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Immunometabolic impact of pancreastatin inhibitor PSTi8 in MCD induced mouse model of oxidative stress and steatohepatitis
Cytokine. 2023 Sep 4;171:156354. doi: 10.1016/j.cyto.2023.156354. Online ahead of print.ABSTRACTAIM: Pancreastatin, a dysglycemic hormone that encourages inflammation and steatosis in a variety of metabolic disorder animal models. The purpose of this study is to determine the effect of the pancreastatin inhibitor PSTi8 on immunometabolic changes in the liver of MCD-induced NASH mice.MAIN METHODS: Methionine and choline-deficient (MCD) diet was used for the development of NASH. Liver enzymes like SGOT, SGPT, and ALP and lipid profiles were also performed in the serum. Further, immunophenotyping study was performed in the li...
Source: Cytokine - September 6, 2023 Category: Molecular Biology Authors: Umesh K Goand Inklisan Patel Saurabh Verma Shubhi Yadav Debalina Maity Naveen Singh Sachin Vishwakarma Shivam Rathaur Richa Garg Jiaur R Gayen Source Type: research
Lipid profile changes associated with antiretroviral therapies in a real-world cohort
CONCLUSIONS: The lipid profile among elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide fumarate group worsened throughout the follow-up, both in naïve and experienced patients, not so remarkable in the dolutegravir/abacavir/lamivudine group. Both regimens were well tolerated, with similar rates of cardiovascular events.PMID:37673703 | DOI:10.1016/j.farma.2023.07.005
Source: Farmacia Hospitalaria - September 6, 2023 Category: Drugs & Pharmacology Authors: Sandra Rotea-Salvo V íctor Giménez-Arufe Alejandro Mart ínez-Pradeda Carla Fern ández-Oliveira Álvaro Mena-de-Cea Luis Margusino-Frami ñán Isabel Mart ín-Herranz Purificaci ón Cid-Silva Source Type: research
Long-term ozone exposure is negatively associated with estimated glomerular filtration rate in Chinese middle-aged and elderly adults
In this study, we aimed to investigate the association of 1 y ozone exposure with renal function among the older adults in Xiamen City, China. We recruited 6024 eligible participants with a median age of 65.00 years, estimated their ozone exposure data, and collected questionnaires on demographic status and lifestyle factors as well as information on healthcare access. A generalized linear model was used to assess the association. An increase of 10 μg/m3 of 1 y ozone exposure was negatively associated with the estimated glomerular filtration rate (eGFR) [-3.12 (95% CI: -4.76, -1.48)]. The associations were stronger in men...
Source: Chemosphere - September 6, 2023 Category: Chemistry Authors: Yiqin Zhang Chen Tang Yuwen Liu Hanxiang Jiang Jiaosheng Lu Zhonghua Lu Liping Xu Siyu Zhang Lina Zhou Jing Ye Xianfa Xuan Ting Wu Xia Cao Benhua Zhao Liangquan Lin Yuxin Wang Jie Zhang Source Type: research
Multiplex metabolic pathway engineering of Monascus pilosus enhances lovastatin production
Appl Microbiol Biotechnol. 2023 Sep 6. doi: 10.1007/s00253-023-12747-2. Online ahead of print.ABSTRACTMonascus sp. is an important food microbial resource with the production of cholesterol-lowering agent lovastatin and other healthy metabolites. However, the mycotoxin citrinin naturally produced by Monascus sp. and the insufficient productivity of lovastatin limit its large-scale use in food industry. The aim of this paper is to modify a lovastatin-producing strain Monascus pilosus GN-01 through metabolic engineering to obtain a citrinin-free M. pilosus strain with higher yield of lovastatin. The citrinin synthesis regula...
Source: Applied Microbiology and Biotechnology - September 6, 2023 Category: Microbiology Authors: Xiaokun Hong Tianlong Guo Xinqi Xu Juan Lin Source Type: research
Long-term ozone exposure is negatively associated with estimated glomerular filtration rate in Chinese middle-aged and elderly adults
In this study, we aimed to investigate the association of 1 y ozone exposure with renal function among the older adults in Xiamen City, China. We recruited 6024 eligible participants with a median age of 65.00 years, estimated their ozone exposure data, and collected questionnaires on demographic status and lifestyle factors as well as information on healthcare access. A generalized linear model was used to assess the association. An increase of 10 μg/m3 of 1 y ozone exposure was negatively associated with the estimated glomerular filtration rate (eGFR) [-3.12 (95% CI: -4.76, -1.48)]. The associations were stronger in men...
Source: Chemosphere - September 6, 2023 Category: Chemistry Authors: Yiqin Zhang Chen Tang Yuwen Liu Hanxiang Jiang Jiaosheng Lu Zhonghua Lu Liping Xu Siyu Zhang Lina Zhou Jing Ye Xianfa Xuan Ting Wu Xia Cao Benhua Zhao Liangquan Lin Yuxin Wang Jie Zhang Source Type: research
Trimethylamine-N-oxide (TMAO) and predicted risk of cardiovascular events after partial nephrectomy
CONCLUSION: Uremic toxin levels increased after PN correlating with reduced GFR. Higher TMAO independently associated with greater predicted 10-year CVe risk. Parenchymal mass preserved rather than ischemia time or type associated with increased TMAO.PMID:37673746 | DOI:10.1016/j.asjsur.2023.08.104
Source: Asian Journal of Surgery - September 6, 2023 Category: Surgery Authors: Xiangpeng Zou Longbin Xiong Zhixing Guo Yuchen Li Kang Ning Xiaohua Liu Ye Xie Yulu Peng Yixuan Liu Xinyang Cai Boxin Zhao Fangjian Zhou Chunping Yu Xia Zheng Steven C Campbell Zhiling Zhang Source Type: research
Effect of cholesterol on the mechanical stability of gel-phase phospholipid bilayers studied by AFM force spectroscopy
Eur Phys J E Soft Matter. 2023 Sep 6;46(9):77. doi: 10.1140/epje/s10189-023-00338-y.ABSTRACTThe remarkably low sliding friction of articular cartilage in the major joints such as hips and knees, which is crucial for its homeostasis and joint health, has been attributed to lipid bilayers forming lubricious boundary layers at its surface. The robustness of such layers, and thus their lubrication efficiency at joint pressures, depends on the lipids forming them, including cholesterol which is a ubiquitous component, and which may act to strengthen of weaken the bilayer. In this work, a systematic study using an atomic force m...
Source: Health Physics - September 6, 2023 Category: Physics Authors: Salom é Mielke Raya Sorkin Jacob Klein Source Type: research
Trimethylamine-N-oxide (TMAO) and predicted risk of cardiovascular events after partial nephrectomy
CONCLUSION: Uremic toxin levels increased after PN correlating with reduced GFR. Higher TMAO independently associated with greater predicted 10-year CVe risk. Parenchymal mass preserved rather than ischemia time or type associated with increased TMAO.PMID:37673746 | DOI:10.1016/j.asjsur.2023.08.104
Source: Asian Journal of Surgery - September 6, 2023 Category: Surgery Authors: Xiangpeng Zou Longbin Xiong Zhixing Guo Yuchen Li Kang Ning Xiaohua Liu Ye Xie Yulu Peng Yixuan Liu Xinyang Cai Boxin Zhao Fangjian Zhou Chunping Yu Xia Zheng Steven C Campbell Zhiling Zhang Source Type: research
Efficacy of Vitamin D < sub > 2 < /sub > in maintaining serum total vitamin D concentrations and bone mineralization in adult dogs fed a plant-based (vegan) diet in a three-month randomized trial
Br J Nutr. 2023 Sep 6:1-41. doi: 10.1017/S0007114523001952. Online ahead of print.ABSTRACTDogs are considered omnivores based on their evolution, consuming diets that include animal tissue. Few feeding trials evaluating the nutritional suitability of exclusively plant-based (vegan) diets in dogs have been published, and the efficacy of vitamin D2 in maintaining canine serum vitamin D levels has not been clearly determined. A blinded dietary trial included 61 healthy desexed adult dogs: 31 fed an experimental extruded vegan diet (PLANT) and 30 fed a commercial extruded meat-based diet (MEAT) for three months. Dogs were scre...
Source: The British Journal of Nutrition - September 6, 2023 Category: Nutrition Authors: Sarah As Dodd Jennifer Adolphe Cate Dewey Deep Khosa Sarah K Abood Adronie Verbrugghe Source Type: research
Comprehensive Lipid Profiling Recapitulates Enhanced Lipolysis and Fatty Acid Metabolism in Intimal Foamy Macrophages From Murine Atherosclerotic Aorta
Immune Netw. 2023 Jun 15;23(4):e28. doi: 10.4110/in.2023.23.e28. eCollection 2023 Aug.ABSTRACTLipid accumulation in macrophages is a prominent phenomenon observed in atherosclerosis. Previously, intimal foamy macrophages (FM) showed decreased inflammatory gene expression compared to intimal non-foamy macrophages (NFM). Since reprogramming of lipid metabolism in macrophages affects immunological functions, lipid profiling of intimal macrophages appears to be important for understanding the phenotypic changes of macrophages in atherosclerotic lesions. While lipidomic analysis has been performed in atherosclerotic aortic tiss...
Source: Atherosclerosis - September 6, 2023 Category: Cardiology Authors: Jae Won Seo Kyu Seong Park Gwang Bin Lee Sang-Eun Park Jae-Hoon Choi Myeong Hee Moon Source Type: research
A liposomal platform for the delivery of ion channel proteins for treatment of channelopathies - Application in therapy of cystic fibrosis
Int J Biol Macromol. 2023 Sep 4:126652. doi: 10.1016/j.ijbiomac.2023.126652. Online ahead of print.ABSTRACTChannelopathies arise from ion channel dysfunction. Successful treatment entails delivery of functional ion channels to replace dysfunctional ones. Glycine receptor (GlyR)-rich cell membrane fragments (CMF) were previously delivered to target cell membranes using fusogenic liposomes. Here, cystic fibrosis transmembrane conductance regulator (CFTR)-bearing CMF were similarly delivered to target cells. We studied the effect of lipid composition on liposomes' ability to incorporate CMF and fuse with target cell membranes...
Source: International Journal of Biological Macromolecules - September 6, 2023 Category: Biochemistry Authors: Noha T ElNashar Ulrike Breitinger Hans-Georg Breitinger Samar Mansour Salma N Tammam Source Type: research
Lipid profile changes associated with antiretroviral therapies in a real-world cohort
CONCLUSIONS: The lipid profile among elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide fumarate group worsened throughout the follow-up, both in naïve and experienced patients, not so remarkable in the dolutegravir/abacavir/lamivudine group. Both regimens were well tolerated, with similar rates of cardiovascular events.PMID:37673703 | DOI:10.1016/j.farma.2023.07.005
Source: Farmacia Hospitalaria - September 6, 2023 Category: Drugs & Pharmacology Authors: Sandra Rotea-Salvo V íctor Giménez-Arufe Alejandro Mart ínez-Pradeda Carla Fern ández-Oliveira Álvaro Mena-de-Cea Luis Margusino-Frami ñán Isabel Mart ín-Herranz Purificaci ón Cid-Silva Source Type: research
Bempedoic Acid can Reduce Cardiovascular Events in Combination with Statins or As Monotherapy: A Systematic Review and Meta-analysis
ConclusionBempedoic acid may reduce the risk of cardiovascular events regardless of whether the patient is taking stains or not.Registration: PROSPERO registration number CRD42023422932.
Source: American Journal of Cardiovascular Drugs - September 6, 2023 Category: Cardiology Source Type: research
Point-of-care testing compared to gold-standard laboratory methods in the measurement of serum lipids
CONCLUSION: The Fujifilm™ NX700 POCT compared favourably with gold-standard laboratory methods in the determination of serum lipid measurements, allowing for rapid screening at the primary healthcare level.PMID:37667971 | DOI:10.5830/CVJA-2023-039
Source: Cardiovascular Journal of Africa - September 5, 2023 Category: Cardiology Authors: Brett S Mansfield Belinda Stevens Frederick J Raal Farzahna Mohamed Source Type: research
Modulating Plaque Inflammation < em > via < /em > Targeted mRNA Nanoparticles for the Treatment of Atherosclerosis
ACS Nano. 2023 Sep 5. doi: 10.1021/acsnano.3c00958. Online ahead of print.ABSTRACTAtherosclerosis is a common pathology present in many cardiovascular diseases. Although the current therapies (including statins and inhibitors of the serine protease PCSK9) can effectively reduce low-density lipoprotein (LDL) cholesterol levels to guideline-recommended levels, major adverse cardiovascular events still occur frequently. Indeed, the subendothelial retention of lipoproteins in the artery wall triggers multiple events of inflammation in macrophages and is a major contributor to the pathological progression of atherosclerosis. It...
Source: Atherosclerosis - September 5, 2023 Category: Cardiology Authors: Mingzhu Gao Maoping Tang William Ho Yilong Teng Qijing Chen Lei Bu Xiaoyang Xu Xue-Qing Zhang Source Type: research
