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Infectious Disease: COVID-19
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"It's already stressful being a foster parent": A qualitative inquiry into foster parenting stress during COVID-19
CONCLUSIONS: Findings from this study demonstrated foster parents experienced both shared and unique parenting challenges during COVID-19. Three areas for further consideration and development in practice included improving online service delivery, strengthening guidance for online parent-child visitation, and enhancing support for foster parents of children with special needs. Developing social support and self-care practices should continue to be ongoing priorities for foster parents and foster parent-serving agencies.PMID:37717544 | DOI:10.1016/j.chiabu.2023.106455
Source: Child Abuse and Neglect - September 17, 2023 Category: Child Development Authors: Erin Findley Source Type: research
Structure adaptation in Omicron SARS-CoV-2/hACE2: Biophysical origins of evolutionary driving forces
Biophys J. 2023 Sep 15:S0006-3495(23)00580-5. doi: 10.1016/j.bpj.2023.09.003. Online ahead of print.ABSTRACTSince its emergence, the COVID-19 threat has been sustained by a series of transmission waves initiated by new variants of the SARS-CoV-2 virus. Some of these arise with higher transmissivity and/or increased disease severity. Here we use molecular dynamics simulations to examine the modulation of the fundamental interactions between the receptor binding domain (RBD) of the spike glycoprotein and the host cell receptor (human angiotensin-converting enzyme 2: hACE2) arising from Omicron variant mutations (BA.1 and BA....
Source: Biophysical Journal - September 17, 2023 Category: Physics Authors: Ya-Wen Hsiao David J Bray Tseden Taddese Guadalupe Jim énez-Serratos Jason Crain Source Type: research
Building parameters linked with indoor transmission of SARS-CoV-2
Environ Res. 2023 Sep 15:117156. doi: 10.1016/j.envres.2023.117156. Online ahead of print.ABSTRACTThe rapid spread of Coronavirus Disease (2019)(COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emphasized the importance of understanding and adapting to the indoor remediation of transmissible diseases to decrease the risk for future pandemic threats. While there were many precautions in place to hinder the spread of COVID-19, there has also been a substantial increase of new research on SARS-CoV-2 that can be utilized to further mitigate the transmission risk of this novel virus. This r...
Source: Environmental Research - September 17, 2023 Category: Environmental Health Authors: Jacqueline Horne Nicholas Dunne Nirmala Singh Md Safiuddin Navid Esmaeili Merve Erenler Ian Ho Edwin Luk Source Type: research
Protocol for a living evidence synthesis on variants of concern and COVID-19 vaccine effectiveness
DISCUSSION: Evidence generated from our living evidence synthesis will be used to inform policy making, modelling, and prioritization of future research on the effectiveness of COVID-19 vaccines against VOC.PMID:37718186 | DOI:10.1016/j.vaccine.2023.09.012
Source: Vaccine - September 17, 2023 Category: Allergy & Immunology Authors: Nicole Shaver Melanie Katz Gideon Darko Asamoah Lori-Ann Linkins Wael Abdelkader Andrew Beck Alexandria Bennett Sarah E Hughes Maureen Smith Mpho Begin Doug Coyle Thomas Piggott Benjamin M Kagina Vivian Welch Caroline Colijn David J D Earn Khaled El Emam Source Type: research
Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS
Semin Immunol. 2023 Sep 15;70:101842. doi: 10.1016/j.smim.2023.101842. Online ahead of print.ABSTRACTVaccines are among the greatest inventions in medicine, leading to the elimination or control of numerous diseases, including smallpox, polio, measles, rubella, and, most recently, COVID-19. Yet, the effectiveness of vaccines varies among individuals. In fact, while some recipients mount a robust response to vaccination that protects them from the disease, others fail to respond. Multiple clinical and epidemiological factors contribute to this heterogeneity in responsiveness. Systems immunology studies fueled by advances in...
Source: Seminars in Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Djamel Nehar-Belaid Mark Sokolowski Sathyabaarathi Ravichandran Jacques Banchereau Damien Chaussabel Duygu Ucar Source Type: research
Oxygen therapy in patients with intermediate-risk acute pulmonary embolism: a randomized trial
Chest. 2023 Sep 15:S0012-3692(23)05431-4. doi: 10.1016/j.chest.2023.09.007. Online ahead of print.ABSTRACTBACKGROUND: The effect of supplemental oxygen therapy in patients with intermediate-risk pulmonary embolism (PE) who do not have hypoxemia at baseline is uncertain.RESEARCH QUESTION: Does supplemental oxygen improve echocardiographic parameters in non-hypoxemic patients with intermediate-risk PE?STUDY DESIGN AND METHODS: This pilot trial randomly assigned non-hypoxemic patients with stable PE and echocardiographic right ventricle (RV) enlargement to receive anticoagulation plus supplemental oxygen for the first 48 hour...
Source: Chest - September 17, 2023 Category: Respiratory Medicine Authors: Deisy Barrios Diego Dur án Carmen Rodr íguez Jorge Mois és Ana Retegui Jos é Luis Lobo Raquel L ópez Leyre Chasco Luis Jara-Palomares Alfonso Muriel Remedios Otero-Candelera Pedro Ruiz-Artacho Manuel Monreal Behnood Bikdeli David Jim énez AIR invest Source Type: research
Resiliency of the comparative endocrinology community in the face of COVID-19
Gen Comp Endocrinol. 2023 Sep 15:114376. doi: 10.1016/j.ygcen.2023.114376. Online ahead of print.NO ABSTRACTPMID:37717790 | DOI:10.1016/j.ygcen.2023.114376
Source: General and Comparative Endocrinology - September 17, 2023 Category: Endocrinology Authors: James A Carr Breanna N Harris Source Type: research
Structure adaptation in Omicron SARS-CoV-2/hACE2: Biophysical origins of evolutionary driving forces
Biophys J. 2023 Sep 15:S0006-3495(23)00580-5. doi: 10.1016/j.bpj.2023.09.003. Online ahead of print.ABSTRACTSince its emergence, the COVID-19 threat has been sustained by a series of transmission waves initiated by new variants of the SARS-CoV-2 virus. Some of these arise with higher transmissivity and/or increased disease severity. Here we use molecular dynamics simulations to examine the modulation of the fundamental interactions between the receptor binding domain (RBD) of the spike glycoprotein and the host cell receptor (human angiotensin-converting enzyme 2: hACE2) arising from Omicron variant mutations (BA.1 and BA....
Source: Biophysical Journal - September 17, 2023 Category: Physics Authors: Ya-Wen Hsiao David J Bray Tseden Taddese Guadalupe Jim énez-Serratos Jason Crain Source Type: research
Targeting C5a is beneficial in critically ill COVID-19 patients
Immunobiology. 2023 Sep 12;228(6):152743. doi: 10.1016/j.imbio.2023.152743. Online ahead of print.NO ABSTRACTPMID:37717470 | DOI:10.1016/j.imbio.2023.152743
Source: Immunobiology - September 17, 2023 Category: Allergy & Immunology Authors: Endry H T Lim Alexander P J Vlaar Matthijs C Brouwer Diederik van de Beek Source Type: research
Increased nationwide use of green spaces in Norway during the COVID-19 pandemic
Environ Int. 2023 Sep 11;180:108190. doi: 10.1016/j.envint.2023.108190. Online ahead of print.ABSTRACTIn recent years, there has been growing concern about the decline in human green space use and nature-based recreation in Western countries. While some evidence suggests that the COVID-19 pandemic led to increased recreational mobility in urban green spaces, it is unclear whether the pandemic led to nationwide changes in green space use in both densely and less densely populated neighborhoods, as well as whether social inequalities in green space use were reinforced or attenuated by the pandemic. To address these questions...
Source: Environment International - September 17, 2023 Category: Environmental Health Authors: Vidar Sandsaunet Ulset Zander Venter Michal Koz ák Emma Charlott Andersson Nordb ø Tilmann von Soest Source Type: research
Regulation of SARS-CoV-2 infection and antiviral innate immunity by ubiquitination and ubiquitin-like conjugation
Biochim Biophys Acta Gene Regul Mech. 2023 Sep 15:194984. doi: 10.1016/j.bbagrm.2023.194984. Online ahead of print.ABSTRACTA global pandemic COVID-19 resulting from SARS-CoV-2 has affected a significant portion of the human population. Antiviral innate immunity is critical for controlling and eliminating the viral infection. Ubiquitination is extensively involved in antiviral signaling, and recent studies suggest that ubiquitin-like proteins (Ubls) modifications also participate in innate antiviral pathways such as RLR and cGAS-STING pathways. Notably, virus infection harnesses ubiquitination and Ubls modifications to faci...
Source: Biochimica et Biophysica Acta - September 17, 2023 Category: Biochemistry Authors: Yi Zheng Huiyu Yang Xuejing Zhang Chengjiang Gao Source Type: research
Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS
Semin Immunol. 2023 Sep 15;70:101842. doi: 10.1016/j.smim.2023.101842. Online ahead of print.ABSTRACTVaccines are among the greatest inventions in medicine, leading to the elimination or control of numerous diseases, including smallpox, polio, measles, rubella, and, most recently, COVID-19. Yet, the effectiveness of vaccines varies among individuals. In fact, while some recipients mount a robust response to vaccination that protects them from the disease, others fail to respond. Multiple clinical and epidemiological factors contribute to this heterogeneity in responsiveness. Systems immunology studies fueled by advances in...
Source: Seminars in Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Djamel Nehar-Belaid Mark Sokolowski Sathyabaarathi Ravichandran Jacques Banchereau Damien Chaussabel Duygu Ucar Source Type: research
Demographic and Geographic Characterization of Excess Mortality During the COVID-19 Pandemic in Baltimore City, MD, March 2020 - March 2021
Am J Epidemiol. 2023 Sep 15:kwad186. doi: 10.1093/aje/kwad186. Online ahead of print.ABSTRACTEstimates of excess mortality can provide insight into direct and indirect impacts of the COVID-19 pandemic beyond deaths specifically attributed to COVID-19. We analyzed death certificate data from Baltimore City, Maryland from March 1, 2020 to March 31, 2021 and found that 1,725 individuals (95% confidence interval, 1,495-1,954) died in excess of what was expected from all-cause mortality trends in 2016-2019. 1,050 (61%) excess deaths were attributed to COVID-19. Observed mortality was 23-32% higher than expected among individual...
Source: Am J Epidemiol - September 16, 2023 Category: Epidemiology Authors: Kyle T Aune Kyra H Grantz Neia Prata Menezes Katherine O Robsky Emily S Gurley Melissa A Marx Darcy F Phelan-Emrick Source Type: research
