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Fight Aging! Newsletter, August 16th 2021
In conclusion, cancer survivors, especially older individuals, demonstrate greater odds of and accelerated functional decline, suggesting that cancer and/or its treatment may alter aging trajectories. Linking Particulate Air Pollution and Dementia in a Small Region of the US https://www.fightaging.org/archives/2021/08/linking-particulate-air-pollution-and-dementia-in-a-small-region-of-the-us/ It is fairly settled that evident particulate air pollution, such as daily exposure to smoke from wood-fueled cooking fires, has a strongly detrimental effect on long-term health. The mechanisms involved are inflamm...
Source: Fight Aging! - August 15, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Should Your Parent Risk an Anesthesia Disaster or Forego Surgery?
  Photo credit Niklas Hamann Just last week a reader asked me whether she should try to sway her mother, who had colon cancer, toward surgery. Her mother, 87, was diagnosed with colon cancer and given the choice of surgery and chemotherapy or letting it alone. If she chose not to have surgery, she could still have chemotherapy and radiation, though she was told that treatment wasn't apt to help a great deal. As expected, the daughter was distraught. She was seeking help in determining what her responsibility to her mother is. The woman mentioned that her mother was mentally sharp, so I told her that, in my opinion......
Source: Minding Our Elders - August 10, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Fight Aging! Newsletter, August 9th 2021
In conclusion, the present study supports that some age-related diseases as well as education are causally related to longevity and highlights several new targets for achieving longevity, including management of venous thromboembolism, appropriate intake of sugar, and control of body fat. Our results warrant further studies to elucidate the underlying mechanisms of these reported causal associations. Pol III Inhibition Extends Longevity in Short-Lived Species https://www.fightaging.org/archives/2021/08/pol-iii-inhibition-extends-longevity-in-short-lived-species/ As this paper notes, Pol III is downstream...
Source: Fight Aging! - August 8, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, August 2nd 2021
This study aimed to determine the association between: (i) cognitive decline and bone loss; and (ii) clinically significant cognitive decline on Mini Mental State Examination (MMSE) over the first 5 years and subsequent fracture risk over the following 10 years. A total of 1741 women and 620 men aged ≥65 years from the population-based Canadian Multicentre Osteoporosis Study were followed from 1997 to 2013. Over 95% of participants had normal cognition at baseline. After multivariable adjustment, cognitive decline was associated with bone loss in women but not men. Approximately 13% of participants experienced sign...
Source: Fight Aging! - August 1, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Treating Aging as a Medical Condition Should Long Have Been a Priority
Aging kills most people in the world, and near all people in the wealthier parts of the world. It doesn't just kill, but also produces decades of declining health and capabilities, increased pain and suffering. Addressing the causes of aging, uncovering the mechanisms of aging and treating them, should have been the top priority in medicine ever since the advent of modern antibiotics allowed for control over the majority of infectious disease. Decades in which meaningful progress could have taken place have been wasted, and work on the mechanisms of aging is still only a small field within the life sciences, a small indust...
Source: Fight Aging! - July 23, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Life sciences vision
Department for Business, Energy& Industrial Strategy - This document outlines government and the life science sector ’s ambitions for the sector over the next decade. It sets out the government's plans to stimulate a thriving UK life sciences sector. It also focuses on how the sector can address the some of the UK ’s most significant healthcare challenges, including cancer, dementia, and obesity.DocumentPress release
Source: Health Management Specialist Library - July 12, 2021 Category: UK Health Authors: The King ' s Fund Library Tags: Digital health and data Source Type: blogs

Fight Aging! Newsletter, July 12th 2021
In conclusion, our study demonstrated that elevated cumulative SBP or DBP was independently associated with increased risk of CVD in the Chinese population. Among participants with 15-year cumulative BP levels higher than the median, that is, 1970.8/1239.9 mmHg-year for cumulative SBP/DBP, which was equivalent to maintaining SBP/DBP level higher than 131/83 mmHg in 15 years, the CVD risk would increase significantly irrespective of whether or not the BP measurements at one examination was high. Our findings emphasize the importance of cumulative BP level in identifying individuals with high risk of CVD in the future. ...
Source: Fight Aging! - July 11, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Emerging Trends: Technology ’s Response To Alzheimer’s Disease
In our new series, Emerging Trends, we are looking at those technologies in digital health that are on a particular ‘hype cycle’ – technologies and solutions that currently stand out from the rest because of their novelty, timeliness, or greatness. These are solutions everyone’s talking about or the ones they should. Technological solutions to cognitive decline and Alzheimer’s disease, in particular, are rising with increasing pipeline drug development, promising biomarkers, and more. Let’s jump right in. Liza Marshall was “over the moon” when she said yes to the love of her life in a small cerem...
Source: The Medical Futurist - June 29, 2021 Category: Information Technology Authors: berci.mesko Tags: Forecast Lifestyle medicine Artificial Intelligence in Medicine E-Patients Future of Medicine Personalized Medicine Robotics Telemedicine & Smartphones alzheimer brain diagnosis digital digital health Healthcare Innovation me Source Type: blogs

Dad with Dementia Knew His Wife Died but Now Can ’t Remember
Photo credit Tim Doerfler Dear Carol: Mom died two years ago, and while my dad had already been diagnosed with Alzheimer’s, he seemed to accept her death because she had been in terrible pain from cancer. Recently, though, he’s started asking for her as if she’s still alive and it’s heartbreaking. When I remind him that she died, he grieves as if it’s new information. Later, he’ll ask for her again as though we never discussed it. It’s breaking my heart to see him keep repeating this new-to-him grief. I know that you’ve said before that people should not contradict someone with dementia. I get that under mo...
Source: Minding Our Elders - June 27, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Fight Aging! Newsletter, June 21st 2021
This study showed that the leakage of this mitochondrial nucleic material may occur as a result of mitochondrial dysfunction, which may involve genetic mutations in genes encoding mitochondrial proteins or incomplete degradation of mitochondrial dsDNA in the lysosome - which is a 'degradation factory' of the cell. Upon the leakage into the cytoplasm, this undegraded dsDNA is detected by a 'foreign' DNA sensor of the cytoplasm (IFI16) which then triggers the upregulation of mRNAs encoding for inflammatory proteins." Using a PD zebrafish model (gba mutant), the researchers demonstrated that a combination of PD-like ph...
Source: Fight Aging! - June 20, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, June 14th 2021
In conclusion, a number of high-income countries, changes in health expectancies over time have not kept pace with the growth in life expectancy. That is, people are living longer but disability and poor health are occupying an increasing proportion of later life. Our findings suggest that countries still need to make significant progress to achieve the WHO's Decade of Healthy Ageing goal of healthier, longer lives for all. Progress on Understanding Why Human Growth Hormone Receptor Variants are Associated with Greater Longevity https://www.fightaging.org/archives/2021/06/progress-on-understanding-why-human-gro...
Source: Fight Aging! - June 13, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Daughter Wants to Help Mom Give Dad Wonderful Last Father ’s Day
Photo credit Seth Hays Dear Carol: Father’s Day is coming up and my mom wants to make Dad’s day special because it’s probably his last one. My brother and I want this too, but how to make it work is where we disagree with Mom. Dad’s been in a nursing home because of several health problems, but terminal cancer is what will take him soon. The problem is that Mom’s physically frail herself and worse, her decision-making is shaky, so we feel that she’s being unrealistic. Dad’s in pain and he tires easily. He needs a wheelchair, and Mom’s apartment has steps. He’s also on oxygen. While we understand whe...
Source: Minding Our Elders - June 13, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Fight Aging! Newsletter, June 7th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - June 6, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Anxiety During Social Outings May Have Worsened for People with Dementia
 Photo image Sander Weeteling Dear Carol: My husband is only 56 but he has early-onset Alzheimer’s. I’ve done my best during COVID to keep him interested in activities and Zoom calls with the kids and friends. Now that we’re vaccinated, he could go out more but I’m having trouble finding the line between giving him the social exposure that’s recommended and pushing him into anxiety. Since he’s still in the earlier stage of dementia, the doctor wants to wait before trying antianxiety medications. Our kids think now that it’s safer I should have him out more. In a way they are right, but he can’t seem t...
Source: Minding Our Elders - June 6, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Fight Aging! Newsletter, May 31st 2021
In conclusion, iMSC-sEVs could rejuvenate the senescence of NPCs and attenuate the development of IVDD. Cell Signaling via Exosomes in the Development of Vascular Calcification https://www.fightaging.org/archives/2021/05/cell-signaling-via-exosomes-in-the-development-of-vascular-calcification/ Vascular calcification is a feature of aging, a process in which cells in the blood vessel wall take on inappropriate identities and activities that are more appropriate to bone tissue. Evidence of recent years implicates chronic inflammation and the presence of senescent cells in this process. Senescent cells caus...
Source: Fight Aging! - May 30, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs