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Total 2868 results found since Jan 2013.

Molecules, Vol. 28, Pages 4044: Pharmacophore-Based Virtual Screening and In-Silico Explorations of Biomolecules (Curcumin Derivatives) of Curcuma longa as Potential Lead Inhibitors of ERBB and VEGFR-2 for the Treatment of Colorectal Cancer
jad Bilal The newly FDA-approved drug, Axitinib, is an effective therapy against RTKs, but it possesses severe adverse effects like hypertension, stomatitis, and dose-dependent toxicity. In order to ameliorate Axitinib’s downsides, the current study is expedited to search for energetically stable and optimized pharmacophore features of 14 curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione) derivatives. The rationale behind the selection of curcumin derivatives is their reported anti-angiogenic and anti-cancer properties. Furthermore, they possessed a low molecular weight and a low toxic...
Source: Molecules - May 12, 2023 Category: Chemistry Authors: Syeda Abida Ejaz Mubashir Aziz Mohamed Fawzy Ramadan Ammara Fayyaz Muhammad Sajjad Bilal Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4026: Nanoparticle-Imprinted Silica Gel for the Size-Selective Capture of Silver Ultrafine Nanoparticles from Water
Lavinia Doveri A synthetic approach has been developed to prepare silica gel monoliths that embed well separated silver or gold spherical nanoparticles (NP), with diameters of 8, 18 and 115 nm. Fe3+, O2/cysteine and HNO3 were all successfully used to oxidize and remove silver NP from silica, while aqua regia was necessary for gold NP. In all cases, NP-imprinted silica gel materials were obtained, with spherical voids of the same dimensions of the dissolved particles. By grinding the monoliths, we prepared NP-imprinted silica powders that were able to efficiently reuptake silver ultrafine NP (Ag-ufNP, d = 8 nm) from ...
Source: Molecules - May 11, 2023 Category: Chemistry Authors: Piersandro Pallavicini Luca Preti Maria L. Protopapa Daniela Carbone Laura Capodieci Yuri A. Diaz Fernandez Chiara Milanese Angelo Taglietti Lavinia Doveri Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4015: Analogy of the Reactions of Aromatic and Aliphatic & pi;-Electrophiles with Nucleophiles
Molecules, Vol. 28, Pages 4015: Analogy of the Reactions of Aromatic and Aliphatic π-Electrophiles with Nucleophiles Molecules doi: 10.3390/molecules28104015 Authors: Michał Barbasiewicz Michał Fedoryński Rafał Loska Mieczysław Mąkosza The aim of this essay is to disclose the similarity of a great variety of reactions that proceed between nucleophiles and π-electrophiles—both aromatic and aliphatic. These reactions proceed via initial reversible addition, followed by a variety of transformations that are common for the adducts of both aliphatic and aromatic electrophiles....
Source: Molecules - May 11, 2023 Category: Chemistry Authors: Micha ł Barbasiewicz Micha ł Fedoryński Rafa ł Loska Mieczys ław Mąkosza Tags: Review Source Type: research

Molecules, Vol. 28, Pages 4038: Tailoring of Mesoporous Silica-Based Materials for Enhanced Water Pollutants Removal
ranadeiro The adsorptive performance of mesoporous silica-based materials towards inorganic (metal ions) and organic (dyes) water pollutants was investigated. Mesoporous silica materials with different particle size, surface area and pore volume were prepared and tailored with different functional groups. These materials were then characterised by solid-state techniques, namely vibrational spectroscopy, elemental analysis, scanning electron microscopy and nitrogen adsorption–desorption isotherms, allowing the successful preparation and structural modifications of the materials to be confirmed. The influen...
Source: Molecules - May 11, 2023 Category: Chemistry Authors: Daniela Flores C. Marisa R. Almeida Carlos R. Gomes Salete S. Balula Carlos M. Granadeiro Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4035: Hybrid Nanocomposites of Tenoxicam: Layered Double Hydroxides (LDHs) vs. Hydroxyapatite (HAP) Inorganic Carriers
ella Bini The search for effective systems to facilitate the release of poorly bioavailable drugs is a forefront topic for the pharmaceutical market. Materials constituted by inorganic matrices and drugs represent one of the latest research strategies in the development of new drug alternatives. Our aim was to obtain hybrid nanocomposites of Tenoxicam, an insoluble nonsteroidal anti-inflammatory drug, with both layered double hydroxides (LDHs) and hydroxyapatite (HAP). The physicochemical characterization on the base of X-ray powder diffraction, SEM/EDS, DSC and FT-IR measurements was useful to verify the possible hybr...
Source: Molecules - May 11, 2023 Category: Chemistry Authors: Lauretta Maggi Valeria Friuli Giovanna Bruni Alessia Rinaldi Marcella Bini Tags: Article Source Type: research

Molecules, Vol. 28, Pages 3973: Aroma Characterization of Roasted Meat and Meat Substitutes Using Gas Chromatography & ndash;Mass Spectrometry with Simultaneous Selective Detection and a Dedicated Software Tool, AromaMS
Molecules, Vol. 28, Pages 3973: Aroma Characterization of Roasted Meat and Meat Substitutes Using Gas Chromatography–Mass Spectrometry with Simultaneous Selective Detection and a Dedicated Software Tool, AromaMS Molecules doi: 10.3390/molecules28093973 Authors: Nitzan Tzanani Ariel Hindi Dana Marder The development of healthier and more sustainable food products, such as plant-based meat substitutes (PBMSs), have received significant interest in recent years. A thorough understanding of the aroma composition can support efforts to improve the sensory properties of PBMS products and promote their consu...
Source: Molecules - May 8, 2023 Category: Chemistry Authors: Nitzan Tzanani Ariel Hindi Dana Marder Tags: Article Source Type: research

Molecules, Vol. 28, Pages 3962: Mitochondria-Targeted Fluorescent Nanoparticles with Large Stokes Shift for Long-Term BioImaging
olin Li Huirong Chi Mitochondria (MITO) play a significant role in various physiological processes and are a key organelle associated with different human diseases including cancer, diabetes mellitus, atherosclerosis, Alzheimer’s disease, etc. Thus, detecting the activity of MITO in real time is becoming more and more important. Herein, a novel class of amphiphilic aggregation-induced emission (AIE) active probe fluorescence (AC-QC nanoparticles) based on a quinoxalinone scaffold was developed for imaging MITO. AC-QC nanoparticles possess an excellent ability to monitor MITO in real-time. This probe dem...
Source: Molecules - May 8, 2023 Category: Chemistry Authors: Xiao Li Tao Zhang Xuebo Diao Yu Li Yue Su Jiapei Yang Zibo Shang Shuai Liu Jia Zhou Guolin Li Huirong Chi Tags: Article Source Type: research

Molecules, Vol. 28, Pages 3959: Cytotoxic Activity, Topoisomerase I Inhibition and In Silico Studies of New Sesquiterpene-aryl Ester Derivatives of (-) Drimenol
In this study, we aimed to evaluate two sets of sesquiterpene-aryl derivatives linked by an ester bond, their cytotoxic activities, and their capacity to activate caspases 3/7 and inhibit human topoisomerase I (TOP1). A total of 13 compounds were synthesized from the natural sesquiterpene (-)-drimenol and their cytotoxic activity was evaluated in vitro against three cancer cell lines: PC-3 (prostate cancer), HT-29 (colon cancer), MCF-7 (breast cancer), and an immortalized non-tumoral cell line (MCF-10). From the results, it was observed that 6a was the most promising compound due to its cytotoxic effect on three cancer cel...
Source: Molecules - May 8, 2023 Category: Chemistry Authors: Ileana Araque Javiera Ram írez Rut Vergara Jaime Mella Pablo Ar ánguiz Luis Espinoza Waleska Vera Iv án Montenegro Cristian O. Salas Joan Villena Mauricio A. Cuellar Tags: Article Source Type: research

Molecules, Vol. 28, Pages 3938: Identification of Small Molecule Inhibitors of Human Cytomegalovirus pUL89 Endonuclease Using Integrated Computational Approaches
This study provided promising starting point for further in vitro and in vivo studies.
Source: Molecules - May 7, 2023 Category: Chemistry Authors: Mazen Almehmadi Ihtisham Ul Haq Ahad Amer Alsaiari Fahad M. Alshabrmi Osama Abdulaziz Mamdouh Allahyani Mohammed Aladhadh Alaa Shafie Abdulelah Aljuaid Rema Turki Alotaibi Jawad Ullah Nada Saud Alharthi Tags: Article Source Type: research

Molecules, Vol. 28, Pages 3934: Use of Euphorbia balsamifera Extract in Precursor Fabrication of Silver Nanoparticles for Efficient Removal of Bromocresol Green and Bromophenol Blue Toxic Dyes
In this study, we present a new eco-friendly approach based on the use of Euphorbia balsamifera extract (EBE) in the green synthesis of silver nanoparticles (Ag-NPs), which are then applied as a reducing and stabilizing agent for the efficient removal of water-based reactive dyes such as bromocresol green (BCG) and bromophenol blue (BPB). The as-prepared Ag-NPs are quasi-spherical in shape, with an average diameter of 20–34 nm. Diverse characterization methods, including X-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron micro...
Source: Molecules - May 6, 2023 Category: Chemistry Authors: Salha M. Aljubiri Walaa H. El-Shwiniy Ayman A. O. Younes Eid H. Alosaimi Badr Abd El-wahaab Tags: Article Source Type: research

Molecules, Vol. 28, Pages 3931: Comparative Analysis of Stable Gold Nanoparticles Synthesized Using Sonochemical and Reduction Methods for Antibacterial Activity
This study focuses on the influence of synthetic methods on the aggregation stability and antibacterial activity of gold nanoparticles (NPs) prepared by using sodium citrate as a reducing and capping agent against Staphylococcus aureus (S. aureus). Gold NPs were synthesized using a simple and rapid sonochemical method and compared to gold NPs synthesized using a reduction method. The physicochemical features of gold NPs were characterized using UV-vis, XRD, TEM, and zeta potential, and the TEM results showed that the sonochemical method produced monodispersed spherical gold NPs with an average diameter of 18.5 nm, while th...
Source: Molecules - May 6, 2023 Category: Chemistry Authors: Mohammed Ali Dheyab Azlan Abdul Aziz Nazila Oladzadabbasabadi Alyaa Alsaedi Farhank Saber Braim Mahmood S. Jameel Asmeit Ramizy Mohammad Alrosan Ali Madi Almajwal Tags: Article Source Type: research

Molecules, Vol. 28, Pages 3929: Interactions between Layered Double Hydroxide Nanoparticles and Egg Yolk Lecithin Liposome Membranes
Na Du The burgeoning need to study the applications of nanoparticles (NPs) in biomedical and pharmaceutical fields requires an understanding of their interactions with lipid membranes for further in vivo studies. In this paper, negatively charged egg yolk lecithin liposome (EYL) has been prepared and used as model lipid membranes. Positively charged Mg3Al-layered double hydroxides (LDHs) are viewed as models of clay particles. The ability of the LDH NPs, a two-dimensional nanostructure with an average diameter of 100 nm (LDHs-100) or 500 nm (LDHs-500) to cross the membranes, has been thoroughly investigated via (high-r...
Source: Molecules - May 6, 2023 Category: Chemistry Authors: Bin Liu Yanlan Wang Na Du Tags: Article Source Type: research

Molecules, Vol. 28, Pages 3922: DNA-Guided Metallization of Nanomaterials and Their Biomedical Applications
Zhenbao Liu Precise control of the structure of metallic nanomaterials is critical for the advancement of nanobiotechnology. As DNA (deoxyribonucleic acid) can readily modify various moieties, such as sulfhydryl, carboxyl, and amino groups, using DNA as a directing ligand to modulate the morphology of nanomaterials is a promising strategy. In this review, we focus on the use of DNA as a template to control the morphology of metallic nanoparticles and their biomedical applications, discuss the use of DNA for the metallization of gold and silver, explore the factors that influence the process, and outline its biomedical ...
Source: Molecules - May 6, 2023 Category: Chemistry Authors: Ke Li Yanfei Liu Beibei Lou Yifu Tan Liwei Chen Zhenbao Liu Tags: Review Source Type: research

Molecules, Vol. 28, Pages 3904: (-)-Epigallocatechin-3-Gallate Attenuates the Adverse Reactions Triggered by Selenium Nanoparticles without Compromising Their Suppressing Effect on Peritoneal Carcinomatosis in Mice Bearing Hepatocarcinoma 22 Cells
Xianqing Huang Increasing evidence shows that selenium and polyphenols are two types of the most reported compounds in tumor chemoprevention due to their remarkable antitumor activity and high safety profile. The cross-talk between polyphenols and selenium is a hot research topic, and the combination of polyphenols and selenium is a valuable strategy for fighting cancer. The current work investigated the combination anti-peritoneal carcinomatosis (PC) effect of selenium nanoparticles (SeNPs) and green tea (Camellia sinensis) polyphenol (-)-epigallocatechin-3-gallate (EGCG) in mice bearing murine hepatocarcinoma 22 (...
Source: Molecules - May 5, 2023 Category: Chemistry Authors: Qiuyan Ban Wenjing Chi Xiaoxiao Wang Shiqiong Wang Dan Hai Guangshan Zhao Qiuyan Zhao Daniel Granato Xianqing Huang Tags: Article Source Type: research

Molecules, Vol. 28, Pages 3868: Selective Photooxidation of Valencene and Thymol with Nano-TiO2 and O2 as Oxidant
Ortega The selective photocatalytic oxidation with O2 as oxidant of valencene and thymol was evaluated using nanostructured TiO2 under UV-Vis radiation at atmospheric conditions. The effect of the morphology and optical properties of TiO2 nanotubes and aminate nanoparticles was studied. Different scavengers were used to detect the presence of positive holes (h+), electrons (e−), hydroxyl radicals (•OH), and the superoxide radical anion (O2−) during the photooxidation reaction. Superoxide anion radical is the main oxidizing specie formed, which is responsible for the selective fo...
Source: Molecules - May 4, 2023 Category: Chemistry Authors: Henry Mart ínez Jane Neira Álvaro A. Amaya Edgar A. P áez-Mozo Fernando Mart ínez Ortega Tags: Article Source Type: research