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A Conceptual Shift to (Finally) Seeing Aging as the Cause of Age-Related Disease
The mainstream of the scientific community has for decade after decade followed an entirely incorrect strategy in the matter of aging, and it was only comparatively recently that this state of affairs was changed for the better by the advocacy of groups like the SENS Research Foundation, Methuselah Foundation, and their allies, alongside advances in the science of slowing and reversing aging that couldn't be easily dismissed, much of that funded by philanthropy rather than established institutions. Given a poor strategy, in which age-related diseases were studied separately from aging, and in their end stages, and without ...
Source: Fight Aging! - January 21, 2021 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs

Staying Positive While Caregiving
Dear Candid Caregiver: My dad is in the middle stages of Alzheimer’s disease. Meanwhile, my mom is recovering from cancer surgery, and the prognosis isn’t good. I’m trying my best to be a good caregiver for both of them and stay positive while doing it, but it’s hard. I recognize that we’re fortunate in that my parents are able to hire an agency that supplies a rotation of in-home caregivers. The other side of it is that I have a brother and a sister, both living hundreds of miles away from our parents and me, so they can’t help out much. They try to be sympathetic and appreciative of what I’m doi...
Source: Minding Our Elders - January 21, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Advocating the Use of Low Dose Ionizing Radiation as a Hormetic Treatment
Many forms of mild cellular stress produce benefits to health because they trigger the more efficient operation of cellular maintenance processes such as autophagy. That in turn causes better cell and tissue function, and thus improved health. This stress response and benefit is known as hormesis, and has been robustly proven to take place for calorie restriction, heat, cold, low dose ionizing radiation, and numerous other environmental circumstances. When it comes to slowing aging, the benefits of hormesis to life span are much larger in short-lived species. The short-term changes to metabolism are very similar, however, ...
Source: Fight Aging! - January 20, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, January 18th 2021
In this study, Desferal, deferoxamine mesylate for injection, which is approved for the treatment of acute iron intoxication and chronic iron overload, was used to explore the beneficial effects on preventing aging-induced bone loss and mitigating dysfunction of aged BMSCs. High-dose Desferal significantly prevented bone loss in aged rats. Compared with controls, the ex vivo experiments showed that short-term Desferal administration could promote the potential of BMSC growth and improve the rebalance of osteogenic and adipogenic differentiation, as well as rejuvenate senescent BMSCs and revise the expression of stemness/se...
Source: Fight Aging! - January 17, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Why Won ’t the Doctor Do More Tests on Older Parent?
Photo Credit Unsplash Dear Carol: My mom is 78 and she’s thrilled because her doctor told her that since she’s over 75, she’s done with taking colonoscopies and “a bunch of other tests.” I was alarmed, but she said that there’s not a lot of good to be gotten from the tests at her age, and there are risks in having them. Mom is healthy and I want to keep her that way. What if she develops colon cancer? Granted, she has no sign of any problem with her test last year, but the possibility still worries me. Is this policy just to save the health insurance companies money or is this ageism because older people ...
Source: Minding Our Elders - January 17, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Fight Aging! Newsletter, January 11th 2021
This study demonstrates the potential of a natural (o-Vanillin) and a synthetic (RG-7112) senolytic compounds to remove senescent IVD cells, decrease SASP factors release, reduce the inflammatory environment and enhance the IVD matrix production. Removal of senescent cells, using senolytics drugs, could lead to improved therapeutic interventions and ultimately decrease pain and a provide a better quality of life of patients living with intervertebral disc degeneration and low back pain. From Ying Ann Chiao of Oklahoma Medical Research Foundation: Mitochondrial dysfunction plays a central role in aging and cardiovasc...
Source: Fight Aging! - January 10, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, January 4th 2021
The objective of this study is to quantify the overall and cancer type-specific risks of subsequent primary cancers (SPCs) among adult-onset cancer survivors by first primary cancer (FPC) types and sex. Among 1,537,101 survivors (mean age, 60.4 years; 48.8% women), 156,442 SPC cases and 88,818 SPC deaths occurred during 11,197,890 person-years of follow-up (mean, 7.3 years). Among men, the overall risk of developing any SPCs was statistically significantly higher for 18 of the 30 FPC types, and risk of dying from any SPCs was statistically significantly higher for 27 of 30 FPC types as compared with risks in the general po...
Source: Fight Aging! - January 3, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Look Back at 2020: Progress Towards the Treatment of Aging as a Medical Condition
While I suspect that COVID-19 will feature prominently in most retrospectives on 2020, I'll say only a little on it. The data on mortality by year end, if taken at face value, continues to suggest that the outcome will fall at the higher end of the early estimates of a pandemic three to six times worse than a bad influenza year, ten times worse than a normal influenza year. The people who die are near entirely the old, the co-morbid, and the immunocompromised. They die because they are suffering the damage and dysfunction of aging. Yet the societal conversation and the actions of policy makers ignore this. There is ...
Source: Fight Aging! - December 31, 2020 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs

Fight Aging! Newsletter, December 28th 2020
In conclusion, our study demonstrated that the molecular processes of aging are relatively subtle in their progress, and the aging process of every tissue depends on the tissue's specialized function and environment. Hence, individual gene or process alone cannot be described as the key of aging in the whole organism. Mouse Age Matters: How Age Affects the Murine Plasma Metabolome A large part of metabolomics research relies on experiments involving mouse models, which are usually 6 to 20 weeks of age. However, in this age range mice undergo dramatic developmental changes. Even small age differences may l...
Source: Fight Aging! - December 27, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Better Cardiovascular Fitness in Mid-Life Correlates with Lower Risk of Later Dementia
In this study, we observed that having the ideal CVH metrics, and ideal behavioral CVH metrics in particular, from midlife onwards is associated with a reduced risk of dementia as compared with people having poor CVH metrics. Maintaining life-long health behaviors may be crucial to reduce late-life risk of dementia. Link: https://doi.org/10.1371/journal.pmed.1003474
Source: Fight Aging! - December 22, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, December 21st 2020
In this study, we have found that administration of a specific Sgk1 inhibitor significantly reduces the dysregulated form of tau protein that is a pathological hallmark of AD, restores prefrontal cortical synaptic function, and mitigates memory deficits in an AD model. These results have identified Sgk1 as a potential key target for therapeutic intervention of AD, which may have specific and precise effects." Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer's disease Epigenetic aberration is implicated in aging and neurodegeneration. Using p...
Source: Fight Aging! - December 20, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Quality of Epigenetic Clocks Continues to Improve
There is at present a diverse exploration of clocks that assess biological age, these clocks constructed as weighted combinations of data picked from the epigenome, transcriptome, or proteome, all of which change in characteristic ways with age. Many different clocks are at various stages of development and refinement. The goal is the production of a robust, low-cost, rapid way to assess the efficacy of potential rejuvenation therapies: if one can use a blood test ten days before and ten days after a treatment, that would be a great deal easier than having to wait and see over the course of a life span. Unfortunate...
Source: Fight Aging! - December 16, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

The Spectrum of Alzheimer's: An Interview With Gayatri Devi, M.D.
For years, the push to do something about Alzheimer’s disease-focused almost entirely on drug development. Find a cure. Develop a vaccine to prevent the disease. Develop a drug to “manage” people who live with Alzheimer’s and other types of dementia. What many people weren’t noticing, however, was that in tandem with this effort was a quiet revolution doggedly moving forward.  Long championed by Dr. Bill Thomas of Changing Aging among others, the thinking behind this movement has always been to recognize that people living with Alzheimer’s and other dementia were first and foremost...
Source: Minding Our Elders - December 16, 2020 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Fight Aging! Newsletter, December 14th 2020
In conclusion, aging alters the cerebral vasculature to impair mitochondrial function and mitophagy and increase IL-6 levels. These alterations may impair BBB integrity and potentially reduce cerebrovascular health with aging. Senescent Cells Fail to Maintain Proteostasis https://www.fightaging.org/archives/2020/12/senescent-cells-fail-to-maintain-proteostasis/ Given the newfound consensus in the research community regarding the importance of senescent cells to degenerative aging, it isn't surprising to see a great deal more fundamental research into the biochemistry of cellular senescence now taking pla...
Source: Fight Aging! - December 13, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Incontinence Management Change Up Could Make Dad ’s Buddy Trip Possible
Dear Carol: My father is 72 and is in the moderate stages of dementia. Before his dementia diagnosis, he was an active hunter and fisherman. He also has incontinence issues due to prostate cancer, surgery, and treatment. This requires an external urinary attachment system to maintain an active daily life. My mother, as his primary caregiver, works diligently to keep the system and attachments clean and in working order. However, he is at the stage in his dementia journey where he is not able to maintain this attachment on his own. Yet he is defiant when we try to explain that he cannot go on trips with friends becaus...
Source: Minding Our Elders - December 10, 2020 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs