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Infectious Disease: COVID-19

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Simultaneous Targeting of IL-1-Signaling and IL-6-Trans-Signaling Preserves Human Pulmonary Endothelial Barrier Function During a Cytokine Storm
CONCLUSIONS: These findings strongly suggest a major role for both IL-6 trans-signaling and IL-1β signaling in the pathological increase in permeability of the human lung microvasculature and reveal combinatorial strategies that enable the gradual control of pulmonary endothelial barrier function in response to a cytokine storm.PMID:37732482 | DOI:10.1161/ATVBAHA.123.319695
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 21, 2023 Category: Cardiology Authors: Natalia Col ás-Algora Pablo Mu ñoz-Pinillos Cristina Cacho-Navas Jos é Avendaño-Ortiz Gema de Rivas Susana Barroso Eduardo L ópez-Collazo Jaime Mill án Source Type: research

Dichlorodiphenyltrichloroethane for Malaria and Agricultural Uses and Its Impacts on Human Health
Bull Environ Contam Toxicol. 2023 Sep 20;111(4):45. doi: 10.1007/s00128-023-03789-3.ABSTRACTPesticides are widely used in agriculture and disease control, and dichlorodiphenyltrichloroethane (DDT) is one of the most used pesticides in human history. Besides its significant contributions in pest control in agriculture, DDT was credited as having saved millions of human lives for controlling malaria and other deadly insect-transmitted diseases. Even today, the use of DDT in some countries for malaria control cannot be replaced without endangering people who live there. The recent COVID-19 pandemic has changed our lives and r...
Source: Bulletin of Environmental Contamination and Toxicology - September 21, 2023 Category: Environmental Health Authors: Benjamin A Li Breanna M Li Zhenghong Bao Qingyang Li Malcolm Xing Bingyun Li Source Type: research

Sociodemographic Factors, Mental Health, and Emotional Eating Associated With Concern for COVID-19 Contagion in Nurses: A Cross-Sectional Study
CONCLUSION: These findings provide resources for future research on the comprehensive well-being of nursing staff by exploring various sociodemographic aspects and mental conditions associated with greater concern about COVID-19. Meanwhile, years of experience and emotional eating behavior were associated with lower concern about COVID-19. Future studies could incorporate this information to preserve the mental and physical health of nurses in the face of potential occupational threats.PMID:37731344 | DOI:10.1177/21501319231200400
Source: Primary Care - September 21, 2023 Category: Primary Care Authors: Yanela Ricalde-Castillo Milagros Celis-Mendoza Mardel Morales-Garc ía Salom ón Huancahuire-Vega Yaquelin E Calizaya-Milla Jacksaint Saintila Liset Z Sairitupa-Sanchez Sandra B Morales-Garc ía Wilter C Morales-Garc ía Source Type: research

A Comparison of the effect of patient-specific vs. weight-based protocols to treat vaso-occlusive episodes (VOE) in the emergency department
CONCLUSIONS: We found a shorter ED length of stay for patients assigned to a PSP. Patients in both groups experienced good pain relief without significant side effects.PMID:37731093 | DOI:10.1111/acem.14805
Source: Accident and Emergency Nursing - September 21, 2023 Category: Emergency Medicine Authors: Paula Tanabe Stephanie Ibemere Ava E Pierce Caroline E Freiermuth Hayden B Bosworth Hongqui Yang Ifeyinwa Osunkwo James H Paxton John J Strouse Joseph Miller Judith A Paice Padmaja Veeramreddy Patricia L Kavanagh R Gentry Wilkerson Robert Hughes Huiman X Source Type: research

Education and implementation of home spirometry in an adolescent cystic fibrosis population
CONCLUSION: Home spirometry, when properly implemented with structured education and active participant engagement, has potential to provide meaningful data and feedback to CF care teams. Implementation of this process requires substantial resources and active participation from an adolescent population who are at higher risk for non-adherence. Future studies are needed to determine the impact of home spirometry on clinical outcomes and reliability over time and to address barriers to consistent and enduring engagement in the adolescent population.PMID:37734233 | DOI:10.1016/j.resmer.2023.101040
Source: Respiratory Care - September 21, 2023 Category: Respiratory Medicine Authors: Sarah Schaffer Abigail Strang Ambika Shenoy Dawn Selhorst Aaron Chidekel Source Type: research

The influence of the COVID-19 pandemic on total hip and knee arthroplasty in Ontario: a population-level analysis
CONCLUSION: The effects of the COVID-19 pandemic on elective THA and TKA case volumes and wait times was significant. Patients having surgery during the pandemic were less medically complex, had shorter length of hospital stays and had significantly less health care utilization.PMID:37734851 | DOI:10.1503/cjs.016122
Source: Canadian Journal of Surgery - September 21, 2023 Category: Surgery Authors: Jhase Sniderman Amir Khoshbin Jesse Wolfstadt Source Type: research

Epidemiology of COVID 19-Associated Mucormycosis in the United States
Chest. 2023 Sep 19:S0012-3692(23)05512-5. doi: 10.1016/j.chest.2023.09.012. Online ahead of print.NO ABSTRACTPMID:37734565 | DOI:10.1016/j.chest.2023.09.012
Source: Chest - September 21, 2023 Category: Respiratory Medicine Authors: Aditya Sharma Aditi Sharma Ayman O Soubani Source Type: research

Can variants, reinfection, symptoms and test types affect COVID-19 diagnostic performance? A large-scale retrospective study of AG-RDTs during circulation of Delta and Omicron variants, Czechia, December 2021 to February 2022
ConclusionSensitivity for Omicron was lower in subgroups that may become more common if SARS-CoV-2 becomes an endemic virus.PMID:37733239 | DOI:10.2807/1560-7917.ES.2023.28.38.2200938
Source: Euro Surveill - September 21, 2023 Category: Infectious Diseases Authors: Tom áš Kliegr Ji ří Jarkovský Helena Ji řincová Jaroslav Kucha ř Tom áš Karel David Chud án Stanislav Voj íř Michal Zav řel Ond řej Šanca Ruth Tachezy Source Type: research

Surveillance of SARS-CoV-2 infection based on self-administered swabs, Denmark, May to July 2022: evaluation of a pilot study
ConclusionParticipants successfully performed self-swabs and answered symptom questionnaires. Also, WGS analysis of samples was possible. The system can support surveillance of respiratory pathogens and also holds potential as a diagnostic tool, easing access to test for at-risk groups, while also reducing the burden on healthcare system resources.PMID:37733236 | DOI:10.2807/1560-7917.ES.2023.28.38.2200907
Source: Euro Surveill - September 21, 2023 Category: Infectious Diseases Authors: Kamille Fogh Tine Graakj ær Larsen Cyril Jean-Marie Martel Frederik Trier M øller Lasse Skafte Vestergaard Ramona Trebbien Anne-Marie Vangsted Tyra Grove Krause Source Type: research

Continued challenges in pediatric anesthesia during COVID-19 in 2022: An international survey from the pediatric anesthesia COVID-19 collaborative
CONCLUSION: Our study found that COVID-19 has continued to impact pediatric anesthesiology. There are major discrepancies between what anesthesiologists believe are important for job satisfaction and faculty retention compared to implemented initiatives. Data from this survey provide insight for institutions and departments for addressing these challenges.PMID:37732382 | DOI:10.1111/pan.14762
Source: Paediatric Anaesthesia - September 21, 2023 Category: Anesthesiology Authors: John Zhong Victoria Bradford Allison M Fernandez Andrew Infosino Codruta N Soneru Steven J Staffa Vidya T Raman Joseph Cravero David Zurakowski Petra M Meier Pediatric Anesthesia COVID-19 Collaborative Source Type: research

Network pharmacology and molecular docking to scientifically validate the potential mechanism of Lonicerae japonicae flos in the clinical treatment of COVID-19
Nat Prod Res. 2023 Sep 21:1-8. doi: 10.1080/14786419.2023.2260070. Online ahead of print.ABSTRACTUsing network pharmacology and molecular docking, we predicted the potential mechanisms of Lonicerae japonicae flos (LJF) therapy for COVID-19. A total of 493 component-related targets and 6,233 COVID-19-related genes were identified, and 267 core genes with overlapping of the two types of genes were identified. The target AKT1, CASP3, IL1B, IL6, PTGS2, TNF and JUN were the hub genes in PPI network according to MCODE score. Component-Target analysis showed the close relationship between targets and components. The results of fu...
Source: Natural Product Research - September 21, 2023 Category: Biochemistry Authors: Yisheng Huang Yan Fang Huanhuan Jie Hongbiao Yang Wen Zhou Yijian Chen Baolin Zhong Source Type: research

Review: Factors influencing parents' decisions to vaccinate children against COVID-19
CONCLUSION: This review identified critical factors affecting parents' vaccination behavior for their children. Awareness of these factors may reduce parents' COVID-19 vaccine refusal for their children and guide future planning and development of public health studies.PMID:37735055 | DOI:10.1016/j.vaccine.2023.09.020
Source: Vaccine - September 21, 2023 Category: Allergy & Immunology Authors: Haifa S Alharbi Source Type: research

Nervous system-related tropism of SARS-CoV-2 and autoimmunity in COVID-19 infection
This article is protected by copyright. All rights reserved.PMID:37733584 | DOI:10.1002/eji.202250230
Source: European Journal of Immunology - September 21, 2023 Category: Allergy & Immunology Authors: Robert Weissert Source Type: research

Effects of low concentrations of ozone gas exposure on percutaneous oxygen saturation and inflammatory responses in a mouse model of Dermatophagoides farinae-induced asthma
Arch Toxicol. 2023 Sep 21. doi: 10.1007/s00204-023-03593-2. Online ahead of print.ABSTRACTOzone gas is widely used in hospitals as well as homes to control COVID-19 infection owing to its cost-effectiveness. Safety standard value and the tolerable value of ozone gas are set at 0.05 ppm and 0.1 ppm, respectively, in developed countries; however, this value was principally determined for healthy individuals, and the risks associated with ozone gas inhalation in patients with pulmonary diseases remains unknown. Recently, we demonstrated that 0.1 ppm ozone gas exposure significantly aggravates the symptoms of acute lung injury...
Source: Archives of Toxicology - September 21, 2023 Category: Toxicology Authors: Chiharu Ohira Kengo Tomita Mao Kaneki Naoki Iwashita Yoshiichi Takagi Takashi Kurihara Masaki Nagane Junichi Kamiie Tomoki Fukuyama Source Type: research