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Total 2868 results found since Jan 2013.

Molecules, Vol. 28, Pages 4299: Evaluation of the Analgesic Effect of High-Cannabidiol-Content Cannabis Extracts in Different Pain Models by Using Polymeric Micelles as Vehicles
In conclusion, CBD/PMs could be promising therapeutics for pain management in the future.
Source: Molecules - May 24, 2023 Category: Chemistry Authors: Yoreny Rom án-Vargas Juli án David Porras-Arguello Lucas Bland ón-Naranjo Le ón Darío Pérez-Pérez Dora Mar ía Benjumea Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4288: ReS2 Nanoflowers-Assisted Confined Growth of Gold Nanoparticles for Ultrasensitive and Reliable SERS Sensing
Xiantong Yu Yu Chen ReS2, as a new member of transition metal dichalcogenides (TMDCs), has emerged as a promising substrate for semiconductor surface-enhanced Raman spectroscopy (SERS) due to its unique optoelectronic properties. Nevertheless, the sensitivity of the ReS2 SERS substrate poses a significant challenge to its widespread application in trace detection. In this work, we present a reliable approach for constructing a novel ReS2/AuNPs SERS composite substrate, enabling ultrasensitive detection of trace amounts of organic pesticides. We demonstrate that the porous structures of ReS2 nanoflowers can effectivel...
Source: Molecules - May 24, 2023 Category: Chemistry Authors: Yongping Li Haohui Liao Shaobing Wu Xiaoyu Weng Yiping Wang Liwei Liu Junle Qu Jun Song Shuai Ye Xiantong Yu Yu Chen Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4320: The Effects of 1-O-Acetylbritannilactone Isolated from Inula britannica Flowers on Human Neutrophil Elastase and Inflammation of RAW 264.7 Cells and Zebrafish Larvae
Sook Kim During a search for natural inflammatory inhibitors, 1-O-acetylbritannilactone (ABL), a sesquiterpene lactone, was isolated from the flowers of Inula britannica. ABL significantly inhibited human neutrophil elastase (HNE) with a half-maximal inhibitory concentration (IC50) of 3.2 ± 0.3 µM, thus did so more effectively than the positive control material (epigallocatechin gallate) (IC50 7.2 ± 0.5 µM). An enzyme kinetic study was performed. ABL noncompetitively inhibited HNE with an inhibition constant Ki of 2.4 µM. ABL inhibited lipopolysac...
Source: Molecules - May 24, 2023 Category: Chemistry Authors: Ik Soo Lee Yu-Ri Lee Jea Heon Sim Ki Mo Kim Young Sook Kim Tags: Communication Source Type: research

Molecules, Vol. 28, Pages 4285: Seaweeds and Corals from the Brazilian Coast: Review on Biotechnological Potential and Environmental Aspects
an Silva Pereira Aníbal de Freitas Santos Júnior Brazil has a megadiversity that includes marine species that are distributed along 800 km of shoreline. This biodiversity status holds promising biotechnological potential. Marine organisms are important sources of novel chemical species, with applications in the pharmaceutical, cosmetic, chemical, and nutraceutical fields. However, ecological pressures derived from anthropogenic actions, including the bioaccumulation of potentially toxic elements and microplastics, impact promising species. This review describes the current status of the biotechnological and environ...
Source: Molecules - May 23, 2023 Category: Chemistry Authors: Gustavo Souza dos Santos Thais Luz de Souza Thaiz Rodrigues Teixeira Jo ão Pedro Cezário Brandão Keila Almeida Santana Luan Henrique Santos Barreto Samantha de Souza Cunha Daniele Cristina Muniz Batista dos Santos Conor R. Caffrey Natan Silva Pereira A Tags: Review Source Type: research

Molecules, Vol. 28, Pages 4258: Investigation of Antimicrobial Effects of Polydopamine-Based Composite Coatings
in Yu Herein, polydopamine (PDA)-based antimicrobial coatings loaded with silver nanoparticles (Ag NPs) and gentamicin were designed and prepared on glass slides using two different approaches. To our knowledge, this study was performed for the first time with the aim to compare these methods (viz., in situ loading and physical adsorption method) regarding the loading and release behavior of payloads. In one method, gentamicin was in situ loaded on PDA-coated substrates during PDA polymerization followed by Ag NPs immobilization (named as Ag@Gen/PDA); for the second method, Ag NPs and gentamicin were simultaneously loa...
Source: Molecules - May 23, 2023 Category: Chemistry Authors: Rahila Batul Mrinal Bhave Aimin Yu Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4242: Cocrystallization of Progesterone with Nitrogen Heterocyclic Compounds: Synthesis, Characterization, Calculation and Property Evaluation
ng Ning Progesterone injection is oily because of its poor solubility. It is necessary to develop new dosage forms or delivery methods for Progesterone. Six cocrystals of Progesterone with nitrogen heterocyclic compounds (2,6-diaminopyridine, isonicotinamide, 4-aminopyridine, aminopyrazine, picolinamide and pyrazinamide) have been designed and prepared by ethyl acetate-assisted grinding, of which four cocrystals (2,6-diaminopyridine, isonicotinamide, 4-aminopyridine and aminopyrazine) had single crystal data in 1:1 stoichiometry. Metadynamics-genetic crossing was used to search and optimize various cluster structures t...
Source: Molecules - May 22, 2023 Category: Chemistry Authors: Juan Xu Wei Gao Qi Zhang Lifeng Ning Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4226: M & ouml;ssbauer and Structure-Magnetic Properties Analysis of AyB1 & minus;yCxFe2 & minus;xO4 (C=Ho,Gd,Al) Ferrite Nanoparticles Optimized by Doping
Molecules, Vol. 28, Pages 4226: Mössbauer and Structure-Magnetic Properties Analysis of AyB1−yCxFe2−xO4 (C=Ho,Gd,Al) Ferrite Nanoparticles Optimized by Doping Molecules doi: 10.3390/molecules28104226 Authors: Qing Lin Fang Yang Qian Zhang Kaimin Su Huiren Xu Yun He Jinpei Lin AyB1−yCxFe2−xO4 (C=Ho,Gd,Al) ferrite powders have been synthesized by the sol-gel combustion route. The X-ray diffraction of the CoHoxFe2−xO4 (x = 0~0.08) results indicated the compositions of single-phase cubic ferrites. The saturation magnetisation of CoHoxFe2...
Source: Molecules - May 22, 2023 Category: Chemistry Authors: Qing Lin Fang Yang Qian Zhang Kaimin Su Huiren Xu Yun He Jinpei Lin Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4203: Biosynthesis and Characterization of Silver Nanoparticles Using Tribulus terrestris Seeds: Revealed Promising Antidiabetic Potentials
ahed Fahad Alrefaei Green synthesis is the most effective and environmentally friendly way to produce nanoparticles. The present research aimed at the biosynthesizing of silver nanoparticles (AgNPs) using Tribulus terrestris seed extract as the reducing and stabilizing agent and investigating their anti-diabetic properties. Fourier transformation infrared (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and UV-Vis spectroscopy were used to analyze the synthesized silver nanoparticles from Tribulus terrestris (TT-AgNPs). The spectroscopic characterization revealed a surface Plasmon resonance band at ...
Source: Molecules - May 20, 2023 Category: Chemistry Authors: Abdur Rahman Gauhar Rehman Nasrullah Shah Muhammad Hamayun Sajid Ali Abid Ali Said karim Shah Waliullah Khan Muhammad Ishaq Ali Shah Abdulwahed Fahad Alrefaei Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4198: The Reducing Agents in Sonochemical Reactions without Any Additives
i It has been experimentally reported that not only oxidation reactions but also reduction reactions occur in aqueous solutions under ultrasound without any additives. According to the numerical simulations of chemical reactions inside an air or argon bubble in water without any additives under ultrasound, reducing agents produced from the bubbles are H, H2, HO2 (which becomes superoxide anion (O2−) in liquid water), NO, and HNO2 (which becomes NO2− in liquid water). In addition, H2O2 sometimes works as a reducing agent. As the reduction potentials of H and H2 (in s...
Source: Molecules - May 19, 2023 Category: Chemistry Authors: Kyuichi Yasui Tags: Review Source Type: research

Molecules, Vol. 28, Pages 4199: Trisubstituted 1,3,5-triazines as Histamine H4 Receptor Antagonists with Promising Activity In Vivo
Dorota Łażewska Pain is a very unpleasant experience that makes life extremely uncomfortable. The histamine H4 receptor (H4R) is a promising target for the treatment of inflammatory and immune diseases, as well as pain. H4R ligands have demonstrated analgesic effects in a variety of pain models, including inflammatory pain. Continuing the search for active H4R ligands among the alkyl derivatives of 1,3,5-triazine, we obtained 19 new compounds in two series: acyclic (I) and aliphatic (II). In vitro pharmacological evaluation showed their variable affinity for H4R. The majority of compounds showed a moderate affinity ...
Source: Molecules - May 19, 2023 Category: Chemistry Authors: Agnieszka Olejarz-Maciej Szczepan Mogilski Tadeusz Karcz Tobias Werner Katarzyna Kami ńska Jaros ław Kupczyk Ewelina Honkisz-Orzechowska Gniewomir Latacz Holger Stark Katarzyna Kie ć-Kononowicz Dorota Łażewska Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4200: Nanocomposites Based on Spin-Crossover Nanoparticles and Silica-Coated Gold Nanorods: A Nonlinear Optical Study
ngoulis A nanocomposite based on silica-coated AuNRs with the aminated silica-covered spin-crossover nanoparticles (SCO NPs) of the 1D iron(II) coordination polymer with the formula [Fe(Htrz)2(trz)](BF4) is presented. For the synthesis of the SCO NPs, the reverse micelle method was used, while the gold nanorods (AuNRs) were prepared with the aspect ratio AR = 6.0 using the seeded-growth method and a binary surfactant mixture composed of cetyltrimethylammonium bromide (CTAB) and sodium oleate (NaOL). The final nanocomposite was prepared using the heteroaggregation method of combining different amounts of SCO NPs with th...
Source: Molecules - May 19, 2023 Category: Chemistry Authors: Eleni Zygouri Aristeidis Stathis Stelios Couris Vassilis Tangoulis Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4184: Chemical Profile, Antibacterial, Antibiofilm, and Antiviral Activities of Pulicaria crispa Most Potent Fraction: An In Vitro and In Silico Study
lal El Menofy Infectious diseases caused by viruses and bacteria are a major public health concern worldwide, with the emergence of antibiotic resistance, biofilm-forming bacteria, viral epidemics, and the lack of effective antibacterial and antiviral agents exacerbating the problem. In an effort to search for new antimicrobial agents, this study aimed to screen antibacterial and antiviral activity of the total methanol extract and its various fractions of Pulicaria crispa (P. crispa) aerial parts. The P. crispa hexane fraction (HF) was found to have the strongest antibacterial effect against both Gram-positive and Gra...
Source: Molecules - May 19, 2023 Category: Chemistry Authors: Fatma Abo-Elghiet Areej Rushdi Mona H. Ibrahim Sara H. Mahmoud Mohamed A. Rabeh Saad Ali Alshehri Nagwan Galal El Menofy Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4182: Synthesis of Transition-Metal-Doped Nanocatalysts with Antibacterial Capabilities Using a Complementary Green Method
uly Reena Rawat A facile single-step wet chemical synthesis of a transition-metal-doped molybdate derivative was achieved via an Ocimum tenuiflorum extract-mediated green approach. The Synthesized nanomaterials of doped molybdate were characterized by optical and other spectroscopic techniques, which confirmed the size of nanocrystalline (~27.3 nm). The thermal stability of the nanomaterials confirmed through thermogravimetric analysis showed similarity with nanomaterials of Mn-ZnMoO4. Moreover, the nanoparticles displayed a non-toxic nature and showed antibactericidal activity. The impact of doping was reflected in ...
Source: Molecules - May 19, 2023 Category: Chemistry Authors: Anshul Singh Ranjana Choudhary Ahirwar Kavindra Borgaonkar Neeta Gupta Muhammad Ahsan Jyoti Rathore P. Das S. Ganguly Reena Rawat Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4181: Characterization of the Nonpolar and Polar Extractable Components of Glanded Cottonseed for Its Valorization
Qi Zhao Cottonseed is the second major product of cotton (Gossypium spp.) crops after fiber. Thus, the characterization and valorization of cottonseed are important parts of cotton utilization research. In this work, the nonpolar and polar fractions of glanded (Gd) cottonseed were sequentially extracted by 100% hexane and 80% ethanol aqueous solutions and subjected to 13C and 1H nuclear magnetic resonance (NMR) spectroscopy and Fourier-transform ion cyclotron resonance mass spectrometry (FT-ICR MS), respectively. The nonpolar (crude oil) extracts showed the characteristic NMR peak features of edible plant oils with the...
Source: Molecules - May 19, 2023 Category: Chemistry Authors: Zhongqi He Sunghyun Nam Shasha Liu Qi Zhao Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4157: Antitumor Effect of Bleomycin Nanoaerosol in Murine Carcinoma Model
v Igor L. Kanev Bleomycin, which is widely used as an antitumor agent, possesses serious adverse effects such as pulmonary toxicity. Local nanoaerosol deposition for lung cancer treatment is a promising alternative to drug delivery to lung lesions. The aim of this work is to test the hypothesis that bleomycin nanoaerosol can be effectively used to treat multiple lung metastases. To obtain bleomycin nanoaerosol, an aerosol generator based on electrospray of a solution of a nonvolatile substance with gas-phase neutralization of charged aerosol particles was used. Lung metastases in murine Lewis lung carcinoma and B16 m...
Source: Molecules - May 18, 2023 Category: Chemistry Authors: Saida S. Karshieva Gulalek Babayeva Vadim S. Pokrovsky Yuri M. Shlyapnikov Elena A. Shlyapnikova Anna E. Bugrova Alexey S. Kononikhin Evgeny N. Nikolaev Igor L. Kanev Tags: Article Source Type: research