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Fight Aging! Newsletter, March 16th 2020
We report a new class of natural-product-inspired covalent inhibitors of telomerase that target the catalytic active site.
Age-Related Epigenetic Changes that Suppress Mitochondrial Function
https://www.fightaging.org/archives/2020/03/age-related-epigenetic-changes-that-suppress-mitochondrial-function/
Today's open access research reports on two specific epigenetic changes observed in old individuals that act to reduce mitochondrial function. This joins an existing list of genes for which expression changes are known to impact mitochondrial function with age. A herd of hundreds of mitochondria are found ...
Source: Fight Aging! - March 15, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Insulin Resistance: the silent killer that you can completely reverse – even if your doctor doesn ’ t know how
You may have already heard the term “insulin resistance,” as it has been widely discussed by doctors and the media. But did you know that you can reduce or reverse it in the vast majority of people?
Insulin resistance, i.e., the inability of the body’s cells, especially liver, muscle, and brain, to respond to insulin and allow blood sugar to enter cells, drives numerous abnormal health conditions including type 2 diabetes, hypertension, coronary heart disease, fatty liver, Alzheimer’s dementia, and cancer. It is therefore a driving force behind so many modern and common chronic health conditions.
Yo...
Source: Wheat Belly Blog - March 12, 2020 Category: Cardiology Authors: Dr. Davis Tags: Open can belly fat can insulin resistance be reversed lose weight reduce belly fat reverse inflammation visceral fat wheat belly Source Type: blogs
Fight Aging! Newsletter, March 9th 2020
In this study, we intravenously administrated the young mitochondria into aged mice to evaluate whether energy production increase in aged tissues or age-related behaviors improved after the mitochondrial transplantation. The results showed that heterozygous mitochondrial DNA of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only prov...
Source: Fight Aging! - March 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
In Rats, Calorie Restriction Started in Later Life Prevents Many Age-Related Changes in Gene Expression
Researchers here apply modern genomics approaches to assessing the ability of calorie restriction to slow the progression of aging. As is usually the case, beyond greater understanding of the complexities of the metabolic response to calorie restriction, the goal is to find potential points of intervention that have as yet gone unremarked. Single genes where expression might be changed in order to mimic some fraction of the response to a lower calorie intake. Taken more broadly, exploration that might lead to the development of novel calorie restriction mimetics represents a sizable fraction of all present work on interven...
Source: Fight Aging! - March 5, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, March 2nd 2020
In conclusion, the recently demonstrated protective effects of NMN treatment on neurovascular function can be attributed to multifaceted sirtuin-mediated anti-aging changes in the neurovascular transcriptome. Our present findings taken together with the results of recent studies using mitochondria-targeted interventions suggest that mitochondrial rejuvenation is a critical mechanism to restore neurovascular health and improve cerebral blood flow in aging.
Wnt/β-Catenin Signaling as a Point of Intervention to Spur Greater Neural Regeneration
https://www.fightaging.org/archives/2020/02/wnt-%ce%b2-catenin-signali...
Source: Fight Aging! - March 1, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Should Patients Diagnosed With Alzheimer ’s Or Dementia Be Able To Choose Assisted Suicide?
I was on KPCC (NPR) in Los Angeles, yesterday, to address the question "Should Patients Diagnosed With Alzheimer’s Or Dementia Be Able To Choose Assisted Suicide?"
A recent op-ed in the L.A. Times titled, “My friend has dementia and wants to end her life. California’s assisted-suicide law excludes her,” shines a light on the complexities of expanding the state’s law beyond patients with a cancer diagnosis or terminal illness.
The law, passed in 2015 and modeled after a 1997 Oregon statute, allows physicians to give lethal drugs to mentally competent adults when they’re faced with a termi...
Source: blog.bioethics.net - February 26, 2020 Category: Medical Ethics Authors: Thaddeus Mason Pope, JD, PhD Tags: Health Care syndicated Source Type: blogs
When your doctor says you have dementia, don ’t argue with her
I know you want to. I know you would rather have anything other than dementia —even cancer. I know you are happy with your life and want it to continue as it is. If it has to change, I bet you’d like to slowly become more frail until one night you just die in your sleep. […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more.
Source: Kevin, M.D. - Medical Weblog - February 24, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/mary-braun" rel="tag" > Mary Braun, MD < /a > < /span > Tags: Conditions Neurology Source Type: blogs
Fight Aging! Newsletter, February 24th 2020
In conclusion, taller body height at the entry to adulthood, supposed to be a marker of early-life environment, is associated with lower risk of dementia diagnosis later in life. The association persisted when adjusted for educational level and intelligence test scores in young adulthood, suggesting that height is not just acting as an indicator of cognitive reserve.
A Comparison of Biological Age Measurement Approaches
https://www.fightaging.org/archives/2020/02/a-comparison-of-biological-age-measurement-approaches/
Researchers here assess the performance of a range of approaches to measuring biological...
Source: Fight Aging! - February 23, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Deacetylation of the NLRP3 Inflammasome as a Way to Control Chronic Inflammation
Chronic inflammation is an important component of degenerative aging. Excessive inflammatory signaling and activation of the immune system arises due to a combination of many factors, of which some are more important than others, such as the presence of lingering senescent cells. Most of the research focused on controlling inflammation is more interested in sabotaging the mechanisms of control than in removing root causes, however. The work here is an example of the type, in which scientists identify an important feature of the regulatory system controlling inflammation. Forcing a sizable reduction of inflammation via this...
Source: Fight Aging! - February 13, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Neurologist Shares Her Thoughts on the Individuality of Each Person Living with Dementia
"For years, the push to do something about Alzheimer’s disease-focused almost entirely on drug development. Find a cure. Develop a vaccine to prevent the disease. Develop a drug to “manage” people who live with Alzheimer’s and other types of dementia. What many people weren’t noticing, however, was that in tandem with this effort was a quiet revolution doggedly moving forward...Developing dementia doesn’t take away your individuality or humanity any more than developing cancer or diabetes. Therefore, rather than concentrate only on drugs, we need to help caregivers – and yes professionals – better understan...
Source: Minding Our Elders - January 29, 2020 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Fight Aging! Newsletter, January 27th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 26, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Letter to Ms. Judy Faulkner & Mr. Tommy Thompson
By GRACE CORDOVANO PhD, BCPA
Being a patient or a carepartner can be a lonely, powerless
place.
There’s no high powered legal or lobbying team to help support
you in your or your loved one’s health care journey. There’s no PR team at your
beck and call. There’s no advisory board, no executive committee, no
assistants, no chatbots or AI-powered technology coming to the rescue. There’s
no funding or a company sponsoring your efforts.
There’s no course in how to be a professional patient or
carepartner.
There’s no one there in the stillness and dark of the night, when
you are in the quiet of your tho...
Source: The Health Care Blog - January 24, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Health Policy Patients caregivers carepartner Grace Cordovano Judy Faulkner patient advocacy Patient advocates Tommy Thompson Source Type: blogs
Ten Tips for Aging with Depression
Major Depression — the clinical type — is not a normal part of aging. Though it can appear at any age, older adults are at an increased risk. The Centers for Disease Control and Prevention (CDC) distinguishes this condition from having “the blues” and likens it to other medical illnesses that are treatable, like diabetes or hypertension. Overwhelming sadness and anxiety can last for weeks at a time or much longer, with a wide range of other discouraging symptoms. Yet, there are things that can help.
Statistics tell us that later in life, at least one chronic disease will affect 80 percent of us. It natura...
Source: World of Psychology - January 24, 2020 Category: Psychiatry & Psychology Authors: Jan McDaniel Tags: Aging Depression depression risk Elderly seniors Source Type: blogs
The truth about fatty liver
The majority of doctors will tell you that there is nothing you can do to reverse fatty liver and that health problems such as cirrhosis and liver failure may be in your future that they will address with the awful “solution” of liver transplant.
The truth is the opposite: fatty liver is easily and readily reversible in virtually everybody, provided you take action before irreversible changes take place and are given the right information and tools. In this video, I discuss the three basic phenomena that drive fat deposition, liver damage, and inflammation that lead to this condition:
Carbohydrate consumption ...
Source: Wheat Belly Blog - January 23, 2020 Category: Cardiology Authors: Dr. Davis Tags: Open bowel flora carbohydrates carbs Inflammation NAFLD nash triglycerides undoctored wheat belly Source Type: blogs
