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Ginsenoside Rb1 alleviates chronic intermittent hypoxia-induced diabetic cardiomyopathy in db/db mice by regulating the adenosine monophosphate-activated protein kinase/Nrf2/heme oxygenase-1 signaling pathway
CONCLUSION: Rb1 treatment alleviated CIH-induced diabetic cardiomyopathy and glycolipid metabolism disorders in db/db mice by inhibiting oxidative stress and regulating the AMPK/Nrf2/HO-1 signaling pathway.PMID:37679978 | PMC:PMC10465847 | DOI:10.19852/j.cnki.jtcm.20221206.004
Source: Journal of Traditional Chinese Medicine - September 8, 2023 Category: Complementary Medicine Authors: Liu Bingbing L I Jieru S I Jianchao Chen Qi Yang Shengchang J I Ensheng Source Type: research
Efficacy and safety of Buyang Huanwu decoction for diabetic peripheral neuropathy: a systematic review and Metaanalysis
CONCLUSIONS: Our study suggests that BYHWD has a significant therapeutic effect on DPN. Highquality, largescale RCTs are needed to provide more reliable evidence.PMID:37679971 | PMC:PMC10465838 | DOI:10.19852/j.cnki.jtcm.20230802.002
Source: Journal of Traditional Chinese Medicine - September 8, 2023 Category: Complementary Medicine Authors: Zhang Meizhen Hao Xiaohui Tang Yiting Chen Yupeng H E Puyu Zhao Liming Pang Bing N I Qing Source Type: research
Ginsenoside Rb1 alleviates chronic intermittent hypoxia-induced diabetic cardiomyopathy in db/db mice by regulating the adenosine monophosphate-activated protein kinase/Nrf2/heme oxygenase-1 signaling pathway
CONCLUSION: Rb1 treatment alleviated CIH-induced diabetic cardiomyopathy and glycolipid metabolism disorders in db/db mice by inhibiting oxidative stress and regulating the AMPK/Nrf2/HO-1 signaling pathway.PMID:37679978 | PMC:PMC10465847 | DOI:10.19852/j.cnki.jtcm.20221206.004
Source: Journal of Traditional Chinese Medicine - September 8, 2023 Category: Complementary Medicine Authors: Liu Bingbing L I Jieru S I Jianchao Chen Qi Yang Shengchang J I Ensheng Source Type: research
Efficacy and safety of Buyang Huanwu decoction for diabetic peripheral neuropathy: a systematic review and Metaanalysis
CONCLUSIONS: Our study suggests that BYHWD has a significant therapeutic effect on DPN. Highquality, largescale RCTs are needed to provide more reliable evidence.PMID:37679971 | PMC:PMC10465838 | DOI:10.19852/j.cnki.jtcm.20230802.002
Source: Journal of Traditional Chinese Medicine - September 8, 2023 Category: Complementary Medicine Authors: Zhang Meizhen Hao Xiaohui Tang Yiting Chen Yupeng H E Puyu Zhao Liming Pang Bing N I Qing Source Type: research
Ginsenoside Rb1 alleviates chronic intermittent hypoxia-induced diabetic cardiomyopathy in db/db mice by regulating the adenosine monophosphate-activated protein kinase/Nrf2/heme oxygenase-1 signaling pathway
CONCLUSION: Rb1 treatment alleviated CIH-induced diabetic cardiomyopathy and glycolipid metabolism disorders in db/db mice by inhibiting oxidative stress and regulating the AMPK/Nrf2/HO-1 signaling pathway.PMID:37679978 | PMC:PMC10465847 | DOI:10.19852/j.cnki.jtcm.20221206.004
Source: Journal of Traditional Chinese Medicine - September 8, 2023 Category: Complementary Medicine Authors: Liu Bingbing L I Jieru S I Jianchao Chen Qi Yang Shengchang J I Ensheng Source Type: research
Efficacy and safety of Buyang Huanwu decoction for diabetic peripheral neuropathy: a systematic review and Metaanalysis
CONCLUSIONS: Our study suggests that BYHWD has a significant therapeutic effect on DPN. Highquality, largescale RCTs are needed to provide more reliable evidence.PMID:37679971 | PMC:PMC10465838 | DOI:10.19852/j.cnki.jtcm.20230802.002
Source: Journal of Traditional Chinese Medicine - September 8, 2023 Category: Complementary Medicine Authors: Zhang Meizhen Hao Xiaohui Tang Yiting Chen Yupeng H E Puyu Zhao Liming Pang Bing N I Qing Source Type: research
Comparison of the effect of uric acid/albumin ratio on coronary colleteral circulation with other inflammation-based markers in stable coronary artery disease patients
CONCLUSION: UAR was identified as a strong and independent predictor of CCC. In this context, UAR may be a useful biomarker in the risk prediction of patients with stable CAD.PMID:37674333 | DOI:10.1177/02676591231202105
Source: Perfusion - September 7, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Kenan Toprak R üstem Yılmaz Mustafa Kaplangoray Tolga Memio ğlu Mehmet İnanır Selahattin Akyol Kaya Özen Asuman Bi çer Recep Demirba ğ Source Type: research
Bone marrow mesenchymal stem cellsderived exosomes stabilize atherosclerosis through inhibiting pyroptosis
CONCLUSION: AS can induce pyroptosis, and BMSC-EXO can reduce inflammation and alleviate the progression of AS by inhibiting NLRP3/Caspase-1/GSDMD in the pyroptosis pathway.PMID:37679676 | DOI:10.1186/s12872-023-03453-y
Source: Atherosclerosis - September 7, 2023 Category: Cardiology Authors: Zhibin Bai Haolin Hu Fangfang Hu Jiajie Ji Zhenling Ji Source Type: research
Hepatic steatosis aggravates atherosclerosis via small extracellular vesicle-mediated inhibition of cellular cholesterol efflux
CONCLUSION: Steatotic hepatocytes-derived sEVs promote foam cells formation and facilitate atherogenesis by miR-30a-3p/ABCA1 axis. Targeting and reducing hepatic steatotic sEVs secretion or miR-30a-3p may be potential therapeutic approaches to slow the NAFLD-driven AS progression.IMPACT AND IMPLICATIONS: The prevalence of non-alcoholic fatty liver disease (NAFLD) is associated with atherosclerosis (AS). However, the key molecular mechanism of how NAFLD affects atherosclerosis progression is still unclear. Herein, we identified small extracellular vesicles (sEVs) from steatotic hepatocytes as a trigger to accelerate AS prog...
Source: Atherosclerosis - September 7, 2023 Category: Cardiology Authors: Xu Chen Shen Chen Juan Pang Rong Huang Yiran You Haoyang Zhang Jinghe Xiao Hongliang Xue Wenhua Ling Source Type: research
Targeting pharmacotherapies for inflammatory and cardiorenal endpoints in kidney disease
J Cardiovasc Pharmacol. 2023 Sep 5. doi: 10.1097/FJC.0000000000001482. Online ahead of print.ABSTRACTInflammation is an important contributor to excess cardiovascular risk and progressive renal injury in people with CKD. Dysregulation of the innate and adaptive immune system is accelerated by CKD and results in increased systemic inflammation, a heightened local vascular inflammatory response leading to accelerated atherosclerosis, and dysfunction of the cardiac and renal endothelium and microcirculation. Understanding and addressing the dysregulated immune system is a promising approach to modifying cardiorenal outcomes i...
Source: Atherosclerosis - September 7, 2023 Category: Cardiology Authors: Daniel M Huck Leo F Buckley Anil Chandraker Ron Blankstein Brittany Weber Source Type: research
Metabolic Health and Carotid Intima-Media Thickness: Association of Different Definitions in Women
In conclusion, we found that in a contemporary cohort of middle-aged women, the NCEP-ATPIII definition of the metabolic syndrome was more strongly associated with atherosclerosis as determined by the CIMT than the International Diabetes Federation definition or other definitions of metabolic health; it was also more strongly associated than body mass index or waist circumference. Our results need to be validated by other investigators in other populations.PMID:37677881 | DOI:10.1016/j.amjcard.2023.08.003
Source: Atherosclerosis - September 7, 2023 Category: Cardiology Authors: Caroline Jane Magri Sara Xuereb Rachel-Anne Xuereb Stephen Fava Source Type: research
PAR4 Inhibition Reduces Coronary Artery Atherosclerosis and Myocardial Fibrosis in SR-B1/LDLR Double Knockout Mice
CONCLUSIONS: The PAR4 inhibitory RAG8 pepducin reduced coronary artery atherosclerosis and myocardial fibrosis in SR-B1/LDLR double knockout mice fed a high-fat, high-cholesterol diet containing cholate. Furthermore, RAG8 reduced VCAM-1 in nonatherosclerotic coronary arteries and reduced leukocyte and platelet accumulation in atherosclerotic coronary arteries. These findings identify PAR4 as an attractive target in reducing coronary artery disease development, and the use of RAG8 may potentially be beneficial in cardiovascular disease.PMID:37675637 | DOI:10.1161/ATVBAHA.123.319767
Source: Atherosclerosis - September 7, 2023 Category: Cardiology Authors: Samuel K Lee Rida Malik Ji Zhou Wei Wang Peter Gross Jeffrey Weitz Rithwik Ramachandran Bernardo L Trigatti Source Type: research
Elucidation of the melitidin biosynthesis pathway in pummelo
This study establishes a biosynthetic pathway for melitidin, which provides genetic resources for the breeding and genetic improvement of pummelo aimed at fortifying the content of biologically active metabolites. This article is protected by copyright. All rights reserved.PMID:37675654 | DOI:10.1111/jipb.13564
Source: Journal of Integrative Plant Biology - September 7, 2023 Category: Biology Authors: Shuangqian Shen Shouchuang Wang Chenkun Yang Chao Wang Qianqian Zhou Shen Zhou Ran Zhang Yufei Li Zixuan Wang Liupan Dai Wenjv Peng Yingchen Hao Hao Guo Guangping Cao Xianqing Liu Fan Yao Qiang Xu Alisdair R Fernie Jie Luo Source Type: research
MicroRNAs Regulate Function in Atherosclerosis and Clinical Implications
Conclusion. In general, the expression levels of some microRNAs changed significantly in different stages of atherosclerosis pathogenesis; therefore, MicroRNAs may become new diagnostic biomarkers for atherosclerosis. In addition, microRNAs are also involved in the regulation of core processes such as endothelial dysfunction, plaque formation and stabilization, and cholesterol metabolism, which also suggests the great potential of microRNAs as a therapeutic target.PMID:37675243 | PMC:PMC10480027 | DOI:10.1155/2023/2561509
Source: Atherosclerosis - September 7, 2023 Category: Cardiology Authors: Zhaoyi Li Yidan Zhao Sei Suguro Rinkiko Suguro Source Type: research
PAR4 Inhibition Reduces Coronary Artery Atherosclerosis and Myocardial Fibrosis in SR-B1/LDLR Double Knockout Mice
CONCLUSIONS: The PAR4 inhibitory RAG8 pepducin reduced coronary artery atherosclerosis and myocardial fibrosis in SR-B1/LDLR double knockout mice fed a high-fat, high-cholesterol diet containing cholate. Furthermore, RAG8 reduced VCAM-1 in nonatherosclerotic coronary arteries and reduced leukocyte and platelet accumulation in atherosclerotic coronary arteries. These findings identify PAR4 as an attractive target in reducing coronary artery disease development, and the use of RAG8 may potentially be beneficial in cardiovascular disease.PMID:37675637 | DOI:10.1161/ATVBAHA.123.319767
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 7, 2023 Category: Cardiology Authors: Samuel K Lee Rida Malik Ji Zhou Wei Wang Peter Gross Jeffrey Weitz Rithwik Ramachandran Bernardo L Trigatti Source Type: research
