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Total 2868 results found since Jan 2013.

Molecules, Vol. 28, Pages 4169: The Power of Field-Flow Fractionation in Characterization of Nanoparticles in Drug Delivery
ica Lin Asymmetric-flow field-flow fractionation (AF4) is a gentle, flexible, and powerful separation technique that is widely utilized for fractionating nanometer-sized analytes, which extend to many emerging nanocarriers for drug delivery, including lipid-, virus-, and polymer-based nanoparticles. To ascertain quality attributes and suitability of these nanostructures as drug delivery systems, including particle size distributions, shape, morphology, composition, and stability, it is imperative that comprehensive analytical tools be used to characterize the native properties of these nanoparticles. The capacity for A...
Source: Molecules - May 18, 2023 Category: Chemistry Authors: Juan Bian Nemal Gobalasingham Anatolii Purchel Jessica Lin Tags: Review Source Type: research

Molecules, Vol. 28, Pages 4168: Poly(styrene sulfonic acid)-Grafted Carbon Black Synthesized by Surface-Initiated Atom Transfer Radical Polymerization
hoon Choi Owing to their excellent electrical conductivity and robust mechanical properties, carbon-based nanocomposites are being used in a wide range of applications and devices, such as electromagnetic wave interference shielding, electronic devices, and fuel cells. While several approaches have been developed for synthesizing carbon nanotubes and carbon-black-based polymer nanocomposites, most studies have focused on the simple blending of the carbon material with a polymer matrix. However, this results in uncontrolled interactions between the carbon filler and the polymer chains, leading to the agglomeration of th...
Source: Molecules - May 18, 2023 Category: Chemistry Authors: Artavazd Kirakosyan Donghyun Lee Yoonseong Choi Namgee Jung Jihoon Choi Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4148: Interaction of Graphene Oxide Nanoparticles with Human Mesenchymal Stem Cells Visualized in the Cell-IQ System
Svetlana Zamorina Graphene oxide is a promising nanomaterial with many potential applications. However, before it can be widely used in areas such as drug delivery and medical diagnostics, its influence on various cell populations in the human body must be studied to ensure its safety. We investigated the interaction of graphene oxide (GO) nanoparticles with human mesenchymal stem cells (hMSCs) in the Cell-IQ system, evaluating cell viability, mobility, and growth rate. GO nanoparticles of different sizes coated with linear or branched polyethylene glycol (P or bP, respectively) were used at concentrations of 5 and 25 ...
Source: Molecules - May 17, 2023 Category: Chemistry Authors: Sergey Lazarev Sofya Uzhviyuk Mikhail Rayev Valeria Timganova Maria Bochkova Olga Khaziakhmatova Vladimir Malashchenko Larisa Litvinova Svetlana Zamorina Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4146: Targeted Drug Administration onto Cancer Cells Using Hyaluronic Acid & ndash;Quercetin-Conjugated Silver Nanoparticles
Molecules, Vol. 28, Pages 4146: Targeted Drug Administration onto Cancer Cells Using Hyaluronic Acid–Quercetin-Conjugated Silver Nanoparticles Molecules doi: 10.3390/molecules28104146 Authors: Rasha H. Al-Serwi Mohamed A. Eladl Mohamed El-Sherbiny Mohamed A. Saleh Gamal Othman Sultan M. Alshahrani Rasha Alnefaie Afnan M. Jan Sulaiman M. Alnasser Aishah E. Albalawi Jamal Moideen Muthu Mohamed Farid Menaa Quercetin (QtN) displays low systemic bioavailability caused by poor water solubility and instability. Consequently, it exerts limited anticancer action in vivo. One solution to incre...
Source: Molecules - May 17, 2023 Category: Chemistry Authors: Rasha H. Al-Serwi Mohamed A. Eladl Mohamed El-Sherbiny Mohamed A. Saleh Gamal Othman Sultan M. Alshahrani Rasha Alnefaie Afnan M. Jan Sulaiman M. Alnasser Aishah E. Albalawi Jamal Moideen Muthu Mohamed Farid Menaa Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4147: Synthesis of Chitosan Oligosaccharide-Loaded Glycyrrhetinic Acid Functionalized Mesoporous Silica Nanoparticles and In Vitro Verification of the Treatment of APAP-Induced Liver Injury
Conclusion: this study demonstrated for the first time that formulation and delivery schemes using natural drug COSM and nanocarrier MSN have a protective effect on APAP-induced hepatocyte injury. This result provides a potential nano-delivery scheme for the targeted therapy of acute drug-induced liver injury.
Source: Molecules - May 17, 2023 Category: Chemistry Authors: Xinghua Guo Chengcheng Zhang Yan Bai Qishi Che Hua Cao Jiao Guo Zhengquan Su Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4139: Fabrication and Characterization of Ag-Graphene Nanocomposites and Investigation of Their Cytotoxic, Antifungal and Photocatalytic Potential
afari Firoozabadi In the present study, we aimed to synthesize (Ag)1−x(GNPs)x nanocomposites in variable ratios (25% GNPs–Ag, 50% GNPs–Ag, and 75% GNPs–Ag) via an ex situ approach to investigate the incremental effects of GNPs (graphene nanoparticles) on AgNPs (silver nanoparticles). The prepared nanocomposites were successfully characterized using different microscopic and spectroscopic techniques, including X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, ultraviolet spectroscopy, and Raman spectroscopic analysis. For the evaluation of mo...
Source: Molecules - May 17, 2023 Category: Chemistry Authors: Sidra Batool Malik Asma Gul Javed Iqbal Saggu Banzeer Ahsan Abbasi Beenish Azad Javed Iqbal Mohsin Kazi Wadie Chalgham Seyed Arshia Mirjafari Firoozabadi Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4138: Editorial: Nanomedicine-Based Drug Delivery Systems: Recent Developments and Future Prospects
l Since the discovery of nanomedicine-based drug delivery carriers such as nanoparticles, liposomes, and self-nanoemulsifying drug delivery systems (SNEDDS), enormous progress has been achieved in the field of innovative active biomolecule drug delivery systems [...]
Source: Molecules - May 17, 2023 Category: Chemistry Authors: Faiyaz Shakeel Tags: Editorial Source Type: research

Molecules, Vol. 28, Pages 4124: Highly Flexible Poly(1,12-dodecylene 5,5 & prime;-isopropylidene-bis(ethyl 2-furoate)): A Promising Biobased Polyester Derived from a Renewable Cost-Effective Bisfuranic Precursor and a Long-Chain Aliphatic Spacer
Molecules, Vol. 28, Pages 4124: Highly Flexible Poly(1,12-dodecylene 5,5′-isopropylidene-bis(ethyl 2-furoate)): A Promising Biobased Polyester Derived from a Renewable Cost-Effective Bisfuranic Precursor and a Long-Chain Aliphatic Spacer Molecules doi: 10.3390/molecules28104124 Authors: Sami Zaidi Abdelkader Bougarech Majdi Abid Souhir Abid Armando J. D. Silvestre Andreia F. Sousa The continuous search for novel biobased polymers with high-performance properties has highlighted the role of monofuranic-based polyesters as some of the most promising for future plastic industry but has neglected th...
Source: Molecules - May 16, 2023 Category: Chemistry Authors: Sami Zaidi Abdelkader Bougarech Majdi Abid Souhir Abid Armando J. D. Silvestre Andreia F. Sousa Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4122: Nanoparticle-Based Radioconjugates for Targeted Imaging and Therapy of Prostate Cancer
wski Prostate cancer is the second most frequent malignancy in men worldwide and the fifth leading cause of death by cancer. Although most patients initially benefit from therapy, many of them will progress to metastatic castration-resistant prostate cancer, which still remains incurable. The significant mortality and morbidity rate associated with the progression of the disease results mainly from a lack of specific and sensitive prostate cancer screening systems, identification of the disease at mature stages, and failure of anticancer therapy. To overcome the limitations of conventional imaging and therapeutic strat...
Source: Molecules - May 16, 2023 Category: Chemistry Authors: Anna Lankoff Malwina Czerwi ńska Marcin Kruszewski Tags: Review Source Type: research

Molecules, Vol. 28, Pages 4107: Chitosan, Chitosan/IgG-Loaded, and N-Trimethyl Chitosan Chloride Nanoparticles as Potential Adjuvant and Carrier-Delivery Systems
a-Barrera This work proposes a feasible, reproducible, and low-cost modified method to manufacture chitosan, chitosan/IgG-protein-loaded, and trimethylated chitosan nanoparticles, using microfluidics combined with the microemulsion technique, which differs from the traditional batch process of chitosan-based nanoparticles. The synthesis process consists of generating microreactors of chitosan-based polymer in a poly-dimethylsiloxane ψ-shaped microfluidic device and then crosslinking with sodium tripolyphosphate outside the cell. Transmission electron microscopy demonstrates an improvement in size control an...
Source: Molecules - May 15, 2023 Category: Chemistry Authors: Aldo Y. Tenorio-Barajas Mar ía de la L. Olvera Gabriel Romero-Paredes Victor Altuzar Efra ín Garrido-Guerrero Claudia Mendoza-Barrera Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4101: Investigation of Polyphenolic Compounds in Different Varieties of Black Chokeberry Aronia melanocarpa
V. Ramenskaya The purpose of this work was to study the qualitative and quantitative composition of the main groups of biologically active substances in the fresh fruits of five different varieties of black chokeberry (Aronia melanocarpa (Michx.) Elliot), carried out within the framework of the search for available and cost-effective raw materials for food product fortification. Samples of aronia chokeberry were grown at the Federal Scientific Center named after I.V. Michurin in the Tambov region of Russia. Using a modern chemical–analytical methodology, the contents and profiles of anthocyanin pigments, ...
Source: Molecules - May 15, 2023 Category: Chemistry Authors: Makar A. Gerasimov Irina B. Perova Konstantin I. Eller Michail Y. Akimov Anna M. Sukhanova Galina M. Rodionova Galina V. Ramenskaya Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4100: Bioinformatic Analysis of Key Regulatory Genes in Adult Asthma and Prediction of Potential Drug Candidates
Lihua Zhang Asthma is a common chronic disease that is characterized by respiratory symptoms including cough, wheeze, shortness of breath, and chest tightness. The underlying mechanisms of this disease are not fully elucidated, so more research is needed to identify better therapeutic compounds and biomarkers to improve disease outcomes. In this present study, we used bioinformatics to analyze the gene expression of adult asthma in publicly available microarray datasets to identify putative therapeutic molecules for this disease. We first compared gene expression in healthy volunteers and adult asthma patients to obtai...
Source: Molecules - May 15, 2023 Category: Chemistry Authors: Shaojun Chen Jiahao Lv Yiyuan Luo Hongjiang Chen Shuwei Ma Lihua Zhang Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4083: Flexible and Wearable Strain & ndash;Temperature Sensors Based on Chitosan/Ink Sponges
Molecules, Vol. 28, Pages 4083: Flexible and Wearable Strain–Temperature Sensors Based on Chitosan/Ink Sponges Molecules doi: 10.3390/molecules28104083 Authors: Xiaoying Lin Feng Wu Yunqing He Mingxian Liu A simple and economic strategy to construct a chitosan-ink carbon nanoparticle sponge sensor was proposed by freeze-drying of chitosan and Chinese ink mixture solution. The microstructure and physical properties of the composite sponges with different ratios are characterized. The interfacial compatibility of chitosan and carbon nanoparticles in ink is satisfied, and the mechanical property and po...
Source: Molecules - May 14, 2023 Category: Chemistry Authors: Xiaoying Lin Feng Wu Yunqing He Mingxian Liu Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4073: The Chemical Space of Marine Antibacterials: Diphenyl Ethers, Benzophenones, Xanthones, and Anthraquinones
M. Afonso The emergence of multiresistant bacteria and the shortage of antibacterials in the drug pipeline creates the need to search for novel agents. Evolution drives the optimization of the structure of marine natural products to act as antibacterial agents. Polyketides are a vast and structurally diverse family of compounds that have been isolated from different marine microorganisms. Within the different polyketides, benzophenones, diphenyl ethers, anthraquinones, and xanthones have shown promising antibacterial activity. In this work, a dataset of 246 marine polyketides has been identified. In order to characteri...
Source: Molecules - May 13, 2023 Category: Chemistry Authors: Jos é X. Soares In ês Afonso Adaleta Omerbasic Daniela R. P. Loureiro Madalena M. M. Pinto Carlos M. M. Afonso Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4046: Ionizable Lipids with Triazole Moiety from Click Reaction for LNP-Based mRNA Delivery
Yan Zhang Ionizable lipid-containing lipid nanoparticles (LNPs) as a non-viral vector with good safety and potency have been considered as an ideal delivery system for gene therapy. The screening of ionizable lipid libraries with common features but diverse structures holds the promise of finding new candidates for LNPs to deliver different nucleic acid drugs such as messenger RNAs (mRNAs). Chemical strategies for the facile construction of ionizable lipid libraries with diverse structure are in high demand. Here, we report on the ionizable lipids containing the triazole moiety prepared by the copper-catalyzed alkyne...
Source: Molecules - May 12, 2023 Category: Chemistry Authors: Yixiang Wang Xiao Si Yi Feng Dan Feng Xiaoyu Xu Yan Zhang Tags: Communication Source Type: research