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Total 3421 results found since Jan 2013.
Novel Vectors and Administrations for mRNA Delivery
This article mainly introduces two types of novel delivery vectors (biomacromolecules and inorganic nanoparticles) as well as two types of novel administration methods (controlled-release and non-invasive) for mRNA drugs, and innovatively analyzes their fusion. Their development and coordination are expected to achieve many anticipated application scenarios for mRNA drugs. AbstractmRNA therapy has shown great potential in infectious disease vaccines, cancer immunotherapy, protein replacement therapy, gene editing, and other fields due to its central role in all life processes. However, mRNA is challenging to pass through t...
Source: Small - July 21, 2023 Category: Nanotechnology Authors: Chenghai Bai,
Chen Wang,
Yuan Lu Tags: Review Source Type: research
A Simple and Effective Physical Ball ‐Milling Strategy to Prepare Super‐Tough and Stretchable PVA@MXene@PPy Hydrogel for Flexible Capacitive Electronics
A simple and efficient physical ball-milling strategy is developed to achieve a highly stretchable polyvinyl alcohol (PVA) hydrogel hybrids for durable and wearable capacitive strain sensor. Benefiting from the interaction of 1D polypyrrole (PPy) nanoparticles and 2D MXene nanosheets in 3D hydrogel network, the hydrogel-based sensor exhibits large strain range, excellent mechanical durability, high sensitivity, and low hysteresis for wearable devices. AbstractBiomimetic flexible electronics for E-skin have received increasing attention, due to their ability to sense various movements. However, the development of smart skin...
Source: Small - July 21, 2023 Category: Nanotechnology Authors: Zipeng Qin,
Gang Zhao,
Yaoyang Zhang,
Zhiheng Gu,
Yuhan Tang,
John Tosin Aladejana,
Junna Ren,
Yunhong Jiang,
Zhanhu Guo,
Xiangfang Peng,
Xuehua Zhang,
Ben Bin Xu,
Tingjie Chen Tags: Research Article Source Type: research
Tumor Vascular Destruction and cGAS ‐STING Activation Induced by Single Drug‐Loaded Nano‐Micelles for Multiple Synergistic Therapies of Cancer
A vascular disruptor-loaded nano-micelle is prepared to mediate photothermal therapy, radiotherapy, starvation therapy, and immunotherapy of breast cancer via inducing tumor-specific vascular destruction. This treatment strategy, together with anti-PD-L1, could almost achieve complete elimination of primary, metastatic, and recurrent tumors. AbstractCancer and its metastasis/recurrence still threaten human health, despite various advanced treatments being employed. It is of great significance to develop simple drug formulations to enhance the efficacy and synergistic integration of various monotherapies. Herein, DMXAA, a v...
Source: Small - July 21, 2023 Category: Nanotechnology Authors: Jingyu Gu,
Xinpei Liu,
Zhongfang Ji,
Mengling Shen,
Minqian Zhu,
Yuanyuan Ren,
Li Guo,
Kai Yang,
Teng Liu,
Xuan Yi Tags: Research Article Source Type: research
Fluorocarbon Modified Chitosan to Enable Transdermal Immunotherapy for Melanoma Treatment
This study approach offered an attractive transdermal approach in combined with ICB therapy for combined immunotherapy, particularly suitable for melanoma treatment.
Source: Small - July 19, 2023 Category: Nanotechnology Authors: Qi Zhuang,
Ting Chao,
Yuanyuan Wu,
Ting Wei,
Jiacheng Ren,
Zhiqing Cao,
Rui Peng,
Zhuang Liu Tags: Research Article Source Type: research
Plasma ‐Induced Formation of Pt Nanoparticles with Optimized Surface Oxidation States for Methanol Oxidation and Oxygen Reduction Reactions to Achieve High‐Performance DMFCs
Plasm treatment and reduction are used to synthesize Pt nanoparticles (NPs) on nitrogen-doped CNTs (p-Pt/p-NCNT) with a low Pt content. The p-Pt/p-NCNTs shows superior catalytic activities and good stabilities for oxygen reduction reaction (ORR) and methanol oxidation reaction (MOR). The density functional theory (DFT) calculations indicate that the defects generated in the plasma treatment can help the growth of the Pt NPs. The plasma reduction gives the Pt NPs with a reduced fraction of surface atoms at high oxidation states. AbstractPlasma treatment and reduction are used to synthesize Pt nanoparticles (NPs) on nitrogen...
Source: Small - July 19, 2023 Category: Nanotechnology Authors: Tingting Hu,
Weiheng Chen,
Yubing Liu,
Longxiang Gong,
Zhongqing Jiang,
Dinesh Bhalothia,
Thandavarayan Maiyalagan,
Zhong ‐Jie Jiang Tags: Research Article Source Type: research
Liposome ‐Templated Green Synthesis of Mesoporous Metal Nanostructures with Universal Composition for Biomedical Application
This study develops a facile synthesis strategy to mediate the formation of mesoporous metallic nanostructures in a controllable fashion. Various monodispersed nanostructures with well-defined mesoporous shape and large mesopores ( ≈40 nm) are successfully synthesized from mono-, bi-, and tri-noble metals. AbstractPorous noble metal nanoparticles have received particular attention recently for their unique optical, thermal, and catalytic functions in biomedicine. However, limited progress has been made to synthesize such porous metallic nanostructures with large mesopores ( ≥25 nm). Here, a green yet facile synthesis ...
Source: Small - July 15, 2023 Category: Nanotechnology Authors: Jinping Wang,
Jingyu Sun,
Rahul L. Khade,
Tsengming Chou,
Hailong An,
Yong Zhang,
Hongjun Wang Tags: Research Article Source Type: research
Injectable Hydrogels Including Magnetic Nanosheets for Multidisciplinary Treatment of Hepatocellular Carcinoma via Magnetic Hyperthermia
In this study, a magnetic nanocomposite hydrogel (CG-IM) with iron oxide nanoparticle-loaded mica nanosheets (Iron oxide nanoparticles@Mica, IM) is reported. This biocompatible magnetic hydrogel integrated high injectability, magnetocaloric property, mechanical robustness, wet adhesion, and hemostasis, leading to efficient HCC multidisciplinary therapies including postoperative tumor margin treatment and percutaneous locoregional ablation. After minimally invasive hepatectomy of HCC, the CG-IM hydrogel can facilely seal the bleeding hepatic margin, followed by magnetic hyperthermia ablation to effectively prevent recurrenc...
Source: Small - July 15, 2023 Category: Nanotechnology Authors: Jinyu Gong,
Jinlong Hu,
Xu Yan,
Luyao Xiang,
Sheng Chen,
Huai Yang,
Zichao Chen,
Qingbing Hou,
Yonghong Song,
Yunjun Xu,
Dongquan Liu,
Chaofei Ji,
Qin Qin,
Haiyi Sun,
Junbin Peng,
Baoqiang Cao,
Yang Lu Tags: Research Article Source Type: research
Room Temperature Ion Beam Synthesis of Ultra ‐Fine Molybdenum Carbide Nanoparticles: Toward a Scalable Fabrication Route for Earth‐Abundant Electrodes
A one-step approach to synthesize ultra-fine molybdenum carbides —an earth-abundant alternative to platinum for electrocatalysis is presented. By harnessing the energetic conditions induced by ion implantation, high-temperature and metastable phases of molybdenum carbides are accessed at ambient temperature. The implantation-induced conditions are mapped onto t he Mo-C phase diagram demonstrating the potential of this approach to synthesize phase-controlled and size-controlled carbides. AbstractMolybdenum carbides are promising low-cost electrocatalysts for electrolyzers, fuel cells, and batteries. However, synthesis of ...
Source: Small - July 13, 2023 Category: Nanotechnology Authors: Holger Fiedler,
Niall Malone,
David R. G. Mitchell,
Mitchell Nancarrow,
Vedran Jovic,
Geoffrey I. N. Waterhouse,
John Kennedy,
Prasanth Gupta Tags: Research Article Source Type: research
Breathable Lignin Nanoparticles as Reversible Gas Swellable Nanoreactors
Source: Small - July 12, 2023 Category: Nanotechnology Authors: Adrian Moreno,
Javier Delgado ‐Lijarcio,
Juan C. Ronda,
Virginia Cádiz,
Marina Galià,
Mika H. Sipponen,
Gerard Lligadas Tags: Correction Source Type: research
Donor:Acceptor Janus Nanoparticle ‐Based Films as Photoactive Layers: Control of Assembly and Impact on Performance of Devices (Small 28/2023)
Donor:Acceptor Janus Nanoparticle-Based FilmsIn article number2206907, Yixuan Du, Alla Synytska, and co-workers develop a highly efficient self-assembly process for designing and controlling the morphology of interfacial arrays of organic donor:acceptor nanoparticles (NPs) to form close-packed monolayers. The resulting Janus NP films serve as ideal building blocks for photovoltaic devices, exhibiting competitive performance as a result of their unique structures.
Source: Small - July 12, 2023 Category: Nanotechnology Authors: Yixuan Du,
Yuemeng Wang,
Volodymyr Shamraienko,
Kathrin P öschel,
Alla Synytska Tags: Frontispiece Source Type: research
Highly Efficient Electrochemical Hydrogen Evolution with Ultra ‐Low Loading of Strongly Adhered Pt Nanoparticles on Carbon
Uniformly dispersed, strongly anchored, low loading Pt based acidic hydrogen evolution reaction (HER) electrocatalyst requires low overpotential of 7 and 28 mV to produce 10 and 100 mA cm−2 of current output. Additional coating of Nafion helps in reducing overpotentials and enhancing electrochemical stability. AbstractThe development of robust electrocatalysts with low platinum content for acidic hydrogen evolution reaction (HER) is paramount for large scale commercialization of proton exchange membrane electrolyzers. Herein, a simple strategy is reported to synthesize a well anchored, low Pt containing Vulcan carbon ...
Source: Small - July 12, 2023 Category: Nanotechnology Authors: Soumita Chakraborty,
Swaraj Servottam,
Pankaj Kumar Samal,
Daizy Kalita,
Ankit Rao,
Debabrata Bagchi,
Sebastian C Peter,
Muthusamy Eswaramoorthy Tags: Research Article Source Type: research
Supramolecular Nanoarchitectonics Based on Antagonist Peptide Self ‐Assembly for Treatment of Liver Fibrosis
Peptide nanodrugs are fabricated from rationally designed self-assembling antagonist peptides via the approach of supramolecular nanoarchitectonics. The nanodrugs show selective accumulation and prolonged retention time in liver sites, leading to enhanced anti-fibrotic activity for the treatment of liver fibrosis with good biocompatibility. AbstractTherapeutic peptides have attracted increasing attention as anti-fibrotic drug candidates. However, the rapid degradation and insufficient liver accumulation of therapeutic peptides have seriously hampered their clinical translation. Here, the use of supramolecular nanoarchitect...
Source: Small - July 12, 2023 Category: Nanotechnology Authors: Bowen Li,
Yan Huang,
Jianwei Bao,
Zixuan Xu,
Xuehai Yan,
Qianli Zou Tags: Research Article Source Type: research
Coupling Single ‐Atom Sites and Ordered Intermetallic PtM Nanoparticles for Efficient Catalysis in Fuel Cells
A gas-phase ordered alloying strategy is proposed to construct an effective synergistic catalytic system that blends PtM intermetallic compounds (PtM IMC, M = Fe, Cu, and Ni) and dense isolated transition metal sites (M-N4) on nitrogen-doped carbon (NC). The obtained Pt1Fe1 IMC cooperating with Fe-N4 sites achieves outstanding electrocatalytic activity in oxygen reduction and fuel cells. AbstractThe design of an efficient catalytic system with low Pt loading and excellent stability for the acidic oxygen reduction reaction is still a challenge for the extensive application of proton-exchange membrane fuel cells. Here, a gas...
Source: Small - July 11, 2023 Category: Nanotechnology Authors: Fangyao Zhou,
Yaner Ruan,
Mengzhao Zhu,
Xiaoping Gao,
Wenxin Guo,
Xiaokang Liu,
Wenyu Wang,
Min Chen,
Geng Wu,
Tao Yao,
Huang Zhou,
Yuen Wu Tags: Research Article Source Type: research
PtMo ‐Au Metalloenzymes Regulated Tumor Microenvironment for Enhanced Sonodynamic/Chemodynamic/Starvation Synergistic Therapy
PtMo-Au metalloenzymes are developed for enhanced sonodynamic therapy since the noble metals surface deposition can modulate the bandgap structure to effectively improve the1O2 yield. The PtMo-Au with multi-enzyme activities can significantly regulate the tumor microenvironment to achieve synergistic sonodynamic/chemodynamic/starvation therapy and inhibit tumor growth without any significant side effects. AbstractThe clinical application of sonodynamic therapy (SDT) is greatly limited by the low quantum yield of sonosensitizers and tumor microenvironment (TME). Herein, PtMo-Au metalloenzyme sonosensitizer is synthesized by...
Source: Small - July 11, 2023 Category: Nanotechnology Authors: Jiawei Zhu,
Chenxi Wang,
Qinglin Wei,
Yan Su,
Xinyu Qu,
Wenjun Wang,
Xuejiao Song,
Xiaochen Dong,
Yu Cai Tags: Research Article Source Type: research
A Multidrug Delivery Microrobot for the Synergistic Treatment of Cancer
A multidrug delivery microrobot inspired by the fish structure with three components: skeleton, head, and body, is fabricated. The skeleton is made by poly(ethylene glycol) diacrylate (PEGDA) photoresist embedding with Fe3O4 nanoparticles and can respond to magnetic fields for microrobot actuation and drug-targeted delivery. The drug storage structures, head, and body, made by biodegradable GelMA exhibit enzyme-responsive drug release. AbstractMultidrug combination therapy provides an effective strategy for malignant tumor treatment. This paper presents the development of a biodegradable microrobot for on-demand multidrug ...
Source: Small - July 10, 2023 Category: Nanotechnology Authors: Yanfang Li,
Dingran Dong,
Yun Qu,
Junyang Li,
Shuxun Chen,
Han Zhao,
Qi Zhang,
Yang Jiao,
Lei Fan,
Dong Sun Tags: Research Article Source Type: research
