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J-filter: An experiment to simplify and isolate specific signals in < sup > 1 < /sup > H NMR spectra of complex mixtures based on scalar coupling constants
Magn Reson Chem. 2023 Sep 19. doi: 10.1002/mrc.5396. Online ahead of print.ABSTRACTOne-dimensional selective NMR experiments relying on a J-filter element are proposed to isolate specific signals in crowded 1 H spectral regions. The J-filter allows the edition or filtering of signals in a region of interest of the spectrum by exploiting the specific values of their 1 H-1 H coupling constants and certain parameters of protons coupled to them that appear in less congested parts of the spectrum (chemical shifts and coupling constants). The new experiments permitted the isolation of specific peaks of phytosterol components in ...
Source: Magnetic Resonance in Chemistry : MRC - September 20, 2023 Category: Chemistry Authors: Karen V G óñez Juan Su árez García F Javier Sardina Yolanda Pazos Ángela Saá Manuel Mart ín Pastor Source Type: research
White matter hyperintensity load mediates the relationship between age and cognition
Neurobiol Aging. 2023 Aug 25;132:56-66. doi: 10.1016/j.neurobiolaging.2023.08.007. Online ahead of print.ABSTRACTTo elucidate the relationship between age and cognitive decline, it is important to consider structural brain changes such as white matter hyperintensities (WMHs), which are common in older age and may affect behavior. Therefore, we aimed to investigate if WMH load is a mediator of the relationship between age and cognitive decline. Healthy participants (N = 166, 20-80 years) completed the Montreal Cognitive Assessment (MoCA). WMHs were manually delineated on FLAIR scans. Mediation analysis was conducted to dete...
Source: Neurobiology of Aging - September 20, 2023 Category: Geriatrics Authors: Natalie Busby Sarah Wilson Janina Wilmskoetter Roger Newman-Norlund Sara Sayers Sarah Newman-Norlund Rebecca Roth Chris Rorden Julius Fridriksson Leonardo Bonilha Source Type: research
Exposure to ambient air pollutants, serum miRNA networks, lipid metabolism, and non-alcoholic fatty liver disease in young adults
CONCLUSIONS: Exposure to AAP may contribute to adverse lipid profiles and NAFLD risk among young adults via altered expression of microRNA profiles.PMID:37729806 | DOI:10.1016/j.ecoenv.2023.115486
Source: Ecotoxicology and Environmental Safety - September 20, 2023 Category: Environmental Health Authors: William B Patterson Elizabeth Holzhausen Bridget Chalifour Jesse Goodrich Elizabeth Costello Frederick Lurmann David V Conti Zhanghua Chen Lida Chatzi Tanya L Alderete Source Type: research
Lipid metabolism and renal function markers in obese adolescents
CONCLUSIONS: Renal function of the obese adolescents included in the study was normal and the associations with lipid metabolism were poorly expressed.PMID:37728460 | PMC:PMC10411080 | DOI:10.5114/pedm.2023.125612
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 20, 2023 Category: Endocrinology Authors: Aleksandra Radosz Anna Obuchowicz Source Type: research
Are menstrual disorders in adolescent girls related to metabolic disorders?
CONCLUSIONS: Adolescent girls with menstrual disorders are insulin resistant, regardless of PCOS diagnosis. The severity of menstrual disorders may be related to the incidence of lipid disorders in adolescent girls.PMID:37728458 | PMC:PMC10411084 | DOI:10.5114/pedm.2023.125364
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 20, 2023 Category: Endocrinology Authors: El żbieta Foryś Adrianna Baran Aleksandra Dziurdzia Ewelina Jarosz-W ójcik Pawe ł Matusik Aneta Gawlik Ryszard Tomaszewski Agnieszka Zachurzok Source Type: research
Maternal obstructive sleep apnea aggravates metabolic dysfunction-associated fatty liver disease via HMGB1-TLR4 signaling-mediated endoplasmic reticulum stress in male offspring rats
CONCLUSIONS: These findings indicate that MOSA can exert prolonged adverse effects manifested as metabolic dysfunction in male offspring. Therefore, surveillance and management of OSA during pregnancy may be necessary to prevent and alleviate MAFLD in offspring.PMID:37730152 | DOI:10.1016/j.bbadis.2023.166889
Source: Biochimica et Biophysica Acta - September 20, 2023 Category: Biochemistry Authors: Ruhua Wang Wei Feng Yan Wang Yonghong Jiang Yiguang Lin Xueqing Chen Source Type: research
Atractylodes macrocephala Koidz polysaccharide improves glycolipid metabolism disorders through activation of aryl hydrocarbon receptor by gut flora-produced tryptophan metabolites
In this study, a heterogeneous acidic heteropolysaccharide with high molecular weight mainly composed of fructose was isolated from Atractylodes macrocephala Koidz (AMP). Supplementation with AMP was shown to improve diet-induced GMD in a rat model, including decreasing the levels of serum triglycerides, total cholesterol, and glucose, and improving hepatic lipidosis and islet cells morphologies. AMP-treated rats also exhibited modified intestinal flora with enrichments of intestinal Lactobacillus and Rothia species, which was accompanied by increased tryptophan metabolites such as indole-3-propionic acid, indole, tryptami...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Ziwen He Jingyan Guo Huiwen Zhang Jingjing Yu Yiqing Zhou Yajun Wang Ting Li Meiqiu Yan Bo Li Yigong Chen Suhong Chen Guiyuan Lv Jie Su Source Type: research
AMPK activators suppress cholesterol accumulation in macrophages via suppression of the mTOR pathway
In this study, we found that activation of AMPK by AICAR and metformin inhibits foam cell formation via suppression of mTOR in macrophages. Specifically, activation of AMPK indirectly reduced the phosphorylation level of mTOR at Ser2448 and promoted the expression of cholesterol efflux transporters and cholesterol efflux. These inhibitory effects on foam cell formation were counteracted by mTOR activators. Metformin, a more nonspecific AMPK activator than AICAR, appears to inhibit foam cell formation via anti-inflammatory effects in addition to suppression of the mTOR pathway. The results of this study suggest that the dev...
Source: Experimental Cell Research - September 20, 2023 Category: Cytology Authors: Reina Owaki Hiromasa Aoki Kohki Toriuchi Yasumichi Inoue Hidetoshi Hayashi Satoru Takeshita Hiroki Kakita Yasumasa Yamada Mineyoshi Aoyama Source Type: research
Thymosin β4 preserves vascular smooth muscle phenotype in atherosclerosis via regulation of low density lipoprotein related protein 1 (LRP1)
Int Immunopharmacol. 2023 Feb;115:109702. doi: 10.1016/j.intimp.2023.109702. Epub 2023 Jan 20.ABSTRACTAtherosclerosis is a progressive, degenerative vascular disease and a leading cause of morbidity and mortality. In response to endothelial damage, platelet derived growth factor (PDGF)-BB induced phenotypic modulation of medial smooth muscle cells (VSMCs) promotes atherosclerotic lesion formation and destabilisation of the vessel wall. VSMC sensitivity to PDGF-BB is determined by endocytosis of Low density lipoprotein receptor related protein 1 (LRP1)-PDGFR β complexes to balance receptor recycling with lysosomal degradat...
Source: International Immunopharmacology - September 19, 2023 Category: Allergy & Immunology Authors: Sonali Munshaw Andia N Redpath Benjamin T Pike Nicola Smart Source Type: research
Apolipoprotein E isoforms differentially affect LCAT-dependent cholesterol esterification
CONCLUSION: The present results suggest that the apoE2 isoform is associated with a higher LCAT-mediated cholesterol esterification. This observation may contribute to the characterization of the peculiar functional properties of apoE2.PMID:37725860 | DOI:10.1016/j.atherosclerosis.2023.117266
Source: Atherosclerosis - September 19, 2023 Category: Cardiology Authors: Cecilia Vitali Chiara Pavanello Marta Turri Sissel Lund-Katz Michael C Phillips Alberico Luigi Catapano Andrea Baragetti Giuseppe Danilo Norata Fabrizio Veglia Laura Calabresi Source Type: research
Thymosin β4 preserves vascular smooth muscle phenotype in atherosclerosis via regulation of low density lipoprotein related protein 1 (LRP1)
Int Immunopharmacol. 2023 Feb;115:109702. doi: 10.1016/j.intimp.2023.109702. Epub 2023 Jan 20.ABSTRACTAtherosclerosis is a progressive, degenerative vascular disease and a leading cause of morbidity and mortality. In response to endothelial damage, platelet derived growth factor (PDGF)-BB induced phenotypic modulation of medial smooth muscle cells (VSMCs) promotes atherosclerotic lesion formation and destabilisation of the vessel wall. VSMC sensitivity to PDGF-BB is determined by endocytosis of Low density lipoprotein receptor related protein 1 (LRP1)-PDGFR β complexes to balance receptor recycling with lysosomal degradat...
Source: Atherosclerosis - September 19, 2023 Category: Cardiology Authors: Sonali Munshaw Andia N Redpath Benjamin T Pike Nicola Smart Source Type: research
Transient left bundle branch block associated with very high coronary artery calcium: a case report
We present a case of very high CAC in a 64-year-old woman with hypertension, type 2 diabetes, and hyperlipidemia presenting with dyspnea. Initial electrocardiogram (ECG) demonstrated normal conduction with a heart rate of 76 beats/min, but new T-wave inversions in V1-V4 and a high-sensitivity troponin-I (hsTnI) value of 6 ng/L (normal < 6 ng/L). Repeat ECG in the emergency department showed normal sinus rhythm (heart rate of 80 beats/min); however, it subsequently demonstrated a left bundle branch block (LBBB) with a repeat hsTnI of 7 ng/L. Stress testing with pharmacologic single-photon emission computerized tomography...
Source: Atherosclerosis - September 19, 2023 Category: Cardiology Authors: Alexander C Razavi Sindhu Prabakaran Mariem Sawan Lakshmi Tummala Ifeoma Onuorah Sagar B Amin Marly van Assen Carlo N De Cecco Arshed A Quyyumi Seamus P Whelton Laurence S Sperling Francois G Rollin Source Type: research
Untargeted metabolomics analysis of plasma metabolic characteristics in patients with acne and insulin resistance
This study aimed to identify significantly different metabolites and related metabolic pathways in the serum of acne vulgaris patients with or without insulin resistance. LC-MS/MS was used to analyze serum samples from patients about acne with insulin resistance (n = 51) and acne without insulin resistance (n = 69) to identify significant metabolites and metabolic pathways. In this study, 18 significant differential metabolites were screened for the first time. In the positive-ion mode, the upregulated substances were creatine, sarcosine, D-proline, uracil, Phe-Phe, L-pipecolic acid, and DL-phenylalanine; the downregulated...
Source: Amino Acids - September 19, 2023 Category: Biochemistry Authors: Qingqing He Huiling Shu Yu Peng Yang Xu Li Liu Jie Zhou Juan Zhao Xia Xiong Changqiang Li Source Type: research
Evaluating the prevalence of lipid assessments in children in Alberta, Canada
CMAJ Open. 2023 Sep 19;11(5):E820-E825. doi: 10.9778/cmajo.20220163. Print 2023 Sep-Oct.ABSTRACTBACKGROUND: Familial hypercholesterolemia is a common, inherited, life-threatening and treatable condition that is characterized by marked elevations of low-density lipoprotein cholesterol (LDL-C), resulting in a high risk of cardiovascular disease, but treatment starting in childhood dramatically reduces this risk. We sought to evaluate the prevalence of pediatric lipid assessments among children in Alberta.METHODS: We reviewed laboratory and administrative data from Alberta Health between Apr. 1, 2012, and Dec. 31, 2021. We ev...
Source: cmaj - September 19, 2023 Category: General Medicine Authors: Susan Christian Ross Ridsdale Mu Lin Michael Khoury Source Type: research
Statins and portal hypertension: a systematic review and meta-analysis of randomized controlled trials
CONCLUSION: Treatment with statins did not decrease significantly portal hypertension.PMID:37723637 | DOI:10.2174/0929867331666230918114451
Source: Current Medicinal Chemistry - September 19, 2023 Category: Chemistry Authors: Tannaz Jamialahmadi Željko Reiner Maryam Matbou Riahi Seyed Ahmad Emami Zahra Tayarani-Najaran Sepideh Salehabadi Prashant Kesharwani Khalid Al-Rasadi Amirhossein Sahebkar Source Type: research
