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Infectious Disease: COVID-19
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Total 240369 results found since Jan 2013.
Simultaneous Targeting of IL-1-Signaling and IL-6-Trans-Signaling Preserves Human Pulmonary Endothelial Barrier Function During a Cytokine Storm
CONCLUSIONS: These findings strongly suggest a major role for both IL-6 trans-signaling and IL-1β signaling in the pathological increase in permeability of the human lung microvasculature and reveal combinatorial strategies that enable the gradual control of pulmonary endothelial barrier function in response to a cytokine storm.PMID:37732482 | DOI:10.1161/ATVBAHA.123.319695
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 21, 2023 Category: Cardiology Authors: Natalia Col ás-Algora Pablo Mu ñoz-Pinillos Cristina Cacho-Navas Jos é Avendaño-Ortiz Gema de Rivas Susana Barroso Eduardo L ópez-Collazo Jaime Mill án Source Type: research
The role of Pannexin-1 channels, ATP, and purinergic receptors in the pathogenesis of HIV and SARS-CoV-2
Curr Opin Pharmacol. 2023 Sep 19;73:102404. doi: 10.1016/j.coph.2023.102404. Online ahead of print.ABSTRACTInfectious agents such as human immune deficiency virus-1 (HIV) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) use host proteins to infect, replicate, and induce inflammation within the host. A critical component of these diseases is the axis between pannexin-1 channels, extracellular ATP, and purinergic receptors. Here, we describe the potential therapeutic role of Pannexin-1/purinergic approaches to prevent or reduce the devastating consequences of these pathogens.PMID:37734241 | DOI:10.1016/j.coph.2023.102404
Source: Current Opinion in Pharmacology - September 21, 2023 Category: Drugs & Pharmacology Authors: Cristian A Hernandez Eliseo A Eugenin Source Type: research
Emerging Challenges in Diagnosis and Treatment of Invasive Fungal Infections: Addressing the Impact of COVID-19 and New Pathogens
The objective of this study involved conducting a comprehensive literature search, followed by a rigorous selection process to identify relevant studies. Subsequently, a critical analysis of the literature was undertaken, and the obtained information was carefully synthesized to achieve the research aim.Recent FindingsRecent advances in diagnosis and treatment have greatly improved our ability to detect and manage of IFIs. The non-culture-based techniques have increased the accuracy and speed of fungal detection, while new antifungal drugs and immunotherapies have shown promising results in the treatment of IFIs. The princ...
Source: Current Fungal Infection Reports - September 21, 2023 Category: Infectious Diseases Source Type: research
Children's Daily Living Routine Mediates the Relations Between Parent-Child Relationships and Child Adjustment Problems During School Suspension in Hong Kong
This study examines how children's routine mediated the associations between parent-child relationships and child adjustment problems during the fifth wave of the COVID-19 pandemic in Hong Kong, when schools were suspended. The study collected data from 937 parents (87.8% mothers) of children aged 5-12 (M = 7.35 years, SD = 2.09; 50.5% girls). Parents reported on parent-child relationships, children's daily living routine, and child adjustment problems in an online survey. Our findings from structural equation modeling indicate that parent-child closeness was negatively related to child adjustment problems, whereas conflic...
Source: Child Psychiatry and Human Development - September 20, 2023 Category: Child Development Authors: Xiao-Yuan Wu Eva Yi Hung Lau Jian-Bin Li Derwin King Chung Chan Source Type: research
A New Strategy for Rejuvenating Primary Healthcare: The Government-Society Partnership Model
J Prim Care Community Health. 2023 Jan-Dec;14:21501319231200763. doi: 10.1177/21501319231200763.ABSTRACTPrimary healthcare systems worldwide are under stress as increased demands during pandemic surges have exposed deficiencies in the system. Primary healthcare centers have significant responsibilities but are often underfunded and understaffed. Recent events, including the COVID-19 pandemic, have highlighted the importance of a strong primary health center network to promote community health and save lives. Most governments have multiple competing financial needs for scarce resources, ultimately limiting the advancement o...
Source: Primary Care - September 20, 2023 Category: Primary Care Authors: Siddarth S Kasi Source Type: research
Novel inflammatory biomarkers in the prognosis of COVID-19
CONCLUSIONS: In summary, this meta-analysis provides the most up-to-date and comprehensive evidence for the role of the mentioned novel inflammatory biomarkers in the prognosis of COVID-19, especially in evaluating death and other poor prognoses, with most biomarkers showing a better discriminatory ability.PMID:37727063 | DOI:10.1177/17534666231199679
Source: Adv Data - September 20, 2023 Category: Epidemiology Authors: Kegang Zhan Luhan Wang Hao Lin Xiaoyu Fang Hong Jia Xiangyu Ma Source Type: research
Effect of therapeutic-dose heparin on severe acute kidney injury and death in noncritically ill patients hospitalized for COVID-19: a prespecified secondary analysis of the ACTIV4a and ATTACC randomized trial
CONCLUSION: Therapeutic-dose heparin was associated with a high probability of superiority to reduce the incidence of in-hospital severe AKI or death in patients hospitalized for COVID-19.PMID:37727846 | PMC:PMC10506136 | DOI:10.1016/j.rpth.2023.102167
Source: Thrombosis and Haemostasis - September 20, 2023 Category: Hematology Authors: Nathaniel R Smilowitz Erinn M Hade Lucy Z Kornblith Lana A Castellucci Mary Cushman Michael Farkouh Michelle N Gong Anna Heath Beverly J Hunt Keri S Kim Andrei Kindzelski Patrick Lawler David E Leaf Ewan Goligher Eric S Leifer Bryan J McVerry Harmony R Re Source Type: research
Strict self-isolation did not protect Swedish cancer patients on active treatment from the risk of becoming seropositive for SARS-CoV-2
Conclusion: For Swedish patients on active cancer treatment, high self-assessed COVID-19-related anxiety or strict adherence to self-isolation guidelines were not associated with a lower risk of COVID-19. Patients with HM were less likely to develop serological antibody response after COVID-19 and were more likely to require advanced hospital care, but expressed less COVID-19-related anxiety than patients with SM.PMID:37729083 | DOI:10.1080/0284186X.2023.2257873
Source: Acta Oncologica - September 20, 2023 Category: Cancer & Oncology Authors: Beatrice Ginman Simon Pahnke Eva Freyhult Tove Hoffman Linda Kolstad Bengt R önnberg Åke Lundkvist Kerstin Hamberg Levedahl Gunilla Enblad Ingrid Glimelius Source Type: research
Neonatal erythema multiforme associated with a rotavirus infection: A case report
CONCLUSION: The possibility of rotavirus, a major cause of pediatric gastrointestinal infections, being a trigger for neonatal EM should be considered.PMID:37727716 | PMC:PMC10506005 | DOI:10.12998/wjcc.v11.i24.5749
Source: Herpes - September 20, 2023 Category: Infectious Diseases Authors: Jung Jae Kim Joon Kee Lee Source Type: research
Changes in smoking due to COVID-19 pandemic among persons of migrant origin compared with the general population: a population-based study
CONCLUSIONS: The findings of this study contribute to better identification of at-risk populations in future crises situations. This will allow for more efficient targeting and tailoring of health promotion services, including smoking cessation.PMID:37726894 | DOI:10.1177/14034948231199792
Source: Scandinavian Journal of Public Health - September 20, 2023 Category: International Medicine & Public Health Authors: Otto Ruokolainen Eero Lilja Hanna Ollila Anu E Castaneda P äivikki Koponen Natalia Skogberg Source Type: research
"The obesity pandemic" in the COVID-19 pandemic - new treatment for an old problem
This article provides a review of the literature on the recent worsening of obesity in the paediatric population, with particular emphasis on the importance of the COVID-19 pandemic. New methods of fighting obesity with the use of telemedicine and current methods of pharmacotherapy, including new drugs, are presented.PMID:37728462 | DOI:10.5114/pedm.2023.129342
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 20, 2023 Category: Endocrinology Authors: Kalina Fabin-Czepiel Karolina Pieczy ńska-Chapuła Gra żyna Deja Source Type: research
Exploring the Access and Use of Social Technologies by Older Adults in Support of Their Mental Health During the COVID-19 Pandemic: A Rapid Review
This study aimed to explore the accessibility, outcomes, and challenges of social technology use among community-dwelling older adults, older adults in long-term care, older adults with neurocognitive disorder, and older adults with pre-frailty and frailty, to help guide future research in this area. A rapid review was conducted, and articles were retrieved from four online databases, including Medline, AgeLine, EconLit and CINAHL, and grey literature from Google Scholar. Of the 131 articles retrieved, 24 were included in this review. The positive outcomes of social technology use include improved mental and physical healt...
Source: Canadian Journal on Aging - September 20, 2023 Category: Geriatrics Authors: Joelle R DesCh âtelets Asif R Khowaja Kristin Mechelse Henriette Koning Dominic Ventresca Source Type: research
Social Connectedness Between Family Caregivers and Older Adults Living in Long-Term Care Homes in the Context of COVID-19
Can J Aging. 2023 Sep 20:1-12. doi: 10.1017/S0714980823000351. Online ahead of print.ABSTRACTThe coronavirus disease (COVID-19) pandemic and resulting restrictions on physical access to long-term care homes culminated in health declines for older adults living there and their families. Knowledge gaps exist regarding maintaining social connectedness when physically separated. The study aimed to explore family members' perceptions of the impact that restrictions on physical access to long-term care homes had on the experience of social connectedness between family members and older adults living in long-term care. The method...
Source: Canadian Journal on Aging - September 20, 2023 Category: Geriatrics Authors: Anna Garnett Hannah Pollock Natalie Floriancic Kristin Prentice Lorie Donelle Carri Hand Abe Oudshoorn Yolanda Babenko-Mould Cheryl Forchuk Source Type: research
The Pathogenesis of COVID-19-Related Taste Disorder and Treatments
J Dent Res. 2023 Sep 20:220345231182926. doi: 10.1177/00220345231182926. Online ahead of print.ABSTRACTCOVID-19, mainly manifested as acute respiratory distress syndrome, has afflicted millions of people worldwide since 2019. Taste dysfunction is a common early-stage symptom of COVID-19 infection that burdens patients for weeks or even permanently in some cases. Owing to its subjectivity and complexity, the mechanism of taste disorder is poorly studied. Previous studies have reported that the COVID-19 entry receptors are highly expressed in taste buds, thereby intensifying the cytocidal effect. Taste receptor cells are vul...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: J Wang R Liu H Ma W Zhang Source Type: research
Cinnamaldehyde inhibits cytokine storms induced by the ORF3a protein of SARS-CoV-2 via ROS-elimination in activated T cells
Phytother Res. 2023 Sep 19. doi: 10.1002/ptr.8016. Online ahead of print.ABSTRACTCytokine storms are the cause of complications in patients with severe COVID-19, and it becomes the target of therapy. Several natural compounds were selected to screen the inhibitory effect on T-cell proliferation by Fluorescence-Activated Cell Sorting (FACS) and cytokine production by enzyme-linked immunosorbent assay (ELISA). Open reading frame 3a (ORF3a) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stimulates the specific T-cell activation model in vivo and in vitro. The coculture system included the macrophage cell line...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Jing Ma Xu Chen Rui Xue Fei Wang Jun Dong Ning Tao Zhihai Qin Source Type: research
