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LXA4 Levels in the Brain Decrease With Age, Perhaps Increasing Inflammation and Accelerating Neurodegeneration
Chronic inflammation in brain tissue is connected to the onset and progression of neurodegenerative conditions, so it is reasonable to expect that researchers will, from time to time, discover evidence for regulators of inflammation to be involved in aging and neurodegeneration. Here, scientists discuss LXA4, which has a role in resolution of the inflammatory response, and declines in abundance with age. Delivery of LXA4 produces functional benefits and greater resistance to inflammation in mouse models, making it a potentially interesting target for the development of therapies. The question, as always for attempts to sup...
Source: Fight Aging! - October 20, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Weekly Australian Health IT Links – 17 October, 2022.
Here are a few I have come across the last week or so. Note: Each link is followed by a title and a few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment.General Comment-----We seem to have an epidemic of cyber leaks this week.Otherwise a few fun bits as usual and a few new apps.-----https://itwire.com/science-news/health/a-free-mobile-app-helps-people-track-early-dementia-diagnosis.htmlThursday, 13 October 2022 11:15A free mobile app helps people track early dementia diagnosisByKenn Anthony MendozaHe...
Source: Australian Health Information Technology - October 17, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Fight Aging! Newsletter, October 17th 2022
This study investigated whether multimorbidity is associated with incident dementia and whether associations vary by different clusters of disease and genetic risk for dementia. The study used data from the UK Biobank cohort, with baseline data collected between 2006 and 2010 and with up to 15 years of follow-up. Participants included women and men without dementia and aged at least 60 years at baseline. The presence of at least 2 long-term conditions from a preselected list of 42 conditions was used to define multimorbidity. A total of 206,960 participants (mean age 64.1 years) were included in the final sample, of...
Source: Fight Aging! - October 16, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

More Support from Healthcare System Essential for End-of-Life Care
Discussions with Elders about HousingCalming a Person with Dementia Begins with Joining Their WorldNeeds of Solo Agers a Growing Concern in Aging Population 
Source: Minding Our Elders - October 16, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Life Does Go on After a Dementia Diagnosis: Try Art
Discussions with Elders about HousingNeeds of Solo Agers a Growing Concern in Aging Population 
Source: Minding Our Elders - October 14, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Caregivers: We Need to Stop Second-Guessing Ourselves
Photo credit Karolina Grabowska Like most adults, I’ve second-guessed many of my own decisions. While most were made with my own future in mind, that all changed when I became a family caregiver for an ever-increasing number of older adults – a time that also coincided with raising two young children, one with health challenges. A dying aunt, a budding son: My aunt Marion, who had no children of her own, was in the hospital dying of cancer. While my parents visited her much of the time, I’d been close to her since I first learned to walk, so I tried to see her as much as possible. One afternoon, it had become...
Source: Minding Our Elders - October 6, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Fight Aging! Newsletter, October 3rd 2022
In conclusion, based on the analysis of proteomics and transcriptome, we identified four SRMs that may affect aging and speculated their possible mechanisms, which provides a new target for preventing aging, especially skin aging. A Popular Science Article on the State of Epigenetic Clocks https://www.fightaging.org/archives/2022/09/a-popular-science-article-on-the-state-of-epigenetic-clocks/ This popular science article is a good view of the present state of development and use of epigenetic clocks, covering the issues as well as the promise. Epigenetic age can be measured, with many different clocks ...
Source: Fight Aging! - October 2, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Frailty Index Strongly Correlates with Mortality Risk
Age-related frailty is a late stage manifestation of degenerative aging, a state of physical weakness and vulnerability that precedes death. Aging is the accumulation of damage and dysfunction, and the burden of such damage and dysfunction needed to produce frailty is one step removed from the amount needed to cause one of the many forms of fatal system failure that cause human mortality. Whether death is eventually due to cardiovascular disease, dementia, or kidney failure, frailty is a proximate indicator. In this long-term population-based prospective cohort comprising 9,912 participants, we evaluated the risk ...
Source: Fight Aging! - September 29, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, September 26th 2022
This study examined the dose-response association between daily step count and intensity and incidence of all-cause dementia among adults in the UK. This was a UK Biobank prospective population-based cohort study (February 2013 to December 2015) with 6.9 years of follow-up (data analysis conducted May 2022). A total of 78,430 of 103,684 eligible adults aged 40 to 79 years with valid wrist accelerometer data were included. Registry-based dementia was ascertained through October 2021. We found no minimal threshold for the beneficial association of step counts with incident dementia. Our findings suggest that approxima...
Source: Fight Aging! - September 25, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

5 Tips for Keeping Your Brain Healthy While Caregiving
Many of us cope with the stress of caring for someone who has dementia. We agonize over the increasing losses that our loved one faces as dementia works its way through their brains. We also worry about ourselves. Will we, too, end our lives without recognizing the people we love? What, if anything, can we do to protect our own brains? With this question in mind, I asked two brain experts for their input on how caregivers can practice self-care and reduce worry about their health—specifically their brain health.  What's good for the heart is good for the brain: First, I questioned Benjamin T. Mast, Ph....
Source: Minding Our Elders - September 14, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Fight Aging! Newsletter, September 5th 2022
Conclusion Coupled with the animal data, and the existing human trial data for safety, the results here suggests that someone should run a formal, controlled trial of flagellin immunization in older people, 65 and over. The goal would be to see whether (a) this sort of outcome holds up in a larger group of people, and (b) there is a meaningful impact on chronic inflammation and other parameters of health that are known to be affected by the aging of the gut microbiome. The most interesting part of the data is perhaps the decline in microbial diversity, when considered against the gains elsewhere. Microbial dive...
Source: Fight Aging! - September 4, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Senolytics, a Promising New Field of Medicine in the Treatment of Aging
It is becoming harder for the world at large to ignore the field of senolytics, the large number of research groups and companies working towards therapies that clear a fraction of senescent cells from aged tissues. Senescent cells accumulate in later life, likely because the immune system becomes less able to remove them promptly. Lingering senescent cells actively disrupt normal tissue function and provoke chronic inflammation, thus contributing to age-related degeneration. Scores of mouse studies conducted over the last decade demonstrate that senolytic treatments produce rapid, reliable reversal of many age-related con...
Source: Fight Aging! - September 1, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, August 29th 2022
This study demonstrates that adoptive astrocytic Mt transfer enhances neuronal Mn-SOD-mediated anti-oxidative defense and neuroplasticity in the brain, which potentiate functional recovery following ICH. First Generation Stem Cell Therapies Remain Comparatively Poorly Understood https://www.fightaging.org/archives/2022/08/first-generation-stem-cell-therapies-remain-comparatively-poorly-understood/ We are something like thirty years into the increasingly widespread use of first generation stem cell therapies. Cells are derived from a variety of sources, processed, and transplanted into patients. Near all ...
Source: Fight Aging! - August 28, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

How not go get cancer
The Global Burden of Disease project is a decades long international collaboration, based at the Institute for Health Metrics and Evaluation at the University of Washington, but involving researchers around the world. It was originally funded by the World Bank, and now receives its principal support from the Bill and Melinda Gates Foundation. GBD (not to be confused with golden brown and delicious) essentially tries to quantify the prevalence of diseases, and injuries around the world; the prevalence of associated disability; causes of death; and risk factors. They use a lot of complicated methods. If you ' re really ...
Source: Stayin' Alive - August 19, 2022 Category: American Health Source Type: blogs

Fight Aging! Newsletter, August 15th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - August 14, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs