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Total 3421 results found since Jan 2013.
Effects of Skeleton Structure of Mesoporous Silica Nanoadjuvants on Cancer Immunotherapy
Three commonly used mesoporous silica nanoparticles (MSNs) with different skeletons are synthesized by using different silica sources, such as TEOS for MSN, TEOS/BTEE for EMSN, and TEOS/BTES for TMSN. Compared with other two OMSNs, the OTMSN effectively targeted lymph nodes, activated DCs maturation, stimulated the proliferation of CD4+, CD8+ T cells, and polarized M2 phenotype macrophages into M1 phenotype macrophages, and reversed immunosuppressive tumor microenvironment. AbstractMesoporous silica nanoparticles (MSNs) have been widely praised as nanoadjuvants in vaccine/tumor immunotherapy thanks to their excellent bioco...
Source: Small - September 13, 2023 Category: Nanotechnology Authors: Jia Tan,
Binbin Ding,
Hao Chen,
Qi Meng,
Jing Li,
Chunzheng Yang,
Wenying Zhang,
Xinyang Li,
Di Han,
Pan Zheng,
Ping'an Ma,
Jun Lin Tags: Research Article Source Type: research
Stress Mitigation of Nanosilicon Anode to Achieve Energy ‐Dense and Highly‐Stable Full Cell
The expansion-induced stress concentration in a Si anode is successfully mitigated by constructing a porous structure out of a flexible Cu network that is metallurgically bonded to uniformly dispersed Si nanoparticles. Chemo-mechanical simulation and in (ex)-situ observation of structural evolution show how the high-strength flexible metallic network and metallurgical bonding interface affect the stress. AbstractNanosilicon (nano-Si) anode is subjected to significant stress concentration, which is caused by extrusion deformation of expanded Si nanoparticles with uneven distribution. The low-strength binder and adhesive int...
Source: Small - September 13, 2023 Category: Nanotechnology Authors: Li Cao,
Min Zheng,
Guochen Dong,
Jiejie Xu,
Rongshi Xiao,
Ting Huang Tags: Research Article Source Type: research
Direct Laser Writing Photonic Crystal Hydrogels with a Supramolecular Sacrificial Scaffold
A reversible and degradable supramolecular photonic crystal hydrogel (PCH) is formulated with agarose and monodispersed silica nanoparticles. Micro-PCHs with precise and sophisticated structures can be easily fabricated via direct laser writing using the supramolecular PCH as a sacrificial scaffold. With this strategy, the unexplored structural-designed micro-PCH mechanical sensors are created. AbstractPhotonic crystal hydrogels (PCHs), with smart stimulus-responsive abilities, have been widely exploited as colorimetric sensors for years. However, the current fabrication technologies are mostly applicable to produce PCHs w...
Source: Small - September 12, 2023 Category: Nanotechnology Authors: Yi Zeng,
Keliang Liu,
Haibo Ding,
Zhejun Chong,
Yanfang Niu,
Yijun Guo,
Mengxiao Wei,
Xin Du,
Zhongze Gu Tags: Research Article Source Type: research
Guiding the Path to Healing: CuO2 ‐Laden Nanocomposite Membrane for Diabetic Wound Treatment
Electrospun fibers with then-CuO2 NPs loaded PVP/PCL as the sheath and PCL as the core. When exposed to the wound's moist environment, PVP disintegrates to release the embeddedn-CuO2, to trigger the H2O2 self-supplied chemodynamic therapy (CDT) for antibacterial, antiinflammation, and angiogenesis properties. Simultaneously, the dissolution of PVP also exposes nano-grooved patterns for cell-guiding function to accelerate skin regeneration. AbstractDiabetic chronic wounds pose significant clinical challenges due to their characteristic features of impaired extracellular matrix (ECM) function, diminished angiogenesis, chroni...
Source: Small - September 9, 2023 Category: Nanotechnology Authors: Lin Qi,
Yong Huang,
Dan Sun,
Zheng Liu,
Yulin Jiang,
Jiangshan Liu,
Jing Wang,
Limin Liu,
Ganjun Feng,
Yubao Li,
Li Zhang Tags: Research Article Source Type: research
Deciphering the Mechanisms of Photo ‐Enhanced Catalytic Activities in Plasmonic Pd‐Au Heteromeric Nanozymes for Colorimetric Analysis
This study not only provides a straightforward approach for regulating nanozyme activity through plasmonic heterostructures but also sheds light on the mechanism of plasmon-enhanced catalysis of nanozymes.
Source: Small - September 8, 2023 Category: Nanotechnology Authors: Xueqing Sang,
Shiyu Xia,
Lu Cheng,
Fengxia Wu,
Yu Tian,
Chenxi Guo,
Guobao Xu,
Yali Yuan,
Wenxin Niu Tags: Research Article Source Type: research
Charge ‐Reversible Nanoparticles: Advanced Delivery Systems for Therapy and Diagnosis
Charge-reversible nanoparticles are drug delivery systems that change their surface charge in response to specific stimuli like the pH, redox-conditions, enzymes, exogenous stimuli, or a combination of them. This charge reversion from negative to positive enhances cellular uptake and targeted release of the payloads, promising more effective and precise treatments for various diseases. AbstractThe past two decades have witnessed a rapid progress in the development of surface charge-reversible nanoparticles (NPs) for drug delivery and diagnosis. These NPs are able to elegantly address the polycation dilemma. Converting thei...
Source: Small - September 7, 2023 Category: Nanotechnology Authors: Florina Veider,
Eva Sanchez Armengol,
Andreas Bernkop ‐Schnürch Tags: Review Source Type: research
Cobalt/Nitrogen Co ‐Doped Carbon Materials Enhance the Reaction Rate of Sodium–Potassium Alloy Electrodes
In this paper, we prepared a sodium-potassium alloy electrode to replace the potassium mental negative electrode, and utilized the synergistic effect of nano-Co and Co─Nx present in Co- and N-doped carbon nanotubes to effectively reduce the diffusion energy barrier of K+ and improve the electrochemical performance of the electrodes. AbstractSodium –potassium (NaK) alloy electrodes are ideal for next-generation dendrite-free alkali metal electrodes due to their dendrite-free nature. However, issues such as slow diffusion kinetics due to the large K+ radius and the loss of active potassium during the reaction severely ...
Source: Small - September 7, 2023 Category: Nanotechnology Authors: Yusheng Luo,
Jiaxin Xu,
Peizhi Mou,
Laiping Li,
Yong Chen,
Lei Yan,
Haoxiang Yu,
Jie Shu,
Liyuan Zhang Tags: Research Article Source Type: research
Butyrate Modification Promotes Intestinal Absorption and Hepatic Cancer Cells Targeting of Ferroptosis Inducer Loaded Nanoparticle for Enhanced Hepatocellular Carcinoma Therapy (Small 36/2023)
Enhanced Hepatocellular Carcinoma TherapyFirst-line hepatocellular carcinoma treatment is sorafenib, but effectiveness of sorafenib is relatively low due to a lack of tumor-targeted accumulation and a lack of therapeutic efficacy. In article number2301149, Yuan Huang and co-workers design orally administered butyrate-modified nanoparticles, which could strongly bind to monocarboxylate transporter 1 (MCT-1) receptors and efficiently penetrate the intestinal epithilium to deliver ferroptosis inducers for the treatment of liver tumors by pronounced ferroptosis damage.
Source: Small - September 6, 2023 Category: Nanotechnology Authors: Yinglan Yu,
Xinran Shen,
Xin Xiao,
Lian Li,
Yuan Huang Tags: Frontispiece Source Type: research
An Overview of Nanoparticle Protein Corona Literature (Small 36/2023)
Nanoparticle Protein CoronaThe protein corona forms at the surface of nanoparticles when they are introduced into biological fluids. In article number2301838, Markita P. Landry, Morteza Mahmoudi, and co-workers analyze the characteristics of the formed protein corona at the surface of 1702 nanoparticle systems (extracted from 470 papers spanning 2000 –2021).
Source: Small - September 6, 2023 Category: Nanotechnology Authors: Mohammad J. Hajipour,
Reihaneh Safavi ‐Sohi,
Shahriar Sharifi,
Nouf Mahmoud,
Ali Akbar Ashkarran,
Elizabeth Voke,
Vahid Serpooshan,
Milad Ramezankhani,
Abbas S. Milani,
Markita P. Landry,
Morteza Mahmoudi Tags: Inside Back Cover Source Type: research
Light ‐Driven Biomimetic Nanomotors for Enhanced Photothermal Therapy
4T1-JPGSs-IND nanomotors are developed to realize enhanced photothermal therapy (PTT) and alleviated PTT-induced inflammation under near-infraredn (NIR) irradiation. The NIR-actuated nanomotors can target homologous tumors, generate hyperthermia, and release IND. Hyperthermia is able to help them diffuse through a self-thermophoretic effect, allowing deeper penetration into tumor lesions for tumor cell destruction. AbstractNanotechnology-based strategy has recently drawn extensive attention for the therapy of malignant tumors due to its distinct strengths in cancer diagnosis and treatment. However, the limited intratumoral...
Source: Small - September 6, 2023 Category: Nanotechnology Authors: Hong Wang,
Junbin Gao,
Cong Xu,
Yuejun Jiang,
Meihuan Liu,
Hanfeng Qin,
Yicheng Ye,
Li Zhang,
Wanxian Luo,
Bin Chen,
Lingli Du,
Fei Peng,
Yingjia Li,
Yingfeng Tu Tags: Research Article Source Type: research
Multi ‐Functional Applications of H‐Glass Embedded with Stable Plasmonic Gold Nanoislands
H-glass material is developed to enhance adherence and amplify plasmonic gold nanoislands' stability. Various functional properties highlight the competence of H-glass with gold nanoislands to be used as a NO2 chemiresistive sensor at room temperature, as a saturable absorber to generate the laser pulses, and as a substrate for surface-enhanced Raman scattering to identify molecular analytes. AbstractMetal nanoparticles (MNPs) are synthesized using various techniques on diverse substrates that significantly impact their properties. However, among the substrate materials investigated, the major challenge is the stability ...
Source: Small - September 6, 2023 Category: Nanotechnology Authors: Jagannath Gangareddy,
Pratyasha Rudra,
Manohar Chirumamilla,
Sudheer Ganisetti,
Subramanian Kasimuthumaniyan,
Sourav Sahoo,
K. Jayanthi,
Jagannath Rathod,
Venugopal Rao Soma,
Subrata Das,
Nitya Nand Gosvami,
N. M. Anoop Krishnan,
Kjeld Pederse Tags: Research Article Source Type: research
Spatiotemporally Programmed Disassembly of Multifunctional Integrated DNAzyme Nanoplatfrom for Amplified Intracellular MicroRNA Imaging
A highly compact and robust Zn@DDz nanoplatform is disassembled on-demand for achieving the amplified intracellular imaging of microRNA via the integration of a unimolecular microRNA-responsive DNA-cleaving DNAzyme (DDz) probe with the requisite DNAzyme Zn2+-cofactor. AbstractThe sensing performance of DNAzymes in live cells is tremendously hampered by the inefficient and inhomogeneous delivery of DNAzyme probes and their incontrollable off-site activation, originating from their susceptibility to nuclease digestion. This requires the development of a more compact and robust DNAzyme-delivering system with site-specific D...
Source: Small - September 6, 2023 Category: Nanotechnology Authors: Qingqing Zhang,
Shanshan Yu,
Jinhua Shang,
Shizhen He,
Xiaoqing Liu,
Fuan Wang Tags: Research Article Source Type: research
NaYF4:Yb/Er@Mn3O4@GOX Nanocomposite for Upconversion Fluorescence Imaging and Synergistic Cascade Cancer Therapy by Apoptosis and Ferroptosis
A versatile self-cascading nanocomposite is synthesized by encapsulating glucose oxidase (GOX) within NaYF4:Yb/Er@Mn3O4 (UCMn@GOX) nanoparticles. This ingeniously designed nanocomposite holds immense promise for seamlessly integrating tumor diagnosis and treatment through synergistic cascade reactions. AbstractThe cell elimination strategy based on reactive oxygen species (ROS) is a promising method for tumor therapy. However, its efficacy is significantly limited by ROS deficiency caused by H2O2 substrate deficiency and up-regulation of cellular antioxidant defense induced by high glutathione (GSH) content in tumor cells....
Source: Small - September 4, 2023 Category: Nanotechnology Authors: Yinyin Chen,
Haoran Li,
Baoshan Hou,
Aimin Wu,
Wei Wu,
Chunxia Li,
Hao Wang,
Daiwen Chen,
Xianxiang Wang Tags: Research Article Source Type: research
Design and Construction of Carbon ‐Coated Fe3O4/Cr2O3 Heterostructures Nanoparticles as High‐Performance Anodes for Lithium Storage
An all-in-one synergy strategy is proposed involving electronic structure tailoring, nanosized active components, built-in electric field construction, and component modulation. Theoretical calculations reveal that multiphase interfacial coupling synergies excite electrochemical properties. The introduction of the heterogeneous component Cr enhances the connection with the carbon layer, constructs a built-in electric field, modulates the electronic structure, and promotes ion migration. AbstractTransition metal oxides, highly motivated anodes for lithium-ion batteries due to high theoretical capacity, typically afflict by ...
Source: Small - September 4, 2023 Category: Nanotechnology Authors: Huan Liu,
Weibin Zhang,
Weili Wang,
Guifang Han,
Jingde Zhang,
Shiwei Zhang,
Jianchuan Wang,
Yong Du Tags: Research Article Source Type: research
The Developed Wave Cancellation Theory Contributing to Understand Wave Absorption Mechanism of ZIF Derivatives with Controllable Electromagnetic Parameters
In this paper, the wave cancellation theory is innovatively absorbed and developed to better understand the effect of various thickness and electromagnetic parameters on electromagnetic wave absorption abilities. As such, herein a suitable electromagnetic parameter to synergistically regulate the conduction loss and dipole polarization capability for the electromagnetic wave absorbers film is reported. AbstractHow to better understand the influence of electromagnetic parameters on the absorbing properties of electromagnetic wave absorbers (EMAs) is an essential prerequisite for further synthesis and development of high-per...
Source: Small - September 4, 2023 Category: Nanotechnology Authors: Yukang Zhou,
Peng He,
Wenjun Ma,
Peiyuan Zuo,
Jian Xu,
Chuanhao Tang,
Qixin Zhuang Tags: Research Article Source Type: research
