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Fight Aging! Newsletter, December 26th 2022
This article on senolytic therapies to selectively remove senescent cells in old tissues is in part a matter of Unity Biotechnology talking up their position. The company suffered from first mover disadvantage in bringing senolytic drugs into clinical development. The field has made progress very rapidly over the last decade, and startups founded even just a couple of years after Unity's launch benefited from greater knowledge and a selection of better technologies to work with. Still, one can be talking up one's position and also be right. The accumulation of senescent cells is profoundly harmful, a significant contributi...
Source: Fight Aging! - December 25, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, December 12th 2022
In conclusion, selective removal of senescent dermal fibroblasts can improve the skin aging phenotype, indicating that BPTES may be an effective novel therapeutic agent for skin aging.
Non-Dividing Neurons Do In Fact Become Senescent, Impairing Brain Function
https://www.fightaging.org/archives/2022/12/non-dividing-neurons-do-in-fact-become-senescent-impairing-brain-function/
Cellular senescence is generally thought of as a characteristic of replicating cells; it is an end state reached when telomeres, reduced in length with each cell division, become too short. This is followed by programmed cell death ...
Source: Fight Aging! - December 11, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, December 5th 2022
In conclusion, the PAAIs examined (i.e. mTOR loss of function, Ghrhr loss of function, intermittent fasting-based version of dietary restriction) often influenced age-sensitive traits in a direct way and not by slowing age-dependent change. Previous studies often failed to include young animals subjected to PAAI to account for age-independent PAAI effects. However, any study not accounting for such age-independent intervention effects will be prone to overestimate the extent to which an intervention delays the effects of aging on the phenotypes studied. This can result in a considerable bias of our view on how modifiable a...
Source: Fight Aging! - December 4, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, November 28th 2022
This study explored whether determining the gain or loss of specific taxa represent a more precise metric of healthy/unhealthy aging than summary microbiome statistics, such as diversity and uniqueness. We analyzed microbiome diversity and four measures of microbiome uniqueness in 21,000 gut microbiomes for their relationship with aging and health. We show that diversity and uniqueness measures are not synonymous; uniqueness is not a uniformly desirable feature of the aging microbiome, nor is it an accurate biomarker of healthy aging. Different measures of uniqueness show different associations with diversity and with mark...
Source: Fight Aging! - November 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Overcoming Denial to Seek Potential Dementia Diagnosis
An article in the UK Telegraph reported on a survey showing that two-thirds of people over the age of 50 are more afraid of developing dementia than of getting cancer. Other surveys show similar percentages.
One reason for this intense fear of Alzheimer's is obvious. While many types of cancer can be cured, most types of dementia cannot. However, another reason is that the idea of being betrayed by our brains to the point that we are essentially lost in the disease is abhorrent to most of us. This fear, unfortunately, tends to make many people less than willing to see a physician for dementia testing even whe...
Source: Minding Our Elders - November 21, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Fight Aging! Newsletter, November 21st 2022
In this study researchers added new insight, showing that high-intensity aerobic exercise, which derives its energy from sugar, can reduce the risk of metastatic cancer by as much as 72%. If so far the general message to the public has been 'be active, be healthy', now researchers can explain how aerobic activity can maximize the prevention of the most aggressive and metastatic types of cancer.
The study combined an animal model in which mice were trained under a strict exercise regimen, with data from healthy human volunteers examined before and after running. The human data, obtained from an epidemiological study ...
Source: Fight Aging! - November 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, November 14th 2022
In this study, we show that TXNIP is vital for the cell fate choice when cells are challenged by various stress signals. Furthermore, prolonged IGF1 treatment leads to the establishment of a premature senescence phenotype characterized by a unique senescence network signature. Combined IGF1/TXNIP-induced premature senescence can be associated with a typical secretory inflammatory phenotype that is mediated by STAT3/IL-1A signaling. Finally, these mechanistic insights might help with the understanding of basic aspects of IGF1-related pathologies in the clinical setting.
Investigating the Ability of Type 2 Diabetes...
Source: Fight Aging! - November 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Dementia: Moving Beyond Diagnosis
For most anyone who has been diagnosed with dementia or has loved someone with a type of dementia, the formal diagnosis was a moment frozen in time. A moment where the thought of possibly having a brain-destroying disease became a confirmed reality. That pivotal moment is life-changing; however, people can move beyond that moment in time and learn to live with dementia.
For our family, that moment arrived after my dad came out of surgery that was supposed to repair damage caused by a World War II brain injury. We had seen Dad wheeled into surgery. He’d propped himself up on one elbow and given us a signal that all would...
Source: Minding Our Elders - November 12, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Cardiovascular disease in England: supporting leaders to take actions
This report aims to inform and support national and local leaders to take action to accelerate progress on tackling CVD.Read the report
Source: Health Management Specialist Library - November 11, 2022 Category: UK Health Authors: The King ' s Fund Library Tags: Public health and health inequalities Source Type: blogs
Aging in Place or Assisted Living: It ' s About Choices
It's not hard to understand why 60-year-olds would say that they want to remain in their home for life rather than move to assisted living or a nursing home. These are generally people who are relatively healthy and feel that they can hire help for whatever they need down the road.
Indeed, aging in place sounds like a wonderful concept. What could possibly be wrong with it? The Washington Post interviewed Stephen M. Golant, a University of Florida professor of gerontology, about the trend. Golant views the current. He feels that people should have choices and that aging in place is just one of them. Golant said in the int...
Source: Minding Our Elders - November 10, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Fight Aging! Newsletter, November 7th 2022
In conclusion, the national prevalence of dementia and MCI in 2016 found in this cross-sectional study was similar to that of other US-based studies.
Clearing Microglia Reverses Age-Related Disruption of Sleeping Patterns in Mice
https://www.fightaging.org/archives/2022/11/clearing-microglia-reverses-age-related-disruption-of-sleeping-patterns-in-mice/
Microglia are innate immune cells of the central nervous system. They are analogous to macrophages in the rest of the body, but undertake additional duties relating to the function of neurons and in brain tissue. Microglia become overly active and inflamma...
Source: Fight Aging! - November 6, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
With Safety Upgrades, Aging-in-place an Alternative to Moving
Photo credit Mark Timberlake
Dear Carol: My parents are still vigorous and healthy, which is wonderful, but that doesn’t change the fact that they are in their 80s. I’ve been encouraging them to start a plan so they can move out of their home to a safer living situation. They don’t need assisted living yet, but independent living or even a condo or apartment would be safer for them than their big house. When I mention the idea, they sort of agree but then evade and put off doing anything. I understand that they love their home and its memories, but change is needed. How do I motivate them? - DM
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Source: Minding Our Elders - November 6, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Driving and Memory Loss: Tips to Help Elders Give Up Driving
For many of us, a car is a sign of independence. But this emotional connection to our automobiles is part of what makes convincing a person that he or she is no longer capable of driving such a volatile battle. The longer adult children or others wait to discuss driving issues with a loved one, the harder it can be.
Occasionally, people in the earlier stages of cognitive or physical decline will recognize the signs of that decline when they have a close call while driving and scare themselves into giving up their right to drive. More frequently, if the person has developed Alzheimer’s or another type of dementia, and th...
Source: Minding Our Elders - November 5, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Strategies for Getting (and Staying) Organized While Caregiving
Photo credit Ekaterina Bolovtsova
Caring for a vulnerable elder can be rewarding as well as frustrating. It can increase our self-esteem to know that we are helping someone in need, but it can also burden us as we grapple with difficult care decisions and the fact that we aren’t perfect caregivers. (Hint: No one is.) Caregiving requires continual learning and adjustments, and no two situations are identical. But, becoming as organized as possible and making a consistent effort to stay that way can help you relieve caregiver stress and use your time and energy more efficiently. It might seem overwhelming to maintai...
Source: Minding Our Elders - November 4, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Fight Aging! Newsletter, October 24th 2022
This study shows the uncoupling of lifespan and healthspan parameters (aerobic fitness and spontaneous activity) and provides new insights into SIRT3 function in CR adaptation, fuel utilization, and aging.
HDL Level, Age, and Smoking are the Largest Determinants of Mortality Risk in Old People
https://www.fightaging.org/archives/2022/10/hdl-level-age-and-smoking-are-the-largest-determinants-of-mortality-risk-in-old-people/
An interesting epidemiological study here stratifies the contributions of various metrics to mortality in later life, age 70 and older. The authors find that the largest effects arise ...
Source: Fight Aging! - October 23, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
