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Fight Aging! Newsletter, June 13th 2022
In conclusion, long-term cumulative BP was associated with subsequent cognitive decline, dementia risk, and all-cause mortality in cognitively healthy adults aged ≥50 years. Efforts are required to control long-term systolic BP and pulse pressure and to maintain adequate diastolic BP.
Longer-Lived Mammals Tend to Have Lower Expression of Inflammation-Related Genes
https://www.fightaging.org/archives/2022/06/longer-lived-mammals-tend-to-have-lower-expression-of-inflammation-related-genes/
Researchers here make a few interesting observations on gene expression data from a range of mammalian species with ...
Source: Fight Aging! - June 12, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Republican Health Policies Disproportionally Harm White Citizens in Their States
BY MIKE MAGEE
“As I’ve said before, I believe Dr. Ladapo is an anti-science quack who doesn’t belong anywhere near our state’s Surgeon General office, let alone running it. But now that he’s been confirmed, it’s my sincere hope that he and Governor DeSantis choose to focus on saving lives and preventing unnecessary illness instead of continuing their absurd promotion of conspiracy theories and opposition to proven public health measures — but I’m not going to hold my breath.”
If you identified these as the words of the former governor, and now Congressman Charlie Crisp, currently running to retake t...
Source: The Health Care Blog - June 10, 2022 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Politics ACA Affordable Care Act Charlie Crisp Medicaid Medicaid Expansion Source Type: blogs
Cancer Correlates with Increased Risk of Later Onset of Type 2 Diabetes
Researchers here note a correlation between cancer diagnosis and greater risk of later onset of type 2 diabetes. A reasonable guess is that this is mediated by the increased burden of cellular senescence produced by chemotherapy and radiotherapy, though, as the researchers point out, the widely different risks by cancer type may indicate that tumors are metabolically active in ways that specifically promote the metabolic dysfunction that leads to type 2 diabetes.
For patients with cancer, prevalent type 2 diabetes at the date of cancer diagnosis is associated with increased cancer-specific and all-cause mortality....
Source: Fight Aging! - June 9, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, June 6th 2022
This study examines evidence suggesting that mitochondrial dysfunction plays a significant early impact on AD pathology.
Although mitochondrial dysfunction is a typical indication of Alzheimer's disease, it is unclear whether the cellular systems that maintain mitochondrial integrity malfunction, aggravating mitochondrial pathology. Different levels of vigilance and preventive methods are used to reduce mitochondrial damage and efficiently destroy faulty mitochondria to maintain the mitochondrial equilibrium. The form and function of mitochondria are regulated by mitochondrial fusion and fission. In contrast, mitoch...
Source: Fight Aging! - June 5, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
How patient education can save lives
A patient undergoing chemotherapy for breast cancer was diagnosed on April 20th with profound secondary adrenal insufficiency (hypophysitis: ACTH undetectable, cortisol 0.2) caused by immunotherapy (pembrolizumab). She was started on corticosteroids and sent home from the hospital on April 24th with a prescription for only five days of prednisone. After completing the five days ofRead more …How patient education can save lives originally appeared inKevinMD.com.
Source: Kevin, M.D. - Medical Weblog - June 4, 2022 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/post-author/david-m-mitchell" rel="tag" data-wpel-link="internal" > David M. Mitchell, MD, PhD < /a > < /span > Tags: Conditions Endocrinology Hospital-Based Medicine Source Type: blogs
Navitoclax is Better than Dasatinib and Quercetin at Clearing Senescent Cells Produced by Radiotherapy
It is now well known that many of the negative consequences resulting from chemotherapy and radiotherapy are mediated by a raised burden of senescent cells. One of the goals of cancer therapy is to drive cancerous cells into senescence: better to have senescent cells than cancerous cells! Nonetheless, gaining a greater burden of senescent cells is literally accelerated aging, as these additional senescent cells actively degrade tissue function and create chronic inflammation via their secretions. Thus senolytic therapies should be of great benefit to cancer survivors, removing this harmful side-effect of cancer therapy.
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Source: Fight Aging! - May 30, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Cancer
I just finished reading The Emperor of All Maladies: A biography of cancer, by Siddhartha Mukherjee. I have a quibble with the title -- it should be history, not biography. By personifying cancer, he plays into just the mythologizing he is trying to dispel. But that aside, I found the book very informative. I knew the general outline of the story, but not a lot of the details. What I want to comment on here, which I believe is the key takeaway, is that medical practice is subject to ideological capture, even in the modern era of " scientific " medicine. In the center of the book is the horror story of radical mastecto...
Source: Stayin' Alive - May 29, 2022 Category: American Health Source Type: blogs
Wireless Implant for Anti-Cancer Photodynamic Therapy
Researchers at Texas A&M University created a wireless device that aims to illuminate and destroy residual tumor cells left after cancer resection. The device can be used by surgeons to illuminate the tumor bed after resection. It works in combin...
Source: Medgadget - April 28, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Oncology Radiology Surgery TAMU Source Type: blogs
Fight Aging! Newsletter, April 4th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 3, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
To my patient who is going to lose her hair from chemotherapy PODCAST
“I understand that the biggest fear you have about going through chemotherapy is losing your hair. I just want to tell you. You will be fine. Trust me. I know it ’s barbaric. Why don’t we have medicines to treat cancer that will not make you lose your hair in this day and age? Strange, right?Read more …To my patient who is going to lose her hair from chemotherapy [PODCAST] originally appeared inKevinMD.com.
Source: Kevin, M.D. - Medical Weblog - March 22, 2022 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/post-author/the-podcast-by-kevinmd" rel="tag" > The Podcast by KevinMD < /a > < /span > Tags: Podcast Oncology/Hematology Source Type: blogs
Fight Aging! Newsletter, March 14th 2022
This study tests the feasibility of chronically elevating skeletal muscle NAD+ in mice and investigates the putative effects on mitochondrial respiratory capacity, insulin sensitivity, and gene expression. The metabolic effects of NR and PT treatment were modest. We conclude that the chronic elevation of skeletal muscle NAD+ by the intravenous injection of NR is possible but does not affect muscle respiratory capacity or insulin sensitivity in either sedentary or physically active mice. Our data have implications for NAD+ precursor supplementation regimens.
Muscle Strengthening Activities in Later Life Correlate ...
Source: Fight Aging! - March 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Many Mediocre Cancer Therapies Become Much Better When More Targeted to Cancerous Tissues
One of the important areas of cancer research and development that appears to receive a great deal of attention and funding, but in practice seems slow to make it from the laboratory to the clinic, is the targeting of therapeutics to cancerous cells. Reductio ad absurdum, near any of dozens of existing chemotherapeutics would do the job of completely clearing tumors, with minimal to no side-effects, if one could only find a way to delivery tiny amounts of the therapeutic to every cancer cell while avoiding every healthy cell. The inability to target treatments this effectively is exactly why cancer remains such a problem. ...
Source: Fight Aging! - March 9, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Hairy Nanocrystals Capture Chemo Drugs
Researchers at Penn State working with collaborators have developed a nanomaterial that can ‘mop up’ chemotherapeutics in the bloodstream, helping to reduce off-target effects. The technology is intended for use in situations where a chemotherape...
Source: Medgadget - January 12, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine Nanomedicine Oncology PennState Source Type: blogs
Fight Aging! Newsletter, December 20th 2021
In conclusion, the low dose, prolonged angiotensin II exposure is associated with the induction of senescence in kidneys and the promotion of an inflammatory microenvironment through both secreted factors and immune cells. Endothelial cells appear to be a major cell type impacted. The elimination of senescent cells in the INK-ATTAC transgenic model prevents these effects of angiotensin II and reveals a novel pathophysiologic mechanism amenable to targeting by senolytic drugs in development.
CYTOR Upregulation as a Path to Improved Muscle Function in Later Life
https://www.fightaging.org/archives/2021/12/cytor-u...
Source: Fight Aging! - December 19, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
To my patient who is going to lose her hair from chemotherapy
I understand that the biggest fear you have about going through chemotherapy is losing your hair. I just want to tell you. You will be fine. Trust me. I know it ’s barbaric. Why don’t we have medicines to treat cancer that will not make you lose your hair in this day and age? Strange, right?Read more …To my patient who is going to lose her hair from chemotherapy originally appeared inKevinMD.com.
Source: Kevin, M.D. - Medical Weblog - November 25, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/farhan-s-imran" rel="tag" > Farhan S. Imran, MD < /a > < /span > Tags: Conditions Oncology/Hematology Source Type: blogs
