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Fight Aging! Newsletter, May 15th 2023
In this study, we examined the average telomere length and telomerase activity, as well as the formation of telomere associated foci (TAFs) and the mRNA expression levels of the shelterin components in cultured primary cells of Spalax, a long-lived, hypoxia-tolerant, and cancer-resistant blind mole-rat species. We showed that with cell passages, Spalax fibroblasts demonstrated significant shortening in telomere length, similar to rat cells, and in line with the processes observed earlier in tissues. We also demonstrated that the average telomere length in Spalax fibroblasts was significantly higher than the average ...
Source: Fight Aging! - May 14, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Reviewing T Cell Immunotherapies to Treat Cancer
The use of immunotherapies will most likely replace chemotherapy and radiation therapy for the treatment near all cancers over the next twenty years, and has already done so for many types of cancer. We should expect immunotherapies to in turn be replaced by approaches that target the telomere lengthening essential to all cancers. The wheel turns slowly, but this progress will lead steadily to an end to the suffering and loss of life accompanying cancer. Cancer will become a mild, annoying but controllable condition within a matter of decades, within the lifetimes of most of those reading this now. The review paper noted h...
Source: Fight Aging! - May 10, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

I ' m thinking about moving this blog...
 ...to another platform. Hi, it ' s been a while. I haven ' t written anything this year. My last post was December 31, 2022.The main reason is that I ' ve had to deal with more loss and grief in my life. Someone close to me was diagnosed with cancer, endured months of radiation and chemotherapy, and died anyway.1 I ' ve also had some deflating garbage to wade through at work. My enthusiasm for doing anything has been rather low.Besides all that, Blogger is aterrible platform for blogging. The interface changed a while a back and ever since then, composing in the little box has been unpleasant. It takes forever t...
Source: The Neurocritic - May 9, 2023 Category: Neuroscience Authors: The Neurocritic Source Type: blogs

Memora Health Announces $30M Investment to Scale Intelligent Care Enablement Platform With New Health System Partners
The strategic investment was led by General Catalyst and a cohort of leading health system partners and will enable care teams to give more patients a high-touch care experience Memora Health, the leading intelligent care enablement platform, today announced a strategic investment of $30 million led by General Catalyst with participation from Northwell Holdings, the venture investment arm of Northwell Health, NorthShore – Edward-Elmhurst Health, PagsGroup, and other strategic investors. The funding also included follow-on investments from existing investors Andreessen Horowitz, Transformation Capital, and Frist Cressey V...
Source: EMR and HIPAA - May 1, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Andreessen Horowitz Care Delivery Chris Bischoff Dr. David Lubarsky Dr. Toby Cosgrove Edward Elmhurst Health Frist Cressey Ventures General Catalyst Health IT Funding Health IT Fundings Health IT Inv Source Type: blogs

Fight Aging! Newsletter, May 1st 2023
In conclusion, frailty progression accelerates in males with one LTCs and females with two LTCs or more. Health providers should be aware of planning a suitable intervention once the elderly have two or more health conditions. Plasma Transfer Lowers Epigenetic Age and Mortality in Rats https://www.fightaging.org/archives/2023/04/plasma-transfer-lowers-epigenetic-age-and-mortality-in-rats/ Plasma transfer from young to old individuals has produced mixed results in animals and little to no benefit in humans where assessed rigorously. These studies were driven by the hypothesis that young plasma contains me...
Source: Fight Aging! - April 30, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, March 6th 2023
In this study, we develop a rFOXN1 fusion protein that contains the N-terminal of CCR9, FOXN1, and TAT. We show here that, when injected intravenously (i.v.) into aged mice, the rFOXN1 fusion protein can migrate into the thymus and enhance T cell generation in the thymus, resulting in increased number of peripheral T cells. Our results suggest that the rFOXN1 fusion protein has the potential to be used in preventing and treating T cell immunodeficiency in the older adult. Increased miR-181a-5p Expression Improves Neural Stem Cell Activity, Learning, and Memory in Old Mice https://www.fightaging.org/archives/202...
Source: Fight Aging! - March 5, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, February 20th 2023
In this study, researchers stimulate the ghrelin receptor using a suitable small molecule for much of the lifespan of mice, and observe the results. The overall extension of life span is a quarter of that produced by calorie restriction, and so we might draw some conclusions from that as to the relative importance of hunger in the benefits resulting from the practice of calorie restriction or fasting. Interestingly, the short term weight gains observed in mice given this ghrelin receptor agonist in the past don't appear in this long term study, in which the controls are the heaver animals. This is possibly because the rese...
Source: Fight Aging! - February 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Request for Startups in the Rejuvenation Biotechnology Space, 2023 Edition
It is time once again for my once-yearly set of unsolicited thoughts on biotech startups that I'd like to see join those already working hard on the basis for human rejuvenation. The industry is growing rapidly, but patchily. Partial reprogramming has received enormous attention, as has the development of senolytics. Meanwhile, other important goals in rejuvenation research languish, or presently have only one or two companies involved in clinical translation of promising academic projects. Many plausible paths forward go undeveloped; there are just as many opportunities to make a real difference in the world as there were...
Source: Fight Aging! - February 13, 2023 Category: Research Authors: Reason Tags: Investment Source Type: blogs

Fight Aging! Newsletter, February 13th 2023
This study investigated whether taller Polish adults live longer than their shorter counterparts. Data on declared height were available from 848,860 individuals who died in the years 2004-2008 in Poland. To allow for the cohort effect, the Z-values were generated. Separately for both sexes, Pearson's r coefficients of correlation were calculated. Subsequently, one way ANOVA was performed. The correlation between adult height and longevity was negative and statistically significant in both men and women. After eliminating the effects of secular trends in height, the correlation was very weak (r = -0.0044 in men and ...
Source: Fight Aging! - February 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, January 30th 2023
In conclusion, deletion of p16Ink4a cells did not negatively impact beta-cell mass and blood glucose under basal and HFD conditions and proliferation was restored in a subset of HFD mice opening further therapeutic targets in the treatment of diabetes. Communication Between Blood and Brain in Aging and Rejuvenation https://www.fightaging.org/archives/2023/01/communication-between-blood-and-brain-in-aging-and-rejuvenation/ As noted here, joining the circulatory systems of an old and young mouse results in some degree of rejuvenation in the old mouse. Where brain function is improved, researchers are inter...
Source: Fight Aging! - January 29, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Ultrasound is Ultra-Cool
This study is also a major step forward for the exciting possibility of combining focused ultrasound with targeted delivery of medications or antibodies that normally have limited capability to cross the blood brain barrier from the blood to the brain.”  Similarly, researchers at Yonsei University College of Medicine (South Korea) found that focused ultrasound improved the delivery of Alzheimer’s drugs by over eight times.  “While there is no complete cure for dementia, we hope that open BBB [blood brain barrier] surgery using FUS surgery can help give hope to dementia patients,” the lead researcher said. ...
Source: The Health Care Blog - January 25, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Tech 3D printing ChatGPT DSP Kim Bellard Ultrasound Source Type: blogs

Senotherapeutics Will Reduce the Side-Effects of Cancer Radiotherapy
Treatment with radiation to kill cancerous cells results in an increased burden of senescent cells, both in and around the tumor. This is a fair trade-off; a senescent cancerous cell may be harmful in and of itself, but it is a good deal less harmful in the long run than an active cancer cell. Unfortunately senescent cells produce pro-growth, pro-inflammatory signaling that is disruptive of tissue function, raises the risk of suffering a range of age-related conditions, and increases the risk of both reoccurrence of the treated cancer and the development of later unrelated cancers. Thus given the work taking place o...
Source: Fight Aging! - January 24, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Cancer as a model of diversity: To be an ally, ask
I was brought to tears today, suddenly, unexpectedly, by the ringing of a bell. I had passed a small sign earlier, and I knew that the ringing signified the completion of someone’s chemotherapy. As I heard cheers, I thought how amazing this group of individuals (who I could not see, closeted as I was behind Read more… Cancer as a model of diversity: To be an ally, ask originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - January 22, 2023 Category: General Medicine Authors: Tags: Physician Oncology/Hematology Source Type: blogs

Evidence based medicine and politics
I ' m not sure if you can read this -- I have a cookie that gives me access, but the URL doesn ' t include the proxy server and it appears to be accessible. Let me know. Anyway, it ' sa discussion in NEJM of the U.S. Preventive Services Task Force. The USPSTF is a panel of clinical experts convened by the Agency for Healthcare Research and Quality, AHRQ, which is usually pronounced like ark. It draws on available research to evaluate screening tests and preventive interventions. An A or B grade means they recommend it. A C grade means it might be worthwhile for some people, but you should discuss it with your doctor and ma...
Source: Stayin' Alive - January 5, 2023 Category: American Health Source Type: blogs

Fight Aging! Newsletter, January 2nd 2023
In conclusion, circulating monocytes in older adults exhibit increased expression of activation, adhesion, and migration markers, but decreased expression of co-inhibitory molecules. MERTK Inhibition Increases Bone Density via Increased Osteoblast Activity https://www.fightaging.org/archives/2022/12/mertk-inhibition-increases-bone-density-via-increased-osteoblast-activity/ Bone density results from the balance of constant activity on the part of osteoblasts and osteoclasts, the former building bone, the latter breaking it down. With advancing age, the balance of activity shifts to favor osteoclasts, prod...
Source: Fight Aging! - January 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs