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Hopeful Cord Blood Treatment for Multiple Sclerosis
Multiple Sclerosis (MS) is a disabling disease of the central nervous system that disrupts the flow of information within the brain, and between the brain and body.
Our central nervous system is covered in myelin, a “fatty white substance” that surrounds and protects the nerve fibers that are responsible for transmitting information to the brain, spinal cord, and the rest of the body. Multiple sclerosis attacks and destroys the myelin and as these nerve cells deteriorate, symptoms of MS such as “numbness, loss of vision, fatigue and tremors” start to occur.
There are different phases or “courses” of MS most oft...
Source: Cord Blood News - July 24, 2017 Category: Perinatology & Neonatology Authors: Maze Cord Blood Tags: Cord Blood medical research stem cells multiple sclerosis Source Type: blogs
Diagnostic evaluation of dysphagia in multiple sclerosis patients using a Persian version of DYMUS questionnaire
Conclusion The oropharyngeal dysphagia in MS patients is very common even in early stages of the disease; therefore, it is important to assess these patients carefully and to initiate a treatment program if needed.
Source: Multiple Sclerosis and Related Disorders - September 2, 2017 Category: Neurology Source Type: research
Next: Brain scans to identify children at high risk of developing multiple sclerosis (MS) before symptoms appear
Conclusions: We describe the clinical characteristics and outcomes of children with incidental MRI findings highly suggestive of CNS demyelination. Children with RIS had a substantial risk of subsequent clinical symptoms and/or radiologic evolution. The presence of oligoclonal bands in CSF and spinal cord lesions on MRI were associated with an increased risk of a first clinical event.
News in Context
Next: Harnessing brain scans to personalize autism-related behavioral interventions
Can brain scans identify ADHD and help predict treatment response?
Brain waves help predict stress-related sleep problems
Cognitive therapy ...
Source: SharpBrains - October 18, 2017 Category: Neuroscience Authors: SharpBrains Tags: Cognitive Neuroscience Health & Wellness Technology brain changes brain-scans clinical headache MRI MS multiple-sclerosis radiologic radiologically isolated syndrome RIS Source Type: blogs
Epidemiological and clinical characteristics of multiple sclerosis in paediatric population in Slovenia: A descriptive nation-wide study
Conclusion The clinical pattern of pMS in our cohort of patients was characterized by polysymptomatic presentation and predominantly sensory symptoms at onset, developing a relapsing-remitting pMS pattern. It is important to gather more information about the incidence of pMS and its initial presentation and clinical course to improve early recognition and appropriate initiation of immunomodulatory treatment.
Source: Multiple Sclerosis and Related Disorders - November 12, 2017 Category: Neurology Source Type: research
Predicting Falls in Multiple Sclerosis: Do Electrophysiological measures have a better predictive accuracy compared to clinical measures? To be published in: Multiple Sclerosis and Related Disorders
Conclusion P13, N10 and P37 latencies were the most accurate in predicting a future fall when compared to clinical measures.
Source: Multiple Sclerosis and Related Disorders - February 2, 2018 Category: Neurology Source Type: research
Evolution of Visual Outcomes in Clinical Trials for Multiple Sclerosis Disease-Modifying Therapies
Conclusions:
Visual impairment represents a significant component of overall disability in MS. LCLA and OCT enhance the detection of visual pathway injury and can be used as measures of axonal and neuronal integrity. Continued investigation is ongoing to further incorporate these vision-based assessments into clinical trials of MS therapies.
Source: Journal of Neuro-Ophthalmology - May 18, 2018 Category: Opthalmology Tags: Disease of the Year: Multiple Sclerosis Source Type: research
Hypothesis: Multiple Sclerosis is caused by three-hits, strictly in order, in genetically susceptible persons
Publication date: Available online 4 July 2018 Source:Multiple Sclerosis and Related Disorders Author(s): Patrick K A Kearns, Helen A Casey, John Paul Leach Multiple Sclerosis is a chronic, progressive and debilitating neurological disease which, despite extensive study for over 100 years, remains of enigmatic aetiology. Drawn from the epidemiological evidence, there exists a consensus that there are environmental (possibly infectious) factors that contribute to disease pathogenesis that have not yet been fully elucidated. Here we propose a three-tiered hypothesis: 1) a clinic-epidemiological model of multiple sclerosis a...
Source: Multiple Sclerosis and Related Disorders - July 5, 2018 Category: Neurology Source Type: research
Coping strategies and quality of life in Mexican Multiple Sclerosis patients: physical, psychological and social factors relationship
CONCLUSIONThe use of positive coping strategies in conjunction with a suitable psycho-social environment and good physical health result in a better perception of QoL in Mexican patients living with MS. Still, the negative factors are ineffectively diagnosed and hence generally under treated in medical MS monitoring. An interdisciplinary evaluation will provide the adequate tools to confront the diagnosis and the uncertainty of multiple sclerosis evolution, benefiting the QoL of Mexican patients with MS.
Source: Multiple Sclerosis and Related Disorders - July 5, 2018 Category: Neurology Source Type: research
Epidemiology of Multiple Sclerosis in Northeast of Iran during 1985-2016; Conversion of a Rare Disease to a Middle-high Prevalence Disease
Publication date: Available online 7 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Vahid Kazemi Moghaddam, Mohammad Sarmadi, Maryam Tatari, Fereshteh Najafi, Amir Esmaeili, Mostafa HadeiAbstractMany researchers believed that the risk of multiple sclerosis (MS) is associated with latitude gradient. Due to the increasing prevalence of MS in some areas around the equator such as Iran, this theory has been criticized in recent years. Since the distribution of multiple sclerosis in Iran is not uniform, this study was designed to describe the prevalence and incidence of MS in Northeastern area of Iran.The p...
Source: Multiple Sclerosis and Related Disorders - July 8, 2018 Category: Neurology Source Type: research
Coping strategies and quality of life in Mexican Multiple Sclerosis patients: physical, psychological and social factors relationship
CONCLUSIONThe use of positive coping strategies in conjunction with a suitable psycho-social environment and good physical health result in a better perception of QoL in Mexican patients living with MS. Still, the negative factors are ineffectively diagnosed and hence generally under treated in medical MS monitoring. An interdisciplinary evaluation will provide the adequate tools to confront the diagnosis and the uncertainty of multiple sclerosis evolution, benefiting the QoL of Mexican patients with MS.
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research
Oligoclonal bands in multiple sclerosis; functional significance and therapeutic implications. Does the specificity matter?
Publication date: Available online 20 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Gareth Pryce, David BakerAbstractSince their discovery, the existence of secreted oligoclonal immunoglobulin in the central nervous system in people with multiple sclerosis has been the subject of scientific investigation and debate over several decades. Although autoantibodies can be detected in some individuals, probably secondary to release of neo-antigens after damage, evidence for a major, primary involvement of damaging antibodies is still relatively lacking. However it is possible to construct a working hypothes...
Source: Multiple Sclerosis and Related Disorders - July 20, 2018 Category: Neurology Source Type: research
Metabolomic profile of insulin resistance in patients with multiple sclerosis is associated to the severity of the disease
ConclusionInsulin resistance is frequent in patients with multiple sclerosis and might contribute to metabolic complications and general disability. Early markers of dysglycemia should be sought for in these patients to avoid additional deterioration of their quality of life.
Source: Multiple Sclerosis and Related Disorders - August 26, 2018 Category: Neurology Source Type: research
Bacterial and CMV pneumonia in a patient treated with alemtuzumab for multiple sclerosis
We describe the case of a patient that developed both viral (CMV) and bacterial pneumonia one month after alemtuzumab infusion for multiple sclerosis. Physicians dealing with this drug should be aware of this serious but treatable complication.
Source: Multiple Sclerosis and Related Disorders - October 5, 2018 Category: Neurology Source Type: research
Erythema Nodosum in A Patient With Multiple Sclerosis on Dimethyl Fumarate
Publication date: Available online 25 December 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Hussein Algahtani, Bader Shirah, Siham Marghalani, Ayed AlgarniAbstractErythema nodosum is an uncommon cutaneous hypersensitivity reaction characterized by tender round slightly raised red nodules that become bruise-like and then resolve without scarring. It may be caused by infections, pregnancy, malignancy, systemic illnesses, or idiopathic. Several drugs have been reported in association with erythema nodosum including oral contraceptive pills, penicillin, and sulphonamides. Glatiramer acetate is the only medica...
Source: Multiple Sclerosis and Related Disorders - December 25, 2018 Category: Neurology Source Type: research
