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Dietary palm oil enhances SREBP2-mediated cholesterol biosynthesis through inducing endoplasmic reticulum stress in muscle of large yellow croaker ( < em > Larimichthys crocea < /em > )
Br J Nutr. 2023 Sep 13:1-27. doi: 10.1017/S0007114523001344. Online ahead of print.ABSTRACTSterol regulatory element-binding protein 2 (SREBP2) is considered to be a major regulator to control cholesterol homeostasis in mammals. However, the role of SREBP2 in teleost remains poorly understand. Here, we explored the molecular characterization of SREBP2 and identified SREBP2 as a key modulator for 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and 7-dehydrocholesterol reductase (DHCR7) which were rate-limiting enzymes of cholesterol biosynthesis. Moreover, dietary palm oil (PO) in vivo or palmitic acid (PA) treatmen...
Source: The British Journal of Nutrition - September 12, 2023 Category: Nutrition Authors: Zengqi Zhao Baolin Li Qiang Chen Xiaojun Xiang Xiang Xu Shangzhe Han Wencong Lai Yueru Li Wei Xu Kangsen Mai Qinghui Ai Source Type: research
Flunitrazepam and its metabolites exposure disturb the zebrafish gut-liver axis: Combined microbiome and metabolomic analysis
In this study, we investigated the effects of the benzodiazepine drug flunitrazepam (FLZ) and its metabolite 7-aminoflunitrazepam (7-FLZ) on the gut-liver axis of zebrafish. Zebrafish were exposed to two concentrations of FLZ and 7-FLZ (0.05 and 1 μg/L) for 30 days. Results showed that both FLZ and 7-FLZ exposure altered the relative abundance of Proteobacteria at the phylum level, with significant differences observed at the genus level for pathogenic bacteria such as Paracoccus, Shewanella, and Aeromonas. Metabolomics results showed both exposures significantly interfered with nucleotide and amino acid metabolism. The i...
Source: Aquatic Toxicology - September 12, 2023 Category: Toxicology Authors: Wenting Lin Yingjun Qin Xinying Wang Mingluo Du Yukai Wang Xiaohui Chen Yuan Ren Source Type: research
Dietary palm oil enhances SREBP2-mediated cholesterol biosynthesis through inducing endoplasmic reticulum stress in muscle of large yellow croaker ( < em > Larimichthys crocea < /em > )
Br J Nutr. 2023 Sep 13:1-27. doi: 10.1017/S0007114523001344. Online ahead of print.ABSTRACTSterol regulatory element-binding protein 2 (SREBP2) is considered to be a major regulator to control cholesterol homeostasis in mammals. However, the role of SREBP2 in teleost remains poorly understand. Here, we explored the molecular characterization of SREBP2 and identified SREBP2 as a key modulator for 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and 7-dehydrocholesterol reductase (DHCR7) which were rate-limiting enzymes of cholesterol biosynthesis. Moreover, dietary palm oil (PO) in vivo or palmitic acid (PA) treatmen...
Source: The British Journal of Nutrition - September 12, 2023 Category: Nutrition Authors: Zengqi Zhao Baolin Li Qiang Chen Xiaojun Xiang Xiang Xu Shangzhe Han Wencong Lai Yueru Li Wei Xu Kangsen Mai Qinghui Ai Source Type: research
Association of oxidized ApoB and oxidized ApoA-I with high-risk coronary plaque features in cardiovascular disease
CONCLUSION: Our findings suggest that the investigated OMLs are associated with high-risk coronary plaque features and progression over time in CVD patients.TRIAL REGISTRATION: URL: https://www.CLINICALTRIALS: gov. Unique identifier: NCT01621594.FUNDING: This work was supported by the National Heart, Lung and Blood Institute (NHLBI) at the National Institutes of Health Intramural Research Program. The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript f...
Source: Atherosclerosis - September 12, 2023 Category: Cardiology Authors: Alexander V Sorokin Christin G Hong Angel M Aponte Elizabeth M Florida Jingrong Tang Nidhi Patel Irina N Baranova Haiou Li Philip M Parel Vicky Chen Sierra R Wilson Emily L Ongstad Anna Coll én Martin P Playford Thomas L Eggerman Marcus Y Chen Kazuhiko K Source Type: research
Dietary palm oil enhances SREBP2-mediated cholesterol biosynthesis through inducing endoplasmic reticulum stress in muscle of large yellow croaker ( < em > Larimichthys crocea < /em > )
Br J Nutr. 2023 Sep 13:1-27. doi: 10.1017/S0007114523001344. Online ahead of print.ABSTRACTSterol regulatory element-binding protein 2 (SREBP2) is considered to be a major regulator to control cholesterol homeostasis in mammals. However, the role of SREBP2 in teleost remains poorly understand. Here, we explored the molecular characterization of SREBP2 and identified SREBP2 as a key modulator for 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and 7-dehydrocholesterol reductase (DHCR7) which were rate-limiting enzymes of cholesterol biosynthesis. Moreover, dietary palm oil (PO) in vivo or palmitic acid (PA) treatmen...
Source: The British Journal of Nutrition - September 12, 2023 Category: Nutrition Authors: Zengqi Zhao Baolin Li Qiang Chen Xiaojun Xiang Xiang Xu Shangzhe Han Wencong Lai Yueru Li Wei Xu Kangsen Mai Qinghui Ai Source Type: research
Cardiovascular risk assessments in patients with cortisol-producing adenoma: impact of clinical features and genetic characteristics
Heart Vessels. 2023 Sep 11. doi: 10.1007/s00380-023-02309-x. Online ahead of print.ABSTRACTThe causes of adrenal Cushing's syndrome (CS) encompass a wide spectrum of adrenal cortisol proliferations that exhibit clinical and molecular heterogeneity. The aims of our study were to investigate whether clinical and molecular heterogeneity influences endothelial function and metabolic abnormalities in patients with cortisol-producing adenoma (CPA). We retrospectively enrolled 25 patients with CPA and 45 patients with essential hypertension (EH). All CPAs were studied by direct sequencing of PRKACA. Flow-mediated vasodilation (FM...
Source: Atherosclerosis - September 11, 2023 Category: Cardiology Authors: Daisuke Watanabe Satoshi Morimoto Noriko Morishima Atsuhiro Ichihara Source Type: research
Low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol in type 1 diabetes and type 2 diabetes: Lipid goal attainment in a large German-Austrian diabetes registry
CONCLUSION: Approximately 2 years after publication of the guidelines, LDL-C and non-HDL-C goal attainment was rarely achieved in patients with T1D and T2D with a high or very high cardiovascular risk.PMID:37694759 | DOI:10.1111/dom.15264
Source: Atherosclerosis - September 11, 2023 Category: Cardiology Authors: Julia Brandts Sascha R Tittel Peter Bramlage Thomas Danne Johanna M Brix Stefan Zimny Christoph H J Heyer Reinhard W Holl Dirk M üller-Wieland Source Type: research
Effect of β-sitosterol on insulin resistance & amp; protein expression of insulin signalling molecules in quadriceps muscle of high fat diet-induced type-2 diabetic rats
Bioinformation. 2022 Nov 30;18(11):1098-1104. doi: 10.6026/973206300181098. eCollection 2022.ABSTRACTChanges in life style, such as high-calorie diet intake and lack of exercise, have increased the global prevalence of obesity and diabetes. The major pathophysiological event contributing to the development of type 2 diabetes mellitus is the target tissues to insulin action. Currently available drugs are unsuccessful for the treatment of type 2 diabetes due to their unwanted side effects. Hence, search drugs, from plant sources. β-sitosterol is plant sterols with structurally almost like that of cholesterol. It is widely p...
Source: Bioinformation - September 11, 2023 Category: Bioinformatics Authors: Gayathri Sekar Merlin G Madhan Krishnan Shyamaladevi Babu Padmini K Pushpa Konduru Mangai S Source Type: research
Kaempferia parviflora rhizome extract exerts anti-obesity effect in high-fat diet-induced obese C57BL/6N mice
Food Nutr Res. 2023 Aug 23;67. doi: 10.29219/fnr.v67.9413. eCollection 2023.ABSTRACTKaempferia parviflora (KP) rhizome, also called black ginger, has been used as a herbal medicine for many centuries. This current study was aimed at exploring whether KP rhizome extract (KPE) had anti-obesity effects and the mechanism involved. Five-week-old C57BL/6N male mice were allocated into five groups for 8-week feeding with control diet (CD), high-fat diet (HFD), HFD + 150 mg/kg body weight (BW)/day KPE (HFD+K150), HFD + 300 mg/kg BW/day KPE (HFD+K300), and HFD + 600 mg/kg BW/day KPE (HFD+K600). KPE decreased BW, body fat mass, adip...
Source: Food and Nutrition Research - September 11, 2023 Category: Nutrition Authors: Hyun Sook Lee Young Eun Jeon Riyo Awa Susumu Yoshino Eun Ji Kim Source Type: research
Transcriptomics integrated with metabolomics reveals perfluorobutane sulfonate (PFBS) exposure effect during pregnancy and lactation on lipid metabolism in rat offspring
Chemosphere. 2023 Sep 9:140120. doi: 10.1016/j.chemosphere.2023.140120. Online ahead of print.ABSTRACTEmerging epidemiological evidence indicates potential associations between gestational perfluorobutane sulfonate (PFBS) exposure and adverse metabolic outcomes in offspring. However, the underlying mechanisms remain unclear. Our study aimed to investigate PFBS exposure effects during pregnancy and lactation on rat offspring lipid profiles and the possible underlying mechanisms. Although the biochemical index difference including total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprot...
Source: Chemosphere - September 11, 2023 Category: Chemistry Authors: Xi Meng Guoqi Yu Tingyu Luo Ruiyuan Zhang Jun Zhang Yongjie Liu Source Type: research
Statins improve endothelial function via suppression of epigenetic-driven EndMT
Nat Cardiovasc Res. 2023 May;2(5):467-485. doi: 10.1038/s44161-023-00267-1. Epub 2023 May 8.ABSTRACTThe pleiotropic benefits of statins in cardiovascular diseases that are independent of their lipid-lowering effects have been well documented, but the underlying mechanisms remain elusive. Here we show that simvastatin significantly improves human induced pluripotent stem cell-derived endothelial cell functions in both baseline and diabetic conditions by reducing chromatin accessibility at transcriptional enhanced associate domain elements and ultimately at endothelial-to-mesenchymal transition (EndMT)-regulating genes in a ...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Chun Liu Mengcheng Shen Wilson L W Tan Ian Y Chen Yu Liu Xuan Yu Huaxiao Yang Angela Zhang Yanxia Liu Ming-Tao Zhao Mohamed Ameen Mao Zhang Eric R Gross Lei S Qi Nazish Sayed Joseph C Wu Source Type: research
Transcriptomics integrated with metabolomics reveals perfluorobutane sulfonate (PFBS) exposure effect during pregnancy and lactation on lipid metabolism in rat offspring
Chemosphere. 2023 Sep 9:140120. doi: 10.1016/j.chemosphere.2023.140120. Online ahead of print.ABSTRACTEmerging epidemiological evidence indicates potential associations between gestational perfluorobutane sulfonate (PFBS) exposure and adverse metabolic outcomes in offspring. However, the underlying mechanisms remain unclear. Our study aimed to investigate PFBS exposure effects during pregnancy and lactation on rat offspring lipid profiles and the possible underlying mechanisms. Although the biochemical index difference including total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprot...
Source: Chemosphere - September 11, 2023 Category: Chemistry Authors: Xi Meng Guoqi Yu Tingyu Luo Ruiyuan Zhang Jun Zhang Yongjie Liu Source Type: research
Association of outdoor artificial light at night with metabolic syndrome and the modifying effect of tree and grass cover
CONCLUSIONS: Outdoor ALAN exposure is associated with an increased MetS risk, especially in males, the elderly, urban residents, those lacking physical activity, and those living in lower levels of grass cover and tree cover.PMID:37696078 | DOI:10.1016/j.ecoenv.2023.115452
Source: Ecotoxicology and Environmental Safety - September 11, 2023 Category: Environmental Health Authors: Weizhuo Yi Weiqiang Wang Zhiwei Xu Li Liu Ning Wei Rubing Pan Rong Song Xuanxuan Li Jintao Liu Jiajun Yuan Jian Song Jian Cheng Yuee Huang Hong Su Source Type: research
