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Fish-Shaped Microrobots to Deliver Chemotherapy to Tumors
Researchers from the University of Science and Technology of China, working with outside collaborators, have developed shape-shifting microrobots that are designed to be guided to a target area in the body using magnets, and then release a drug cargo...
Source: Medgadget - November 19, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine Oncology Radiology Source Type: blogs
Cold Cap Therapy for Chemo Patients: Interview with Kate Dilligan, CEO of Cooler Heads Care
Cooler Heads Care, a medtech company based in San Diego, created Amma, a cold cap therapy device that aims to help chemotherapy patients to preserve their hair. Hair loss is a very common side-effect of chemo, and poses a significant psychological ch...
Source: Medgadget - November 16, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Medicine Oncology Source Type: blogs
Weighing Cancer Cells for Chemotherapy Susceptibility Testing
A collaboration between groups at MIT and Dana-Farber Cancer Institute led to the creation of a system that allows for quick determination of the susceptibility of cancer cells to specific drugs, without the need to rely on genomic markers. The techn...
Source: Medgadget - October 11, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Oncology Source Type: blogs
Antimicrobial Coating Prevents Infections Around Ortho Implants
A group at Duke University engineered an antibiotic delivery system to make the surfaces of orthopedic implants resistant to bacterial infiltration. The technique involves spraying or painting a combination of hydrophilic and hydrophobic polymers, mi...
Source: Medgadget - September 29, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Materials Orthopedic Surgery Duke Source Type: blogs
Fight Aging! Newsletter, September 20th 2021
In conclusion, inhibiting the lysosomal oxidation of LDL in atherosclerotic lesions by antioxidants targeted at lysosomes causes the regression of atherosclerosis and improves liver and muscle characteristics in mice and might be a promising novel therapy for atherosclerosis in patients.
NANOG Expression versus Cellular Senescence
https://www.fightaging.org/archives/2021/09/nanog-expression-versus-cellular-senescence/
Are there many strategies that can reverse cellular senescence? There are certainly strategies that can lower levels of cellular senescence over time, both in cell cultures and in living an...
Source: Fight Aging! - September 19, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Is it Possible to Safely Tip the Balance in Cancer Treatment Towards Cell Death Rather than Cell Senescence?
Most cancer treatments produce a lot of senescent cells in the course of killing cancerous cells. This is thought to be the primary reason as to why cancer survivors have a reduced life expectancy and greater burden of age-related disease. Senescent cells secrete disruptive, inflammatory signals that harm tissue function when consistently present. Growing numbers of senescent cells in old tissues are an important contribution to degenerative aging.
The straightforward approach to this issue would be to treat cancer patients with senolytic therapies to clear senescent cells after the anti-cancer treatment is complete...
Source: Fight Aging! - September 13, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The FDA ’s Culture: Should Safety Dominate All Practices?
By STEVEN ZECOLA
An organization’s culture is an internal set of shared values, attitudes and practices. The cohesiveness of the organizational culture will affect whether the entity will meet its vision, purpose, and goals.
One type of organizational culture is hierarchical in nature. Unlike a risk-taking culture, this structure features policy, process and precision. It is best suited for mature and stable organizations.
The disadvantage of a hierarchal culture is that its stability and control can turn into rigidity. In many cases, the organization develops a negative attitude towards ideas s...
Source: The Health Care Blog - August 26, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Health Policy FDA Parkinson's Disease Steven Zecola Source Type: blogs
Fight Aging! Newsletter, August 16th 2021
In conclusion, cancer survivors, especially older individuals, demonstrate greater odds of and accelerated functional decline, suggesting that cancer and/or its treatment may alter aging trajectories.
Linking Particulate Air Pollution and Dementia in a Small Region of the US
https://www.fightaging.org/archives/2021/08/linking-particulate-air-pollution-and-dementia-in-a-small-region-of-the-us/
It is fairly settled that evident particulate air pollution, such as daily exposure to smoke from wood-fueled cooking fires, has a strongly detrimental effect on long-term health. The mechanisms involved are inflamm...
Source: Fight Aging! - August 15, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Worse Functional Decline with Age is Observed in Cancer Survivors
In conclusion, cancer survivors, especially older individuals, demonstrate greater odds of and accelerated functional decline, suggesting that cancer and/or its treatment may alter aging trajectories.
Source: Fight Aging! - August 12, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
If FDA Won ’t Rethink Rules on Off‐Label Drug Use, Courts Should
Walter OlsonAs Cato writershave longpointedout, the law takes a paradoxical stance toward so ‐called “off‐label” use of drugs approved for use by the Food and Drug Administration (FDA). On the one hand, it’s completely lawful for physicians to prescribe approved drugs for other than the FDA‐approved uses, and such uses are vital in everyday practice. Indeed, off‐la bel compounds oftenconstitute a “gold standard” of care in chemotherapy cancer treatments and other fields of medicine. On the other hand, the agency strictly prohibits makers of the compounds frompromoting such use, even when ...
Source: Cato-at-liberty - August 11, 2021 Category: American Health Authors: Walter Olson Source Type: blogs
Health Care You Do Not See
By KIM BELLARD
Within a mile from my home in one direction, there are two pharmacies and a primary care office. In another direction, there’s a multi-specialty physician practice, complete with lab and pharmacy. And in a third direction, an urgent care center. Widen the circle another mile, and there are more physician offices, a plethora of other health care professionals, another urgent care, a retail clinic, and an imaging center. Add a couple more miles and hospitals – plural – to start show up.
I’m not sure that’s a good thing.
Admittedly, not everyone has so many options.&nb...
Source: The Health Care Blog - August 10, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Health Tech Health Technology Kim Bellard Source Type: blogs
Should Your Parent Risk an Anesthesia Disaster or Forego Surgery?
Photo credit Niklas Hamann
Just last week a reader asked me whether she should try to sway her mother, who had colon cancer, toward surgery. Her mother, 87, was diagnosed with colon cancer and given the choice of surgery and chemotherapy or letting it alone. If she chose not to have surgery, she could still have chemotherapy and radiation, though she was told that treatment wasn't apt to help a great deal. As expected, the daughter was distraught. She was seeking help in determining what her responsibility to her mother is. The woman mentioned that her mother was mentally sharp, so I told her that, in my opinion......
Source: Minding Our Elders - August 10, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Fight Aging! Newsletter, August 9th 2021
In conclusion, the present study supports that some age-related diseases as well as education are causally related to longevity and highlights several new targets for achieving longevity, including management of venous thromboembolism, appropriate intake of sugar, and control of body fat. Our results warrant further studies to elucidate the underlying mechanisms of these reported causal associations.
Pol III Inhibition Extends Longevity in Short-Lived Species
https://www.fightaging.org/archives/2021/08/pol-iii-inhibition-extends-longevity-in-short-lived-species/
As this paper notes, Pol III is downstream...
Source: Fight Aging! - August 8, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senescent T Cells in the Context of Cancer
Cells become senescent in response to potentially cancer-inducing stresses and damage, to tissue injury, or when they reach the Hayflick limit on cellular replication. Senescent cells cease to replicate and secrete pro-inflammatory, pro-growth signals. They are cleared by the immune system or via programmed cell death mechanisms. Their presence is beneficial in the short term, an important part of the panoply of mechanisms devoted to, separately, cancer suppression and regeneration. When senescent cells begin to linger, however, their secretions become highly disruptive to normal tissue function. Senescent cell accumulatio...
Source: Fight Aging! - August 4, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, August 2nd 2021
This study aimed to determine the association between: (i) cognitive decline and bone loss; and (ii) clinically significant cognitive decline on Mini Mental State Examination (MMSE) over the first 5 years and subsequent fracture risk over the following 10 years. A total of 1741 women and 620 men aged ≥65 years from the population-based Canadian Multicentre Osteoporosis Study were followed from 1997 to 2013. Over 95% of participants had normal cognition at baseline. After multivariable adjustment, cognitive decline was associated with bone loss in women but not men. Approximately 13% of participants experienced sign...
Source: Fight Aging! - August 1, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
