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Total 3421 results found since Jan 2013.
A Bone ‐Penetrating Precise Controllable Drug Release System Enables Localized Treatment of Osteoporotic Fracture Prevention via Modulating Osteoblast‐Osteoclast Communication
In this study, a featured radial extracorporeal shock wave (rESW) responsive nano-drug delivery system (NDDS) is developed for local treatment. Based on a mechanic simulation, a sequence of hollow zoledronic acid (ZOL)-contained nanoparticles (HZNs) with controllable shell thickness that predicts various mechanical responsive properties is constructed by controlling the deposition time of ZOL and Ca2+ on liposome templates. Attributed to the controllable shell thickness, the fragmentation of HZNs and the release of ZOL and Ca2+ can be precisely controlled with the intervention of rESW. Furthermore, the distinct effect of H...
Source: Small - March 27, 2023 Category: Nanotechnology Authors: Haojun Liang,
Kui Chen,
Jing Xie,
Lei Yao,
Yunpeng Liu,
Fan Hu,
Hao Li,
Yinze Lei,
Yujiao Wang,
Linwen Lv,
Ziteng Chen,
Sen Liu,
Qiuyang Liu,
Zhijie Wang,
Jiacheng Li,
Ya ‐Nan Chang,
Juan Li,
Hui Yuan,
Gengyan Xing,
Gengmei Xing Tags: Research Article Source Type: research
Moisture ‐Adaptive Contractile Biopolymer‐Derived Fibers for Wound Healing Promotion
A biopolymer composite fiber that can rapidly absorb wound tissue fluid and produce a large moisture-adaptive dynamic lengthwise contractile force with the desorption of water molecules. The wound healing-accelerated textile knitted by these composite fibers features excellent breathability and generates adaptive contraction in the target direction for wound healing promotion. AbstractThe advancement in thermosensitive active hydrogels has opened promising opportunities to dynamic full-thickness skin wound healing. However, conventional hydrogels lack breathability to avoid wound infection and cannot adapt to wounds with d...
Source: Small - March 27, 2023 Category: Nanotechnology Authors: Lizhong Dong,
Wei Zhang,
Ming Ren,
Yuxuan Li,
Yulian Wang,
Yurong Zhou,
Yulong Wu,
Zhijun Zhang,
Jiangtao Di Tags: Research Article Source Type: research
High ‐Activity Fe3C as pH‐Universal Electrocatalyst for Boosting Oxygen Reduction Reaction and Zinc‐Air Battery
This study provides some constructive insights for preparation of advanced ORR catalysts in green energy conversion units correlated systems.
Source: Small - March 27, 2023 Category: Nanotechnology Authors: Qi ‐Dong Ruan,
Rui Feng,
Jiu‐Ju Feng,
Yi‐Jing Gao,
Lu Zhang,
Ai‐Jun Wang Tags: Research Article Source Type: research
A Cascade Enzyme System Integrating Peroxidase Mimic with Catalase for Linear Range Expansion of H2O2 Assay: A Mechanism and Application Study
This study brings up a kind of POD/CAT cascade enzyme system and provides a new concept for accurate and facile H2O2 detection. Additionally, it replenishes a new enzyme-substrate model of achieving the same pattern with competitive inhibition in enzyme reactions.
Source: Small - March 27, 2023 Category: Nanotechnology Authors: Haiwei Hou,
Lan Liu,
Qiuyue Li,
Jianming Wang,
Baoji Du Tags: Research Article Source Type: research
Flattening of Lithium Plating in Carbonate Electrolytes Enabled by All ‐In‐One Separator
CPP separator is developed. The one-body structure minimizes the sacrifice in energy density even with the inorganic particle introduction. Polar CaCO3 alters the solvation structure of Li+, enhancing Li+ mobility and reducing concentration overpotential. Concurrently, CaCO3 reacts with Li to form lithiophilic CaLi alloy spontaneously, reducing the nucleation overpotential. Because of the overall overpotential control, dendrite-free Li deposition is achieved. AbstractThe uncontrollable dendritic growth of metallic lithium during repeated cycling in carbonate electrolytes is a crucial obstacle hindering the practical use...
Source: Small - March 27, 2023 Category: Nanotechnology Authors: Yong Min Kim,
Hyun ‐seung Kim,
Bo Keun Park,
Jin Hyeok Yang,
Han Jun Leem,
Jisang Yu,
Siwon Kim,
So Yeun Kim,
Jong‐Won Lee,
Min‐Sik Park,
Ki Jae Kim Tags: Research Article Source Type: research
Perovskite ‐Type Manganese Vanadate Sonosensitizers with Biodegradability for Enhanced Sonodynamic Therapy of Cancer
Perovskite-type manganese vanadate (MnVO3) nanoparticles are designed as biodegradable sonosensitizers for enhanced sonodynamic therapy. Due to the inherent properties of perovskites with narrow bandgap and oxygen vacancies, MnVO3 exhibits a facilely sono-triggered electrons-holes separation and restrained recombination. The decomposition property of perovskite structure bestows the sonosensitizers with superior biodegradability, which is favorable for fast clearance without long-term toxicity. AbstractSonodynamic therapy (SDT) has attracted intensive attention, but is still hindered by low sonosensitization and non-biodeg...
Source: Small - March 27, 2023 Category: Nanotechnology Authors: Lina Sun,
Yi Cao,
Wenjing Li,
Li Wang,
Pi Ding,
Zhongzhong Lu,
Fanshu Ma,
Zheng Wang,
Renjun Pei Tags: Research Article Source Type: research
Histidine ‐Mediated Synthesis of Chiral Cobalt Oxide Nanoparticles for Enantiomeric Discrimination and Quantification
The effect of chemical states on the chirality origin and chiroptical activity of chiral cobalt oxide nanoparticles mediated by histidine (Co3O4@His NPs) is investigated theoretically and experimentally. In addition, the chiral Co3O4@His NPs are applied for the enantiomeric discrimination and quantification of cysteine and penicillamine enantiomers. AbstractChiral transition metal oxide nanoparticles (CTMOs) are attracting a lot of attention due to their fascinating properties. Nevertheless, elucidating the chirality induction mechanism often remains a major challenge. Herein, the synthesis of chiral cobalt oxide nanopar...
Source: Small - March 27, 2023 Category: Nanotechnology Authors: Xing Liu,
Yanli Du,
Shenli Wang,
Yu Huang,
Yongzhi Tian,
Daniel Garc ía‐Lojo,
Ignacio Pérez‐Juste,
Jorge Pérez‐Juste,
Isabel Pastoriza‐Santos,
Guangchao Zheng Tags: Research Article Source Type: research
Stimuli ‐Responsive Silica Silanol Conjugates: Strategic Nanoarchitectonics in Targeted Drug Delivery
The silica surface silanol chemistry and its conjugation to different cargos through stimuli-responsive linkers are highly desired. This review elucidates silica's surface chemistry, types of silanols, silanol number and chemistry, chemical and physical identification, functionalization, and stimuli-responsive for precise drug delivery systems. AbstractThe design of novel drug delivery systems is exceptionally critical in disease treatments. Among the existing drug delivery systems, mesoporous silica nanoparticles (MSNs) have shown profuse promise owing to their structural stability, tunable morphologies/sizes, and ability...
Source: Small - March 27, 2023 Category: Nanotechnology Authors: Shan Mohanan,
Xinwei Guan,
Mingtao Liang,
Ajay Karakoti,
Ajayan Vinu Tags: Review Source Type: research
A Nanoparticle Ink Allowing the High Precision Visualization of Tissue Engineered Scaffolds by MRI
In this study, a magnetic ink based on ultra-small iron oxide nanoparticles (USPIONs;<5 nm diameter cores) is developed and integrated into biocompatible alginate hydrogel used in cell scaffolding applications. Relaxometric properties of the magnetic hydrogel are measured, as well as biocompatibility and MR-visibility (T1-weighted mode; in vitro and in vivo). A 2-week MR follow-up study is performed in the mouse model, demonstrating no image artifacts, and the retention of “positive” contrast overtime, which allows very precise delineation of tissue grafts with MRI. Finally, a 3D-contouring procedure developed to ...
Source: Small - March 25, 2023 Category: Nanotechnology Authors: Samila Leon ‐Chaviano,
Mariia Kiseleva,
Philippe Legros,
Simon Collin,
Théophraste Lescot,
Céline Henoumont,
Yves Gossuin,
Sophie Laurent,
Dominique Mayrand,
Julie Fradette,
André Bégin‐Drolet,
Jean Ruel,
Marc‐André Fortin Tags: Research Article Source Type: research
Physicochemical Properties and Route of Systemic Delivery Control the In Vivo Dynamics and Breakdown of Radiolabeled Gold Nanostars
This work shows the long-term biodistribution and fate of ligand functionalized gold nanostars in vivo over three months as a function of route of systemic delivery. By combining both in vitro and in vivo experiments, and computations it is shown for the first time the breakdown of nanostars in vivo making them amenable to renal and hepatobiliary clearance. AbstractThe in vivo dynamics of nanoparticles requires a mechanistic understanding of multiple factors. Here, for the first time, the surprising breakdown of functionalized gold nanostars (F-AuNSs) conjugated with antibodies and64Cu radiolabels in vivo and in artificial...
Source: Small - March 25, 2023 Category: Nanotechnology Authors: Xiaona Wen,
Luping Ou,
Gabriel Cutshaw,
Saji Uthaman,
Yu ‐Chuan Ou,
Tian Zhu,
Sarah Szakas,
Brandon Carney,
Jacob Houghton,
Alexander Gundlach‐Graham,
Marjan Rafat,
Kai Yang,
Rizia Bardhan Tags: Research Article Source Type: research
Coordinating Interface Polymerization with Micelle Mediated Assembly Towards Two ‐Dimensional Mesoporous Carbon/CoNi for Advanced Lithium–Sulfur Battery
A novel 2D mesoporous N-doped carbon nanosheet with confined bimetallic CoNi nanoparticles sandwiched graphene (mNC-CoNi@rGO) serves as a robust host material that endows lithium-sulfur batteries with a high reversible capacity of 1115 mAh g−1 at 0.2 C after 100 cycles, superior rate capability, and excellent cycling stability with 679.2 mAh g−1 capacity retention over 700 cycles at 1 C. AbstractLithium-sulfur battery has attracted significant attention by virtues of their high theoretical energy density, natural abundance, and environmental friendliness. However, the notorious shuttle effect of polysulfides intermedia...
Source: Small - March 25, 2023 Category: Nanotechnology Authors: Zheng Huang,
Dongsheng Ma,
Pei Nian,
Yu Zhou,
Dong Wang,
Xueqing Gong,
Zheng Wang,
Qin Yue Tags: Research Article Source Type: research
Construction of ZnIn2S4/CdS/PdS S ‐Scheme Heterostructure for Efficient Photocatalytic H2 Production
The ZnIn2S4/CdS/PdS heterostructure is designed via the confinement effect for the first time. The S-scheme heterostructure is confirmed by in situ irradiated XPS and EPR. The optimized ZnIn2S4/CdS/PdS sample exhibits a high H2 production rate (19.1 mmol g−1 h−1) and AQE (26.26%). AbstractIt is facing a tremendous challenge to develop the desirable hybrids for photocatalytic H2 generation by integrating the advantages of a single semiconductor. Herein, an all-sulfide ZnIn2S4/CdS/PdS heterojunction is constructed for the first time, where CdS and PdS nanoparticles anchor in the spaces of ZnIn2S4 micro-flowers due to the...
Source: Small - March 25, 2023 Category: Nanotechnology Authors: Guotai Sun,
Zige Tai,
Fan Li,
Qian Ye,
Ting Wang,
Zhiyu Fang,
Lichao Jia,
Wei Liu,
Hongqiang Wang Tags: Research Article Source Type: research
Glycol ‐Split Heparin‐Linked Prodrug Nanoparticles Target the Mitochondrion Apparatus for Cancer Metastasis Treatment
This study prepared a new drug conjugate (PTX-GSHP-CYS-ES2, PGCE) by combining polysaccharides (heparin without anticoagulant activity, GSHP), chemotherapeutic drugs (paclitaxel, PTX), and antiangiogenic drugs (ES2). Furthermore, a tumor-targeted prodrug nanoparticle delivery system is established. The nanoparticles appear to accumulate in the mitochondrial of tumor cells and achieve ES2 and PTX release under high glutathione and acidic environment. It has been confirmed that PGCE inhibited the expression of multiple metastasis-related proteins by targeting the tumor cell mitochondrial apparatus and disrupting their struct...
Source: Small - March 25, 2023 Category: Nanotechnology Authors: Feng Sun,
Huiwen Hou,
Yan Li,
Wen Tang,
Jie Wang,
Lu Lu,
Jiaai Fu,
Zengmei Liu,
Didi Gao,
Feiyan Zhao,
Xinqing Gao,
Peixue Ling,
Fengshan Wang,
Haining Tan Tags: Research Article Source Type: research
DNA Mold ‐Based Fabrication of Palladium Nanostructures
The DNA origami mold based fabrication scheme of metallic nanostructures is expanded to palladium. Loading individual molds with functionalized palladium nanoparticles allows a seeded growth of palladium nanostructures within the mold cavity with programmable lengths and patterns. This should allow in the future to further expand the mold-based tool-box to less noble metals including magnetic materials like nickel and cobalt. AbstractDNA origami molds allow a shape-controlled growth of metallic nanoparticles. So far, this approach is limited to gold and silver. Here, the fabrication of linear palladium nanostructures with ...
Source: Small - March 24, 2023 Category: Nanotechnology Authors: Ulrich Kemper,
Jingjing Ye,
David Poppitz,
Roger Gl äser,
Ralf Seidel Tags: Research Article Source Type: research
Ultrahigh Mass Activity Pt Entities Consisting of Pt Single atoms, Clusters, and Nanoparticles for Improved Hydrogen Evolution Reaction
This work synthesizes highly dispersed Pt entities composed of Pt single atoms, clusters, and nanoparticles on mesoporous N-doped carbon nanospheres. This catalyst exhibits ultrahigh hydrogen evolution reaction mass activities, which are respectively 1.5 ± 0.1 and 58 ± 3 times higher than the highest Pt mass activity and the highest catalyst mass activity of Pt single-atom and cluster-based catalysts reported so far. AbstractPlatinum is one of the best-performing catalysts for the hydrogen evolution reaction (HER). However, high cost and scarcity severely hinder the large-scale application of Pt electrocatalysts. Constru...
Source: Small - March 23, 2023 Category: Nanotechnology Authors: Zhiqiang Zeng,
Sven K üspert,
S. Esmael Balaghi,
Haytham E. M. Hussein,
Niklas Ortlieb,
Markus Knäbbeler‐Buß,
Philipp Hügenell,
Stephan Pollitt,
Niclas Hug,
Julia Melke,
Anna Fischer Tags: Research Article Source Type: research
