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PAR4 Inhibition Reduces Coronary Artery Atherosclerosis and Myocardial Fibrosis in SR-B1/LDLR Double Knockout Mice
CONCLUSIONS: The PAR4 inhibitory RAG8 pepducin reduced coronary artery atherosclerosis and myocardial fibrosis in SR-B1/LDLR double knockout mice fed a high-fat, high-cholesterol diet containing cholate. Furthermore, RAG8 reduced VCAM-1 in nonatherosclerotic coronary arteries and reduced leukocyte and platelet accumulation in atherosclerotic coronary arteries. These findings identify PAR4 as an attractive target in reducing coronary artery disease development, and the use of RAG8 may potentially be beneficial in cardiovascular disease.PMID:37675637 | DOI:10.1161/ATVBAHA.123.319767
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 7, 2023 Category: Cardiology Authors: Samuel K Lee Rida Malik Ji Zhou Wei Wang Peter Gross Jeffrey Weitz Rithwik Ramachandran Bernardo L Trigatti Source Type: research
Comparison of the effect of uric acid/albumin ratio on coronary colleteral circulation with other inflammation-based markers in stable coronary artery disease patients
CONCLUSION: UAR was identified as a strong and independent predictor of CCC. In this context, UAR may be a useful biomarker in the risk prediction of patients with stable CAD.PMID:37674333 | DOI:10.1177/02676591231202105
Source: Perfusion - September 7, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Kenan Toprak R üstem Yılmaz Mustafa Kaplangoray Tolga Memio ğlu Mehmet İnanır Selahattin Akyol Kaya Özen Asuman Bi çer Recep Demirba ğ Source Type: research
Physiologically based pharmacokinetic modelling to characterize enterohepatic recirculation and predict food effect on the pharmacokinetics of hyzetimibe
CONCLUSIONS: The established PBPK model could describe the concentration-time profiles of hyzetimibe and M1 well with good prediction performance. A fully mechanistic model of enterohepatic recirculation warrants further investigation.PMID:37678518 | DOI:10.1016/j.ejps.2023.106576
Source: European Journal of Pharmaceutical Sciences - September 7, 2023 Category: Drugs & Pharmacology Authors: Wenjun Chen Zourong Ruan Honggang Lou Dandan Yang Jinliang Chen Rong Shao Bo Jiang Source Type: research
PAR4 Inhibition Reduces Coronary Artery Atherosclerosis and Myocardial Fibrosis in SR-B1/LDLR Double Knockout Mice
CONCLUSIONS: The PAR4 inhibitory RAG8 pepducin reduced coronary artery atherosclerosis and myocardial fibrosis in SR-B1/LDLR double knockout mice fed a high-fat, high-cholesterol diet containing cholate. Furthermore, RAG8 reduced VCAM-1 in nonatherosclerotic coronary arteries and reduced leukocyte and platelet accumulation in atherosclerotic coronary arteries. These findings identify PAR4 as an attractive target in reducing coronary artery disease development, and the use of RAG8 may potentially be beneficial in cardiovascular disease.PMID:37675637 | DOI:10.1161/ATVBAHA.123.319767
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 7, 2023 Category: Cardiology Authors: Samuel K Lee Rida Malik Ji Zhou Wei Wang Peter Gross Jeffrey Weitz Rithwik Ramachandran Bernardo L Trigatti Source Type: research
Pathophysiology and targeted treatment of cholesterol crystal embolism and the related thrombotic angiopathy
FASEB J. 2023 Oct;37(10):e23179. doi: 10.1096/fj.202301316R.ABSTRACTCholesterol crystal (CC) embolism is a complication of advanced atherosclerotic plaques located in the major arteries. This pathological condition is primarily induced by interventional and surgical procedures or occurs spontaneously. CC can induce a wide range of tissue injuries including CC embolism syndrome, a spontaneous or intervention-induced complication of advanced atherosclerosis, while treatment of CC embolism has remained empiric. Vascular occlusions caused by CC embolism may exceed the ischemia tolerance of many tissues, particularly when small...
Source: Atherosclerosis - September 7, 2023 Category: Cardiology Authors: Chongxu Shi Elmina Mammadova-Bach Cong Li Dong Liu Hans-Joachim Anders Source Type: research
PAR4 Inhibition Reduces Coronary Artery Atherosclerosis and Myocardial Fibrosis in SR-B1/LDLR Double Knockout Mice
CONCLUSIONS: The PAR4 inhibitory RAG8 pepducin reduced coronary artery atherosclerosis and myocardial fibrosis in SR-B1/LDLR double knockout mice fed a high-fat, high-cholesterol diet containing cholate. Furthermore, RAG8 reduced VCAM-1 in nonatherosclerotic coronary arteries and reduced leukocyte and platelet accumulation in atherosclerotic coronary arteries. These findings identify PAR4 as an attractive target in reducing coronary artery disease development, and the use of RAG8 may potentially be beneficial in cardiovascular disease.PMID:37675637 | DOI:10.1161/ATVBAHA.123.319767
Source: Atherosclerosis - September 7, 2023 Category: Cardiology Authors: Samuel K Lee Rida Malik Ji Zhou Wei Wang Peter Gross Jeffrey Weitz Rithwik Ramachandran Bernardo L Trigatti Source Type: research
MicroRNAs Regulate Function in Atherosclerosis and Clinical Implications
Conclusion. In general, the expression levels of some microRNAs changed significantly in different stages of atherosclerosis pathogenesis; therefore, MicroRNAs may become new diagnostic biomarkers for atherosclerosis. In addition, microRNAs are also involved in the regulation of core processes such as endothelial dysfunction, plaque formation and stabilization, and cholesterol metabolism, which also suggests the great potential of microRNAs as a therapeutic target.PMID:37675243 | PMC:PMC10480027 | DOI:10.1155/2023/2561509
Source: Atherosclerosis - September 7, 2023 Category: Cardiology Authors: Zhaoyi Li Yidan Zhao Sei Suguro Rinkiko Suguro Source Type: research
PAR4 Inhibition Reduces Coronary Artery Atherosclerosis and Myocardial Fibrosis in SR-B1/LDLR Double Knockout Mice
CONCLUSIONS: The PAR4 inhibitory RAG8 pepducin reduced coronary artery atherosclerosis and myocardial fibrosis in SR-B1/LDLR double knockout mice fed a high-fat, high-cholesterol diet containing cholate. Furthermore, RAG8 reduced VCAM-1 in nonatherosclerotic coronary arteries and reduced leukocyte and platelet accumulation in atherosclerotic coronary arteries. These findings identify PAR4 as an attractive target in reducing coronary artery disease development, and the use of RAG8 may potentially be beneficial in cardiovascular disease.PMID:37675637 | DOI:10.1161/ATVBAHA.123.319767
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 7, 2023 Category: Cardiology Authors: Samuel K Lee Rida Malik Ji Zhou Wei Wang Peter Gross Jeffrey Weitz Rithwik Ramachandran Bernardo L Trigatti Source Type: research
Elucidation of the melitidin biosynthesis pathway in pummelo
This study establishes a biosynthetic pathway for melitidin, which provides genetic resources for the breeding and genetic improvement of pummelo aimed at fortifying the content of biologically active metabolites. This article is protected by copyright. All rights reserved.PMID:37675654 | DOI:10.1111/jipb.13564
Source: Journal of Integrative Plant Biology - September 7, 2023 Category: Biology Authors: Shuangqian Shen Shouchuang Wang Chenkun Yang Chao Wang Qianqian Zhou Shen Zhou Ran Zhang Yufei Li Zixuan Wang Liupan Dai Wenjv Peng Yingchen Hao Hao Guo Guangping Cao Xianqing Liu Fan Yao Qiang Xu Alisdair R Fernie Jie Luo Source Type: research
PAR4 Inhibition Reduces Coronary Artery Atherosclerosis and Myocardial Fibrosis in SR-B1/LDLR Double Knockout Mice
CONCLUSIONS: The PAR4 inhibitory RAG8 pepducin reduced coronary artery atherosclerosis and myocardial fibrosis in SR-B1/LDLR double knockout mice fed a high-fat, high-cholesterol diet containing cholate. Furthermore, RAG8 reduced VCAM-1 in nonatherosclerotic coronary arteries and reduced leukocyte and platelet accumulation in atherosclerotic coronary arteries. These findings identify PAR4 as an attractive target in reducing coronary artery disease development, and the use of RAG8 may potentially be beneficial in cardiovascular disease.PMID:37675637 | DOI:10.1161/ATVBAHA.123.319767
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 7, 2023 Category: Cardiology Authors: Samuel K Lee Rida Malik Ji Zhou Wei Wang Peter Gross Jeffrey Weitz Rithwik Ramachandran Bernardo L Trigatti Source Type: research
Physiologically based pharmacokinetic modelling to characterize enterohepatic recirculation and predict food effect on the pharmacokinetics of hyzetimibe
CONCLUSIONS: The established PBPK model could describe the concentration-time profiles of hyzetimibe and M1 well with good prediction performance. A fully mechanistic model of enterohepatic recirculation warrants further investigation.PMID:37678518 | DOI:10.1016/j.ejps.2023.106576
Source: European Journal of Pharmaceutical Sciences - September 7, 2023 Category: Drugs & Pharmacology Authors: Wenjun Chen Zourong Ruan Honggang Lou Dandan Yang Jinliang Chen Rong Shao Bo Jiang Source Type: research
Effect of cholesterol on the mechanical stability of gel-phase phospholipid bilayers studied by AFM force spectroscopy
Eur Phys J E Soft Matter. 2023 Sep 6;46(9):77. doi: 10.1140/epje/s10189-023-00338-y.ABSTRACTThe remarkably low sliding friction of articular cartilage in the major joints such as hips and knees, which is crucial for its homeostasis and joint health, has been attributed to lipid bilayers forming lubricious boundary layers at its surface. The robustness of such layers, and thus their lubrication efficiency at joint pressures, depends on the lipids forming them, including cholesterol which is a ubiquitous component, and which may act to strengthen of weaken the bilayer. In this work, a systematic study using an atomic force m...
Source: Health Physics - September 6, 2023 Category: Physics Authors: Salom é Mielke Raya Sorkin Jacob Klein Source Type: research
Multiplex metabolic pathway engineering of Monascus pilosus enhances lovastatin production
Appl Microbiol Biotechnol. 2023 Sep 6. doi: 10.1007/s00253-023-12747-2. Online ahead of print.ABSTRACTMonascus sp. is an important food microbial resource with the production of cholesterol-lowering agent lovastatin and other healthy metabolites. However, the mycotoxin citrinin naturally produced by Monascus sp. and the insufficient productivity of lovastatin limit its large-scale use in food industry. The aim of this paper is to modify a lovastatin-producing strain Monascus pilosus GN-01 through metabolic engineering to obtain a citrinin-free M. pilosus strain with higher yield of lovastatin. The citrinin synthesis regula...
Source: Applied Microbiology and Biotechnology - September 6, 2023 Category: Microbiology Authors: Xiaokun Hong Tianlong Guo Xinqi Xu Juan Lin Source Type: research
Cryo-EM structures of human organic anion transporting polypeptide OATP1B1
In this study, we determined cryo-EM structures of human OATP1B1 bound with representative endogenous metabolites (bilirubin and estrone-3-sulfate), a clinical drug (simeprevir), and a fluorescent indicator (2',7'-dichlorofluorescein), in both outward- and inward-open states. These structures reveal major and minor substrate binding pockets and conformational changes during transport. In combination with mutagenesis studies and molecular dynamics simulations, our work comprehensively elucidates the transport mechanism of OATP1B1 and provides the structural basis for DDI predictions involving OATP1B1, which will greatly pro...
Source: Cell Research - September 6, 2023 Category: Cytology Authors: Ziyang Shan Xuemei Yang Huihui Liu Yafei Yuan Yuan Xiao Jing Nan Wei Zhang Wenqi Song Jufang Wang Feiwen Wei Yanqing Zhang Source Type: research
