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Fight Aging! Newsletter, March 29th 2021
Discussion of Systemic Inflammation and its Contribution to Dementia
Fisetin Reduces D-Galactose Induced Cognitive Loss in Mice
Reprogramming Cancer Cells into Normal Somatic Cells
Considering Longevity Medicine and the Education of Physicians
Researchers Generate Thyroid Organoids Capable of Restoring Function in Mice
In Search of Transcriptional Signatures of Aging
A Pace of Aging Biomarker Correlates with Manifestations of Aging
Targeting Tissues with Extracellular Vesicles
Calorie Restriction Slows Aging of the Gut Microbiome in Mice
Mitochondrial DNA Heteroplasmy in the Aging Heart
Evidence for Hea...
Source: Fight Aging! - March 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, March 22nd 2021
This article expresses sentiments regarding medical technology and human longevity that we'd all like to see more of in the mainstream media. At some point, it will come to be seen by the average person as basically sensible to work towards minimizing the tide of suffering and death caused aging and age-related disease. It has been, in hindsight, a strange thing to live in a world in which most people were reflexively opposed to that goal.
Death and aging constitute a mystery. Some of us die more quickly. We often ask about it as children, deny it in youth, and reluctantly come to accept it as adults. Aging is uni...
Source: Fight Aging! - March 21, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Prevalence of Cellular Senescence May Explain the Inverse Correlation Between Cancer and Neurodegeneration
One of the more curious aspects of aging is that risk of Alzheimer's disease and risk of cancer is inversely correlated. Why is this the case? Researchers here suggest that cellular senescence may be an important component of this relationship. If cells in a given individual are more than averagely prone to becoming senescent in response to stress and damage, then this may lower the risk of cancer, as precancerous cells will be blocked from replication and removed by the immune system more efficiently. On the other hand, increased cellular senescence in the aging brain will more rapidly drive chronic inflammation and neuro...
Source: Fight Aging! - March 19, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Future of Human Longevity will be Very Different from the Past
Human life expectancy has increased through two distinct process; firstly a reduction in child mortality, and second a reduction in the burden of damage accumulated over an adult life span. Control of infectious disease has played a large role in both components of gains in life expectancy. The trend has been slow. In recent decades, something like 0.2 years of life expectancy at birth and 0.1 years of remaining life expectancy at age 60 have been added with each passing calendar year.
Life expectancy is an artificial measure, of course: it is the length of life remaining, on average, assuming that nothing changes i...
Source: Fight Aging! - March 16, 2021 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
The Popular Science Media Fails to Distinguish Between Potentially High Yield and Probably Low Yield Treatments for Aging
It is of great importance to distinguish, where we can, between promising and poor approaches to the treatment of aging. If only poor approaches are developed, then we'll age, suffer, and die on much the same schedule as our grandparents. In the article here, metformin and senolytics are crammed together side by side, as though the same thing. They are very much not the same thing.
Metformin is almost certainly a poor approach to the treatment of aging. The animal data is terrible, while the human data shows only a modest effect size. Senolytics are most likely a promising approach. The animal data is amazing: robus...
Source: Fight Aging! - March 16, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, March 15th 2021
In conclusion, PLG attenuates high calcium/phosphate-induced vascular calcification by upregulating P53/PTEN signaling in VSMCs.
Tsimane and Moseten Hunter-Gatherers Exhibit Minimal Levels of Atrial Fibrillation
https://www.fightaging.org/archives/2021/03/tsimane-and-moseten-hunter-gatherers-exhibit-minimal-levels-of-atrial-fibrillation/
Epidemiological data for the Tsimane and Moseten populations in Bolivia shows that they suffer very little cardiovascular disease in later life, despite a presumably greater lifetime burden of infectious disease (and consequent inflammation) than is the case for people i...
Source: Fight Aging! - March 14, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, March 1st 2021
This study may have important implications for preventing cell senescence and aging-induced tendinopathy, as well as for the selection of novel therapeutic targets of chronic tendon diseases.
Our results showed that the treatment of bleomycin, a DNA damaging agent, induced rat patellar TSC (PTSC) cellular senescence. The senescence was characterized by an increase in the senescence-associated β-galactosidase activity, as well as senescence-associated changes in cell morphology. On the other hand, rapamycin could extend lifespan in multiple species, including yeast, fruit flies, and mice, by decelerating DNA damage ...
Source: Fight Aging! - February 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards a Cure for Aging
Work on treating aging as a medical condition, targeting the mechanisms that cause aging in order to slow or reverse its progression, has advanced to the point at which the popular science and medical resources of the world are writing overviews on the topic, seeking to better inform the public at large. We have come a long way in the past decade. The compelling animal data for approaches such as the targeted removal of senescent cells, showing rejuvenation in mice, is melting some of the skepticism that previously characterized attitudes towards the treatment of aging.
Heart disease. Cancer. Diabetes. Dementia. R...
Source: Fight Aging! - February 22, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 22nd 2021
In conclusion, long term LRIC could decrease blood pressure and ameliorate vascular remodeling via inflammation regulation.
The Damage of a Heart Attack Causes the Immune System to Overreact
https://www.fightaging.org/archives/2021/02/the-damage-of-a-heart-attack-causes-the-immune-system-to-overreact/
Researchers here note a mechanism that causes T cells of the adaptive immune system to spur chronic inflammation and tissue damage following a heart attack. As the researchers note, not all inflammation is the same. Some is maladaptive, and this is particularly the case in older individuals. The aged immune...
Source: Fight Aging! - February 21, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, February 15th 2021
This study assessed cancer risk associations for 3 recently developed methylation-based biomarkers of aging: PhenoAge, GrimAge, and predicted telomere length.
We observed relatively strong associations of age-adjusted PhenoAge with risk of colorectal, kidney, lung, mature B-cell, and urothelial cancers. Similar findings were obtained for age-adjusted GrimAge, but the association with lung cancer risk was much larger, after adjustment for smoking status, pack-years, starting age, time since quitting, and other cancer risk factors. Most associations appeared linear, larger than for the first-generation measures, and w...
Source: Fight Aging! - February 14, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, February 8th 2021
This study was divided in two phases: CALERIE-1 and CALERIE-2. CALERIE-1 study was performed to assess the possible effects induced by a reduction of 10-30% of caloric intake on body composition parameters and lipid profile after 6 and 12 months in a population of middle-aged non-obese subjects. CALERIE-1 results showed an improvement in lipid and glycemic profile and a reduction in body weight (BW) and fat mass.
CALERIE-2 was the largest multi-center study on CRD. A total of 220 subjects were enrolled randomly with a 2:1 allocation into two subgroups: 145 in the CRD group and 75 in the ad libitum group. The CRD gro...
Source: Fight Aging! - February 7, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, February 1st 2021
In this study, we characterize age-related phenotypes of human hematopoietic stem cells (HSCs). We report increased frequencies of HSC, hematopoetic progenitor cells (HPC), and lineage negative cells in the elderly but a decreased frequency of multi-lymphoid progenitors. Aged human HSCs further exhibited a delay in initiating division ex vivo though without changes in their division kinetics. The activity of the small RhoGTPase Cdc42 was elevated in aged human hematopoietic cells and we identified a positive correlation between Cdc42 activity and the frequency of HSCs upon aging.
The frequency of human HSCs polar fo...
Source: Fight Aging! - January 31, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, January 25th 2021
In conclusion, our studies highlight the important role of the tyrosine degradation pathway and position TAT as a link between neuromediator production, dysfunctional mitochondria, and aging.
Source: Fight Aging! - January 24, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Giving Comfort, Finding Comfort: The Emotional Turmoil of Bedside Vigils
Photo credit Samuel Edwards
Dear Carol: My mother has had and beaten back several types of cancer, but then, at 83, she developed bowel cancer that spread. She said when this cancer was diagnosed that she didn’t want treatment and was at peace with her pending death. Mom’s on hospice care and is at home, though she’s non-responsive for the most part. The staff is good and uses the proper protocol for COVID so I’m incredibly grateful to them. I can work from home which is also helpful. Mom seems comfortable, so I have no complaints there either. It’s just that I don’t want to lose her. Of course, I don’t want ...
Source: Minding Our Elders - January 24, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
How is AI Impacting Health Care Today?
By John Halamka and Paul Cerrato*We are often asked this question during interviews, podcasts and speaking engagements. It ’s a complicated question that requires context. A closer look at the research and product offerings in digital health demonstrates that there are several high-quality, well-documented algorithms now available, but there are also several questionable vendors that have rushed to market with little evidence to support their claims. Separating the wheat from the chaff can be a full-time occupation.We recently received a press release from a large U.S. company highlighting a new AI system that may be abl...
Source: Life as a Healthcare CIO - January 22, 2021 Category: Information Technology Source Type: blogs
