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OncoSenX Raises $3 Million to Adapt the Oisin Biotechnologies Platform to Cancer
Oisin Biotechnologies uses a form of programmable suicide gene therapy to target senescent cells for destruction. The therapy can be triggered by expression of specific genes inside a cell, and so beyond senescent cells there is a long, long list of possibly harmful cell populations in aging and disease that it would be beneficial to remove. The obvious first choice is cancerous cells with a mutation in one of the common cancer suppressor genes, such that the gene is expressed but not helping. Thus Oisin Biotechnologies spun out OncoSenX last year. The company is moving forward towards trials, and recently raised a seed ro...
Source: Fight Aging! - July 10, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 8th 2019
In this study, we identify a link between members of the genus Veillonella and exercise performance. We observed an increase in Veillonella relative abundance in marathon runners postmarathon and isolated a strain of Veillonella atypica from stool samples. Inoculation of this strain into mice significantly increased exhaustive treadmill run time.
Veillonella utilize lactate as their sole carbon source, which prompted us to perform a shotgun metagenomic analysis in a cohort of elite athletes, finding that every gene in a major pathway metabolizing lactate to propionate is at higher relative abundance postexercise. Us...
Source: Fight Aging! - July 7, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Efforts Continue to Understand the Senescence-Associated Secretory Phenotype
While the primary focus for the development of rejuvenation therapies to address the contribution of senescent cells to the aging process is to destroy these harmful, errant cells, many research groups are more interested in modulating or suppressing the senescence-associated secretory phenotype (SASP). The SASP is a potent mix of inflammatory and other signals that disrupts tissue function and produces a sizable fraction of the chronic inflammation associated with aging, driving the progression of all of the common age-related conditions. In principle, eliminating the SASP should eliminate the contribution of senescent ce...
Source: Fight Aging! - July 1, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
MKSAP: 62-year-old woman with ovarian cancer
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 62-year-old woman is evaluated during a follow-up visit for recently diagnosed stage IIIA high-grade serous ovarian cancer. She underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy and completed six c ycles of chemotherapy with cisplatin and paclitaxel. The patient’s paternal aunt was […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more.
Source: Kevin, M.D. - Medical Weblog - June 22, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > < /span > Tags: Conditions OB/GYN Oncology/Hematology Source Type: blogs
MRI Could Be Better than Mammography at Detecting Breast Cancer
Magnetic Resonance Imaging detects breast cancer at earlier stages than mammography, according to a studyrecently published inOncology.Around 15 percent of women with breast cancer were diagnosed despite having no causative hereditary gene mutation but had a family history of breast cancer. To better understand diagnosis rates, researchers from Erasmus University in the Netherlands implemented a randomized controlled trial (FaMRIsc) throughout 12 hospitals in the Netherlands to compare the efficacy of MRI screening against mammography in women with a family history of breast cancer.The study took place between January 1,...
Source: radRounds - June 22, 2019 Category: Radiology Authors: Julie Morse Source Type: blogs
How is Alex Trebek doing with his pancreatic cancer treatment?
In a recent People article, Jeopardy! host Alex Trebek shared some good news. Diagnosed with stage 4 pancreatic cancer in March, Trebek said he was told that he has been responding very well to his chemotherapy regimen, and that he’s in“near remission.” He went on to say,“It’s kind of mind-boggling.… The doctors said they hadn’t seen this […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more.
Source: Kevin, M.D. - Medical Weblog - June 20, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/michele-r-berman-and-mark-s-boguski" rel="tag" > Michele R. Berman, MD and Mark S. Boguski, MD, PhD < /a > < /span > Tags: Conditions Oncology/Hematology Source Type: blogs
Fight Aging! Newsletter, June 17th 2019
In this study, analysis of antioxidant defense was performed on the blood samples from 184 "aged" individuals aged 65-90+ years, and compared to the blood samples of 37 individuals just about at the beginning of aging, aged 55-59 years. Statistically significant decreases of Zn,Cu-superoxide dismutase (SOD-1), catalase (CAT), and glutathione peroxidase (GSH-Px) activities were observed in elderly people in comparison with the control group. Moreover, an inverse correlation between the activities of SOD-1, CAT, and GSH-Px and the age of the examined persons was found. No age-related changes in glutathione reductase activiti...
Source: Fight Aging! - June 16, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Spasers: Nanoscale Lasers Small Enough to Destroy Cancer Cells from Within
Lasers are known to do remarkable things in medicine, but their use in targeting diseased tissue is not as widespread as everyone expected it to be decades ago. One issue is that lasers are pretty indiscriminate and traditionally have beams that are ...
Source: Medgadget - June 14, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Nanomedicine Oncology Source Type: blogs
Reviewing the Biochemistry of Survival in Senescent Cells
Now that senescent cells are conclusively demonstrated to be highly influential in the progression of degenerative aging, and broad reversal of aspects of aging is regularly demonstrated in mice via the use of various senolytic therapies, there is considerably more interest and funding in the research community for investigations of the fundamental biochemistry of senescent cells. Senescent cells are generated constantly in all tissues, and are primed for self-destruction via apoptosis. The vast majority either self-destruct or are destroyed by the immune system, quite soon after their creation. Those that linger in tissue...
Source: Fight Aging! - June 10, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, June 10th 2019
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
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Source: Fight Aging! - June 9, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
(Maybe) I Got Bit by a Snake
I saw my hand by the morning light streaming through my blinds and felt like I was looking at something that wasn ’t a part of me. A crimson, half-inch lesion rose above the right side of my right hand like Mary’s Rock. Swelling puffed up the skin like a balloon, leaving me with one apparent knuckle. I flipped my arm over. Red streaks crawled up it like fingers stretching to grasp my heart.My instinct was to call my dermatologist. “Good morning, I’d like to schedule an appointment.”“If this is for body sculpting, I’ll transfer you to that receptionist.”Nope. I rapid-fired my problem: yesterday afternoon, I ...
Source: cancerslayerblog - June 7, 2019 Category: Cancer & Oncology Tags: a day in my life animals death Source Type: blogs
Recap of the first day of the AANP annual meeting
Dr. Maria Martinez-Lage was kind enough to write the following summary of events at today ’s American Association of Neuropathologists meeting in Atlanta:The opening day of the 95th Annual Meeting of the American Association of Neuropathologists in Atlanta featured a special course dedicated to a topic both old and new: what happens when treatments go awry? Under the title “Unintended Consequences: The Iatrogenic Neuropathology of Systemic Therapies” the faculty discussed neurologic adverse effects of novel immunotherapies,other cancer and non-cancer related treatments, a...
Source: neuropathology blog - June 7, 2019 Category: Radiology Tags: meetings Source Type: blogs
Senolytic Therapies to Clear Senescent Cells Should Benefit Cancer Patients
It is well known that the present dominant approaches to cancer therapy - meaning toxic, damaging chemotherapy and radiotherapy, only slowly giving way to immunotherapy - produce a significant burden of senescent cells. Indeed, forcing active cancer cells into senescence is the explicit goal for many treatments, and remains an aspirational goal for a large fraction of ongoing cancer research. Most senescent cells self-destruct, or are destroyed by the immune system, but some always linger - and more so in older people, due to the progressive incapacity of the immune system. An immune system that becomes ineffective in supp...
Source: Fight Aging! - June 6, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, June 3rd 2019
In conclusion, there is solid evidence that obesity deregulates cellular mechanisms related to nutrient sensing.
Altered Intercellular Communication
It is accepted that aging impacts the organism at the cellular level, but also decreases the capacity of cells of an organism to interact. During aging, there is a decreased communication at the neuronal, neuroendocrine, and endocrine levels. Two of the most compelling examples of impaired communication are inflammaging and immunosenescence. The inflammaging phenotype results in elevated cytokines. These cytokines can accelerate and propagate the aging process. T...
Source: Fight Aging! - June 2, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
