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Dose-Dependent Testicular Injury and Recovery after Total-Body Irradiation in Rhesus Monkeys
We examined the testes from 143 irradiated and control male rhesus monkeys, who were part of the Radiation Late Effects Cohort over a four-year period. Irradiated animals were exposed to doses ranging from 3.5 to 8.5 Gy of total-body irradiation. The testes were assessed using computed tomography (CT) volumetry, serum testosterone, and histology for deceased members of the cohort. Irradiated animals exhibited dose-dependent testicular atrophy as well as decreased serum testosterone during the winter breeding season when compared to age-matched unirradiated controls. No significant difference in summer testosterone levels w...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: George W Schaaf John D Olson Greg O Dugan Betsy A Pray Jacob A Cleary J Mark Cline Source Type: research
Improvement in Lung Clearance Index and Chest CT Scores with Elexacaftor/Tezacaftor/Ivacaftor Treatment in People with Cystic Fibrosis Aged 12 Years and Older - The RECOVER Study
CONCLUSIONS: ETI is associated with substantial improvements in LCI2.5, spirometry and PRAGMA-CF CT scores in people with CF aged 12 years and older. ETI led to improved nutrition and quality of life. People in the F508del/F508del group have significantly lower sweat chloride on ETI treatment compared to the F508del/MF group. Clinical trial registration available at www.CLINICALTRIALS: gov, ID: NCT04602468.PMID:37703083 | DOI:10.1164/rccm.202308-1317OC
Source: Am J Respir Crit Car... - September 13, 2023 Category: Intensive Care Authors: Paul McNally Karen Lester Gavin Stone Basil Elnazir Michael Williamson Des Cox Barry Linnane Laura Kirwan David Rea Paul O'Regan Tom Semple Clare Saunders Harm A W M Tiddens Edward McKone Jane C Davies Source Type: research
Value of PET imaging in head and neck cancer
HNO. 2023 Sep 13. doi: 10.1007/s00106-023-01354-2. Online ahead of print.ABSTRACTThe combination of positron-emission tomography (PET) with cross-sectional imaging in particular is becoming increasingly important in the diagnosis of head and neck tumors because, in addition to pure anatomy, the metabolic activity of tissue can be visualized and assessed. The combination of PET and computed tomography (CT) is already an established procedure in head and neck tumor patients in some indications, e.g., for primary tumor detection in cancer of unknown primary (CUP) syndrome or also after completed primary radio(chemo)therapy fo...
Source: Nuklearmedizin - September 13, 2023 Category: Radiology Authors: Julia P Lingl Felix B öhm Patrick J Schuler Thomas K Hoffmann Katharina Deininger Meinrad Beer Ambros J Beer Wolfgang Thaiss Source Type: research
Opportunities for prostate-specific membrane antigen hybrid imaging in prostate cancer
Urologie. 2023 Sep 13. doi: 10.1007/s00120-023-02189-z. Online ahead of print.ABSTRACTProstate-specific membrane antigen (PSMA) hybrid imaging is a promising new technique gaining importance in the field of prostate cancer (PCa) diagnosis and treatment planning. By combining PSMA radioligands and computed tomography (CT) or magnetic resonance imaging (MRI), PSMA hybrid imaging opens up new diagnostic opportunities. PSMA-PET/CT (PET: positron-emission tomography) is already well established in high-risk PCa for primary staging and tumor localization when biochemical recurrence occurs. Further potential indications for PSMA-...
Source: Nuklearmedizin - September 13, 2023 Category: Radiology Authors: Anna-Sophie Strau ß Christian Bolenz Ambros J Beer Friedemann Zengerling Meinrad Beer Jonathan Miksch Source Type: research
Miliary tuberculosis mimicking COVID-19 multisystemic inflammatory syndrome in children
We present the case of a 6-year-old girl with no remarkable history who had recurrent fever for 3 months. She was initially diagnosed with, and treated for, refractory multisystem inflammatory syndrome in children (MIS-C). When the study was extended to other differential diagnoses, thoraco-abdominopelvic computed tomography revealed miliary pulmonary nodules in addition to lymph nodes and spleen lesions. Magnetic resonance imaging of the brain revealed multiple tuberculomas. The tuberculin test results were positive. The course of the disease was favorable under quadruple therapy.PMID:37704522 | DOI:10.1016/j.arcped.2023.08.003
Source: Archives de Pediatrie - September 13, 2023 Category: Pediatrics Authors: Roeya Kolsi Mariem Ammar Lamia Sfaihi Fatma Charfi Ines Maaloul Thouraya Kammoun Source Type: research
Intravascular Ultrasound in Detection of Bridging Stent Graft Instability During Fenestrated and Branched Endovascular Aneurysm Repair Procedures: A Multicentre Study on 274 Target Vessels
CONCLUSION: This study suggests that IVUS is a safe and potentially valuable adjunct imaging technology for intra-operative detection of TVV instability. Further long term investigations on larger cohorts are required to validate these promising results and to compare IVUS with alternative technologies in terms of efficiency, radiation exposure, procedural time, and costs.PMID:37704100 | DOI:10.1016/j.ejvs.2023.09.009
Source: PubMed: Eur J Vasc Endovasc ... - September 13, 2023 Category: Surgery Authors: Giuseppe Asciutto Abdulhakim Ibrahim Nicola Leone Gennai Stefano Michele Piazza Michele Antonello Anders Wanhainen Kevin Mani David Lindstr öm Lisa Struk Alexander Oberhuber Source Type: research
Food texture and vitamin D influence mouse mandible form and molar roots
Anat Rec (Hoboken). 2023 Sep 13. doi: 10.1002/ar.25315. Online ahead of print.ABSTRACTIndustrialization influenced several facets of lifestyle, including softer nutrient-poor diets that contributed to vitamin D deficiency in post-industrzialized populations, with concomitantly increased dental problems. Here we simulated a post-industrialized diet in a mouse model to test the effects of diet texture and vitamin D level on mandible and third molar (M3) forms. Mice were raised on a soft diet with vitamin D (VitD) or without it (NoD), or on a hard diet with vitamin D. We hypothesized that a VitD/hard diet is optimal for norma...
Source: Anatomical Record - September 13, 2023 Category: Anatomy Authors: Elsa M Van Ankum Kadin B Majcher Allan T Dolovich James D Johnston Kennedy P Flegel Julia C Boughner Source Type: research
Improvement in Lung Clearance Index and Chest CT Scores with Elexacaftor/Tezacaftor/Ivacaftor Treatment in People with Cystic Fibrosis Aged 12 Years and Older - The RECOVER Study
CONCLUSIONS: ETI is associated with substantial improvements in LCI2.5, spirometry and PRAGMA-CF CT scores in people with CF aged 12 years and older. ETI led to improved nutrition and quality of life. People in the F508del/F508del group have significantly lower sweat chloride on ETI treatment compared to the F508del/MF group. Clinical trial registration available at www.CLINICALTRIALS: gov, ID: NCT04602468.PMID:37703083 | DOI:10.1164/rccm.202308-1317OC
Source: Respiratory Care - September 13, 2023 Category: Respiratory Medicine Authors: Paul McNally Karen Lester Gavin Stone Basil Elnazir Michael Williamson Des Cox Barry Linnane Laura Kirwan David Rea Paul O'Regan Tom Semple Clare Saunders Harm A W M Tiddens Edward McKone Jane C Davies Source Type: research
Dose-Dependent Testicular Injury and Recovery after Total-Body Irradiation in Rhesus Monkeys
We examined the testes from 143 irradiated and control male rhesus monkeys, who were part of the Radiation Late Effects Cohort over a four-year period. Irradiated animals were exposed to doses ranging from 3.5 to 8.5 Gy of total-body irradiation. The testes were assessed using computed tomography (CT) volumetry, serum testosterone, and histology for deceased members of the cohort. Irradiated animals exhibited dose-dependent testicular atrophy as well as decreased serum testosterone during the winter breeding season when compared to age-matched unirradiated controls. No significant difference in summer testosterone levels w...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: George W Schaaf John D Olson Greg O Dugan Betsy A Pray Jacob A Cleary J Mark Cline Source Type: research
Does unenhanced computerized tomography as imaging standard post-retrograde intrarenal surgery paradoxically reduce stone-free rate and increase additional treatment for residual fragments? Outcomes from 5395 patients in the FLEXOR study by the TOWER group
CONCLUSIONS: CT is the only reliable imaging to assess the burden of RFs following RIRS and urologist should consider at least one CT scan to determine the same and definitely plan reintervention only based on CT rather than ultrasound and X-ray combination.PMID:37701535 | PMC:PMC10493056 | DOI:10.1177/17562872231198629
Source: Adv Data - September 13, 2023 Category: Epidemiology Authors: Vineet Gauhar Daniele Castellani Ben Hall Chew Daron Smith Chu Ann Chai Khi Yung Fong Jeremy Yuen-Chun Teoh Olivier Traxer Bhaskar Kumar Somani Thomas Tailly Source Type: research
Nondeformed Ultrasound Image Production Method for Ultrasound-Guided Radiotherapy
Conclusion: The pixel displacement-based deformation correction method can solve the limitation imposed by image deformation on image alignment in US-guided radiotherapy. Compared with USdef, the alignment results of USrev with CT were better.PMID:37700675 | PMC:PMC10501062 | DOI:10.1177/15330338231194546
Source: Technology in Cancer Research and Treatment - September 13, 2023 Category: Cancer & Oncology Authors: Qixuan Li Fan Zhang Qianyi Xi Zhuqing Jiao Xinye Ni Source Type: research
Value of PET imaging in head and neck cancer
HNO. 2023 Sep 13. doi: 10.1007/s00106-023-01354-2. Online ahead of print.ABSTRACTThe combination of positron-emission tomography (PET) with cross-sectional imaging in particular is becoming increasingly important in the diagnosis of head and neck tumors because, in addition to pure anatomy, the metabolic activity of tissue can be visualized and assessed. The combination of PET and computed tomography (CT) is already an established procedure in head and neck tumor patients in some indications, e.g., for primary tumor detection in cancer of unknown primary (CUP) syndrome or also after completed primary radio(chemo)therapy fo...
Source: Nuklearmedizin - September 13, 2023 Category: Radiology Authors: Julia P Lingl Felix B öhm Patrick J Schuler Thomas K Hoffmann Katharina Deininger Meinrad Beer Ambros J Beer Wolfgang Thaiss Source Type: research
Opportunities for prostate-specific membrane antigen hybrid imaging in prostate cancer
Urologie. 2023 Sep 13. doi: 10.1007/s00120-023-02189-z. Online ahead of print.ABSTRACTProstate-specific membrane antigen (PSMA) hybrid imaging is a promising new technique gaining importance in the field of prostate cancer (PCa) diagnosis and treatment planning. By combining PSMA radioligands and computed tomography (CT) or magnetic resonance imaging (MRI), PSMA hybrid imaging opens up new diagnostic opportunities. PSMA-PET/CT (PET: positron-emission tomography) is already well established in high-risk PCa for primary staging and tumor localization when biochemical recurrence occurs. Further potential indications for PSMA-...
Source: Nuklearmedizin - September 13, 2023 Category: Radiology Authors: Anna-Sophie Strau ß Christian Bolenz Ambros J Beer Friedemann Zengerling Meinrad Beer Jonathan Miksch Source Type: research
Benefits and drawbacks of CT scan as a triple rule-out exam in acute chest pain to exclude acute coronary syndrome, pulmonary embolism and aortic dissection
Ann Cardiol Angeiol (Paris). 2023 Sep 11;72(5):101641. doi: 10.1016/j.ancard.2023.101641. Online ahead of print.ABSTRACTChest pain is one of the major causes for admission in the Emergency Room in most countries and one of the principal reasons for urgent consultation with a cardiologist or a general practitioner. After clinical examination and initial biological measurements, substantial patients require further explorations. CT scan allows the search for pulmonary embolism in the early stage of pulmonary arteries iodine contrast exploration. During the same exam at the systemic arterial phase, the search for aortic disse...
Source: Annales de Cardiologie et d'Angeiologie - September 13, 2023 Category: Cardiology Authors: Adrien Pasteur-Rousseau Karam Souibri David Fouassier Benjamin Mehier Tatiana Wong Jean-Fran çois Paul Source Type: research
Intravascular Ultrasound in Detection of Bridging Stent Graft Instability During Fenestrated and Branched Endovascular Aneurysm Repair Procedures: A Multicentre Study on 274 Target Vessels
CONCLUSION: This study suggests that IVUS is a safe and potentially valuable adjunct imaging technology for intra-operative detection of TVV instability. Further long term investigations on larger cohorts are required to validate these promising results and to compare IVUS with alternative technologies in terms of efficiency, radiation exposure, procedural time, and costs.PMID:37704100 | DOI:10.1016/j.ejvs.2023.09.009
Source: PubMed: Eur J Vasc Endovasc ... - September 13, 2023 Category: Surgery Authors: Giuseppe Asciutto Abdulhakim Ibrahim Nicola Leone Gennai Stefano Michele Piazza Michele Antonello Anders Wanhainen Kevin Mani David Lindstr öm Lisa Struk Alexander Oberhuber Source Type: research
