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Peptide Coated Nanoparticles as a Basis for a Non-Invasive Test for Cancer
A reliable, low-cost means of early detection of cancer would be of great benefit. Approaches to the treatment are advancing to the point at which very early stage cancer has a high rate of survival, and the side-effects of treatments for early stage cancer are becoming less onerous. In the ideal world, a yearly physical would include a low-cost cancer screen that robustly detects even small volumes of cancerous tissue. Various approaches are under development, such as those based on identification of signal molecules in the bloodstream. The alternative approach noted here, based on the use of engineered nanoparticles, is ...
Source: Fight Aging! - July 27, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Oscillating Magnetic Field Shrinks Glioblastoma Tumor
At the Houston Methodist Neurological Institute, researchers have developed a device that generates a magnetic field and used it to successfully shrink a glioblastoma tumor in a patient volunteer. The device is worn on the head each day during treatm...
Source: Medgadget - July 26, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Neurology Neurosurgery Oncology Source Type: blogs

Fight Aging! Newsletter, May 31st 2021
In conclusion, iMSC-sEVs could rejuvenate the senescence of NPCs and attenuate the development of IVDD. Cell Signaling via Exosomes in the Development of Vascular Calcification https://www.fightaging.org/archives/2021/05/cell-signaling-via-exosomes-in-the-development-of-vascular-calcification/ Vascular calcification is a feature of aging, a process in which cells in the blood vessel wall take on inappropriate identities and activities that are more appropriate to bone tissue. Evidence of recent years implicates chronic inflammation and the presence of senescent cells in this process. Senescent cells caus...
Source: Fight Aging! - May 30, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Off Our Chests: No Secrets Left Behind
By CHADI NABHAN She was a successful corporate lawyer turned professional volunteer and a housewife. He was a charismatic, successful, and world-renowned researcher in gastrointestinal oncology. He was jealous of all breast cancer research funding and had declared that disease his nemesis. They were married; life was becoming a routine, and borderline predictable. Both appeared to have lost some appreciation of each other and their sacrifices. Then, she saw a lump, and was diagnosed with breast cancer. Not any breast cancer, but triple negative breast cancer. The kind that is aggressive and potentially lethal. ...
Source: The Health Care Blog - May 27, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Patients Physicians Book Review Breast cancer Chadi Nabhan illness narratives John Marshall Liza Marshall Off Our Chests triple negative breast cancer Source Type: blogs

Trojan Horse Virus Makes Tumors Destroy Themselves
Researchers at the University of Zurich have developed a virus-based therapy that causes a tumor to destroy itself. They modified an adenovirus, which is a common virus that typically infects the respiratory tract and which is already widely used in ...
Source: Medgadget - May 19, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Materials Medicine Oncology Source Type: blogs

Fight Aging! Newsletter, May 17th 2021
This study is consistent with previous evidence showing that inflammaging, or age-related inflammation, is naturally heightened in the nervous system. Moreover, the authors disproved their hypothesis that anti-inflammatory microglia-specific genes are responsible for the elevated inflammatory response in aged brains since the expression of anti-inflammatory mediators was elevated in middle-aged brains following infection. Thus, the cause for the increase in pro-inflammatory genes remains to be elucidated. Mixed Results in Animal Studies of Gene Therapy Targeting Axonal Regrowth https://www.fightaging.org/archiv...
Source: Fight Aging! - May 16, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Standing on Your Own Two Feet …at the bottom of the abyss
My chemotherapy for Hodgkin’s lymphoma started just four weeks after I got the cancerous vertebrae removed from my lower back. They’d inserted a metal cage inserted in its place, to hold my back together. The doctor said this procedure would keep me from being in a wheelchair for the rest of my life. I had just turned 33 years old. But there I was: back in a wheelchair.  Already. Just two chemo infusions into the long process ahead of me and I was responding so poorly that my body could no longer walk. I was feeling vulnerable, scared and scarred. I was dropping weight and popping pain pills. It was a time of e...
Source: PickTheBrain | Motivation and Self Improvement - May 13, 2021 Category: Consumer Health News Authors: Kristi Nelson Tags: confidence creativity depression featured happiness philosophy psychology self-improvement cancer empowerment healing inspiration motivation Source Type: blogs

Reviewing Recent Work on the Mechanisms of Cellular Senescence
Impressive results have been produced in mice via clearance of senescent cells: rejuvenation, extension of life, and reversal of numerous different age-related conditions. This has provoked an increasing number of research groups to focus on the mechanisms of cellular senescence, in search of novel ways to identify and destroy these cells, or to suppress the senescence-associated secretory phenotype (SASP) that they produce. The secreted signal molecules of the SASP alter surrounding cell behavior and rouse the immune system to chronic inflammation. This is the means by which the comparatively small number of lingering sen...
Source: Fight Aging! - May 11, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, May 10th 2021
This study suggests that some of those changes contribute to age-related hypertension, providing yet another reason to put resources into the near term development of therapies that can reverse the aging of the gut microbiome, such as flagellin vaccination or fecal microbiota transplantation. "Previous studies from our lab have shown that the composition of the gut microbiota in animal models of hypertension, such as the SHRSP (spontaneously hypertensive stroke-prone) rat model, is different from that in animals with normal blood pressure. Further, transplanting dysbiotic gut microbiota from a hypertensive animal ...
Source: Fight Aging! - May 9, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

ABL1 Inhibition Increases Neural Stem Cell Activity in the Aging Brain
Putting stem cells back to work is the theme of a great of the research that takes place in the regenerative medicine community. Stem cells are responsible for producing a supply of daughter somatic cells, required to replace losses and maintain functional tissue. Stem cell activity throughout the body declines with age, however. Much of this decline is not caused by intrinsic cell and tissue damage that would prevent activity, but is rather an evolved reaction to the presence of that damage. Suppressing stem cell activity likely serves to reduce cancer risk in later life. The more cell activity there is in a damage...
Source: Fight Aging! - May 5, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, April 26th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 25, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Calorie Restriction as an Adjuvant Cancer Treatment
Calorie restriction and intermittent fasting have been extensively studied in the context of aging, and most of the age-slowing interventions so far tested in animal studies are derived in some way from a knowledge of the stress response mechanisms triggered by a lowered calorie intake. The long term effects of calorie restriction and fasting in short-lived species are quite different from those in long-lived species: only the short-lived species exhibit a meaningful extension of life span, as much as 40% in mice. Yet the short-term effects on metabolism and cellular mechanisms are very similar. The beneficial response to ...
Source: Fight Aging! - April 19, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Implantable Pump Delivers Chemotherapy to Brain Tumors
Researchers at Linköping University, Sweden, and the Medical University of Graz, Austria have developed an electrical pump that can precisely deliver chemotherapeutic drugs into the brain. The technology is conceived as being implantable into brain ...
Source: Medgadget - April 19, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Neurology Neurosurgery Oncology Source Type: blogs

Can some postmenopausal women with breast cancer skip chemotherapy?
Breast cancer remains the most common cancer among women. In the last two decades, the treatment of breast cancers has become personalized. This has been possible due to the subtyping of breast cancers. Breast cancers have been subtyped based on the receptors on the breast cancer cell. The most clinically significant receptors — those that have targeted therapies — are the estrogen and progesterone receptors and the human epidermal growth factor receptor 2 (HER2). Cancers that have the estrogen and progesterone receptors are termed hormone receptor (HR)-positive cancers. The development of hormone therapy for HR-positi...
Source: Harvard Health Blog - April 15, 2021 Category: Consumer Health News Authors: Salewa T. Salewa Oseni, MD Tags: Cancer Medical Research Women's Health Source Type: blogs

Fight Aging! Newsletter, April 12th 2021
In conclusion, the MR exhibited the protective effects against age-related behavioral disorders, which could be partly explained by activating circulating FGF21 and promoting mitochondrial biogenesis, and consequently suppressing the neuroinflammation and oxidative damages. These results demonstrate that FGF21 can be used as a potential nutritional factor in dietary restriction-based strategies for improving cognition associated with neurodegeneration disorders. Senescent T Cells Cause Changes in Fat Tissue that are Harmful to Long-Term Health https://www.fightaging.org/archives/2021/04/senescent-t-cells-cause-...
Source: Fight Aging! - April 11, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs