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Total 3421 results found since Jan 2013.
Magnetically Powered Immunogenic Macrophage Microrobots for Targeted Multimodal Cancer Therapy
Magnetic-powered macrophage-based microrobots are developed by endocytosing magnetic nanoparticles and bioengineered bacterial outer membrane vesicles (OMVs) via macrophages. Such cell robots preserve intrinsic properties of macrophages for tumor suppression and targeting, and bioengineered OMVs for antitumor immune regulation and fused anticancer peptides. These features enable targeted accumulation of cell robots at the tumor site upon magnetic manipulation for multimodal therapy. AbstractMotile microrobots open a new realm for disease treatment. However, the concerns of possible immune elimination, targeted capability a...
Source: Small - June 10, 2023 Category: Nanotechnology Authors: Yangyang Li,
Zhaoqing Cong,
Leiming Xie,
Songsong Tang,
Chunyu Ren,
Xiqi Peng,
Daitian Tang,
Fangchen Wan,
Hong Han,
Xueji Zhang,
Wei Gao,
Song Wu Tags: Research Article Source Type: research
Selective and Stable CO2 Electroreduction to CH4 via Electronic Metal –Support Interaction upon Decomposition/Redeposition of MOF
A copper-based metal-organic framework is synthesized via a solvent-free method. Upon CO2 electroreduction, it undergoes in situ decomposition/redeposition to form abundant interfacial sites between copper nanoparticles and amorphous carbon supports, which stabilize the key intermediates for CH4 formation. Stable production of CH4 with Faradaic efficiency of ≈55% is achieved for 12.5 h. AbstractThe CO2 electroreduction to fuels is a feasible approach to provide renewable energy sources. Therefore, it is necessary to conduct experimental and theoretical investigations on various catalyst design strategies, such as electro...
Source: Small - June 10, 2023 Category: Nanotechnology Authors: Guanyu Liu,
Quang Thang Trinh,
Haojing Wang,
Shuyang Wu,
Juan Manuel Arce ‐Ramos,
Michael B. Sullivan,
Markus Kraft,
Joel W. Ager,
Jia Zhang,
Rong Xu Tags: Research Article Source Type: research
Regulating Electrochemical Kinetics of CoP by Incorporating Oxygen on Surface for High ‐Performance Li–S Batteries
CoP nanoparticles with high oxygen content on surface embedded in hollow carbon nanocages (C/O-CoP) are prepared to functionalize the separators in L –S batteries. Systematic experiments and calculations show that CoP with high oxygen content on surface can enhance binding energies toward LiPSs and promote the conversion kinetics of LiPSs, which is beneficial to improve battery capacity and cycle stability. AbstractLithium –sulfur (Li–S) batteries are widely studied because of their high theoretical specific capacity and environmental friendliness. However, the further development of Li–S batteries is hindered by t...
Source: Small - June 9, 2023 Category: Nanotechnology Authors: Rui Sun,
Meixiu Qu,
Lin Peng,
Weiwei Yang,
Zhenhua Wang,
Yu Bai,
Kening Sun Tags: Research Article Source Type: research
Standardization Approaches for Extracellular Vesicle Loading with Oligonucleotides and Biologics
Extracellular vesicles (EVs) hold promise as drug delivery systems, especially for RNA and biologics. As the research field expands, standardization approaches are becoming increasingly important for the EV drug delivery field. This review condenses recent methods on EV drug loading under the perspective of standardization efforts in order to increase the comparability of future studies. AbstractExtracellular vesicles (EVs) are widely recognized for their potential as drug delivery systems. EVs are membranous nanoparticles shed from cells. Among their natural features are their ability to shield cargo molecules against deg...
Source: Small - June 8, 2023 Category: Nanotechnology Authors: Josepha Roerig,
Michaela Schulz ‐Siegmund Tags: Review Source Type: research
Encapsulation of Nano ‐Bortezomib in Apoptotic Stem Cell‐Derived Vesicles for the Treatment of Multiple Myeloma
This study establishes a naturally occurring apoptotic encapsulation system (AES) in apoptotic mesenchymal stem cells to efficiently generate stable nanodrug-apoVs (apoptotic vesicles) capable of improving multiple myeloma treatment in mice. The experimental evidence indicates that this AES can serve as an approach to produce large-scale clinical grade nanodrug-apoVs, which can be expanded to the application in other diseases. AbstractExtracellular vesicles (EVs) are lipid bilayer nanovesicles released from living or apoptotic cells that can transport DNA, RNA, protein, and lipid cargo. EVs play critical roles in cell –c...
Source: Small - June 7, 2023 Category: Nanotechnology Authors: Zeyuan Cao,
Peiyi Li,
Yuzhen Li,
Manjin Zhang,
Meng Hao,
Wenwen Li,
Xueli Mao,
Lijie Mo,
Chuan Yang,
Xin Ding,
Yi Yan Yang,
Peiyan Yuan,
Songtao Shi,
Xiaoxing Kou Tags: Research Article Source Type: research
Porous Host –Guest MOF‐Semiconductor Hybrid with Multisites Heterojunctions and Modulable Electronic Band for Selective Photocatalytic CO2 Conversion and H2 Evolution
The integration of MOF-derived porous Co3O4 host and ZnxCd1-xS guest with distinct self-assembled hybrid structure and amenable electronic band exhibits remarkable catalytic activity and selectivity for dual photocatalytic CO2 conversion and H2 evolution. Zinc constituent is found to favorably regulate light absorption, conduction band, CO2 absorption, energy of specific reaction intermediates, thus realizing the selectivity control toward CO2 reduction. AbstractOptimizing catalysts for competitive photocatalytic reactions demand individually tailored band structure as well as intertwined interactions of light absorption, ...
Source: Small - June 5, 2023 Category: Nanotechnology Authors: Tianxi Zhang,
Fanlu Meng,
Minmin Gao,
Jishi Wei,
Kane Jian Hong Lim,
Kang Hui Lim,
Prae Chirawatkul,
Andrew See Weng Wong,
Sibudjing Kawi,
Ghim Wei Ho Tags: Research Article Source Type: research
Magnetic Field Boosts the Transmembrane Transport Efficiency of Magnesium Ions from PLLA Bone Scaffold
Magnetite nanoparticles are introduced into the Mg-polymer scaffold to construct a new magnetic magnesium-loaded composite scaffold, and use SMF to remotely and accurately regulate the activity of MAGT1 on the membrane of bone marrow mesenchymal stem cells . AbstractIn the system of magnesium-loaded scaffolds, the effect of magnesium ions (Mg2+) on the osteogenesis induction is restricted due to the low transmembrane transport efficiency of Mg2+ into the cell, which limits the application for bone defect repair. Inspired by the fact that magnetic field can regulate ion channel proteins on the cell membrane, magnetite nanop...
Source: Small - June 5, 2023 Category: Nanotechnology Authors: Zuyun Yan,
Tianshi Sun,
Wei Tan,
Zhicheng Wang,
Jinpeng Yan,
Jinglei Miao,
Xin Wu,
Pei Feng,
Youwen Deng Tags: Research Article Source Type: research
3D ‐Printed Piezoelectric Scaffolds with Shape Memory Polymer for Bone Regeneration
Shape memory polymer (SMP) is combined with piezoelectric ceramic to develop novel 3D-printed piezoelectric ceramic-SMP composite scaffolds. A piezoelectric nanoparticle is used to improve the piezoelectric properties of the scaffolds by covalent functionalization and conductive Ag nanoparticle deposition. The piezoelectric property of scaffolds can promote bone regeneration by electrical stimulation. AbstractThe application of piezoelectric nanoparticles with shape memory polymer (SMP) to 3D-printed piezoelectric scaffolds for bone defect repair is an attractive research direction. However, there is a significant differen...
Source: Small - June 2, 2023 Category: Nanotechnology Authors: Guanlin Li,
Zehao Li,
Yajun Min,
Shilu Chen,
Ruijia Han,
Zheng Zhao Tags: Research Article Source Type: research
Water ‐Induced Separation of Polymers from High Nanoparticle‐Content Nanocomposite Films
Polymers are spontaneously separated and recovered from high nanoparticle-content nanocomposite films with the aid of water from the vapor or liquid phases. The charge state of nanoparticles plays a significant role in the propensity of water to undergo capillary condensation within the polymer-filled interstitial pores. This work provides insightful guidelines on how to design and fabricate end-of-life recyclable high-performance nanocomposites. AbstractPolymer nanocomposites with high loadings of nanoparticles (NPs) exhibit exceptional mechanical and transport properties. Separation of polymers and NPs from such nanocomp...
Source: Small - June 2, 2023 Category: Nanotechnology Authors: Baekmin Q. Kim,
M áté Füredi,
R. Bharath Venkatesh,
Stefan Guldin,
Daeyeon Lee Tags: Research Article Source Type: research
Wafer ‐Scale Fabrication of Hierarchically Porous Silicon and Silica by Active Nanoparticle‐Assisted Chemical Etching and Pseudomorphic Thermal Oxidation (Small 22/2023)
Porous SilicaIn article number2206842, Stella Gries, Patrick Huber, and co-workers present a novel approach based on silver nanoparticle-assisted chemical etching (MACE) of macroporous silicon for the synthesis of hierarchically porous silicon. The MACE process is mainly guided by a metal-catalyzed redox-reaction where silver nanoparticles drill mesopores into the silicon scaffold structure. The resulting porous silicon can be transformed structure-conserving by thermal oxidation to hierarchically porous silica glass.
Source: Small - June 1, 2023 Category: Nanotechnology Authors: Stella Gries,
Manuel Brinker,
Berit Zeller ‐Plumhoff,
Dagmar Rings,
Tobias Krekeler,
Elena Longo,
Imke Greving,
Patrick Huber Tags: Inside Front Cover Source Type: research
Surface Oxygen Vacancy Inducing Li ‐Ion‐Conducting Percolation Network in Composite Solid Electrolytes for All‐Solid‐State Lithium‐Metal Batteries (Small 22/2023)
All-Solid-State Lithium-Metal BatteriesIn article number2207223, Jeeyoung Yoo, Youn Sang Kim, and co-workers present an all-solid-state lithium-metal battery with composite solid electrolyte. Specifically, the oxygen vacancy-rich indium tin oxide (ITO) nanoparticles (green-colored) induce the Li-ion conducting percolation network (red-colored) at the ITO-poly(ethylene oxide) (PEO) interface. The oxygen vacancy enables fast movement of Li-ions in the interface network. This phenomenon suggests that the vacancy engineering of filler holds strong promise for developing advanced all-solid-state batteries.
Source: Small - June 1, 2023 Category: Nanotechnology Authors: Heejun Yun,
Jinil Cho,
Seokgyu Ryu,
Seonmi Pyo,
Heebae Kim,
Jeewon Lee,
Byeongyun Min,
Yong Hyun Cho,
Harim Seo,
Jeeyoung Yoo,
Youn Sang Kim Tags: Back Cover Source Type: research
An Intelligent Vascular Disrupting Dendritic Nanodevice Incorporating Copper Sulfide Nanoparticles for Immune Modulation ‐Mediated Combination Tumor Therapy
An intelligent dendritic nanodevice incorporated with both copper sulfide nanoparticles and 5,6-dimethylxanthenone-4-acetic acid within the dendrimer internal cavities and surface modified with a targeting agent LyP-1 peptide is developed for immune modulation-mediated combination tumor therapy, simultaneously inhibiting primary tumor growth and tumor metastasis through enhanced photothermal therapy and disruption of both tumor blood vessels and lymphatic vessels. AbstractDevelopment of intelligent nanoplatforms that can simultaneously target multiple factors associated with tumor growth and metastasis remains an extreme c...
Source: Small - June 1, 2023 Category: Nanotechnology Authors: Yiming Zhang,
Zhijun Ouyang,
Mengsi Zhan,
Rui Yang,
Yue Gao,
Lulu Li,
Rui Guo,
Xiangyang Shi,
Xueyan Cao Tags: Research Article Source Type: research
Modulation of p ‐ and n‐Type Transitions in Co3−xNixO4 Nanoparticles for Enhanced Supercapacitor Electrochemical Performance
In this study, the effects of Ni doping at Co3 −xNixO4 nanoparticles on the electronic storage form of the material and resulting changes in the conduction p/n-type are reported. Theoretical calculations demonstrate that n-type conduction with high effective mass of electrons contributes significantly to the redox reaction of electrode materials and is beneficial for improving electrochemical performance. The specific capacitance of Co3 −xNixO4 (x = 0.67) electrode material is 10 times larger than that of Co3O4 due to enhanced orbital hybridization caused by Ni atom doping. The findings provide new directions for exp...
Source: Small - June 1, 2023 Category: Nanotechnology Authors: Xi Chen,
Kewei Zhang,
Mingyan Chuai,
Mingzhe Zhang Tags: Research Article Source Type: research
Correlating the Dipolar Interactions Induced Magneto ‐Viscoelasticity and Thermal Conductivity Enhancements in Nanomagnetic Fluids
This article explores the potential of nanomagnetic fluids (NMFs) for high performance cooling and biomedical applications. The review focuses on the correlation between the thermal and rheological properties of NMFs, including their stability, ferrohydrodynamic equations, and theoretical and experimental models. The article emphasizes the importance of understanding the relationship between these properties to improve the performance of various systems. AbstractThe effective thermal management of electronic system holds the key to maximize their performance. The recent miniaturization trends require a cooling system with ...
Source: Small - May 29, 2023 Category: Nanotechnology Authors: Rahul Singh,
Saurabh Pathak,
Komal Jain,
Noorjahan,
Sang ‐Koog Kim Tags: Review Source Type: research
Uniform Gold Nanostructure Formation via Weakly Adsorbed Gold Films and Thermal Annealing for Reliable Localized Surface Plasmon Resonance ‐Based Detection of DNase‐I
This study presents a novel method, electrochemical deposition, and mild thermal annealing (EDMIT), which is effective in fabricating uniform spherical gold nanoparticles. Mild thermal annealing triggers the rapid restructuring of weakly adsorbed gold nanoislands into spherical nanoparticles via coalescence and Ostwald ripening. The developed platform demonstrates exceptional sensitivity and selectivity in detecting DNASE-1, exhibiting minimal signal variations when analyzed using localized surface plasmon resonance. AbstractDeoxyribonuclease-I (DNase-I), a representative endonuclease, is an important biomarker for the dia...
Source: Small - May 29, 2023 Category: Nanotechnology Authors: Joon ‐Ha Park,
Chi‐Pin James Wang,
Hye‐Jin Lee,
Kyung Soo Hong,
Jung Hong Ahn,
Yeon‐Woo Cho,
Jeong‐Hyeon Lee,
Hee Seung Seo,
Wooram Park,
Se‐Na Kim,
Chun Gwon Park,
Wonhwa Lee,
Tae‐Hyung Kim Tags: Research Article Source Type: research
