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Condition: Cholesterol
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Total 43076 results found since Jan 2013.
Statins and portal hypertension: a systematic review and meta-analysis of randomized controlled trials
CONCLUSION: Treatment with statins did not decrease significantly portal hypertension.PMID:37723637 | DOI:10.2174/0929867331666230918114451
Source: Current Medicinal Chemistry - September 19, 2023 Category: Chemistry Authors: Tannaz Jamialahmadi Željko Reiner Maryam Matbou Riahi Seyed Ahmad Emami Zahra Tayarani-Najaran Sepideh Salehabadi Prashant Kesharwani Khalid Al-Rasadi Amirhossein Sahebkar Source Type: research
Apolipoprotein E isoforms differentially affect LCAT-dependent cholesterol esterification
CONCLUSION: The present results suggest that the apoE2 isoform is associated with a higher LCAT-mediated cholesterol esterification. This observation may contribute to the characterization of the peculiar functional properties of apoE2.PMID:37725860 | DOI:10.1016/j.atherosclerosis.2023.117266
Source: Atherosclerosis - September 19, 2023 Category: Cardiology Authors: Cecilia Vitali Chiara Pavanello Marta Turri Sissel Lund-Katz Michael C Phillips Alberico Luigi Catapano Andrea Baragetti Giuseppe Danilo Norata Fabrizio Veglia Laura Calabresi Source Type: research
Thymosin β4 preserves vascular smooth muscle phenotype in atherosclerosis via regulation of low density lipoprotein related protein 1 (LRP1)
Int Immunopharmacol. 2023 Feb;115:109702. doi: 10.1016/j.intimp.2023.109702. Epub 2023 Jan 20.ABSTRACTAtherosclerosis is a progressive, degenerative vascular disease and a leading cause of morbidity and mortality. In response to endothelial damage, platelet derived growth factor (PDGF)-BB induced phenotypic modulation of medial smooth muscle cells (VSMCs) promotes atherosclerotic lesion formation and destabilisation of the vessel wall. VSMC sensitivity to PDGF-BB is determined by endocytosis of Low density lipoprotein receptor related protein 1 (LRP1)-PDGFR β complexes to balance receptor recycling with lysosomal degradat...
Source: Atherosclerosis - September 19, 2023 Category: Cardiology Authors: Sonali Munshaw Andia N Redpath Benjamin T Pike Nicola Smart Source Type: research
Transient left bundle branch block associated with very high coronary artery calcium: a case report
We present a case of very high CAC in a 64-year-old woman with hypertension, type 2 diabetes, and hyperlipidemia presenting with dyspnea. Initial electrocardiogram (ECG) demonstrated normal conduction with a heart rate of 76 beats/min, but new T-wave inversions in V1-V4 and a high-sensitivity troponin-I (hsTnI) value of 6 ng/L (normal < 6 ng/L). Repeat ECG in the emergency department showed normal sinus rhythm (heart rate of 80 beats/min); however, it subsequently demonstrated a left bundle branch block (LBBB) with a repeat hsTnI of 7 ng/L. Stress testing with pharmacologic single-photon emission computerized tomography...
Source: Atherosclerosis - September 19, 2023 Category: Cardiology Authors: Alexander C Razavi Sindhu Prabakaran Mariem Sawan Lakshmi Tummala Ifeoma Onuorah Sagar B Amin Marly van Assen Carlo N De Cecco Arshed A Quyyumi Seamus P Whelton Laurence S Sperling Francois G Rollin Source Type: research
Treat-to-Target LDL Strategy of Statin Dosing Is Noninferior to High-Intensity Dosing
Am Fam Physician. 2023 Sep;108(3):Online.NO ABSTRACTPMID:37725472
Source: American Family Physician - September 19, 2023 Category: Primary Care Authors: David C Slawson Source Type: research
Thymosin β4 preserves vascular smooth muscle phenotype in atherosclerosis via regulation of low density lipoprotein related protein 1 (LRP1)
Int Immunopharmacol. 2023 Feb;115:109702. doi: 10.1016/j.intimp.2023.109702. Epub 2023 Jan 20.ABSTRACTAtherosclerosis is a progressive, degenerative vascular disease and a leading cause of morbidity and mortality. In response to endothelial damage, platelet derived growth factor (PDGF)-BB induced phenotypic modulation of medial smooth muscle cells (VSMCs) promotes atherosclerotic lesion formation and destabilisation of the vessel wall. VSMC sensitivity to PDGF-BB is determined by endocytosis of Low density lipoprotein receptor related protein 1 (LRP1)-PDGFR β complexes to balance receptor recycling with lysosomal degradat...
Source: International Immunopharmacology - September 19, 2023 Category: Allergy & Immunology Authors: Sonali Munshaw Andia N Redpath Benjamin T Pike Nicola Smart Source Type: research
Evaluating the prevalence of lipid assessments in children in Alberta, Canada
CMAJ Open. 2023 Sep 19;11(5):E820-E825. doi: 10.9778/cmajo.20220163. Print 2023 Sep-Oct.ABSTRACTBACKGROUND: Familial hypercholesterolemia is a common, inherited, life-threatening and treatable condition that is characterized by marked elevations of low-density lipoprotein cholesterol (LDL-C), resulting in a high risk of cardiovascular disease, but treatment starting in childhood dramatically reduces this risk. We sought to evaluate the prevalence of pediatric lipid assessments among children in Alberta.METHODS: We reviewed laboratory and administrative data from Alberta Health between Apr. 1, 2012, and Dec. 31, 2021. We ev...
Source: cmaj - September 19, 2023 Category: General Medicine Authors: Susan Christian Ross Ridsdale Mu Lin Michael Khoury Source Type: research
Treat-to-Target LDL Strategy of Statin Dosing Is Noninferior to High-Intensity Dosing
Am Fam Physician. 2023 Sep;108(3):Online.NO ABSTRACTPMID:37725472
Source: American Family Physician - September 19, 2023 Category: Primary Care Authors: David C Slawson Source Type: research
Pravastatin for lowering lipids
CONCLUSIONS: Pravastatin lowers blood total cholesterol, LDL cholesterol and triglyceride in a dose-dependent linear fashion. This review did not provide a good estimate of the incidence of harms associated with pravastatin because of the lack of reporting of adverse effects in 48.4% of the randomized placebo-controlled trials.PMID:37721222 | DOI:10.1002/14651858.CD013673.pub2
Source: Cochrane Database of Systematic Reviews - September 18, 2023 Category: General Medicine Authors: Stephen P Adams Nima Alaeiilkhchi Sara Tasnim James M Wright Source Type: research
Diseases of the Coronary Microcirculation: Diagnosis and Treatment
CONCLUSION: Approximately 25% of patients with CMD have symptoms that do not respond to intensive treatment with the currently available modalities. New treatments, including interventional therapies, are being studied. Their long-term benefit remains to be assessed and compared to that of the existing methods.PMID:37721132 | DOI:10.3238/arztebl.m2023.0205
Source: Deutsches Arzteblatt International - September 18, 2023 Category: General Medicine Authors: Helen Ullrich-Daub Steffen Daub Maximilian Olschewski Thomas M ünzel Tommaso Gori Source Type: research
Effect of oral versus parenteral vitamin D3 supplementation on nuclear factor- κB and platelet aggregation in type 2 diabetic patients
In conclusion, restoring normal levels of vitamin D is an important determinant to maintain normal platelet function and reduce inflammation. Nevertheless, further long-term studies are still needed.PMID:37721213 | DOI:10.1139/cjpp-2022-0359
Source: Canadian Journal of Physiology and Pharmacology - September 18, 2023 Category: Drugs & Pharmacology Authors: Esraa Habiba Samia Ali Yehia Ghanem Ola Sharaki Wafaa Hewedy Source Type: research
Molecular Complex of HSIM-loaded Polymeric Nanoparticles: Potential Carriers in Osteoporosis
CONCLUSION: Bone-targeting nanoparticles incorporating functionalized simvastatin can target bone. Thus, in order to distribute simvastatin subcutaneously for the treatment of osteoporosis, the developed nanoparticles may act as a promising approach.PMID:37718521 | DOI:10.2174/1389450124666230915092910
Source: Current Drug Targets - September 18, 2023 Category: Drugs & Pharmacology Authors: Malkiet Kaur Manju Nagpal Amarjot Kaur Grewal Samrat Chauhan Chander Parkash Dora Thakur Gurjeet Singh Source Type: research
Nurse Practitioner Care Compared to Primary Care or Nephrologist Care in Early CKD
CONCLUSIONS: Nurse practitioner care for patients with CKD was associated with better guideline-concordant care than primary care alone or nephrologist care, with clinical outcomes that were better than or equivalent to primary care alone, and similar to those with care by nephrologists.PMID:37721865 | DOI:10.2215/CJN.0000000000000305
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 18, 2023 Category: Urology & Nephrology Authors: Matthew T James Tayler D Scory Ellen Novak Braden J Manns Brenda R Hemmelgarn Aminu K Bello Pietro Ravani Bhavneet Kahlon Jennifer M MacRae Paul E Ronksley Source Type: research
Atherosclerosis as a Risk Factor for IBD: A Population-Based Case-Control Study
CONCLUSIONS: A history of an atherosclerotic-related condition is associated with increased odds of developing IBD, particularly among older adults. Future studies should investigate whether drugs targeting atherosclerotic-related inflammation may prevent IBD in higher-risk individuals.PMID:37721310 | DOI:10.14309/ajg.0000000000002502
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Adam S Faye Jordan Axelrad Jiangwei Sun Jonas Halfvarson Jonas S öderling Ola Ol én Jonas F Ludvigsson Source Type: research
