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How does radiation therapy work? A radiation oncologist explains.
Most patients have an idea of how surgery and chemotherapy work.   It’s not difficult to picture a surgeon cutting out a cancer or a medical oncologist prescribing chemotherapy.  But how does radiation therapy work?  For the vast majority of patients, and a good number of physicians, radiation therapy is a completely foreign concept. In my […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - March 12, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/daniel-h-kim" rel="tag" > Daniel H. Kim, MD < /a > < /span > Tags: Conditions Oncology/Hematology Source Type: blogs

An oncologist explains how to get your loved ones tested for cancer
I see several patients daily with cancer. Some days can be tough, but nothing compares to what they are going through. I know that. The physical anguish and toll that chemotherapy, radiation, and surgery can take on the body. The burden that the disease can take on the mind and the soul. It ’s devastating and […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - March 10, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/joshua-mansour" rel="tag" > Joshua Mansour, MD < /a > < /span > Tags: Conditions Oncology/Hematology Primary Care Source Type: blogs

Fight Aging! Newsletter, March 4th 2019
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - March 3, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Cancer-killing viruses
by Gertrud Rey Although cancer therapies have improved dramatically in recent years, the main options for treating cancer still consist of surgery, chemotherapy, and radiation therapy. This limitation is a problem for aggressive cancers like glioblastoma multiforme (GBM), brain cancers which are typically resistant to traditional therapies. GBM is a high grade glioma, an aggressive […]
Source: virology blog - February 28, 2019 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Gertrud Rey Information glioblastoma multiforme herpes simplex virus viral viral oncotherapy viruses Source Type: blogs

Bodily Fluids As The Basis For Digital Health
Blood, saliva, urine, sweat or even ear wax can carry valuable information about an individual’s medical state. Until now, even simpler tests on such bodily fluids had to be carried out at medical facilities, but with the recent uptick in the development of digital diagnostic technologies, more and more solutions appear on the market which enable the patient to do such tests at home. Here we take a look around the bodily fluid business. From bloodletting to digital sweat measurement Blood, yellow bile, black bile, phlegm. Although it doesn’t sound appealing, the ancient Greek already thought that bodily fluids ma...
Source: The Medical Futurist - February 27, 2019 Category: Information Technology Authors: nora Tags: Future of Medicine Health Sensors & Trackers Portable Diagnostics blood bodily fluid digital digital health digital solutions digital tattoo saliva smart smart healthcare sweat technology urine Source Type: blogs

Request for Startups in the Rejuvenation Biotechnology Space, 2019 Edition
I am a little late with the 2019 list of projects in rejuvenation biotechnology that I'd like to see startups tackling sometime soon. In my defense, this year I have a startup of my own to keep up with, and the first part of 2019 was a wall to wall series of conferences alternating between the US and Europe. It continues to be the case that this is a new industry of near endless potential, yet little of that potential is under active development. This is the state of affairs despite the arrival of hundreds of millions of dollars in venture funds managed by the like of Juvenescence, Life Biosciences, and so on. The research...
Source: Fight Aging! - February 25, 2019 Category: Research Authors: Reason Tags: Investment Source Type: blogs

Chemotherapeutic agent causing coronary vasospasm – Cardiology MCQ – Answer
Chemotherapeutic agent causing coronary vasospasm – Cardiology MCQ – Answer Chemotherapeutic agent well known to cause coronary vasospasm:Correct answer: c) 5-fluorouracil 5-fluorouracil and its orally active prodrug capecitabine are fluoropyrimidines, belonging to the class of antimetabolites used for treatment of malignancies of breast, head and neck tumours and gastrointestinal tumours. Mechanisms for coronary vasospasm Endothelial cell damage with cytolysis and denudation Increased endothelin-1 bioactivity leading to vasoconstriction When high dose infusions are given, coronary vasospasm with angina, arrh...
Source: Cardiophile MD - February 22, 2019 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs

Fight Aging! Newsletter, February 18th 2019
This study showed that potential vicious cycles underlying ARDs are quite diverse and unique, triggered by diverse and unique factors that do not usually progress with age, thus casting doubts on the possibility of discovering the single molecular cause of aging and developing the single anti-aging pill. Rather, each disease appears to require an individual approach. However, it still cannot be excluded that some or all of these cycles are triggered by fundamental processes of aging, such as chronic inflammation or accumulation of senescent cells. Nevertheless, experimental data showing clear cause and effect relationships...
Source: Fight Aging! - February 17, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Medicinal Mushrooms: Turkey Tail (Trametes versicolor), Reishi (Ganoderma lucidum) and Lion's mane (Hericium erinaceus)
There some evidence in PubMed than medicinal mushrooms may play a role in treatment of some cancers. Most of the claims of medical benefits are bot backed up by high quality studies as of 2019. References are below.---What is turkey tail?Turkey tail is a type of mushroom that grows on dead logs worldwide. It's named turkey tail because its rings of brown and tan look like the tail feathers of a turkey. Its scientific name is Trametes versicolor or Coriolus versicolor. In traditional Chinese medicine, it is known as Yun Zhi. In Japan, it is known as kawaratake (roof tile fungus). Turkey tail has been used in traditional Chi...
Source: Clinical Cases and Images - Blog - February 13, 2019 Category: Universities & Medical Training Tags: Medicinal Mushrooms Oncology Source Type: blogs

Fight Aging! Newsletter, February 11th 2019
We report that the bone marrow stromal cell senescence is driven by p16INK4a expression. The p16INK4a-expressing senescent stromal cells then feedback to promote AML blast survival and proliferation via the SASP. Importantly, selective elimination of p16INK4a-positive senescent bone marrow stromal cells in vivo improved the survival of mice with leukemia. Next, we find that the leukemia-driven senescent tumor microenvironment is caused by AML induced NOX2-derived superoxide. Finally, using the p16-3MR mouse model we show that by targeting NOX2 we reduced bone marrow stromal cell senescence and consequently reduced A...
Source: Fight Aging! - February 10, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Acute Myeloid Leukemia Produces Senescent Cells to Promote its Own Growth, and is Thus Vulnerable to Senolytics
We report that the bone marrow stromal cell senescence is driven by p16INK4a expression. The p16INK4a-expressing senescent stromal cells then feedback to promote AML blast survival and proliferation via the SASP. Importantly, selective elimination of p16INK4a-positive senescent bone marrow stromal cells in vivo improved the survival of mice with leukemia. Next, we find that the leukemia-driven senescent tumor microenvironment is caused by AML induced NOX2-derived superoxide. Finally, using the p16-3MR mouse model we show that by targeting NOX2 we reduced bone marrow stromal cell senescence and consequently reduced A...
Source: Fight Aging! - February 5, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Preserving fertility during cancer treatments
Cancer treatment — and cancer itself — can threaten fertility. This is a tremendously important survivorship issue for many people. As an oncologist, I’m often asked questions about preserving fertility during cancer treatment. If this issue affects you, here is an overview of key options. When should you talk to your cancer team about fertility? Future children may not be foremost on your mind when you are diagnosed with cancer. Soon afterward, though, it’s worth talking to your doctor about fertility issues, if this is important to you now or might one day become important. Your doctor can explain: the risk that...
Source: Harvard Health Blog - February 4, 2019 Category: Consumer Health News Authors: Ann Partridge, MD, MPH Tags: Cancer Fertility Infertility Source Type: blogs

Alternative therapies for cancer
This study was not designed to directly compare non-conventional therapies with conventional ones, and the results do not mean that all unproven remedies are useless. In fact, an unproven treatment may become conventional if rigorous research proves its worth. There are many types of alternative treatments (including herbs, vitamins, homeopathy, yoga, and acupuncture) that might have different effects and have not yet been well studied. Importantly, this study did not examine the interaction of conventional and alternative treatments (which in some cases may cause problems). In addition, this study did not actually find th...
Source: Harvard Health Blog - February 1, 2019 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Cancer Complementary and alternative medicine Health Source Type: blogs

Fight Aging! Newsletter, January 28th 2019
In this study, we show that calorie restriction is protective against age-related increases in senescence and microglia activation and pro-inflammatory cytokine expression in an animal model of aging. Further, these protective effects mitigated age-related decline in neuroblast and neuronal production, and enhanced olfactory memory performance, a behavioral index of neurogenesis in the SVZ. Our results support the concept that calorie restriction might be an effective anti-aging intervention in the context of healthy brain aging. Greater Modest Activity in Late Life Correlates with Lower Incidence of Dementia ...
Source: Fight Aging! - January 27, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Recent Update on the Use of Immune Ablation and HSCT to Treat Autoimmunity
For more than twenty years now, Richard Burt's research teams have been working on the treatment of autoimmunity through the destruction and recreation of the immune system. Autoimmunity is a malfunction in the self-tolerance of immune cells, leading them to attack patient tissues. The malfunction is entirely contained in the immune system, so if the immune system is destroyed and replaced, the autoimmunity stops. If the genesis of autoimmunity is happenstance, an unfortunate one-time accident, then this is a cure. But if autoimmunity has a trigger outside the immune system in a given patient, it will return after some per...
Source: Fight Aging! - January 22, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs