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Value of PET imaging in head and neck cancer
HNO. 2023 Sep 13. doi: 10.1007/s00106-023-01354-2. Online ahead of print.ABSTRACTThe combination of positron-emission tomography (PET) with cross-sectional imaging in particular is becoming increasingly important in the diagnosis of head and neck tumors because, in addition to pure anatomy, the metabolic activity of tissue can be visualized and assessed. The combination of PET and computed tomography (CT) is already an established procedure in head and neck tumor patients in some indications, e.g., for primary tumor detection in cancer of unknown primary (CUP) syndrome or also after completed primary radio(chemo)therapy fo...
Source: Nuklearmedizin - September 13, 2023 Category: Radiology Authors: Julia P Lingl Felix B öhm Patrick J Schuler Thomas K Hoffmann Katharina Deininger Meinrad Beer Ambros J Beer Wolfgang Thaiss Source Type: research

Opportunities for prostate-specific membrane antigen hybrid imaging in prostate cancer
Urologie. 2023 Sep 13. doi: 10.1007/s00120-023-02189-z. Online ahead of print.ABSTRACTProstate-specific membrane antigen (PSMA) hybrid imaging is a promising new technique gaining importance in the field of prostate cancer (PCa) diagnosis and treatment planning. By combining PSMA radioligands and computed tomography (CT) or magnetic resonance imaging (MRI), PSMA hybrid imaging opens up new diagnostic opportunities. PSMA-PET/CT (PET: positron-emission tomography) is already well established in high-risk PCa for primary staging and tumor localization when biochemical recurrence occurs. Further potential indications for PSMA-...
Source: Nuklearmedizin - September 13, 2023 Category: Radiology Authors: Anna-Sophie Strau ß Christian Bolenz Ambros J Beer Friedemann Zengerling Meinrad Beer Jonathan Miksch Source Type: research

Benefits and drawbacks of CT scan as a triple rule-out exam in acute chest pain to exclude acute coronary syndrome, pulmonary embolism and aortic dissection
Ann Cardiol Angeiol (Paris). 2023 Sep 11;72(5):101641. doi: 10.1016/j.ancard.2023.101641. Online ahead of print.ABSTRACTChest pain is one of the major causes for admission in the Emergency Room in most countries and one of the principal reasons for urgent consultation with a cardiologist or a general practitioner. After clinical examination and initial biological measurements, substantial patients require further explorations. CT scan allows the search for pulmonary embolism in the early stage of pulmonary arteries iodine contrast exploration. During the same exam at the systemic arterial phase, the search for aortic disse...
Source: Annales de Cardiologie et d'Angeiologie - September 13, 2023 Category: Cardiology Authors: Adrien Pasteur-Rousseau Karam Souibri David Fouassier Benjamin Mehier Tatiana Wong Jean-Fran çois Paul Source Type: research

Value of PET imaging in head and neck cancer
HNO. 2023 Sep 13. doi: 10.1007/s00106-023-01354-2. Online ahead of print.ABSTRACTThe combination of positron-emission tomography (PET) with cross-sectional imaging in particular is becoming increasingly important in the diagnosis of head and neck tumors because, in addition to pure anatomy, the metabolic activity of tissue can be visualized and assessed. The combination of PET and computed tomography (CT) is already an established procedure in head and neck tumor patients in some indications, e.g., for primary tumor detection in cancer of unknown primary (CUP) syndrome or also after completed primary radio(chemo)therapy fo...
Source: Nuklearmedizin - September 13, 2023 Category: Radiology Authors: Julia P Lingl Felix B öhm Patrick J Schuler Thomas K Hoffmann Katharina Deininger Meinrad Beer Ambros J Beer Wolfgang Thaiss Source Type: research

Opportunities for prostate-specific membrane antigen hybrid imaging in prostate cancer
Urologie. 2023 Sep 13. doi: 10.1007/s00120-023-02189-z. Online ahead of print.ABSTRACTProstate-specific membrane antigen (PSMA) hybrid imaging is a promising new technique gaining importance in the field of prostate cancer (PCa) diagnosis and treatment planning. By combining PSMA radioligands and computed tomography (CT) or magnetic resonance imaging (MRI), PSMA hybrid imaging opens up new diagnostic opportunities. PSMA-PET/CT (PET: positron-emission tomography) is already well established in high-risk PCa for primary staging and tumor localization when biochemical recurrence occurs. Further potential indications for PSMA-...
Source: Nuklearmedizin - September 13, 2023 Category: Radiology Authors: Anna-Sophie Strau ß Christian Bolenz Ambros J Beer Friedemann Zengerling Meinrad Beer Jonathan Miksch Source Type: research

Dose-Dependent Testicular Injury and Recovery after Total-Body Irradiation in Rhesus Monkeys
We examined the testes from 143 irradiated and control male rhesus monkeys, who were part of the Radiation Late Effects Cohort over a four-year period. Irradiated animals were exposed to doses ranging from 3.5 to 8.5 Gy of total-body irradiation. The testes were assessed using computed tomography (CT) volumetry, serum testosterone, and histology for deceased members of the cohort. Irradiated animals exhibited dose-dependent testicular atrophy as well as decreased serum testosterone during the winter breeding season when compared to age-matched unirradiated controls. No significant difference in summer testosterone levels w...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: George W Schaaf John D Olson Greg O Dugan Betsy A Pray Jacob A Cleary J Mark Cline Source Type: research

Value of PET imaging in head and neck cancer
HNO. 2023 Sep 13. doi: 10.1007/s00106-023-01354-2. Online ahead of print.ABSTRACTThe combination of positron-emission tomography (PET) with cross-sectional imaging in particular is becoming increasingly important in the diagnosis of head and neck tumors because, in addition to pure anatomy, the metabolic activity of tissue can be visualized and assessed. The combination of PET and computed tomography (CT) is already an established procedure in head and neck tumor patients in some indications, e.g., for primary tumor detection in cancer of unknown primary (CUP) syndrome or also after completed primary radio(chemo)therapy fo...
Source: Nuklearmedizin - September 13, 2023 Category: Radiology Authors: Julia P Lingl Felix B öhm Patrick J Schuler Thomas K Hoffmann Katharina Deininger Meinrad Beer Ambros J Beer Wolfgang Thaiss Source Type: research

Opportunities for prostate-specific membrane antigen hybrid imaging in prostate cancer
Urologie. 2023 Sep 13. doi: 10.1007/s00120-023-02189-z. Online ahead of print.ABSTRACTProstate-specific membrane antigen (PSMA) hybrid imaging is a promising new technique gaining importance in the field of prostate cancer (PCa) diagnosis and treatment planning. By combining PSMA radioligands and computed tomography (CT) or magnetic resonance imaging (MRI), PSMA hybrid imaging opens up new diagnostic opportunities. PSMA-PET/CT (PET: positron-emission tomography) is already well established in high-risk PCa for primary staging and tumor localization when biochemical recurrence occurs. Further potential indications for PSMA-...
Source: Nuklearmedizin - September 13, 2023 Category: Radiology Authors: Anna-Sophie Strau ß Christian Bolenz Ambros J Beer Friedemann Zengerling Meinrad Beer Jonathan Miksch Source Type: research

Dose-Dependent Testicular Injury and Recovery after Total-Body Irradiation in Rhesus Monkeys
We examined the testes from 143 irradiated and control male rhesus monkeys, who were part of the Radiation Late Effects Cohort over a four-year period. Irradiated animals were exposed to doses ranging from 3.5 to 8.5 Gy of total-body irradiation. The testes were assessed using computed tomography (CT) volumetry, serum testosterone, and histology for deceased members of the cohort. Irradiated animals exhibited dose-dependent testicular atrophy as well as decreased serum testosterone during the winter breeding season when compared to age-matched unirradiated controls. No significant difference in summer testosterone levels w...
Source: Radiation Research - September 13, 2023 Category: Physics Authors: George W Schaaf John D Olson Greg O Dugan Betsy A Pray Jacob A Cleary J Mark Cline Source Type: research

Association of oxidized ApoB and oxidized ApoA-I with high-risk coronary plaque features in cardiovascular disease
CONCLUSION: Our findings suggest that the investigated OMLs are associated with high-risk coronary plaque features and progression over time in CVD patients.TRIAL REGISTRATION: URL: https://www.CLINICALTRIALS: gov. Unique identifier: NCT01621594.FUNDING: This work was supported by the National Heart, Lung and Blood Institute (NHLBI) at the National Institutes of Health Intramural Research Program. The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript f...
Source: Atherosclerosis - September 12, 2023 Category: Cardiology Authors: Alexander V Sorokin Christin G Hong Angel M Aponte Elizabeth M Florida Jingrong Tang Nidhi Patel Irina N Baranova Haiou Li Philip M Parel Vicky Chen Sierra R Wilson Emily L Ongstad Anna Coll én Martin P Playford Thomas L Eggerman Marcus Y Chen Kazuhiko K Source Type: research

Leukemic-phase mucosa-associated lymphoid tissue lymphoma
Int J Hematol. 2023 Sep 12. doi: 10.1007/s12185-023-03654-3. Online ahead of print.ABSTRACTA 78-year-old man presenting with leukocytosis was admitted to our hospital. The patient was asymptomatic and showed no lymphadenopathy. Peripheral blood flow cytometry revealed a leukemic-phase B-cell lymphoma with medium-to-large abnormal cells with reticulum. Positron emission tomography/computed tomography revealed abnormal uptake in the right orbit, bone marrow, and spleen. We performed immunological staining and fluorescence in situ hybridization on tissues extracted from the right orbit and bone marrow, which led to the diagno...
Source: International Journal of Hematology - September 12, 2023 Category: Hematology Authors: Takayuki Yotsuyanagi Naoto Tomita Yusuke Saiki Akiko Uchida Yu Uemura Yoshinori Suzuki Tsuneaki Hirakawa Masayuki Kato Naoya Nakamura Ayako Arai Source Type: research

The potential role of osteoporosis in unspecific < sup > 18 < /sup > FPSMA-1007 bone uptake
CONCLUSIONS: We observed unspecific bone uptake on [18F]PSMA-1007 PET in more than 1/3 of patients. In this exploratory analysis, we found a significant correlation between blood count parameters and unspecific [18F]PSMA-1007 bone uptake. We may speculate that [18F]PSMA-1007 unspecific bone uptake could be associated with osteoporosis. This hypothesis needs to be further investigated in larger populations and exploring more specific markers of osteoporosis.PMID:37698646 | DOI:10.1007/s00259-023-06424-9
Source: Molecular Medicine - September 12, 2023 Category: Molecular Biology Authors: Gaia Ninatti Cristiano Pini Fabrizia Gelardi Samuele Ghezzo Paola Mapelli Maria Picchio Lidija Antunovic Alberto Briganti Francesco Montorsi Claudio Landoni Martina Sollini Arturo Chiti Source Type: research