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Total 1864 results found since Jan 2013.

Gastroschisis at school age: what do parents report?
Conclusion: Parent-reported outcomes of school-aged children with gastroschisis were mainly reassuring. Clinicians and parents should be aware of the higher risk of cognitive problems, especially in those with neonatal intestinal failure or increased parent-perceived vulnerability. We recommend multidisciplinary follow-up at school age of children with gastroschisis and neonatal intestinal failure.What is Known:• Many infants with gastroschisis experience morbidity in early life.• Data on developmental outcomes and daily functioning in children with gastroschisis beyond the age of 5 years are scarce and conflicting.Wh...
Source: European Journal of Pediatrics - August 15, 2019 Category: Pediatrics Source Type: research

Impact of Clinical Factors on the Intestinal Microbiome in Infants With Gastroschisis.
CONCLUSION: The microbiome of gastroschisis infants is dysbiotic, and mode of birth delivery, antibiotic duration, and gestational age appear to contribute to microbial variation. This article is protected by copyright. All rights reserved. PMID: 32441784 [PubMed - as supplied by publisher]
Source: JPEN Journal Of Parenteral And Enteral Nutrition - May 21, 2020 Category: Nutrition Authors: Wu AJ, Lee DJ, Li F, Tobin NH, Aldrovandi GM, Shew SB, Calkins KL Tags: JPEN J Parenter Enteral Nutr Source Type: research

The association of perinatal and clinical factors with outcomes in infants with gastroschisis —a retrospective multicenter study in Finland
Conclusion: The risk of death is increased in newborns with gastroschisis who have liver herniation, pulmonary hypoplasia, abdominal compartment syndrome, relaparotomy for perforation or necrosis, or central line –associated sepsis. Special care should be taken to minimize the risk of central line sepsis in the clinical setting.What is known:•Gastroschisis is a relatively rare congenital anomaly of the abdominal wall and its incidence is increasing.•Complex gastroschisis has been reported to increase risk of mortality and complications.What is new:•Central line sepsis was found to be independently associated with m...
Source: European Journal of Pediatrics - February 2, 2021 Category: Pediatrics Source Type: research

Regional variation in gastroschisis: a nationwide database review of demographics and outcomes
ConclusionsThere has been a significant increase in gastroschisis incidence over the last three decades. This significant increase appears to be related to an increase in socioeconomic inequality and an alteration in the population demographics in the United States. Further study of regional variations will facilitate the development of best practice guidelines that benefit all.
Source: Pediatric Surgery International - March 31, 2021 Category: Surgery Source Type: research

A retrospective review of gastroschisis epidemiology and referral patterns in northern Ghana
ConclusionsImproving access to surgical care and reducing neonatal mortality related to gastroschisis in northern Ghana is critical. This study provides a baseline to inform future gastroschisis interventions at TTH. Priority areas may include special management of low birth weight newborns, better referral systems, empowerment of community health workers, and increasing access to timely, affordable, and safe neonatal transport.
Source: Pediatric Surgery International - May 31, 2021 Category: Surgery Source Type: research

Gastroschisis Complicated by Colonic Atresia
CONCLUSIONS: Gastroschisis with intestinal atresia is associated with increased hospital length of stay, longer duration of parenteral nutrition, more severe intestinal dysfunction, increased surgical complications, and higher mortality than gastroschisis or intestinal atresia alone. With associated colonic atresia, loss of a significant length of bowel due to necrosis, including the ileocecal region, is almost unavoidable. An already compromised blood supply to the atretic bowel is further impaired by a tight abdominal wall defect and postnatal increases in gravitational force. Complicated gastroschisis remains a complex ...
Source: The American Surgeon - November 3, 2021 Category: Surgery Authors: Hayley M Everett S Dave Bhattacharya Source Type: research

Non-operative management of a rare diagnosis of splenic torsion in a child with a history of giant omphalocele: A case report and literature review.
CONCLUSION: Although rare, splenic torsion should be considered in a child with a history of omphalocele presenting with abdominal pain. Non-operative management of an infarcted spleen can be a safe treatment option to avoid surgery in complex patients. PMID: 24602190 [PubMed - as supplied by publisher]
Source: Patient Safety in Surgery - March 7, 2014 Category: Surgery Authors: Sheikh F, Kim ME, Zamora IJ, Olutoye OO Tags: Patient Saf Surg Source Type: research

GAD65/GAD67 double knockout mice exhibit intermediate severity in both cleft palate and omphalocele compared with GAD67 knockout and VGAT knockout mice
Publication date: 12 March 2015 Source:Neuroscience, Volume 288 Author(s): T. Kakizaki , N. Oriuchi , Y. Yanagawa Inhibitory neurotransmitters, γ-aminobutyric acid (GABA) and glycine, are transported into synaptic vesicles by the vesicular GABA transporter (VGAT). Glutamate decarboxylase (GAD) is a GABA-synthesizing enzyme and two isoforms of GAD, GAD65 and GAD67 are encoded by two independent genes. There was virtually no GABA content in GAD65/GAD67 double knockout (GADs DKO) mouse brains. Neither GABAergic nor glycinergic inhibitory postsynaptic currents were almost detected in VGAT knockout (KO) mouse cultured neuron...
Source: Neuroscience - January 27, 2015 Category: Neuroscience Source Type: research

HDlive imaging of a giant omphalocele sac.
We report a case of fetal giant omphalocele with HDlive images of the giant omphalocele sac containing multiple small bowel loops and almost the entire liver. In our case HDlive view was complementary to 2-D ultrasound in identifying the herniated viscera, particularly the contours of the herniated small bowel and liver which mimicked the post-natal views. PMID: 27299988 [PubMed - as supplied by publisher]
Source: The Ultrasound Review of Obstetrics and Gynecology - June 13, 2016 Category: Radiology Authors: Blumenfeld YJ, Milan KE, Rubesova E, Sylvester KG, Davis AS, Chock VY, Hintz SR Tags: Ultrasound Obstet Gynecol Source Type: research

Accuracy and impact of prenatal diagnosis in infants with omphalocele
ConclusionThe rate of associated malformations that are diagnosed postnatally is high, but the majority was malformations with a minor clinical significance or impact on future health. Beckwith –Wiedemann syndrome was present only in cases of non-giant omphalocele in our cohort.
Source: Pediatric Surgery International - April 10, 2018 Category: Surgery Source Type: research

Mice doubly deficient in Six4 and Six5 show ventral body wall defects reproducing human omphalocele RESEARCH ARTICLE
ABSTRACT Omphalocele is a human congenital anomaly in ventral body wall closure and may be caused by impaired formation of the primary abdominal wall (PAW) and/or defects in abdominal muscle development. Here, we report that mice doubly deficient in homeobox genes Six4 and Six5 showed the same ventral body wall closure defects as those seen in human omphalocele. SIX4 and SIX5 were localized in surface ectodermal cells and somatic mesoderm-derived mesenchymal and coelomic epithelial cells (CECs) in the PAW. Six4–/–;Six5–/– fetuses exhibited a large omphalocele with protrusion of both the liver and in...
Source: DMM Disease Models and Mechanisms - October 25, 2018 Category: Biomedical Science Authors: Takahashi, M., Tamura, M., Sato, S., Kawakami, K. Tags: RESEARCH ARTICLE Source Type: research

Operative versus conservative treatment for giant omphalocele: Study of French and Ivorian management.
CONCLUSION: The tanning treatment has its own place in the therapeutic arsenal in the management of the giant omphalocele no matter where it takes place. However, its realization in surgical environments prevents certain complications related to the technique or the pathology. PMID: 31047764 [PubMed - as supplied by publisher]
Source: Annales de Chirurgie Plastique et Esthetique - April 28, 2019 Category: Cosmetic Surgery Authors: Binet A, Scalabre A, Amar S, Alzahrani K, Boureau C, Bastard F, Lefebvre F, Koffi M, Moufidath S, Nasser D, Ouattara O, Kouame BD, Lardy H Tags: Ann Chir Plast Esthet Source Type: research

Impact of Breast Milk, Respiratory Insufficiency, and Gastroesophageal Reflux Disease on Enteral Feeding in Infants With Omphalocele
Objectives: The aim of this study was to document the process of achieving full enteral feeding in infants with omphalocele and to identify factors that affect feeding success. Methods: After institutional review board approval (study no. 5100169), 123 infants with omphalocele, born between 1993 and 2011 were reviewed. Mortalities were excluded. All survivors had complete follow-up. Variables suspected to impact enteral feeding in infants with non-giant versus giant omphalocele were compared. Independent t test, Mann-Whitney, and χ2 test were used. Regression evaluated for variable independence. Results: Of 123 in...
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Omphalocele in Finland from 1993 to 2014: Trends, Prevalence, Mortality, and Associated Malformations —A Population-Based Study
Conclusion Omphalocele is a rare congenital anomaly, often associated with other malformations. Our data suggest that isolated cases may be more common than previously thought. In the absence of chromosomal defects, survival is reasonably good. Regardless, more than half of these pregnancies are often terminated. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: European Journal of Pediatric Surgery - March 3, 2020 Category: Surgery Authors: Raitio, Arimatias Tauriainen, Asta Syv änen, Johanna Kemppainen, Teemu L öyttyniemi, Eliisa Sankilampi, Ulla Vanamo, Kari Gissler, Mika Hyv ärinen, Anna Helenius, Ilkka Tags: Original Article Source Type: research