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Chemotherapy and hearing loss: Monitoring is essential
Treatment for cancer is a difficult time for patients and their families. While there are significant benefits of chemotherapy in treating and managing many types of cancers, some of the negative side effects may not always be so obvious. One of the potential negative effects of chemotherapy that you may not be aware of is hearing loss. Hearing loss caused by chemotherapy is generally considered a type of sudden hearing loss, so monitoring hearing before and after treatment with hearing tests is important. How are chemotherapy and hearing loss connected? Hearing loss as a potential side effect of chemotherapy is more likel...
Source: Harvard Health Blog - April 13, 2020 Category: Consumer Health News Authors: James Naples, MD Tags: Cancer Ear, nose, and throat Hearing Loss Source Type: blogs

“ Essential Oncology ” : The COVID Challenge
By CHADI NABHAN MD, MBA, FACP One harsh Chicago winter, I remember calling a patient to cancel his appointment because we had deemed it too risky for patients to come in for routine visits—a major snowstorm made us rethink all non-essential appointments. Mr. Z was scheduled for his 3-month follow-up for an aggressive brain lymphoma that was diagnosed the prior year, during which he endured several rounds of intense chemotherapy. His discontent in hearing that his appointment was canceled was palpable; he confessed that he was very much looking forward to the visit so that he could greet the nurses, front-desk staff, ...
Source: The Health Care Blog - April 3, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Hospitals Medical Practice Physicians Chadi Nabhan Clinical Trials coronavirus drug dosing Oncology Pandemic Source Type: blogs

Is it safe to see the pediatrician for vaccines and medical visits?
We’re tackling a few urgent questions from parents in this time of coronavirus and COVID-19. Are you wondering if babies and children should continue to have vaccines on schedule? Thinking about how to manage regular medical appointments, and which situations require in-person visits to a pediatric practice? Read on. Should parents take babies for initial vaccines right now? What about toddlers and older children who are due for vaccines? The answer to this question is going to depend on many factors, including what your doctor’s office is offering. As with all health care decisions, it comes down to weighing risks and...
Source: Harvard Health Blog - March 31, 2020 Category: Consumer Health News Authors: Claire McCarthy, MD Tags: Adolescent health Children's Health Health care Parenting Vaccines Source Type: blogs

Fight Aging! Newsletter, March 23rd 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - March 22, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Two Way Relationship Between Cellular Senescence and Cancer in Bone Marrow
Cells become senescent in response to a variety of circumstances. The vast majority are cases of replicative senescence, somatic cells reaching the Hayflick limit. Cell damage and toxic environments also produce senescence, and senescent cells are also created as a part of the wound healing process. A senescent cell ceases replication and begins to secrete inflammatory and pro-growth signals, altering the nearby extracellular matrix and behavior of surrounding cells - even encouraging them to become senescent as well. Near all senescent cells last a short time only, as they self-destruct or are removed by the immune...
Source: Fight Aging! - March 20, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, March 2nd 2020
In conclusion, the recently demonstrated protective effects of NMN treatment on neurovascular function can be attributed to multifaceted sirtuin-mediated anti-aging changes in the neurovascular transcriptome. Our present findings taken together with the results of recent studies using mitochondria-targeted interventions suggest that mitochondrial rejuvenation is a critical mechanism to restore neurovascular health and improve cerebral blood flow in aging. Wnt/β-Catenin Signaling as a Point of Intervention to Spur Greater Neural Regeneration https://www.fightaging.org/archives/2020/02/wnt-%ce%b2-catenin-signali...
Source: Fight Aging! - March 1, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

USP7 Inhibition Clears Up to Half of Irradiation Induced Senescent Cells From Mouse Tissues
Researchers here report on the discovery of a novel mechanism by which senescent cells can be selectively destroyed. Short-term senolytic treatments to date seem to cluster tightly into two categories: (a) largely ineffective, and (b) able to destroy between 25-50% of senescent cells in tissues. Few have achieved greater clearance so far, and few lie in between these two outcomes. In the present environment, of ample seed stage funding and enthusiasm for targeting senescent cells as a treatment for aging, it seems likely that someone will pick up this new approach for clinical development in the near future. Altho...
Source: Fight Aging! - February 28, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, February 24th 2020
In conclusion, taller body height at the entry to adulthood, supposed to be a marker of early-life environment, is associated with lower risk of dementia diagnosis later in life. The association persisted when adjusted for educational level and intelligence test scores in young adulthood, suggesting that height is not just acting as an indicator of cognitive reserve. A Comparison of Biological Age Measurement Approaches https://www.fightaging.org/archives/2020/02/a-comparison-of-biological-age-measurement-approaches/ Researchers here assess the performance of a range of approaches to measuring biological...
Source: Fight Aging! - February 23, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Gentler Approach to Transplanting Young Hematopoietic Stem Cells into Old Mice Modestly Extends Life Span
Stem cell populations become damaged and dysfunctional with age. Some of this is issues with the stem cells themselves, and some of this results from problem with the signaling environment and function of the stem cell niche. Which of these factors is more important likely varies by stem cell population. Among the best studied of stem cell types, the evidence suggests that muscle stem cells remain capable in old age, but become ever more quiescent, while hematopoietic stem cells become damaged and dysfunctional, unable to perform. Hematopoietic stem cells reside in the bone marrow and are responsible for generating blood a...
Source: Fight Aging! - February 20, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Request for Startups in the Rejuvenation Biotechnology Space, 2020 Edition
This is the latest in a series of yearly posts in which I suggest areas of development for biotech startups I'd like to see actively developed as a part of the longevity industry in the near future. Today, this year, is a good time to be starting a company focused on the production of a novel therapeutic approach to intervening in the aging process. There is a great deal of funding for seed stage investment, and many compelling projects lacking champions, yet to be carried forward from academia into preclinical development. Numerous scientific and industry crossover conferences are now held every year, at which it is possi...
Source: Fight Aging! - February 17, 2020 Category: Research Authors: Reason Tags: Investment Source Type: blogs

Patient Worries as a Central Feature of their Health Care Experiences
By JOHN JAMES, ROBERT R. SCULLY, CASEY QUINLAN, BILL ADAMS, HELEN HASKELL, and POPPY ARFORD Political forces trying to shape and reshape American healthcare without hearing the voice of patients provided the rationale for this work. Our experiences as patients, caregivers, and users of media sources cause us to worry. The Patient Council of the Right Care Alliance developed 6 questions to form a national survey of Americans to guide policy makers. The questions and our rationale were as follows: 1) Finding a doctor I can trust. Trust in our doctors is not as high as it once was. There are stories of serious patient a...
Source: The Health Care Blog - February 6, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Health Policy Patients Research Patient Council of the Right Care Alliance Patient Experience Source Type: blogs

Twenty-first Century Divorce: Who Gets Custody of the Embryos?
A recent CBS news story provides yet another example of the technology and legal cart pulling the ethical horse. In short, in 2014, an Arizona couple used in vitro fertilization (IVF) to preserve her eggs after she learned she had breast cancer and would require chemotherapy. The woman’s then boyfriend originally declined to be the … Continue reading "Twenty-first Century Divorce: Who Gets Custody of the Embryos?"
Source: blog.bioethics.net - February 4, 2020 Category: Medical Ethics Authors: Mark McQuain Tags: Health Care bioethics biotechnology human dignity reproduction syndicated Source Type: blogs

Newer skin cancer treatments improve prognosis for those with cutaneous melanoma
Cutaneous melanoma, also called malignant melanoma, is the type of skin cancer that is most likely to spread to other parts of the body. Though melanoma accounts for only about 1% of skin cancers, it is responsible for more than 90% of skin cancer-related deaths. But thanks to developments in skin cancer treatment (mostly in the last decade), patients with melanoma have much better chances of living longer. What is a melanoma? Melanoma involves the uncontrolled growth of a type of cell known as a melanocyte. One of the most important functions of a normal melanocyte is to protect your skin from the sun’s damaging ultravi...
Source: Harvard Health Blog - February 3, 2020 Category: Consumer Health News Authors: Dominic Wu, MD Tags: Cancer Skin and Hair Care Source Type: blogs

Fight Aging! Newsletter, February 3rd 2020
In conclusion, this study suggests that epigenetic age acceleration is significantly associated with lung function in women older than 50 years. We hypothesised that this could be due to menopause. However, we have observed that menopause has minimal effect and therefore there is possibility of other unknown physiological factors at older age in females mediating the epigenetic age acceleration effect on lung function. While, it is still unknown what exactly epigenetic aging from DNA methylation measures, this study suggests it can be utilised as one of the important factors to assess women's lung health in old age. DNA me...
Source: Fight Aging! - February 2, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

“ Chemofog ” is REAL!!
The New York Times has just informed us all, in an April 29 article, that “Chemotherapy Fog is No Longer… an Illusion”. It’s official now, all you cancer survivors! The Voice of Authority has spoken! (Here’s the full article.) As if you didn’t already know. Seriously, the NY Times article did make the important points that the level of impairment attributable to chemotherapy is a) substantially variable; b) is severe and lasts forever, in about a fifth of treated individuals; c) is greater in patients who undergo heavier chemotherapy regimes; and d) may be amplified by prophylactic drugs...
Source: On the Brain by Dr. Michael Merzenich, Ph.D. - February 1, 2020 Category: Neuroscience Authors: Dr. Merzenich Tags: Brain Fitness Brain Science BrainHQ Posit Science Source Type: blogs