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Infectious Disease: COVID-19
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Prostaglandin E < sub > 2 < /sub > and myocarditis; friend or foe?
Biochem Pharmacol. 2023 Sep 16:115813. doi: 10.1016/j.bcp.2023.115813. Online ahead of print.ABSTRACTThis review article summarizes the role of prostaglandin E2 (PGE2) and its receptors (EP1-EP4) as it relates to the inflammatory cardiomyopathy, myocarditis. During the COVID-19 pandemic, the onset of myocarditis in a subset of patients prompted a debate on the use of nonsteroidal anti-inflammatory drugs (NSAIDs), like ibuprofen, which act to inhibit the actions of prostaglandins. This review aims to further understanding of the role of PGE2 in the pathogenesis or protection of the myocardium in myocarditis. Inflammatory ca...
Source: Biochemical Pharmacology - September 18, 2023 Category: Drugs & Pharmacology Authors: Timothy D Bryson Pamela Harding Source Type: research
Monitoring strategy of COVID-19 vaccination in dialysis patients based on a multiplex immunodot method: The CovidDial study
CONCLUSION: Three doses of mRNA-1273 vaccine induce a robust but time-limited immunologic response in dialysis patients. Lower anti-spike antibodies titers after initial vaccination are associated with a higher risk to subsequently contract SARS-CoV-2, even beyond 6 months.PMID:37718617 | DOI:10.1111/sdi.13175
Source: Seminars in Dialysis - September 18, 2023 Category: Urology & Nephrology Authors: Fr édéric Debelle Vo Thanh Phuong Nguyen Laurence Boitquin Miguel-Ange Guillen-Anaya Fabrice Gankam Anne-Emilie Decl èves CoviDial study group Source Type: research
Outpatient Treatment of Confirmed COVID-19: A Living, Rapid Evidence Review for the American College of Physicians (Version 2)
CONCLUSION: Nirmatrelvir-ritonavir and molnupiravir probably improve outcomes for outpatients with mild to moderate COVID-19.PRIMARY FUNDING SOURCE: American College of Physicians. (PROSPERO: CRD42023406456).PMID:37722115 | DOI:10.7326/M23-1626
Source: Annals of Internal Medicine - September 18, 2023 Category: Internal Medicine Authors: Isolde Sommer Dominic Ledinger Kylie Thaler Andreea Dobrescu Emma Persad Martin Fangmeyer Irma Klerings Gerald Gartlehner Source Type: research
Web Exclusive. Annals Video Summary - Outpatient Treatment of Confirmed COVID-19
Ann Intern Med. 2023 Sep 19:eM232064. doi: 10.7326/M23-2064. Online ahead of print.NO ABSTRACTPMID:37722114 | DOI:10.7326/M23-2064
Source: Annals of Internal Medicine - September 18, 2023 Category: Internal Medicine Source Type: research
Outpatient Treatment of Confirmed COVID-19: Living, Rapid Practice Points From the American College of Physicians (Version 2)
Ann Intern Med. 2023 Sep 19. doi: 10.7326/M23-1636. Online ahead of print.ABSTRACTDESCRIPTION: Evidence for the use of outpatient treatments in adults with confirmed COVID-19 continues to evolve with new data. This is version 2 of the American College of Physicians (ACP) living, rapid practice points focusing on 22 outpatient treatments for COVID-19, specifically addressing the dominant SARS-CoV-2 Omicron variant.METHODS: The Population Health and Medical Science Committee (formerly the Scientific Medical Policy Committee) developed this version of the living, rapid practice points on the basis of a living, rapid review do...
Source: Annals of Internal Medicine - September 18, 2023 Category: Internal Medicine Authors: Amir Qaseem Jennifer Yost George M Abraham Rebecca Andrews Janet A Jokela Matthew C Miller Linda L Humphrey Population Health and Medical Science Committee of the American College of Physicians Source Type: research
COVID-19 Booster Uptake: Are Hesitant Adopters Less Likely to Get a Booster Shot Than Nonhesitant Adopters?
Behav Med. 2023 Sep 18:1-9. doi: 10.1080/08964289.2023.2249168. Online ahead of print.ABSTRACTThe main objective of this study was to assess whether hesitancy toward receiving the initial COVID-19 vaccine was associated with uptake of the COVID-19 booster several months after it became available to all US adults. We ask whether hesitancy toward the initial COVID-19 vaccine was significantly associated with lower odds of COVID-19 booster uptake among adults. We test this association within the context of the highly rural state of Arkansas. By January 2022, the US had set a global record of nearly 1 million daily cases. The ...
Source: Behavioral Medicine - September 18, 2023 Category: Psychiatry Authors: Don E Willis Ramey Moore James P Selig Sheena CarlLee Morgan P Gurel-Headley Lawrence E Cornett Pearl A McElfish Source Type: research
Targeting C5a is beneficial in critically ill COVID-19 patients
Immunobiology. 2023 Sep 12;228(6):152743. doi: 10.1016/j.imbio.2023.152743. Online ahead of print.NO ABSTRACTPMID:37717470 | DOI:10.1016/j.imbio.2023.152743
Source: Immunobiology - September 17, 2023 Category: Allergy & Immunology Authors: Endry H T Lim Alexander P J Vlaar Matthijs C Brouwer Diederik van de Beek Source Type: research
High flow nasal oxygen in frail COVID-19 patients hospitalized in intermediate care units and non-eligible to invasive mechanical ventilation
CONCLUSIONS: We suggest that HFNO is an option in non-ICU skilled units for older and frail patients with a severe COVID-19 pneumonia, otherwise non-suitable for intensive care and mechanical ventilation. Observation of clinical signs of respiratory failure before HFNO initiation was associated with mortality.PMID:37717386 | PMC:PMC10195878 | DOI:10.1016/j.resmer.2023.101026
Source: Respiratory Care - September 17, 2023 Category: Respiratory Medicine Authors: Corentin Meersseman Emmanuel Grolleau Nathalie Freymond Florent Wallet Thomas Gilbert Myriam Locatelli-Sanchez Laurence G érinière Emilie Perrot Pierre-Jean Souquet Clara Fontaine-Delaruelle Jean-St éphane David S ébastien Couraud Source Type: research
"It's already stressful being a foster parent": A qualitative inquiry into foster parenting stress during COVID-19
CONCLUSIONS: Findings from this study demonstrated foster parents experienced both shared and unique parenting challenges during COVID-19. Three areas for further consideration and development in practice included improving online service delivery, strengthening guidance for online parent-child visitation, and enhancing support for foster parents of children with special needs. Developing social support and self-care practices should continue to be ongoing priorities for foster parents and foster parent-serving agencies.PMID:37717544 | DOI:10.1016/j.chiabu.2023.106455
Source: Child Abuse and Neglect - September 17, 2023 Category: Child Development Authors: Erin Findley Source Type: research
National Cross-Sectional Epidemiological Analysis of the Impact of Pandemic COVID-19 on Vascular Procedures in Public Health System: 521,069 procedures over 4 years
CONCLUSIONS: The reorganization of health systems led to a significant reduction in vascular procedures and decrease in financial investments. On the other hand, there was a significant increase in the number of lower limb amputations and vena cava filter placements.PMID:37717819 | DOI:10.1016/j.avsg.2023.07.103
Source: Hand Surgery - September 17, 2023 Category: Surgery Authors: Marcelo Fiorelli Alexandrino da Silva Felipe Soares Oliveira Portela Andressa Cristina Sposato Louzada Marcelo Passos Teivelis Edson Amaro Junior Nelson Wolosker Source Type: research
Protocol for a living evidence synthesis on variants of concern and COVID-19 vaccine effectiveness
DISCUSSION: Evidence generated from our living evidence synthesis will be used to inform policy making, modelling, and prioritization of future research on the effectiveness of COVID-19 vaccines against VOC.PMID:37718186 | DOI:10.1016/j.vaccine.2023.09.012
Source: Vaccine - September 17, 2023 Category: Allergy & Immunology Authors: Nicole Shaver Melanie Katz Gideon Darko Asamoah Lori-Ann Linkins Wael Abdelkader Andrew Beck Alexandria Bennett Sarah E Hughes Maureen Smith Mpho Begin Doug Coyle Thomas Piggott Benjamin M Kagina Vivian Welch Caroline Colijn David J D Earn Khaled El Emam Source Type: research
Resiliency of the comparative endocrinology community in the face of COVID-19
Gen Comp Endocrinol. 2023 Sep 15:114376. doi: 10.1016/j.ygcen.2023.114376. Online ahead of print.NO ABSTRACTPMID:37717790 | DOI:10.1016/j.ygcen.2023.114376
Source: General and Comparative Endocrinology - September 17, 2023 Category: Endocrinology Authors: James A Carr Breanna N Harris Source Type: research
Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS
Semin Immunol. 2023 Sep 15;70:101842. doi: 10.1016/j.smim.2023.101842. Online ahead of print.ABSTRACTVaccines are among the greatest inventions in medicine, leading to the elimination or control of numerous diseases, including smallpox, polio, measles, rubella, and, most recently, COVID-19. Yet, the effectiveness of vaccines varies among individuals. In fact, while some recipients mount a robust response to vaccination that protects them from the disease, others fail to respond. Multiple clinical and epidemiological factors contribute to this heterogeneity in responsiveness. Systems immunology studies fueled by advances in...
Source: Seminars in Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Djamel Nehar-Belaid Mark Sokolowski Sathyabaarathi Ravichandran Jacques Banchereau Damien Chaussabel Duygu Ucar Source Type: research
Structure adaptation in Omicron SARS-CoV-2/hACE2: Biophysical origins of evolutionary driving forces
Biophys J. 2023 Sep 15:S0006-3495(23)00580-5. doi: 10.1016/j.bpj.2023.09.003. Online ahead of print.ABSTRACTSince its emergence, the COVID-19 threat has been sustained by a series of transmission waves initiated by new variants of the SARS-CoV-2 virus. Some of these arise with higher transmissivity and/or increased disease severity. Here we use molecular dynamics simulations to examine the modulation of the fundamental interactions between the receptor binding domain (RBD) of the spike glycoprotein and the host cell receptor (human angiotensin-converting enzyme 2: hACE2) arising from Omicron variant mutations (BA.1 and BA....
Source: Biophysical Journal - September 17, 2023 Category: Physics Authors: Ya-Wen Hsiao David J Bray Tseden Taddese Guadalupe Jim énez-Serratos Jason Crain Source Type: research
Regulation of SARS-CoV-2 infection and antiviral innate immunity by ubiquitination and ubiquitin-like conjugation
Biochim Biophys Acta Gene Regul Mech. 2023 Sep 15:194984. doi: 10.1016/j.bbagrm.2023.194984. Online ahead of print.ABSTRACTA global pandemic COVID-19 resulting from SARS-CoV-2 has affected a significant portion of the human population. Antiviral innate immunity is critical for controlling and eliminating the viral infection. Ubiquitination is extensively involved in antiviral signaling, and recent studies suggest that ubiquitin-like proteins (Ubls) modifications also participate in innate antiviral pathways such as RLR and cGAS-STING pathways. Notably, virus infection harnesses ubiquitination and Ubls modifications to faci...
Source: Biochimica et Biophysica Acta - September 17, 2023 Category: Biochemistry Authors: Yi Zheng Huiyu Yang Xuejing Zhang Chengjiang Gao Source Type: research
