrease in splenomegaly and lymphadenopathy and a reduction in splenic B cell activation and plasmablast numbers. Splenic T cell activation and differentiation were also impacted as demonstrated by an increase in the number of naive CD4+ and CD8+ T cells and a reduction in the number of memory/effector CD4+ and CD8+ T cells. Although serum antinuclear autoantibody levels were not altered, r...
Source: Journal of Immunology - September 18, 2023 Category: Allergy & Immunology Authors: Alex Pellerin Ying Tan Simon Lu Ramon G Bonegio Ian R Rifkin Source Type: research

Inflammatory cytokines in rheumatoid arthritis: Diagnostic Challenges, Pathogenic Mechanisms and their role in depression and management
Curr Top Med Chem. 2023 Sep 15. doi: 10.2174/1568026623666230915095151. Online ahead of print.ABSTRACTDepression being a common comorbidity of rheumatoid arthritis (RA) is found to be responsible for the reduction in the lifespan of the sufferer along with the compromised quality of life. The study quoted below highlights the pathogenic pathways, the frequency of RA along with its impact on patients, thus, raising awareness about the concerned topic. It is found that the chances and frequency of developing depression are 2-3 times higher in patients with RA in comparison to the general population. For such studies, self-re...
Source: Current Topics in Medicinal Chemistry - September 18, 2023 Category: Chemistry Authors: Ayushi Sharma Anjana Goel Source Type: research

Autoimmune responses and therapeutic interventions for systemic lupus erythematosus: a comprehensive review
Endocr Metab Immune Disord Drug Targets. 2023 Sep 15. doi: 10.2174/1871530323666230915112642. Online ahead of print.ABSTRACTSystemic Lupus Erythematosus (SLE) or Lupus is a multifactorial autoimmune disease of multiorgan malfunctioning of extremely heterogeneous and unclear etiology that affects multiple organs and physiological systems. Some racial groups and women of childbearing age are more susceptible to SLE pathogenesis. Impressive progress has been made towards a better understanding of different immune components contributing to SLE pathogenesis. Recent investigations have uncovered the detailed mechanisms of infla...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 18, 2023 Category: Endocrinology Authors: Surya Prakash Pandey Rakesh Bhaskar Sung Soon Han Kannan Badri Narayanan Source Type: research

Genetic Reduction of IRF5 Expression after Disease Initiation Reduces Disease in a Mouse Lupus Model by Impacting Systemic and End-Organ Pathogenic Pathways
In this study, we demonstrate that genetic reduction of IRF5 expression after disease initiation reduces disease severity in the FcγRIIB-/- Y-linked autoimmune accelerating mouse lupus model. Reduction of IRF5 expression resulted in a decrease in splenomegaly and lymphadenopathy and a reduction in splenic B cell activation and plasmablast numbers. Splenic T cell activation and differentiation were also impacted as demonstrated by an increase in the number of naive CD4+ and CD8+ T cells and a reduction in the number of memory/effector CD4+ and CD8+ T cells. Although serum antinuclear autoantibody levels were not altered, r...
Source: Journal of Immunology - September 18, 2023 Category: Allergy & Immunology Authors: Alex Pellerin Ying Tan Simon Lu Ramon G Bonegio Ian R Rifkin Source Type: research

Clinical features, risk factors, and outcomes of diffuse alveolar hemorrhage in antiphospholipid syndrome: A mixed-method approach combining a multicenter cohort with a systematic literature review
CONCLUSION: APS-associated DAH is associated with high morbidity and mortality, particularly when presenting with triple positivity, thrombocytopenia, valvular involvement, and CAPS.PMID:37722463 | DOI:10.1016/j.clim.2023.109775
Source: Clinical Immunology - September 18, 2023 Category: Allergy & Immunology Authors: Gabriel Figueroa-Parra Jose A Meade-Aguilar Hannah E Langenfeld Mariana Gonz ález-Treviño Mehmet Hocaoglu Andrew C Hanson Larry J Prokop M Hassan Murad Rodrigo Cartin-Ceba Ulrich Specks Vikas Majithia Cynthia S Crowson Al í Duarte-García Source Type: research