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Fight Aging! Newsletter, September 9th 2019
We examined human lung tissue from COPD patients and normal control subjects, and found a substantial increase in p16-expressing alveolar cells in COPD patients. Using a transgenic mouse deficient for p16, we demonstrated that lungs of mice lacking p16 were structurally and functionally resistant to CS-induced emphysema due to activation of IGF1/Akt regenerative and protective signaling. Fat Tissue Surrounds Skeletal Muscle to Accelerate Atrophy in Aging and Obesity https://www.fightaging.org/archives/2019/09/fat-tissue-surrounds-skeletal-muscle-to-accelerate-atrophy-in-aging-and-obesity/ Researchers her...
Source: Fight Aging! - September 8, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Work on Senolytic Rejuvenation Therapies Begins to Attract More Mainstream Notice
This popular science piece on the development of senolytic therapies capable of clearing harmful senescent cells from aging tissues is a cut above the average. It is important to see more publicity for this line of work. Not because it will aid the industry, but because the more attention that is given to the field, the faster that existing senolytic treatments such as the dasatinib and quercetin combination will become available through off-label prescription and physician networks. Tens of millions of patients with inflammatory age-related diseases caused in part by senescent cells, and the many cancer survivors with hig...
Source: Fight Aging! - September 4, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Gold Nanostars Help Design New Nanomedicines
Researchers from Northwestern University have developed a novel way to track how nanoparticles interact with cancer cells and whether they reach their tagets. The team’s work shows that if a nanoparticle targets cancer cells, it undergoes more ...
Source: Medgadget - August 27, 2019 Category: Medical Devices Authors: Siavash Parkhideh Tags: Medicine Nanomedicine Source Type: blogs

Cold Plasma to be Tested as Killer of Cancer Cells
Cold plasma is an unusual gaseous substance in which only the electrons are heated to thousands of degrees, with the rest of the material remaining at room temperature. Purdue University researchers have advanced this field and have helped to make it...
Source: Medgadget - August 19, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Oncology Surgery Source Type: blogs

Fight Aging! Newsletter, August 19th 2019
In conclusion, our data show how oncogenic and tumor-suppressive drivers of cellular senescence act to regulate surveillance processes that can be circumvented to enable SnCs to elude immune recognition but can be reversed by cell surface-targeted interventions to purge the SnCs that persist in vitro and in patients. Since eliminating SnCs can prevent tumor progression, delay the onset of degenerative diseases, and restore fitness; since NKG2D-Ls are not widely expressed in healthy human tissues and NKG2D-L shedding is an evasion mechanism also employed by tumor cells; and since increasing numbers of B cells express NKG2D ...
Source: Fight Aging! - August 18, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

DigniCap Delta Hair Loss Prevention System for Chemo Now in U.S.
Dignitana, a company out of Lund, Sweden, won FDA clearance and is now distributing its DigniCap Delta scalp cooling system in the U.S. The University of California, San Francisco (UCSF) will be the first recipient in America of the fourth generation...
Source: Medgadget - August 15, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Medicine Oncology Source Type: blogs

Targeting NKG2D Ligands on the Surface of Persistent Senescent Cells Enables their Destruction by the Immune System
In conclusion, our data show how oncogenic and tumor-suppressive drivers of cellular senescence regulate surveillance processes that can be circumvented to enable SnCs to elude immune recognition but can be reversed by cell surface-targeted interventions to purge the SnCs that persist in vitro and in patients. Since eliminating SnCs can prevent tumor progression, delay the onset of degenerative diseases, and restore fitness; since NKG2D-Ls are not widely expressed in healthy human tissues and NKG2D-L shedding is an evasion mechanism also employed by tumor cells; and since increasing numbers of B cells express NKG2D ligands...
Source: Fight Aging! - August 14, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

A Proposal to Improve Healthcare and Make It More Affordable
By STEVE ZECOLA Americans spend about $3 trillion per year on healthcare, or about $10,000 per person per year. Despite these expenditures, Americans are worse off than their international counterparts with respect to infant mortality, life expectancy and the prevalence of chronic conditions. In policy debates, Republicans mostly prefer to let the marketplace devise the appropriate outcomes, but this approach ignores the market failures that plague the industry. On the other hand, Democrats propose a variety of solutions such as “Medicare for All” which nationalizes all healthcare insurance or, as a variant, ...
Source: The Health Care Blog - August 6, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Health Policy Medicare For All Source Type: blogs

New Biomaterial Improves Brain Cancer Survival in Rats
Researchers from the University of Nottingham have developed a new biomaterial that delivers chemotherapies to treat brain cancer. Their work demonstrates that their biodegradable paste led to increased survival compared to controls, and that half of...
Source: Medgadget - July 24, 2019 Category: Medical Devices Authors: Siavash Parkhideh Tags: Materials Medicine Neurosurgery Oncology Source Type: blogs

Alternative cancer therapies and the promise of false hope
How do you  respond when patients with a good prognosis want to delay chemotherapy to try an anticancer diet for a few months or visit an unregulated clinic for unproven therapies? I’m asking because of an alarming finding of ASCO’s 2018 National Cancer Opinion Survey: “Nearly 4 in 10 Americans believe cancer can be cured solely […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - July 22, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/wendy-s-harpham" rel="tag" > Wendy S. Harpham, MD < /a > < /span > Tags: Physician Oncology/Hematology Source Type: blogs

Chemo Tester Identifies Which Formulation Works for Each Patient
Chemotherapy is challenging for patients, as it can be terribly brutal on their bodies, but also for physicians trying to figure out which medication to deliver. Now, a new device has been developed at Rutgers University that can test whether a given...
Source: Medgadget - July 17, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Oncology Pathology Surgery Source Type: blogs

All Ears: Seeds of Breakthrough on Chemo Side Effect
The post All Ears: Seeds of Breakthrough on Chemo Side Effect appeared first on Johns Hopkins Nursing Magazine.
Source: Nursing Blogs at Johns Hopkins University - July 16, 2019 Category: Nursing Authors: Editor Tags: Cells to Society acupressure auricular point pressure cancer chemotherapy ear neuropathy pain research seeds side effect vaccaria Source Type: blogs

Carbon Dioxide-Based Cancer Cryoablation Probe for Low-Resource Regions
Undergraduate researchers at John Hopkins University have developed a cryoablation probe for breast cancer, which uses carbon dioxide instead of argon, making it more affordable and accessible for use in low resource regions.   Treatments for...
Source: Medgadget - July 15, 2019 Category: Medical Devices Authors: Conn Hastings Tags: Oncology Surgery Source Type: blogs

Fight Aging! Newsletter, July 15th 2019
In conclusion, we show here that sEVs are responsible for mediating paracrine senescence and speculate that they could be involved in inducing bystander senescence during therapy-induced senescence or aging. In fact, when compared to soluble factors, sEVs have different biophysical and biochemical properties as they have a longer lifespan than do soluble factors and they are more resistant to protease degradation. The idea that blocking sEV secretion could be a potential therapeutic approach to alleviate senescence "spreading" during chemotherapy-induced senescence or in aging tissues presents itself as a very attractive t...
Source: Fight Aging! - July 14, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Both Extracellular Vesicles and Secreted Proteins can Spread Cellular Senescence
In conclusion, we show here that sEVs are responsible for mediating paracrine senescence and speculate that they could be involved in inducing bystander senescence during therapy-induced senescence or aging. In fact, when compared to soluble factors, sEVs have different biophysical and biochemical properties as they have a longer lifespan than do soluble factors and they are more resistant to protease degradation. The idea that blocking sEV secretion could be a potential therapeutic approach to alleviate senescence "spreading" during chemotherapy-induced senescence or in aging tissues presents itself as a very attractive tool for the future.
Source: Fight Aging! - July 10, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs