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Does Obesity Literally Accelerate Aging?
In conclusion, there is solid evidence that obesity deregulates cellular mechanisms related to nutrient sensing. Altered Intercellular Communication It is accepted that aging impacts the organism at the cellular level, but also decreases the capacity of cells of an organism to interact. During aging, there is a decreased communication at the neuronal, neuroendocrine, and endocrine levels. Two of the most compelling examples of impaired communication are inflammaging and immunosenescence. The inflammaging phenotype results in elevated cytokines. These cytokines can accelerate and propagate the aging process. T...
Source: Fight Aging! - May 31, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Topical treatment helps prevent actinic keratosis from developing into skin cancer
In this study, 624 patients with multiple actinic keratoses were randomized to treatment with one of the four aforementioned field-directed treatments. The primary endpoint of the study was the percentage of patients who had at least 75% reduction in their number of actinic keratoses after one year. The study found that the percentage of patients who achieved this goal was significantly higher in people treated with topical fluorouracil (75%), compared to those treated with topical imiquimod (54%), photodynamic therapy (38%), and topical ingenol mebutate (29%). This seminal study highlights the important role of field-dire...
Source: Harvard Health Blog - May 30, 2019 Category: Consumer Health News Authors: Kristina Liu, MD, MHS Tags: Cancer Health Immunotherapy Skin and Hair Care Source Type: blogs

Cardiovascular risk in cancer survivors
Improvements in cancer care has its impact on better survival of those with early stage disease in several malignancies. In this scenario, cardiovascular disease has become a competing cause of death. It is not just due to chemotherapy induced myocardial disease, but also due to common risk factors for cardiovascular disease in this population. Hypertension, cigarette smoking and loss of cardiovascular fitness are some of them [1]. Weight gain may be also a problem in some. Those who have survived cancer for over 5 years have a 1.3 to 3.6 fold increased risk of cardiovascular mortality. Increased incidence of cardiovascu...
Source: Cardiophile MD - May 21, 2019 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs

Still Negative on Watchman
Many readers have contacted me to ask whether my negative viewson left atrial appendage occlusion with Watchman have changed since 2017.   The short answer is no. My views are even more negative today.  In 2016, I published an editorial on theHeart.org | Medscape Cardiology arguing that this procedure should stop. One of the rebuttals was that it was a blog post, not an academic editorial. Months later, Andrew Foy, Gerald Naccarelli and I put the same argument into academic-speak and the influential journal Heart Rhythm published it.[1] I have debated and presented this topic multiple times ...
Source: Dr John M - May 17, 2019 Category: Cardiology Authors: Dr John Source Type: blogs

Synthetic Proteins Designed to Halt Growth of Cancers
Stanford University scientists have developed a novel approach to halting the growth of cancer cells while preserving normal function in healthy cells. The research was published in journal Science, and though it was so far conducted only on groups o...
Source: Medgadget - May 17, 2019 Category: Medical Devices Authors: Editors Tags: Genetics Materials Oncology Source Type: blogs

Fight Aging! Newsletter, May 13th 2019
In this study, a significant (30%) increase in maximum lifespan of mice was found after nonablative transplantation of 100 million nucleated bone marrow (BM) cells from young donors, initiated at the age that is equivalent to 75 years for humans. Moreover, rejuvenation was accompanied by a high degree of BM chimerism for the nonablative approach. Six months after the transplantation, 28% of recipients' BM cells were of donor origin. The relatively high chimerism efficiency that we found is most likely due to the advanced age of our recipients having a depleted BM pool. In addition to the higher incorporation rates, ...
Source: Fight Aging! - May 12, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Healthiest Ways to Relax Your Mind, Body and Soul
“Once you learn the art of relaxation, everything happens spontaneously and effortlessly.” – Amma During hectic times, it’s tough to remember that relaxation is more than a luxury. In fact, humans need to relax to maintain balance in their lives. Work stress, family strife, and mounting responsibilities can exact a tremendous toll. Relaxing should be at the top of the list as a healthy coping measure and as a rewarding self-gift. Why do we so often neglect this healing self-care? Do you know the healthiest ways to relax your mind, body and soul? Perhaps the biggest obstacle to relaxing is that some of us have a dif...
Source: World of Psychology - May 9, 2019 Category: Psychiatry & Psychology Authors: Suzanne Kane Tags: Mental Health and Wellness Mindfulness Self-Help Source Type: blogs

Bone Marrow Transplant from Young to Old Mice Extends Remaining Life Span
In this study, a significant (30%) increase in maximum lifespan of mice was found after nonablative transplantation of 100 million nucleated bone marrow (BM) cells from young donors, initiated at the age that is equivalent to 75 years for humans. Moreover, rejuvenation was accompanied by a high degree of BM chimerism for the nonablative approach. Six months after the transplantation, 28% of recipients' BM cells were of donor origin. The relatively high chimerism efficiency that we found is most likely due to the advanced age of our recipients having a depleted BM pool. In addition to the higher incorporation rates, ...
Source: Fight Aging! - May 8, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

A Millennial Doctor ’s Experience with Industrial Medicine
By TALAL HILAL, MD A survey of 200 physicians under the age of 35 showed that 56% reported unhappiness with the current state of medicine. That number didn’t seem surprising to me at first. I was not particularly “happy” at the time of reading this survey either. I’ve aspired to become an oncologist for as long as I can remember. In oncology, despite my inability to cure, I can always try to heal. I form connections with patients and their families as they embark on a journey that is quite often their last. I learn from my patients as much as, and at times more than, they learn from me. But all of this is...
Source: The Health Care Blog - May 6, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Physicians physician burnout Talal Hilal US Healthcare system Source Type: blogs

Fight Aging! Newsletter, April 15th 2019
In this study, we found that senescent chondrocytes isolated from OA patients secrete more EVs compared with nonsenescent chondrocytes. These EVs inhibit cartilage ECM deposition by healthy chondrocytes and can induce a senescent state in nearby cells. We profiled the miR and protein content of EVs isolated from the synovial fluid of OA joints from mice with SnCs. After treatment with a molecule to remove SnCs, termed a senolytic, the composition of EV-associated miR and protein was markedly altered. The senolytic reduced OA development and enhanced chondrogenesis, and these were attributable to several specific differenti...
Source: Fight Aging! - April 14, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Chemotherapy Accelerates Age-Related Tauopathy and Cognitive Decline in Mice
It is fair to say that the extended chemotherapy treatment that is provided to cancer patients has the side-effect of accelerating aging. On the one hand, we can look at the epidemiological data to see the reduction in life expectancy and increased risk of age-related disease suffered by cancer survivors who underwent chemotherapy. It is also possible to look at various aging-associated biomarkers and see that they indicate an older biological age in these former patients. With the modern acceptance of senescent cell accumulation as an important cause of aging, it has become clear that the generation of excess senescent ce...
Source: Fight Aging! - April 11, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

We take requests
Someone is interested in laws regarding vaccination in the United States. There is often a tension between the liberty interest and social welfare in public health, at least from many people ' s perspective. It is a general principle that competent adults cannot be compelled to undergo any medical procedure against their will. Adults can decide to check out of the hospital against medical advice, or to treat their cancer with coffee enemas rather than surgery and chemotherapy, and the state does not get involved. As for people who are ruled not competent, that ' s a whole other discussion, but I will point out that a judge...
Source: Stayin' Alive - April 11, 2019 Category: American Health Source Type: blogs

African American men respond better to treatments for advanced prostate cancer in clinical trials
Racial differences have long been evident in prostate cancer statistics. In particular, African American men are diagnosed with prostate cancer more often than white men, and they’re also nearly twice as likely to die of the disease. But new research also shows that African American men who receive the most advanced treatments for late-stage prostate cancer can live at least as long — or even longer — than their Caucasian counterparts. Why is this the case? Scientists are searching for an explanation. “The fact that African American men have better survival is of huge research interest,” said Dr. Stephen Freedlan...
Source: Harvard Health Blog - March 26, 2019 Category: Consumer Health News Authors: Charlie Schmidt Tags: Living With Prostate Cancer Men's Health Prostate Health Prostate Knowledge Treatments HPK Source Type: blogs

Last Couple of Months in Oncology with Dr. Bishal Gyawali: March 2019
By BISHAL GYAWALI MD, PhD Hey, I’m back! Well, you might not have noticed that my blogs were missing for the last three months but anyways, its good to be back. I was having a little time off blogs and social media as I was transitioning in my career but now I am back. Sometimes, it is very difficult to manage time for things that you must do versus things you enjoy doing, especially when these two don’t intersect. For me, these last few months the things I had to do were all bureaucratic while I couldn’t find the time for things I enjoy doing like writing these blogs. But now that we are back, let’s rec...
Source: The Health Care Blog - March 26, 2019 Category: Consumer Health News Authors: Matthew Holt Tags: Medical Practice Physicians Bishal Gyawali Cancer drugs Clinical Trials Oncology Prostate Cancer RCTs Source Type: blogs

Belluck & Fox Explain How to Care for a Loved One with Mesothelioma
You're reading Belluck & Fox Explain How to Care for a Loved One with Mesothelioma, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. When a loved one is diagnosed with mesothelioma it can be extremely stressful and overwhelming for all involved, but there are things you can do to help provide much needed love and support. A combination of educating yourself so you understand the disease and making it easier for your loved one to manage the disease, both emotionally and physically, can lessen the stress. Mesothelioma ...
Source: PickTheBrain | Motivation and Self Improvement - March 24, 2019 Category: Consumer Health News Authors: Erin Falconer Tags: health and fitness self improvement care mesothelioma Source Type: blogs