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Total 2868 results found since Jan 2013.

Molecules, Vol. 28, Pages 4814: Structure-Based Design of Novel MAO-B Inhibitors: A Review
Debmalya Barh With the significant growth of patients suffering from neurodegenerative diseases (NDs), novel classes of compounds targeting monoamine oxidase type B (MAO-B) are promptly emerging as distinguished structures for the treatment of the latter. As a promising function of computer-aided drug design (CADD), structure-based virtual screening (SBVS) is being heavily applied in processes of drug discovery and development. The utilization of molecular docking, as a helping tool for SBVS, is providing essential data about the poses and the occurring interactions between ligands and target molecules. The current w...
Source: Molecules - June 16, 2023 Category: Chemistry Authors: Emilio Mateev Maya Georgieva Alexandrina Mateeva Alexander Zlatkov Shaban Ahmad Khalid Raza Vasco Azevedo Debmalya Barh Tags: Review Source Type: research

Molecules, Vol. 28, Pages 4795: Discovery of a Potent Highly Biased MOR Partial Agonist among Diastereomeric C9-Hydroxyalkyl-5-phenylmorphans
Jacobson Kenner C. Rice All possible diastereomeric C9-hydroxymethyl-, hydroxyethyl-, and hydroxypropyl-substituted 5-phenylmorphans were synthesized to explore the three-dimensional space around the C9 substituent in our search for potent MOR partial agonists. These compounds were designed to lessen the lipophilicity observed with their C9-alkenyl substituted relatives. Many of the 12 diastereomers that were obtained were found to have nanomolar or subnanomolar potency in the forskolin-induced cAMP accumulation assay. Almost all these potent compounds were fully efficacious, and three of those chosen for in vivo eva...
Source: Molecules - June 15, 2023 Category: Chemistry Authors: Joshua A. Lutz Agnieszka Sulima Eugene S. Gutman Eric W. Bow Dan Luo Sophia Kaska Thomas E. Prisinzano Carol A. Paronis Jack Bergman Gregory H. Imler Andrew T. Kerr Arthur E. Jacobson Kenner C. Rice Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4783: Synthesis, Bioactivity Evaluation and Application of Plant-Based Nanoparticles
gadam Environmental and biomedical fields have various potential applications for the green synthesis of nanoparticles [...]
Source: Molecules - June 15, 2023 Category: Chemistry Authors: Govindasamy Rajakumar Parappurath Narayanan Sudha Muthu Thiruvengadam Tags: Editorial Source Type: research

Molecules, Vol. 28, Pages 4778: Poloxamers Have Vaccine-Adjuvant Properties by Increasing Dissemination of Particulate Antigen at Distant Lymph Nodes
e Sophie Richard Vaccine technology is still facing challenges regarding some infectious diseases, which can be addressed by innovative drug delivery systems. In particular, nanoparticle-based vaccines combined with new types of adjuvants are actively explored as a platform for improving the efficacy and durability of immune protection. Here, biodegradable nanoparticles carrying an antigenic model of HIV were formulated with two combinations of poloxamers, 188/407, presenting or not presenting gelling properties, respectively. The study aimed to determine the influence of poloxamers (as a thermosensitive hydrogel or ...
Source: Molecules - June 15, 2023 Category: Chemistry Authors: Myriam Lamrayah Capucine Phelip Renaud Rovera C éline Coiffier Nora Lazhar Francesca Bartolomei Evelyne Colomb Bernard Verrier Claire Monge Sophie Richard Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4776: Morin Hydrate Encapsulation and Release from Mesoporous Silica Nanoparticles for Melanoma Therapy
da-Silva Melanoma incidence, a type of skin cancer, has been increasing worldwide. There is a strong need to develop new therapeutic strategies to improve melanoma treatment. Morin is a bioflavonoid with the potential for use in the treatment of cancer, including melanoma. However, therapeutic applications of morin are restrained owing to its low aqueous solubility and limited bioavailability. This work investigates morin hydrate (MH) encapsulation in mesoporous silica nanoparticles (MSNs) to enhance morin bioavailability and consequently increase the antitumor effects in melanoma cells. Spheroidal MSNs with a mean siz...
Source: Molecules - June 15, 2023 Category: Chemistry Authors: Catarina Cunha Diogo Marinheiro B árbara J. M. L. Ferreira Helena Oliveira Ana L. Daniel-da-Silva Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4742: Characterizing Counterion-Dependent Aggregation of Rhodamine B by Classical Molecular Dynamics Simulations
n Rivalta The aggregation in a solution of charged dyes such as Rhodamine B (RB) is significantly affected by the type of counterion, which can determine the self-assembled structure that in turn modulates the optical properties. RB aggregation can be boosted by hydrophobic and bulky fluorinated tetraphenylborate counterions, such as F5TPB, with the formation of nanoparticles whose fluorescence quantum yield (FQY) is affected by the degree of fluorination. Here, we developed a classical force field (FF) based on the standard generalized Amber parameters that allows modeling the self-assembling process of RB/F5TPB syste...
Source: Molecules - June 13, 2023 Category: Chemistry Authors: Giacomo Fanciullo Silvia Orlandi Andrey S. Klymchenko Luca Muccioli Ivan Rivalta Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4727: Boosted Tetracycline and Cr(VI) Simultaneous Cleanup over Z-Scheme WO3/CoO p-n Heterojunction with 0D/3D Structure under Visible Light
In this study, a Z-Scheme WO3/CoO p-n heterojunction with a 0D/3D structure was designed and prepared via a simple solvothermal approach to remove the combined pollution of tetracycline and heavy metal Cr(VI) in water. The 0D WO3 nanoparticles adhered to the surface of the 3D octahedral CoO to facilitate the construction of Z-scheme p-n heterojunctions, which could avoid the deactivation of the monomeric material due to agglomeration, extend the optical response range, and separate the photogenerated electronhole pairs. The degradation efficiency of mixed pollutants after a 70 min reaction was significantly higher than tha...
Source: Molecules - June 13, 2023 Category: Chemistry Authors: Changyu Lu Delu Cao Hefan Zhang Luning Gao Weilong Shi Feng Guo Yahong Zhou Jiahao Liu Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4744: Anti-Inflammatory and Cytotoxic Activities of Clerodane-Type Diterpenes
-Ramos The secondary metabolites of clerodane diterpenoids have been found in several plant species from various families and in other organisms. In this review, we included articles on clerodanes and neo-clerodanes with cytotoxic or anti-inflammatory activity from 2015 to February 2023. A search was conducted in the following databases: PubMed, Google Scholar and Science Direct, using the keywords clerodanes or neo-clerodanes with cytotoxicity or anti-inflammatory activity. In this work, we present studies on these diterpenes with anti-inflammatory effects from 18 species belonging to 7 families and those with cytotox...
Source: Molecules - June 13, 2023 Category: Chemistry Authors: Rubria Marlen Mart ínez-Casares Liliana Hern ández-Vázquez Angelica Mandujano Leonor S ánchez-Pérez Salud P érez-Gutiérrez Julia P érez-Ramos Tags: Review Source Type: research

Molecules, Vol. 28, Pages 4701: Functionalized and Nonfunctionalized Nanosystems for Mitochondrial Drug Delivery with Metallic Nanoparticles
athak Background: The application of metallic nanoparticles as a novel therapeutic tool has significant potential to facilitate the treatment and diagnosis of mitochondria-based disorders. Recently, subcellular mitochondria have been trialed to cure pathologies that depend on their dysfunction. Nanoparticles made from metals and their oxides (including gold, iron, silver, platinum, zinc oxide, and titanium dioxide) have unique modi operandi that can competently rectify mitochondrial disorders. Materials: This review presents insight into the recent research reports on exposure to a myriad of metallic nanoparticles that...
Source: Molecules - June 12, 2023 Category: Chemistry Authors: Shashi Kiran Misra Jessica M. Rosenholm Kamla Pathak Tags: Review Source Type: research

Molecules, Vol. 28, Pages 4687: Amphotericin B-Silver Hybrid Nanoparticles Help to Unveil the Mechanism of Biological Activity of the Antibiotic: Disintegration of Cell Membranes
h Grudzinski Amphotericin B is a popular antifungal antibiotic, and despite decades of pharmacological application, the exact mode of its biological activity is still a matter of debate. Amphotericin B-silver hybrid nanoparticles (AmB-Ag) have been reported to be an extremely effective form of this antibiotic to combat fungi. Here, we analyze the interaction of AmB-Ag with C. albicans cells with the application of molecular spectroscopy and imaging techniques, including Raman scattering and Fluorescence Lifetime Imaging Microscopy. The results lead to the conclusion that among the main molecular mechanisms responsible ...
Source: Molecules - June 10, 2023 Category: Chemistry Authors: Sebastian Janik Ewa Grela Sylwia St ączek Agnieszka Zdybicka-Barabas Rafal Luchowski Wieslaw I. Gruszecki Wojciech Grudzinski Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4679: Green Biosynthesis of Zinc Oxide Nanoparticles Using Pluchea indica Leaf Extract: Antimicrobial and Photocatalytic Activities
m Saied Nanotechnology is playing a critical role in several essential technologies with nanoscale structures (nanoparticles) in areas of the environment and biomedicine. In this work, the leaf extract of Pluchea indica was utilized to biosynthesize zinc oxide nanoparticles (ZnONPs) for the first time and evaluated for antimicrobial and photocatalytic activities. Different experimental methods were used to characterize the biosynthesized ZnONPs. The biosynthesized ZnONPs showed maximum Ultraviolet–visible spectroscopy (UV-vis) absorbance at a wavelength of 360 nm. The X-Ray diffraction (XRD) pattern of th...
Source: Molecules - June 9, 2023 Category: Chemistry Authors: Abdulaziz A. Al-Askar Amr H. Hashem Nadeem I. Elhussieny Ebrahim Saied Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4644: Physical Characteristics, Blue-Green Band Emission and Photocatalytic Activity of Au-Decorated ZnO Quantum Dots-Based Thick Films Prepared Using the Doctor Blade Technique
d Mohammad Asif Nanoscale ZnO is a vital semiconductor material whose versatility can be enhanced by sensitizing it with metals, especially noble metals, such as gold (Au). ZnO quantum dots were prepared via a simple co-precipitation technique using 2-methoxy ethanol as the solvent and KOH as the pH regulator for hydrolysis. The synthesized ZnO quantum dots were deposited onto glass slides using a simple doctor blade technique. Subsequently, the films were decorated with gold nanoparticles of different sizes using a drop-casting method. The resultant films were characterized via various strategies to obtain structura...
Source: Molecules - June 8, 2023 Category: Chemistry Authors: Amanullah Fatehmulla Belqes A. Shamsan Ahmed M. El-Naggar Abdullah M. Aldhafiri Nilam Qureshi Taesung Kim Muhammad Atif Asif Mahmood Mohammad Asif Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4629: Synthesis of Green Copper Nanoparticles Using Medicinal Plant Krameria sp. Root Extract and Its Applications
In this study, copper nanoparticles (CuNP) were synthesized via the green method using root extract of the medical plant Rhatany (Krameria sp.) as a reducing and capping agent and used to investigate the influence of microorganisms. The maximum production of CuNP was noted at 70 °C after 3 h of reaction time. The formation of nanoparticles was confirmed through UV-spectrophotometer, and the product showed an absorbance peak in the 422–430 nm range. The functional groups were observed using the FTIR technique, such as isocyanic acid attached to stabilize the nanoparticles. The spherical nature and ...
Source: Molecules - June 8, 2023 Category: Chemistry Authors: Shifaa O. Alshammari Sabry Younis Mahmoud Eman Saleh Farrag Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4654: Synthesis and Assessment of Antimicrobial Composites of Ag Nanoparticles or AgNO3 and Egg Shell Membranes
ik Gideon Brink Engineering research has been expanded by the advent of material fusion, which has led to the development of composites that are more reliable and cost-effective. This investigation aims to utilise this concept to promote a circular economy by maximizing the adsorption of silver nanoparticles and silver nitrate onto recycled chicken eggshell membranes, resulting in optimized antimicrobial silver/eggshell membrane composites. The pH, time, concentration, and adsorption temperatures were optimized. It was confirmed that these composites were excellent candidates for use in antimicrobial applications. The ...
Source: Molecules - June 8, 2023 Category: Chemistry Authors: Samuel Tomi Aina Hilda Dinah Kyomuhimbo Shatish Ramjee Barend Du Plessis Vuyo Mjimba Ali Maged Nils Haneklaus Hendrik Gideon Brink Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4600: Photocatalytic Degradation of Food and Juices Dyes via Photocatalytic Nanomaterials Synthesized through Green Synthetic Route: A Systematic Review
ltaf Shah The unavailability of non-poisonous and hygienic food substances is the most challenging issue of the modern era. The uncontrolled usage of toxic colorant moieties in cosmetics and food manufacturing units leads to major threats to human life. The selection of environmentally benign approaches for the removal of these toxic dyes has gained the utmost attention from researchers in recent decades. This review article’s main aim is the focus on the application of green-synthesized nanoparticles (NPs) for the photocatalytic degradation of toxic food dyes. The use of synthetic dyes in the food indust...
Source: Molecules - June 7, 2023 Category: Chemistry Authors: Kashif Ali Khan Afzal Shah Jan Nisar Abdul Haleem Iltaf Shah Tags: Review Source Type: research